메뉴 건너뛰기




Volumn 10, Issue 6, 2010, Pages 341-353

Strategizing the clone wars: Pharmacological control of cellular sensitivity to radiation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMETABOLITE; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROURACIL; GEFITINIB; GEMCITABINE; IRINOTECAN; LAPATINIB; MERCAPTOPURINE; METHOTREXATE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OXALIPLATIN; PACLITAXEL; PEMETREXED; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TEMOZOLOMIDE; TOPOTECAN; TRASTUZUMAB; VORINOSTAT;

EID: 79551468957     PISSN: 15340384     EISSN: 15432548     Source Type: Journal    
DOI: 10.1124/mi.10.6.3     Document Type: Review
Times cited : (7)

References (114)
  • 1
    • 0034681783 scopus 로고    scopus 로고
    • Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data
    • MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer
    • Pignon JP, Bourhis J, Domenge C, and Designe L (2000) Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet 355:949-955.
    • (2000) Lancet , vol.355 , pp. 949-955
    • Pignon, J.P.1    Bourhis, J.2    Domenge, C.3    Designe, L.4
  • 2
    • 0000278788 scopus 로고    scopus 로고
    • Epidermoid anal cancer: Results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin
    • Anonymous UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research
    • Anonymous (1996) Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research. Lancet 348:1049-1054.
    • (1996) Lancet , vol.348 , pp. 1049-1054
  • 5
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-Year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, et al. (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10:459-466.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    Van Den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6    Ludwin, S.K.7    Allgeier, A.8    Fisher, B.9    Belanger, K.10
  • 6
    • 1842394157 scopus 로고
    • Fluorinated pyrimidines. VI. Effects of 5-fluorouridine and 5-fluoro-2′-deoxyuridine on transplanted tumors
    • Heidelberger C, Griesbach L, Cruz O, Schnitzer RJ, and Grunberg E (1958) Fluorinated pyrimidines. VI. Effects of 5-fluorouridine and 5-fluoro-2′- deoxyuridine on transplanted tumors. Proc Soc Exp Biol Med 97:470-475.
    • (1958) Proc Soc Exp Biol Med , vol.97 , pp. 470-475
    • Heidelberger, C.1    Griesbach, L.2    Cruz, O.3    Schnitzer, R.J.4    Grunberg, E.5
  • 7
    • 0001453884 scopus 로고
    • Combined 5-fluorouracil and supervoltage radiation therapy in the palliative management of advanced gastrointestinal cancer: A pilot study
    • This landmark study was one of the first clinical reports describing the use of concurrent chemotherapy and radiation
    • Moertel CG, Reitemeier RJ, Childs DS, Jr., Colby MY, and Holbrook MA (1964) Combined 5-fluorouracil and supervoltage radiation therapy in the palliative management of advanced gastrointestinal cancer: a pilot study. Mayo Clin Proc 39:767-771. This landmark study was one of the first clinical reports describing the use of concurrent chemotherapy and radiation.
    • (1964) Mayo Clin Proc , vol.39 , pp. 767-771
    • Moertel, C.G.1    Reitemeier, R.J.2    Childs Jr., D.S.3    Colby, M.Y.4    Holbrook, M.A.5
  • 8
    • 0016158491 scopus 로고
    • Combined therapy for cancer of the anal canal: A preliminary report
    • This "preliminary" trial presaged the current standard of care for anal cancer by investigating the use of 5-FU and mitomycin C given concurrently with radiation. Initiated as a pre-op regimen, the unexpectedly high rate of complete patient responses led the Wayne State team to eliminate radical surgery from the initial management of anal cancer
    • Nigro ND, Vaitkevicius VK, and Considine B, Jr. (1974) Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 17:354-356. This "preliminary" trial presaged the current standard of care for anal cancer by investigating the use of 5-FU and mitomycin C given concurrently with radiation. Initiated as a pre-op regimen, the unexpectedly high rate of complete patient responses led the Wayne State team to eliminate radical surgery from the initial management of anal cancer.
    • (1974) Dis Colon Rectum , vol.17 , pp. 354-356
    • Nigro, N.D.1    Vaitkevicius, V.K.2    Considine Jr., B.3
  • 9
    • 0034718966 scopus 로고    scopus 로고
    • A randomized trial of postoperative adjuvantpy in patients with completely resected stage II or IIIA non-small-cell lung cancer
    • Eastern Cooperative Oncology Group
    • Keller SM, Adak S, Wagner H, Herskovic A, Komaki R, Brooks BJ, Perry MC, Livingston RB, and Johnson DH (2000) A randomized trial of postoperative adjuvantpy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern Cooperative Oncology Group. N Engl J Med 343:1217-1222.
    • (2000) N Engl J Med , vol.343 , pp. 1217-1222
    • Keller, S.M.1    Adak, S.2    Wagner, H.3    Herskovic, A.4    Komaki, R.5    Brooks, B.J.6    Perry, M.C.7    Livingston, R.B.8    Johnson, D.H.9
  • 10
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • This is the first randomized trial to demonstrate a survival benefit for a therapeutic antibody given concurrently with radiation
    • Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, et al. (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354:567-578. This is the first randomized trial to demonstrate a survival benefit for a therapeutic antibody given concurrently with radiation.
