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Volumn 63, Issue 20, 2003, Pages 6935-6941

Enhanced Radiosensitization with Gemcitabine in Mismatch Repair-Deficient HCT116 Cells

Author keywords

[No Author keywords available]

Indexed keywords

2',2' DIFLUORO 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; COBALT 60; COMPLEMENTARY DNA; GEMCITABINE; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

EID: 0142219871     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (58)

References (64)
  • 1
    • 0028022127 scopus 로고
    • Gemcitabine: Current status of Phase I and II trials
    • Kaye, S. B. Gemcitabine: current status of Phase I and II trials. J. Clin. Oncol., 12: 1527-1531, 1994.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 1527-1531
    • Kaye, S.B.1
  • 5
    • 0026984625 scopus 로고
    • Effect of 2′,2′-difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro
    • Rockwell, S., and Grindey, G. B. Effect of 2′,2′ -difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro. Oncol. Res., 4: 151-155, 1992.
    • (1992) Oncol. Res. , vol.4 , pp. 151-155
    • Rockwell, S.1    Grindey, G.B.2
  • 6
    • 0028240063 scopus 로고
    • Metabolism of 2′,2′-difluorodeoxycytidine and radiation sensitization of human colon carcinoma cells
    • Shewach, D. S., Hahn, T. M., Chang, E., Hertel, L. W., and Lawrence, T. S. Metabolism of 2′,2′-difluorodeoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res., 54: 3218-3223, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3218-3223
    • Shewach, D.S.1    Hahn, T.M.2    Chang, E.3    Hertel, L.W.4    Lawrence, T.S.5
  • 18
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine
    • Heinemann, V., Hertel, L. W., Grindey, G. B., and Plunkett, W. P. Comparison of the cellular pharmacokinetics and toxicity of 2′,2′ -difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine. Cancer Res., 48: 4024-4031, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 4024-4031
    • Heinemann, V.1    Hertel, L.W.2    Grindey, G.B.3    Plunkett, W.P.4
  • 19
    • 0025737572 scopus 로고
    • 2′-deoxy-2′-methylenecytidine and 2′-deoxy-2′ ,2′-difluorocytidine 5′-diphosphates: Potent mechanism-based inhibitors of ribonucleotide reductase
    • Baker, C. H., Banzon, J., Bollinger, J. M., Stubbe, J., Samano, V., Robins, M. J., Lippert, B., Jarvi, E., and Resvick, R. 2′-Deoxy-2′ -methylenecytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase. J. Med. Chem., 34: 1879-1884, 1991.
    • (1991) J. Med. Chem. , vol.34 , pp. 1879-1884
    • Baker, C.H.1    Banzon, J.2    Bollinger, J.M.3    Stubbe, J.4    Samano, V.5    Robins, M.J.6    Lippert, B.7    Jarvi, E.8    Resvick, R.9
  • 20
    • 0026324313 scopus 로고
    • Action of 2′,2′-diflourodeoxycytidine on DNA synthesis
    • Huang, P., Chubb, S., Hertel, L. W., Grindey, G. B., and Plunkett, W. Action of 2′,2′-diflourodeoxycytidine on DNA synthesis. Cancer Res., 51: 6110-6117, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 6110-6117
    • Huang, P.1    Chubb, S.2    Hertel, L.W.3    Grindey, G.B.4    Plunkett, W.5
  • 21
    • 0027180521 scopus 로고
    • 2′,2′-difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines
    • Ruiz van Haperen, V. W., Veerman, G., Vermorken, J. B., and Peters, G. J. 2′,2′-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines. Biochem. Pharmacol., 46: 762-766, 1993.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 762-766
    • Ruiz van Haperen, V.W.1    Veerman, G.2    Vermorken, J.B.3    Peters, G.J.4
  • 22
    • 0028062981 scopus 로고
    • Molecular effects of 2′,2′-difluoro-deoxycytidine (gemcitabine) on DNA replication in intact HL-60 cells
    • Ross, D. D., and Cuddy, D. P. Molecular effects of 2′,2′ -difluoro-deoxycytidine (gemcitabine) on DNA replication in intact HL-60 cells. Biochem. Pharmacol., 48: 1619-1630, 1994.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1619-1630
    • Ross, D.D.1    Cuddy, D.P.2
  • 23
    • 0029060757 scopus 로고
    • Fludarabinc- and gemcitabine-induced apoptosis: Incorporation of analogs into DNA is a critical event
    • Huang, P., and Plunkett, W. Fludarabinc- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event. Cancer Chemother. Pharmacol., 36: 181-188, 1995.
