Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues

Chemistry - A European Journal

Volumn 10, Issue 11, 2004, Pages 2759-2780

  Bialy, Laurent ^a,b   Waldmann, Herbert ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

Author keywords

Cytostatin; Natural products; Phosphorylation; Protein phosphatases; Total synthesis

Indexed keywords

ALKYLATION; REDUCTION; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

ABSOLUTE CONFIGURATIONS; CYTOSTATIN;

ENZYMES;

CYTOSTATIN DERIVATIVE; FOSTRIECIN; HEXESTROL DIPHOSPHATE; NATURAL PRODUCT; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; TRIETHYLAMMONIUM 2 CYANOETHYL [3 HYDROXY 2 METHYL 1 [3 (3 METHYL 6 OXO 3,6 DIHYDRO 2H PYRAN 2 YL)BUTYL]PENT 4 YNYL]PHOSPHATE; TRIETHYLAMMONIUM HYDROGEN [3 HYDROXY 2 METHYL 1 [3 (3 METHYL 6 OXO 3,6 DIHYDRO 2H PYRAN 2YL)BUTYL]PENT 4 YNYL]PHOSPHATE; TRIETHYLAMMONIUM HYDROGEN [3 HYDROXY 5 IODO 2 METHYL 1 [3 (3 METHYL 6 OXO 3,6 DIHYDRO 2H PYRAN 2 YL)BUTYL]PENT 4 ENYL]PHOSPHATE; TRIETHYLAMMONIUM HYDROGEN [3 HYDROXY 5 IODO 2 METHYL 1 [3 (3 METHYL 6 OXO 3,6 DIHYDRO 2H PYRAN 2 YL)BUTYL]PENT 4 YNYL]PHOSPHATE; TRIETHYLAMMONIUM HYDROGEN [3 HYDROXY 5 IODO 2 METHYL 1 [3 (3 METHYL 6 OXO TETRAHYDRO PYRAN 2 YL)BUTYL]PENT 4 ENYL]PHOSPHATE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; METASTASIS INHIBITION; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ENZYME INHIBITORS; MOLECULAR CONFORMATION; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORIC ACID ESTERS; PHOSPHORIC MONOESTER HYDROLASES; PYRONES; STEREOISOMERISM;

EID: 3042663533     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200305543     Document Type: Article

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