    • (2006) N Engl J Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3    Azarnia, N.4    Shin, D.M.5    Cohen, R.B.6    Jones, C.U.7    Sur, R.8    Raben, D.9    Jassem, J.10
  • 11
    • 14844353135 scopus 로고    scopus 로고
    • Radiation sensitizers: A selective review of molecules targeting DNA and non-DNA targets
    • Kvols LK (2005) Radiation sensitizers: a selective review of molecules targeting DNA and non-DNA targets. J Nucl Med 46 Suppl 1:187S-190S.
    • (2005) J Nucl Med , vol.46 , Issue.SUPPL. 1
    • Kvols, L.K.1
  • 12
    • 77950867012 scopus 로고    scopus 로고
    • Novel therapeutics in combination with radiotherapy to improve cancer treatment: Rationale, mechanisms of action and clinical perspective
    • Verheij M, Vens C, and van Triest B (2010) Novel therapeutics in combination with radiotherapy to improve cancer treatment: rationale, mechanisms of action and clinical perspective. Drug Resist Updat 13:29-43.
    • (2010) Drug Resist Updat , vol.13 , pp. 29-43
    • Verheij, M.1    Vens, C.2    Van Triest, B.3
  • 13
    • 67650667501 scopus 로고    scopus 로고
    • Molecular targets for tumor radiosensit thera ization
    • Tofilon PJ and Camphausen K (2009) Molecular targets for tumor radiosensit thera ization. Chem Rev 109:2974-2988.
    • (2009) Chem Rev , vol.109 , pp. 2974-2988
    • Tofilon, P.J.1    Camphausen, K.2
  • 14
    • 33745311283 scopus 로고    scopus 로고
    • New and emerging radiosensitizers and radioprotectors
    • Spalding AC and Lawrence TS (2006) New and emerging radiosensitizers and radioprotectors. Cancer Invest 24:444-456.
    • (2006) Cancer Invest , vol.24 , pp. 444-456
    • Spalding, A.C.1    Lawrence, T.S.2
  • 15
    • 0003605672 scopus 로고    scopus 로고
    • 6th ed, Lippincott Williams and Wilkins, Philadelphia. Required reading for anyone studying radiation biology, radiation therapy, or utilizing ionizing radiation for research
    • Hall EJ and Giaccia AJ (2006) Radiobiology for the radiologist, 6th ed, Lippincott Williams and Wilkins, Philadelphia. Required reading for anyone studying radiation biology, radiation therapy, or utilizing ionizing radiation for research.
    • (2006) Radiobiology for the Radiologist
    • Hall, E.J.1    Giaccia, A.J.2
  • 16
    • 0034889197 scopus 로고    scopus 로고
    • Drug synergism: Its detection and applications
    • Tallarida RJ (2001) Drug synergism: its detection and applications. J Pharmacol Exp Ther 298:865-872.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 865-872
    • Tallarida, R.J.1
  • 17
    • 0018425119 scopus 로고
    • Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
    • Steel GG and Peckham MJ (1979) Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys 5:85-91.
    • (1979) Int J Radiat Oncol Biol Phys , vol.5 , pp. 85-91
    • Steel, G.G.1    Peckham, M.J.2
  • 18
    • 0023628351 scopus 로고
    • The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes
    • Eastman A (1987) The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes. Pharmacol Ther 34: 155-166.
    • (1987) Pharmacol Ther , vol.34 , pp. 155-166
    • Eastman, A.1
  • 19
    • 0021199197 scopus 로고
    • Toxic variability and radiation sensitization by dichlorodiammineplatinum(II) complexes in Salmonella typhimurium cells
    • Richmond RC (1984) Toxic variability and radiation sensitization by dichlorodiammineplatinum(II) complexes in Salmonella typhimurium cells. Radiat Res 99:596-608. (Pubitemid 14031874)
    • (1984) Radiation Research , vol.99 , Issue.3 , pp. 596-608
    • Richmond, R.C.1
  • 23
    • 0000460127 scopus 로고    scopus 로고
    • Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panel
    • Rixe O, Ortuzar W, Alvarez M, Parker R, Reed E, Paull K, and Fojo T (1996) Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panel. Biochem Pharmacol 52:1855-1865.
    • (1996) Biochem Pharmacol , vol.52 , pp. 1855-1865
    • Rixe, O.1    Ortuzar, W.2    Alvarez, M.3    Parker, R.4    Reed, E.5    Paull, K.6    Fojo, T.7
  • 25
    • 0028304413 scopus 로고
    • Enhanced replicative bypass of platinum-DNA adducts in cisplatin-resistant human ovarian carcinoma cell lines
    • Mamenta EL, Poma EE, Kaufmann WK, Delmastro DA, Grady HL, and Chaney SG (1994) Enhanced replicative bypass of platinum-DNA adducts in cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res 54:3500-3505.
    • (1994) Cancer Res , vol.54 , pp. 3500-3505
    • Mamenta, E.L.1    Poma, E.E.2    Kaufmann, W.K.3    Delmastro, D.A.4    Grady, H.L.5    Chaney, S.G.6
  • 26
    • 0036535537 scopus 로고    scopus 로고
    • Interaction of pemetrexed disodium (ALIMTA, multitargeted antifolate) and irradiation in vitro
    • Bischof M, Weber KJ, Blatter J, Wannenmacher M, and Latz D (2002) Interaction of pemetrexed disodium (ALIMTA, multitargeted antifolate) and irradiation in vitro. Int J Radiat Oncol Biol Phys 52:1381-1388.