    • (1995) Cancer Chemother. Pharmacol. , vol.36 , pp. 181-188
    • Huang, P.1    Plunkett, W.2
  • 24
    • 0142141522 scopus 로고    scopus 로고
    • The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′-deoxycytidine
    • in press
    • Ostruszka, L. J., and Shewach, D. S. The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′ -deoxycytidine. Cancer Chemother. Pharmacol., in press, 2003.
    • (2003) Cancer Chemother. Pharmacol.
    • Ostruszka, L.J.1    Shewach, D.S.2
  • 25
    • 0025058784 scopus 로고
    • Radiosensitization of Chinese hamster V79 cells by bromodeoxyuridine substitution of thymidine: Enhancement of radiation-induced toxicity and DNA strand break production by monofilar and bifilar substitution
    • Ling, L. L., and Ward, J. F. Radiosensitization of Chinese hamster V79 cells by bromodeoxyuridine substitution of thymidine: enhancement of radiation-induced toxicity and DNA strand break production by monofilar and bifilar substitution. Radiat. Res., 121: 76-83, 1990.
    • (1990) Radiat. Res. , vol.121 , pp. 76-83
    • Ling, L.L.1    Ward, J.F.2
  • 26
    • 0026647385 scopus 로고
    • Linear-quadratic analysis of radiosensitization by halogenated pyrimidines. II. Radiosensitization of human colon cancer cells by bromodeoxyuridine
    • Miller, E. M., Fowler, J. F., and Kinsella, T. J. Linear-quadratic analysis of radiosensitization by halogenated pyrimidines. II. Radiosensitization of human colon cancer cells by bromodeoxyuridine. Radiat. Res., 131: 90-97, 1992.
    • (1992) Radiat. Res. , vol.131 , pp. 90-97
    • Miller, E.M.1    Fowler, J.F.2    Kinsella, T.J.3
  • 27
    • 0024371774 scopus 로고
    • Mechanism of radiosensitization by halogenated pyrimidines: Effect of BrdU on radiation induction of DNA and chromosome damage and its correlation with cell killing
    • Iliakis, G., Kurtzman, S., Pantelias, G., and Okayasu, R. Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on radiation induction of DNA and chromosome damage and its correlation with cell killing. Radiat. Res., 119: 286-304, 1989.
    • (1989) Radiat. Res. , vol.119 , pp. 286-304
    • Iliakis, G.1    Kurtzman, S.2    Pantelias, G.3    Okayasu, R.4
  • 28
    • 0025742796 scopus 로고
    • Mechanism of radiosensitization by halogenated pyrimidines: Bromodeoxyuridine and α-arabinofuranosyladenine affect similar subsets of radiation-induced potentially lethal lesions in plateau-phase Chinese hamster ovary cells
    • Iliakis, G., and Kurtzman, S. Mechanism of radiosensitization by halogenated pyrimidines: bromodeoxyuridine and α-arabinofuranosyladenine affect similar subsets of radiation-induced potentially lethal lesions in plateau-phase Chinese hamster ovary cells. Radiat. Res., 127: 45-51, 1991.
