Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 19, 2002, Pages 12037-12042

  Huai, Qing ^a   Kim, Hwa Young ^a   Liu, Yudong ^a   Zhao, Yingdong ^a,c   Mondragon, Angelo ^b,d   Liu, Jun O ^b   Ke, Hengming ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

FK506; FK506 binding protein; Immunosuppressants; Protein phosphatase; T cell

Indexed keywords

ARGININE; CALCINEURIN; CYCLOPHILIN; CYCLOPHILIN A; CYCLOSPORIN; CYCLOSPORIN A; FK 506 BINDING PROTEIN; IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; PROTEIN SUBUNIT; TACROLIMUS;

ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; SURFACE PROPERTY; T LYMPHOCYTE;

CALCINEURIN; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLOPHILIN A; CYCLOSPORINE; ELECTROSTATICS; HUMANS; IMMUNOPHILINS; IMMUNOSUPPRESSIVE AGENTS; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; TACROLIMUS; TACROLIMUS BINDING PROTEINS;

EID: 0037126026     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.192206699     Document Type: Article

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