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 1381-1388
    • Bischof, M.1    Weber, K.J.2    Blatter, J.3    Wannenmacher, M.4    Latz, D.5
  • 28
    • 0038387494 scopus 로고    scopus 로고
    • 5-Fluorouracil: Mechanisms of action and clinical strategies
    • Longley DB, Harkin DP, and Johnston PG (2003) 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 3:330-338.
    • (2003) Nat Rev Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 29
    • 0030862599 scopus 로고    scopus 로고
    • Fluoropyrimidine-Radiation Interactions in Cells and Tumors
    • Lawrence TS, Tepper JE, and Blackstock AW (1997) Fluoropyrimidine- Radiation Interactions in Cells and Tumors. Semin Radiat Oncol 7:260-266.
    • (1997) Semin Radiat Oncol , vol.7 , pp. 260-266
    • Lawrence, T.S.1    Tepper, J.E.2    Blackstock, A.W.3
  • 30
    • 50549086678 scopus 로고    scopus 로고
    • Uracil in DNA: Consequences for carcinogenesis and chemotherapy
    • Berger SH, Pittman DL, and Wyatt MD (2008) Uracil in DNA: consequences for carcinogenesis and chemotherapy. Biochem Pharmacol 76:697-706.
    • (2008) Biochem Pharmacol , vol.76 , pp. 697-706
    • Berger, S.H.1    Pittman, D.L.2    Wyatt, M.D.3
  • 33
    • 40449113435 scopus 로고    scopus 로고
    • Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: A randomized controlled trial
    • Regine WF, Winter KA, Abrams RA, Safran H, Hoffman JP, Konski A, Benson AB, Macdonald JS, Kudrimoti MR, Fromm ML, et al. (2008) Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial. JAMA 299:1019-1026.
    • (2008) JAMA , vol.299 , pp. 1019-1026
    • Regine, W.F.1    Winter, K.A.2    Abrams, R.A.3    Safran, H.4    Hoffman, J.P.5    Konski, A.6    Benson, A.B.7    Macdonald, J.S.8    Kudrimoti, M.R.9    Fromm, M.L.10
  • 34
    • 0028839329 scopus 로고
    • Radiosensitization of human tumor cells by gemcitabine in vitro
    • Shewach DS and Lawrence TS (1995) Radiosensitization of human tumor cells by gemcitabine in vitro. Semin Oncol 22:68-71.
    • (1995) Semin Oncol , vol.22 , pp. 68-71
    • Shewach, D.S.1    Lawrence, T.S.2
  • 35
    • 0030922494 scopus 로고    scopus 로고
    • Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2′,2′-difluoro-2′-deoxycytidine (Gemcitabine)
    • Lawrence TS, Chang EY, Hahn TM, and Shewach DS (1997) Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2′,2′-difluoro-2′-deoxycytidine (Gemcitabine). Clin Cancer Res 3:777-782.
    • (1997) Clin Cancer Res , vol.3 , pp. 777-782
    • Lawrence, T.S.1    Chang, E.Y.2    Hahn, T.M.3    Shewach, D.S.4
  • 37
    • 0142219871 scopus 로고    scopus 로고
    • Enhanced Radiosensitization with Gemcitabine in Mismatch Repair-Deficient HCT116 Cells
    • Robinson BW, Im MM, Ljungman M, Praz F, and Shewach DS (2003) Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT116 cells. Cancer Res 63:6935-6941. (Pubitemid 37322979)
    • (2003) Cancer Research , vol.63 , Issue.20 , pp. 6935-6941
    • Robinson, B.W.1    Im, M.M.2    Ljungman, M.3    Praz, F.4    Shewach, D.S.5
  • 38
    • 0028240063 scopus 로고
    • Metabolism of 2',2'-difluoro-2'-deoxycytidine and radiation sensitization of human colon carcinoma cells
    • Shewach DS, Hahn TM, Chang E, Hertel LW, and Lawrence TS (1994) Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res 54:3218-3223. (Pubitemid 24208931)
    • (1994) Cancer Research , vol.54 , Issue.12 , pp. 3218-3223
    • Shewach, D.S.1    Hahn, T.M.2    Chang, E.3    Hertel, L.W.4    Lawrence, T.S.5
  • 39
    • 24644500678 scopus 로고    scopus 로고
    • Molecular mechanism of antitumor activity of taxanes in lung cancer
    • Review
    • Zhao J, Kim JE, Reed E, and Li QQ (2005) Molecular mechanism of antitumor activity of taxanes in lung cancer (Review). Int J Oncol 27:247-256.
    • (2005) Int J Oncol , vol.27 , pp. 247-256
    • Zhao, J.1    Kim, J.E.2    Reed, E.3    Li, Q.Q.4
  • 40
    • 0026553528 scopus 로고
    • Taxol: A novel radiation sensitizer
    • This study established the radiosensitizing properties of taxol and linked the drug's action to effects on the cell cycle
    • Tishler RB, Schiff PB, Geard CR, and Hall EJ (1992) Taxol: a novel radiation sensitizer. Int J Radiat Oncol Biol Phys 22:613-617. This study established the radiosensitizing properties of taxol and linked the drug's action to effects on the cell cycle.