    • (1991) Radiat. Res. , vol.127 , pp. 45-51
    • Iliakis, G.1    Kurtzman, S.2
  • 29
    • 0030922494 scopus 로고    scopus 로고
    • Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2′,2′-difluoro-2′-deoxycytidine (gemcitabine)
    • Lawrence, T. S., Chang, E. Y., Hahn, T. M., and Shewach, D. S. Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2′,2′-difluoro-2′-deoxycytidine (gemcitabine). Clin. Cancer Res., 3: 777-782, 1997.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 777-782
    • Lawrence, T.S.1    Chang, E.Y.2    Hahn, T.M.3    Shewach, D.S.4
  • 30
    • 0028839329 scopus 로고
    • Radiosensitization of human tumor cells by gemcitabine in vitro
    • Shewach, D. S., and Lawrence, T. S. Radiosensitization of human tumor cells by gemcitabine in vitro. Semin. Oncol., 22: 68-71, 1995.
    • (1995) Semin. Oncol. , vol.22 , pp. 68-71
    • Shewach, D.S.1    Lawrence, T.S.2
  • 32
    • 0034326813 scopus 로고    scopus 로고
    • The role of cell cycle progression in radiosensitization by 2′,2′-difluoro-2′-deoxycytidine
    • Ostruszka, L., and Shewach, D. S. The role of cell cycle progression in radiosensitization by 2′,2′-difluoro-2′-deoxycytidine. Cancer Res., 60: 6080-6088, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 6080-6088
    • Ostruszka, L.1    Shewach, D.S.2
  • 33
    • 0027429568 scopus 로고
    • Effect of template-located 2′,2′-difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klcnow (3′->5′ exonuclease-) fragment
    • Schy, W. E., Hertel, L. W., Kroin, J. S., Bloom, L. B., Goodman, M. F., and Richardson, F. C. Effect of template-located 2′,2′ -difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klcnow (3′->5′ exonuclease-) fragment. Cancer Res., 53: 4582-4587, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 4582-4587
    • Schy, W.E.1    Hertel, L.W.2    Kroin, J.S.3    Bloom, L.B.4    Goodman, M.F.5    Richardson, F.C.6
  • 34
    • 0020398982 scopus 로고
    • Genetic effects of deoxyribonucleotide pool imbalances
    • Kunz, B. A. Genetic effects of deoxyribonucleotide pool imbalances. Environ. Mutagen., 4: 695-725, 1982.
    • (1982) Environ. Mutagen. , vol.4 , pp. 695-725
    • Kunz, B.A.1
  • 35
    • 0026714957 scopus 로고
    • The effects of dNTP pool imbalances on frameshift fidelity during DNA replication
    • Bebenek, K., Roberts, J. D., and Kunkel, T. A. The effects of dNTP pool imbalances on frameshift fidelity during DNA replication. J. Biol. Chem., 267: 3589-3596, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 3589-3596
    • Bebenek, K.1    Roberts, J.D.2    Kunkel, T.A.3
  • 36
    • 0037138464 scopus 로고    scopus 로고
    • Effects of biological DNA precursor pool asymmetry upon accuracy of DNA replication in vitro
    • Martomo, S. A., and Mathews, C. K. Effects of biological DNA precursor pool asymmetry upon accuracy of DNA replication in vitro. Mutat. Res., 499: 197-211, 2002.
    • (2002) Mutat. Res. , vol.499 , pp. 197-211
    • Martomo, S.A.1    Mathews, C.K.2
  • 37
    • 0031841276 scopus 로고    scopus 로고
    • DNA mismatch repair and colorectal cancer
    • Toft, N. J., and Arends, M. J. DNA mismatch repair and colorectal cancer. J. Pathol., 185: 123-129, 1998.
    • (1998) J. Pathol. , vol.185 , pp. 123-129
    • Toft, N.J.1    Arends, M.J.2
  • 38
    • 0033946039 scopus 로고    scopus 로고
    • DNA mismatch repair genes and colorectal cancer
    • Wheeler, J. M., Bodmer, W. F., and Mortensen, N. J. DNA mismatch repair genes and colorectal cancer. Gut, 47: 148-153, 2000.
