Small-molecule inhibitors of ser/thr protein phosphatases: Specificity, use and common forms of abuse

Methods in Molecular Biology

Volumn 365, Issue , 2007, Pages 23-38

  Swingle, Mark ^a   Ni, Li ^a   Honkanen, Richard E ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

calyculin A; cantharidin; fostriecin; microcystin; natural products; Okadaic acid; protein phosphatase inhibitors

Indexed keywords

COLEOPTERA; CYANOBACTERIA; DINOPHYSIS; MELOIDAE; MICROCYSTIS; MICROCYSTIS SP.; NODULARIA; PROROCENTRUM; STREPTOMYCES; STREPTOMYCES SP.;

CALYCULIN A; CANTHARIDIN; CYANOGINOSIN; CYCLOPEPTIDE; ENZYME INHIBITOR; FURAN DERIVATIVE; HEXESTROL DIPHOSPHATE; INDOLE ALKALOID; LACTONE; LIPID; NODULARIN; OKADAIC ACID; ORGANOPHOSPHATE; ORGANOPHOSPHORUS COMPOUND; OXAZOLE DERIVATIVE; PHOSPHOLINE; PHOSPHOPROTEIN PHOSPHATASE; PYRAN DERIVATIVE; PYRONE DERIVATIVE; SPIRO COMPOUND; TAUTOMYCETIN; TAUTOMYCIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG ANTAGONISM;

CANTHARIDIN; ENZYME INHIBITORS; FURANS; INDOLE ALKALOIDS; LACTONES; LIPIDS; MICROCYSTINS; OKADAIC ACID; ORGANOPHOSPHORUS COMPOUNDS; OXAZOLES; PEPTIDES, CYCLIC; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORIC ACID ESTERS; PYRANS; PYRONES; SPIRO COMPOUNDS;

EID: 34447275978     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1385/1-59745-267-X:23     Document Type: Article

References (10)

1. Bialojan, C. and Takai, A. (1988) Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. Biochem. J. 256, 283-290.
2. Honkanen, R. E. and Golden, T. (2002) Regulators of serine/threonine protein phosphatases at the dawn of a clinical era? Curr. Med. Chem. 9, 2055-2075. (Pubitemid 35256504)
3. Sakoff J. A. and McCluskey, A. (2004) Protein phosphatase inhibition: structure based design. Towards new therapeutic agents. Curr. Pharm. Des. 10, 1139-1159. (Pubitemid 38425896)
4. Buck, S. B., Hardouin, C., Ichikawa, S., et al. (2003) Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition. J. Am. Chem. Soc. 125, 15,694-15,695. (Pubitemid 37553657)
5. Lewy, D. S., Gauss, C. M., Soenen D. R., and Boger, D. L. (2002) Fostriecin: chemistry and biology. Curr. Med. Chem. 9, 2005-2032. (Pubitemid 35256502)
6. Ichinose, M., Endo, S., Critz, S. D., Shenolikar, S., and Byrne, J. H. (1990) Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotoninand cAMP-induced currents in sensory neurons of Aplysia californica. Brain Res. 533, 137-140. (Pubitemid 20375809)
7. Fry, D. W., Besserer, J. A., and Boritzki, T. J. (1984) Transport of the antitumor antibiotic Cl-920 into L1210 leukemia cells by the reduced folate carrier system. Cancer Res. 44, 3366-3370. (Pubitemid 14098583)
8. Favre, B., Turowski P., and Hemmings, B. A. (1997) Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J. Biol. Chem. 272, 13,856-13,863. (Pubitemid 27224826)
9. Golden, T. A. and Honkanen, R. E. (2003) Regulating the expression of protein phosphatase type 5. Methods Enzymol. 366, 372-930.
10. Killilea, S. D., Mellgren, R. L., Aylward, J. H., and Lee, E. Y. (1978) Inhibition of phosphorylase phosphatase by polyamines. Biochem. Biophys. Res. Commun. 81, 1040-1046. (Pubitemid 8322561)