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 613-617
    • Tishler, R.B.1    Schiff, P.B.2    Geard, C.R.3    Hall, E.J.4
  • 42
    • 0030887933 scopus 로고    scopus 로고
    • Cytotoxicity and cell-cycle effects of paclitaxel when used as a single agent and in combination with ionizing radiation
    • DOI 10.1016/S0360-3016(96)00535-4, PII S0360301696005354
    • Gupta N, Hu LJ, and Deen DF (1997) Cytotoxicity and cell-cycle effects of paclitaxel when used as a single agent and in combination with ionizing radiation. Int J Radiat Oncol Biol Phys 37:885-895. (Pubitemid 27181323)
    • (1997) International Journal of Radiation Oncology Biology Physics , vol.37 , Issue.4 , pp. 885-895
    • Gupta, N.1    Hu, L.J.2    Deen, D.F.3
  • 43
    • 0030918457 scopus 로고    scopus 로고
    • Subadditive interaction of radiation and Taxol in vitro
    • Ingram ML and Redpath JL (1997) Subadditive interaction of radiation and Taxol in vitro. Int J Radiat Oncol Biol Phys 37:1139-1144.
    • (1997) Int J Radiat Oncol Biol Phys , vol.37 , pp. 1139-1144
    • Ingram, M.L.1    Redpath, J.L.2
  • 45
    • 0029144003 scopus 로고
    • Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel
    • Milas L, Hunter NR, Mason KA, Milross CG, Saito Y, and Peters LJ (1995) Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel. Cancer Res 55:3564-3568.
    • (1995) Cancer Res , vol.55 , pp. 3564-3568
    • Milas, L.1    Hunter, N.R.2    Mason, K.A.3    Milross, C.G.4    Saito, Y.5    Peters, L.J.6
  • 48
    • 53549129722 scopus 로고    scopus 로고
    • Docetaxel and bortezomib downregulate Bcl-2 and sensitize PC-3-Bcl-2 expressing prostate cancer cells to irradiation
    • Cao W, Shiverick K, Namiki K, Sakai Y, Porvasnik S, Urbanek C, and Rosser C (2008) Docetaxel and bortezomib downregulate Bcl-2 and sensitize PC-3-Bcl-2 expressing prostate cancer cells to irradiation. World Journal of Urology 26: 509-516.
    • (2008) World Journal of Urology , vol.26 , pp. 509-516
    • Cao, W.1    Shiverick, K.2    Namiki, K.3    Sakai, Y.4    Porvasnik, S.5    Urbanek, C.6    Rosser, C.7
  • 49
    • 0033378780 scopus 로고    scopus 로고
    • Enhancement of radiation effects by combined docetaxel and carboplatin treatment in vitro
    • Amorino GP, Hamilton VM, and Choy H (1999) Enhancement of radiation effects by combined docetaxel and carboplatin treatment in vitro. Radiat Oncol Investig 7:343-352.
    • (1999) Radiat Oncol Investig , vol.7 , pp. 343-352
    • Amorino, G.P.1    Hamilton, V.M.2    Choy, H.3
  • 50
    • 0028999349 scopus 로고
    • S-phase specificity of cell killing by docetaxel (Taxotere) in synchronised HeLa cells
    • Hennequin C, Giocanti N, and Favaudon V (1995) S-phase specificity of cell killing by docetaxel (Taxotere) in synchronised HeLa cells. Br J Cancer 71:1194-1198.
    • (1995) Br J Cancer , vol.71 , pp. 1194-1198
    • Hennequin, C.1    Giocanti, N.2    Favaudon, V.3
  • 51
    • 0030907319 scopus 로고    scopus 로고
    • Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives
    • Chen AY, Okunieff P, Pommier Y, and Mitchell JB (1997) Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives. Cancer Res 57:1529-1536.
    • (1997) Cancer Res , vol.57 , pp. 1529-1536
    • Chen, A.Y.1    Okunieff, P.2    Pommier, Y.3    Mitchell, J.B.4
  • 52
    • 0036159856 scopus 로고    scopus 로고
    • Radiation enhancement by the combined use of topoisomerase I inhibitors, RFS- 2000 or CPT-11, and topoisomerase II inhibitor etoposide in human lung cancer cells
    • Kim JS, Amorino GP, Pyo H, Cao Q, and Choy H (2002) Radiation enhancement by the combined use of topoisomerase I inhibitors, RFS- 2000 or CPT-11, and topoisomerase II inhibitor etoposide in human lung cancer cells. Radiother Oncol 62:61-67.
    • (2002) Radiother Oncol , vol.62 , pp. 61-67
    • Kim, J.S.1    Amorino, G.P.2    Pyo, H.3    Cao, Q.4    Choy, H.5
  • 53
    • 0042346439 scopus 로고    scopus 로고
    • Catalytic topoisomerase II inhibitors in cancer therapy
    • Larsen AK, Escargueil AE, and Skladanowski A (2003) Catalytic topoisomerase II inhibitors in cancer therapy. Pharmacol Ther 99:167-181.