    • (2000) Gut , vol.47 , pp. 148-153
    • Wheeler, J.M.1    Bodmer, W.F.2    Mortensen, N.J.3
  • 39
    • 0035101436 scopus 로고    scopus 로고
    • DNA mismatch repair and cancer
    • Peltomaki, P. DNA mismatch repair and cancer. Mutat. Res., 488: 77-85, 2001.
    • (2001) Mutat. Res. , vol.488 , pp. 77-85
    • Peltomaki, P.1
  • 40
    • 0036252540 scopus 로고    scopus 로고
    • DNA mismatch repair defects: Role in colorectal carcinogenesis
    • Jacob, S., and Praz, F. DNA mismatch repair defects: role in colorectal carcinogenesis. Biochimie (Paris), 84: 27-47, 2002.
    • (2002) Biochimie (Paris) , vol.84 , pp. 27-47
    • Jacob, S.1    Praz, F.2
  • 42
    • 0031906084 scopus 로고    scopus 로고
    • The role of DNA mismatch repair in drug resistance
    • Fink, D., Aebi, S., and Howell, S. B. The role of DNA mismatch repair in drug resistance. Clin. Cancer Res., 4: 1-6, 1998.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1-6
    • Fink, D.1    Aebi, S.2    Howell, S.B.3
  • 43
    • 0035418619 scopus 로고    scopus 로고
    • The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells
    • Jacob, S., Aguado, M., Fallik, D., and Praz, F. The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Res., 61: 6555-6562, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 6555-6562
    • Jacob, S.1    Aguado, M.2    Fallik, D.3    Praz, F.4
  • 44
    • 0033513097 scopus 로고    scopus 로고
    • Mismatch repair processing of careinogen-DNA adducts triggers apoptosis
    • Wu, J., Gu, L., Wang, H., Geacintov, N. E., and Li, G. Mismatch repair processing of careinogen-DNA adducts triggers apoptosis. Mol. Cell. Biol., 19: 8292-8301, 1999.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8292-8301
    • Wu, J.1    Gu, L.2    Wang, H.3    Geacintov, N.E.4    Li, G.5
  • 46
    • 0033859532 scopus 로고    scopus 로고
    • Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: Effect of TP53 or hMLH1 deficiency
    • Kennedy, A. S., Harrison, G. H., Mansfield, C. M., Zhou, X. J., Xu, J. F., and Balcer-Knbiczek, E. K. Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: effect of TP53 or hMLH1 deficiency. Int. J. Cancer, 90: 175-185, 2000.
    • (2000) Int. J. Cancer , vol.90 , pp. 175-185
    • Kennedy, A.S.1    Harrison, G.H.2    Mansfield, C.M.3    Zhou, X.J.4    Xu, J.F.5    Balcer-Knbiczek, E.K.6
  • 48
    • 0142141521 scopus 로고    scopus 로고
    • Gemcitabine cytotoxicity and radiation sensitivity in mismatch repair proficient and deficient HCT116 cells
    • Robinson, B. W., Ljungman, M., and Shewach, D. S. Gemcitabine cytotoxicity and radiation sensitivity in mismatch repair proficient and deficient HCT116 cells. Proc. Am. Assoc. Cancer Res., 42: 3587, 2001.
    • (2001) Proc. Am. Assoc. Cancer Res. , vol.42 , pp. 3587
    • Robinson, B.W.1    Ljungman, M.2    Shewach, D.S.3
  • 49
    • 0142234252 scopus 로고    scopus 로고
    • The effect of p53 status on gemcitabine cytotoxicity and radiation sensitivity in mismatch repair proficient and deficient HCT116 cells
    • Robinson, B. W., Ljungman, M., and Shewach, D. S. The effect of p53 status on gemcitabine cytotoxicity and radiation sensitivity in mismatch repair proficient and deficient HCT116 cells. Proc. Am. Assoc. Cancer Res., 43: 3947, 2002.