    • (2003) Pharmacol Ther , vol.99 , pp. 167-181
    • Larsen, A.K.1    Escargueil, A.E.2    Skladanowski, A.3
  • 55
    • 0031595047 scopus 로고    scopus 로고
    • Synergistic cytotoxicity of topoisomerase I inhibitors with alkylating agents etoposide in human brain tumor cell lines
    • Janss AJ, Cnaan A, Zhao H, Shpilsky A, Levow C, Sutton L, and Phillips PC (1998) Synergistic cytotoxicity of topoisomerase I inhibitors with alkylating agents etoposide in human brain tumor cell lines. Anticancer Drugs 9:641-652.
    • (1998) Anticancer Drugs , vol.9 , pp. 641-652
    • Janss, A.J.1    Cnaan, A.2    Zhao, H.3    Shpilsky, A.4    Levow, C.5    Sutton, L.6    Phillips, P.C.7
  • 56
    • 0025893984 scopus 로고
    • Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line
    • Kaufmann SH (1991) Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line. Cancer Res 51:1129-1136.
    • (1991) Cancer Res , vol.51 , pp. 1129-1136
    • Kaufmann, S.H.1
  • 57
    • 0028133013 scopus 로고
    • NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA
    • Denny BJ, Wheelhouse RT, Stevens MF, Tsang LL, and Slack JA (1994) NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. Biochemistry 33:9045-9051.
    • (1994) Biochemistry , vol.33 , pp. 9045-9051
    • Denny, B.J.1    Wheelhouse, R.T.2    Stevens, M.F.3    Tsang, L.L.4    Slack, J.A.5
  • 59
    • 0034883452 scopus 로고    scopus 로고
    • 6-alkylating agents and retroviral backbones
    • DOI 10.1034/j.1600-0609.2001.067001002.x
    • Jansen M, Bardenheuer W, Sorg UR, Seeber S, Flasshove M, and Moritz T (2001) Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones. Eur J Haematol 67:2-13. (Pubitemid 32769809)
    • (2001) European Journal of Haematology , vol.67 , Issue.1 , pp. 2-13
    • Jansen, M.1    Bardenheuer, W.2    Sorg, U.R.3    Seeber, S.4    Flasshove, M.5    Moritz, T.6
  • 62
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM and Wilson WR (2004) Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4:437-447.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 64
    • 0033653205 scopus 로고    scopus 로고
    • Tirapazamine: A bioreductive anticancer drug that exploits tumour hypoxia
    • Denny WA and Wilson WR (2000) Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia. Expert Opin Investig Drugs 9:2889-2901.
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2889-2901
    • Denny, W.A.1    Wilson, W.R.2
  • 65
    • 77956458848 scopus 로고    scopus 로고
    • DNA repair targeting and radiotherapy: A focus on the therapeutic ratio
    • Thoms J and Bristow RG (2010) DNA repair targeting and radiotherapy: a focus on the therapeutic ratio. Semin Radiat Oncol 20:217-222.
    • (2010) Semin Radiat Oncol , vol.20 , pp. 217-222
    • Thoms, J.1    Bristow, R.G.2
  • 66
    • 0032815618 scopus 로고    scopus 로고
    • Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death
    • This report described radiation-induced activation of the epidermal growth factor receptor and downstream signaling pathways and provided rationale for investigating inhibitors of EGFR signal transduction pathways as radiosensitizers
    • Dent P, Reardon DB, Park JS, Bowers G, Logsdon C, Valerie K, and Schmidt-Ullrich R (1999) Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol Biol Cell 10:2493-2506. This report described radiation-induced activation of the epidermal growth factor receptor and downstream signaling pathways and provided rationale for investigating inhibitors of EGFR signal transduction pathways as radiosensitizers.
    • (1999) Mol Biol Cell , vol.10 , pp. 2493-2506
    • Dent, P.1    Reardon, D.B.2    Park, J.S.3    Bowers, G.4    Logsdon, C.5    Valerie, K.6    Schmidt-Ullrich, R.7
  • 67
    • 0037030519 scopus 로고    scopus 로고
    • Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells
    • DOI 10.1038/sj.onc.1205500
    • Contessa JN, Hampton J, Lammering G, Mikkelsen RB, Dent P, Valerie K, and Schmidt-Ullrich RK (2002) Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene 21:4032-4041. (Pubitemid 34679244)
    • (2002) Oncogene , vol.21 , Issue.25 , pp. 4032-4041
    • Contessa, J.N.1    Hampton, J.2    Lammering, G.3    Mikkelsen, R.B.4    Dent, P.5    Valerie, K.6    Schmidt-Ullrich, R.K.7
  • 69
    • 29244492286 scopus 로고    scopus 로고
    • Radiation and new molecular agents, part II: Targeting HDAC, HSP90, IGF-1R, PI3K, and Ras
    • Chinnaiyan P, Allen GW, and Harari PM (2006) Radiation and new molecular agents, part II: targeting HDAC, HSP90, IGF-1R, PI3K, and Ras. Semin Radiat Oncol 16:59-64.
    • (2006) Semin Radiat Oncol , vol.16 , pp. 59-64
    • Chinnaiyan, P.1    Allen, G.W.2    Harari, P.M.3
  • 70
    • 76049109947 scopus 로고    scopus 로고
    • Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status
    • Kimple RJ, Vaseva AV, Cox AD, Baerman KM, Calvo BF, Tepper JE, Shields JM, and Sartor CI (2010) Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status. Clin Cancer Res 16:912-923.
    • (2010) Clin Cancer Res , vol.16 , pp. 912-923
    • Kimple, R.J.1    Vaseva, A.V.2    Cox, A.D.3    Baerman, K.M.4    Calvo, B.F.5    Tepper, J.E.6    Shields, J.M.7    Sartor, C.I.8
  • 72
    • 70449686563 scopus 로고    scopus 로고
    • Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK
    • Sambade MJ, Camp JT, Kimple RJ, Sartor CI, and Shields JM (2009) Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK. Radiother Oncol 93:639-644.
    • (2009) Radiother Oncol , vol.93 , pp. 639-644
    • Sambade, M.J.1    Camp, J.T.2    Kimple, R.J.3    Sartor, C.I.4    Shields, J.M.5
  • 73
    • 0028287960 scopus 로고
    • Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
    • This paper demonstrated the potential role of radiation in altering cellular membrane composition and subsequently initiating apoptosis and established the crucial role of non-DNA-mediated effects in the radiation response
    • Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, and Kolesnick RN (1994) Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 180:525-535. This paper demonstrated the potential role of radiation in altering cellular membrane composition and subsequently initiating apoptosis and established the crucial role of non-DNA-mediated effects in the radiation response.
    • (1994) J Exp Med , vol.180 , pp. 525-535
    • Haimovitz-Friedman, A.1    Kan, C.C.2    Ehleiter, D.3    Persaud, R.S.4    McLoughlin, M.5    Fuks, Z.6    Kolesnick, R.N.7
  • 74
    • 0033561522 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
    • Huang SM, Bock JM, and Harari PM (1999) Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 59:1935-1940.
    • (1999) Cancer Res , vol.59 , pp. 1935-1940
    • Huang, S.M.1    Bock, J.M.2    Harari, P.M.3
  • 75
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • Huang SM and Harari PM (2000) Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res 6:2166-2174.
    • (2000) Clin Cancer Res , vol.6 , pp. 2166-2174
    • Huang, S.M.1    Harari, P.M.2
  • 76
    • 34748831698 scopus 로고    scopus 로고
    • Biology of interactions: Antiepidermal growth factor receptor agents
    • Harari PM, Allen GW, and Bonner JA (2007) Biology of interactions: antiepidermal growth factor receptor agents. J Clin Oncol 25:4057-4065.
    • (2007) J Clin Oncol , vol.25 , pp. 4057-4065
    • Harari, P.M.1    Allen, G.W.2    Bonner, J.A.3
  • 77
    • 0033559619 scopus 로고    scopus 로고
    • Monoclonal antibody to HER-2/neu receptor modulates repair of radiation- induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene
    • Pietras RJ, Poen JC, Gallardo D, Wongvipat PN, Lee HJ, and Slamon DJ (1999) Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res 59:1347-1355. (Pubitemid 29136268)
    • (1999) Cancer Research , vol.59 , Issue.6 , pp. 1347-1355
    • Pietras, R.J.1    Poen, J.C.2    Gallardo, D.3    Wongvipat, P.N.4    Lee, J.H.5    Slamon, D.J.6
  • 78
    • 77449113764 scopus 로고    scopus 로고
    • Radiosensitization of chemotherapy-refractory, locally advanced or locally recurrent breast cancer with trastuzumab: A phase II trial
    • Horton JK, Halle J, Ferraro M, Carey L, Moore DT, Ollila D, and Sartor CI (2010) Radiosensitization of chemotherapy-refractory, locally advanced or locally recurrent breast cancer with trastuzumab: a phase II trial. Int J Radiat Oncol Biol Phys 76:998-1004.
    • (2010) Int J Radiat Oncol Biol Phys , vol.76 , pp. 998-1004
    • Horton, J.K.1    Halle, J.2    Ferraro, M.3    Carey, L.4    Moore, D.T.5    Ollila, D.6    Sartor, C.I.7
  • 80
    • 79551504108 scopus 로고    scopus 로고
    • Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer
    • In the phase I trial reported here, we utilized serial biopsies to assess biomarkers of response to dual EGFR/Her2 inhibition
    • Kimple RJ, Sartor CI, Chiu WM, Esler L, Livasy CA, Carey LA, Halle J, and Dees EC (2010) Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer. Int J Radiat Oncol Biol Phys 78:S210. In the phase I trial reported here, we utilized serial biopsies to assess biomarkers of response to dual EGFR/Her2 inhibition.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78
    • Kimple, R.J.1    Sartor, C.I.2    Chiu, W.M.3    Esler, L.4    Livasy, C.A.5    Carey, L.A.6    Halle, J.7    Dees, E.C.8
  • 81
    • 0141869078 scopus 로고    scopus 로고
    • The RAS signal transduction pathway and its role in radiation sensitivity
    • McKenna WG, Muschel RJ, Gupta AK, Hahn SM, and Bernhard EJ (2003) The RAS signal transduction pathway and its role in radiation sensitivity. Oncogene 22:5866-5875.
    • (2003) Oncogene , vol.22 , pp. 5866-5875
    • McKenna, W.G.1    Muschel, R.J.2    Gupta, A.K.3    Hahn, S.M.4    Bernhard, E.J.5
  • 83
    • 77953223359 scopus 로고    scopus 로고
    • Angiogenesis inhibition in cancer therapy: Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy
    • Appelmann I, Liersch R, Kessler T, Mesters RM, and Berdel WE (2010) Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy. Recent Results Cancer Res 180:51-81.
    • (2010) Recent Results Cancer Res , vol.180 , pp. 51-81
    • Appelmann, I.1    Liersch, R.2    Kessler, T.3    Mesters, R.M.4    Berdel, W.E.5
  • 84
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 85
    • 0024420683 scopus 로고
    • Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells
    • Witte L, Fuks Z, Haimovitz-Friedman A, Vlodavsky I, Goodman DS, and Eldor A (1989) Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells. Cancer Res 49:5066-5072.
    • (1989) Cancer Res , vol.49 , pp. 5066-5072
    • Witte, L.1    Fuks, Z.2    Haimovitz-Friedman, A.3    Vlodavsky, I.4    Goodman, D.S.5    Eldor, A.6
  • 86
    • 35048884060 scopus 로고    scopus 로고
    • Radiation therapy plus angiogenesis inhibition with bevacizumab: Rationale and initial experience
    • Nieder C, Wiedenmann N, Andratschke NH, Astner ST, and Molls M (2007) Radiation therapy plus angiogenesis inhibition with bevacizumab: rationale and initial experience. Rev Recent Clin Trials 2:163-168.
    • (2007) Rev Recent Clin Trials , vol.2 , pp. 163-168
    • Nieder, C.1    Wiedenmann, N.2    Andratschke, N.H.3    Astner, S.T.4    Molls, M.5
  • 88
    • 72549116624 scopus 로고    scopus 로고
    • Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: Vasculature-independent radiosensitizing effect of bevacizumab
    • Koukourakis MI, Giatromanolaki A, Sheldon H, Buffa FM, Kouklakis G, Ragoussis I, Sivridis E, and Harris AL (2009) Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab. Clin Cancer Res 15:7069-7076.
    • (2009) Clin Cancer Res , vol.15 , pp. 7069-7076
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sheldon, H.3    Buffa, F.M.4    Kouklakis, G.5    Ragoussis, I.6    Sivridis, E.7    Harris, A.L.8
  • 89
    • 38549166571 scopus 로고    scopus 로고
    • Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway
    • Verbrugge I, de Vries E, Tait SW, Wissink EH, Walczak H, Verheij M, and Borst J (2008) Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway. Oncogene 27:574-584.
    • (2008) Oncogene , vol.27 , pp. 574-584
    • Verbrugge, I.1    De Vries, E.2    Tait, S.W.3    Wissink, E.H.4    Walczak, H.5    Verheij, M.6    Borst, J.7
  • 92
    • 68649092791 scopus 로고    scopus 로고
    • Combination of the pro-apoptotic TRAIL-receptor antibody mapatumumab with ionizing radiation strongly increases long-term tumor control under ambient and hypoxic conditions
    • Marini P, Budach W, Niyazi M, Junginger D, Stickl S, Jendrossek V, and Belka C (2009) Combination of the pro-apoptotic TRAIL-receptor antibody mapatumumab with ionizing radiation strongly increases long-term tumor control under ambient and hypoxic conditions. Int J Radiat Oncol Biol Phys 75:198-202.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 198-202
    • Marini, P.1    Budach, W.2    Niyazi, M.3    Junginger, D.4    Stickl, S.5    Jendrossek, V.6    Belka, C.7
  • 96
  • 97
    • 0022411457 scopus 로고
    • Radiosensitization of human fibroblasts by 3-aminobenzamide: An inhibitor of poly(ADP-ribosylation)
    • Thraves P, Mossman KL, Brennan T, and Dritschilo A (1985) Radiosensitization of human fibroblasts by 3-aminobenzamide: an inhibitor of poly(ADP-ribosylation). Radiat Res 104:119-127.
    • (1985) Radiat Res , vol.104 , pp. 119-127
    • Thraves, P.1    Mossman, K.L.2    Brennan, T.3    Dritschilo, A.4
  • 98
    • 0023729538 scopus 로고
    • Differential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity
    • Kelland LR, Burgess L, and Steel GG (1988) Differential radiosensitization by the poly(ADP-ribose) transferase inhibitor 3-aminobenzamide in human tumor cells of varying radiosensitivity. Int J Radiat Oncol Biol Phys 14:1239-1246.
    • (1988) Int J Radiat Oncol Biol Phys , vol.14 , pp. 1239-1246
    • Kelland, L.R.1    Burgess, L.2    Steel, G.G.3
  • 99
    • 1242271229 scopus 로고    scopus 로고
    • Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase
    • Brock WA, Milas L, Bergh S, Lo R, Szabo C, and Mason KA (2004) Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett 205:155-160.
    • (2004) Cancer Lett , vol.205 , pp. 155-160
    • Brock, W.A.1    Milas, L.2    Bergh, S.3    Lo, R.4    Szabo, C.5    Mason, K.A.6
  • 100
    • 33645469913 scopus 로고    scopus 로고
    • Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis
    • Noel G, Godon C, Fernet M, Giocanti N, Megnin-Chanet F, and Favaudon V (2006) Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis. Mol Cancer Ther 5:564-574.
    • (2006) Mol Cancer Ther , vol.5 , pp. 564-574
    • Noel, G.1    Godon, C.2    Fernet, M.3    Giocanti, N.4    Megnin-Chanet, F.5    Favaudon, V.6
  • 101
    • 33745041170 scopus 로고    scopus 로고
    • Histone deacetylation as a target for radiosensitization
    • Cerna D, Camphausen K, and Tofilon PJ (2006) Histone deacetylation as a target for radiosensitization. Curr Top Dev Biol 73:173-204.
    • (2006) Curr Top Dev Biol , vol.73 , pp. 173-204
    • Cerna, D.1    Camphausen, K.2    Tofilon, P.J.3
  • 102
    • 1642576220 scopus 로고    scopus 로고
    • Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275
    • Camphausen K, Burgan W, Cerra M, Oswald KA, Trepel JB, Lee MJ, and Tofilon PJ (2004) Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275. Cancer Res 64:316-321.
    • (2004) Cancer Res , vol.64 , pp. 316-321
    • Camphausen, K.1    Burgan, W.2    Cerra, M.3    Oswald, K.A.4    Trepel, J.B.5    Lee, M.J.6    Tofilon, P.J.7
  • 103
    • 14044250159 scopus 로고    scopus 로고
    • Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid
    • An intriguing report from a group at the National Cancer Institute that demonstrates the radiosensitizing ability of an agent approved for non-cancer use
    • Camphausen K, Cerna D, Scott T, Sproull M, Burgan WE, Cerra MA, Fine H, and Tofilon PJ (2005) Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid. Int J Cancer 114:380-386. An intriguing report from a group at the National Cancer Institute that demonstrates the radiosensitizing ability of an agent approved for non-cancer use.
    • (2005) Int J Cancer , vol.114 , pp. 380-386
    • Camphausen, K.1    Cerna, D.2    Scott, T.3    Sproull, M.4    Burgan, W.E.5    Cerra, M.A.6    Fine, H.7    Tofilon, P.J.8
  • 104
    • 0042905956 scopus 로고    scopus 로고
    • Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: Defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines
    • Glaser KB, Staver MJ, Waring JF, Stender J, Ulrich RG, and Davidsen SK (2003) Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. Mol Cancer Ther 2:151-163.
    • (2003) Mol Cancer Ther , vol.2 , pp. 151-163
    • Glaser, K.B.1    Staver, M.J.2    Waring, J.F.3    Stender, J.4    Ulrich, R.G.5    Davidsen, S.K.6
  • 105
    • 0033615547 scopus 로고    scopus 로고
    • Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
    • Kim GD, Choi YH, Dimtchev A, Jeong SJ, Dritschilo A, and Jung M (1999) Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase. J Biol Chem 274:31127-31130.
    • (1999) J Biol Chem , vol.274 , pp. 31127-31130
    • Kim, G.D.1    Choi, Y.H.2    Dimtchev, A.3    Jeong, S.J.4    Dritschilo, A.5    Jung, M.6
  • 107
    • 74549189337 scopus 로고    scopus 로고
    • New insights into checkpoint kinase 1 in the DNA damage response signaling network
    • Dai Y and Grant S (2010) New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res 16:376-383.
    • (2010) Clin Cancer Res , vol.16 , pp. 376-383
    • Dai, Y.1    Grant, S.2
  • 112
    • 0034332704 scopus 로고    scopus 로고
    • Four radiation hypersensitivity cases and their implications for clinical radiotherapy
    • Rogers PB, Plowman PN, Harris SJ, and Arlett CF (2000) Four radiation hypersensitivity cases and their implications for clinical radiotherapy. Radiother Oncol 57:143-154.
    • (2000) Radiother Oncol , vol.57 , pp. 143-154
    • Rogers, P.B.1    Plowman, P.N.2    Harris, S.J.3    Arlett, C.F.4
  • 113
    • 70350097395 scopus 로고    scopus 로고
    • High throughput evaluation of gamma-H2AX
    • Compared with standard drug development, the use of high-throughput assays for identification of radiosensitizers has lagged far behind. This paper described a method for performing high-throughput evaluation of DNA-damage as a potential screen for radiosensitizers
    • Avondoglio D, Scott T, Kil WJ, Sproull M, Tofilon PJ, and Camphausen K (2009) High throughput evaluation of gamma-H2AX. Radiat Oncol 4:31. Compared with standard drug development, the use of high-throughput assays for identification of radiosensitizers has lagged far behind. This paper described a method for performing high-throughput evaluation of DNA-damage as a potential screen for radiosensitizers.
    • (2009) Radiat Oncol , vol.4 , pp. 31
    • Avondoglio, D.1    Scott, T.2    Kil, W.J.3    Sproull, M.4    Tofilon, P.J.5    Camphausen, K.6
  • 114
    • 33748412890 scopus 로고    scopus 로고
    • Radiation therapy and biologics: A ripe opportunity?
    • Tepper JE and Sartor CI (2006) Radiation therapy and biologics: a ripe opportunity? Nat Clin Pract Oncol 3:463.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 463
    • Tepper, J.E.1    Sartor, C.I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.