    • (2002) Proc. Am. Assoc. Cancer Res. , vol.43 , pp. 3947
    • Robinson, B.W.1    Ljungman, M.2    Shewach, D.S.3
  • 50
    • 0021244486 scopus 로고
    • Mean inactivation dose: A useful concept for intercomparison of human cell survival curves
    • Fertil, B., Dertinger, H., Courdi, A., and Malaise, E. P. Mean inactivation dose: a useful concept for intercomparison of human cell survival curves. Radiat. Res., 99: 73-84, 1984.
    • (1984) Radiat. Res. , vol.99 , pp. 73-84
    • Fertil, B.1    Dertinger, H.2    Courdi, A.3    Malaise, E.P.4
  • 51
    • 0026801917 scopus 로고
    • Quantitation of deoxyribonucleoside 5′-triphosphates by a sequential boronate and anion-exchange high-pressure liquid chromatographic procedure
    • Shewach, D. S. Quantitation of deoxyribonucleoside 5′ -triphosphates by a sequential boronate and anion-exchange high-pressure liquid chromatographic procedure. Anal. Biochem., 206: 178-182, 1992.
    • (1992) Anal. Biochem. , vol.206 , pp. 178-182
    • Shewach, D.S.1
  • 52
    • 0024398561 scopus 로고
    • Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): Critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram
    • Hoy, C. A., Seamer, L. C., and Schimke, R. T. Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram. Cytometry, 10: 718-725, 1989.
    • (1989) Cytometry , vol.10 , pp. 718-725
    • Hoy, C.A.1    Seamer, L.C.2    Schimke, R.T.3
  • 53
    • 0034890643 scopus 로고    scopus 로고
    • Radiosensitization by gemcitabine in p53 wild-type and mutant MCF-7 breast carcinoma cell lines
    • Robinson, B. W., and Shewach, D. S. Radiosensitization by gemcitabine in p53 wild-type and mutant MCF-7 breast carcinoma cell lines. Clin. Cancer Res., 7: 2581-2589, 2001.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2581-2589
    • Robinson, B.W.1    Shewach, D.S.2
  • 54
    • 0027936057 scopus 로고
    • Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′ -nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
    • Koi, M., Umar, A., Chauhan, D. P., Cherian, S. P., Carethers, J. M., Kunkel, T. A., and Boland, C. R. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′ -nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res., 54: 4308-4312, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 4308-4312
    • Koi, M.1    Umar, A.2    Chauhan, D.P.3    Cherian, S.P.4    Carethers, J.M.5    Kunkel, T.A.6    Boland, C.R.7
  • 55
    • 7144264394 scopus 로고    scopus 로고
    • Radiosensitization of mouse sarcoma cells by fludarabine (F-ara-A) or gemcitabine (dFdC), two nucleoside analogues, is not mediated by an increased induction or a repair inhibition of DNA double-strand breaks as measured by pulsed-field gel electrophoresis
    • Gregoire, V., Beauduin, M., Bruniaux, M., de Coster, B., Octave-Prignot, M., and Scalliet, P. Radiosensitization of mouse sarcoma cells by fludarabine (F-ara-A) or gemcitabine (dFdC), two nucleoside analogues, is not mediated by an increased induction or a repair inhibition of DNA double-strand breaks as measured by pulsed-field gel electrophoresis. Int. J. Radiat. Biol., 73: 511-520, 1998.
    • (1998) Int. J. Radiat. Biol. , vol.73 , pp. 511-520
    • Gregoire, V.1    Beauduin, M.2    Bruniaux, M.3    De Coster, B.4    Octave-Prignot, M.5    Scalliet, P.6
  • 56
    • 0035866361 scopus 로고    scopus 로고
    • p53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin
    • Lin, X., Ramamurthi, K., Mishima, M., Kondo, A., Christen, R. D., and Howell, S. B. p53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin. Cancer Res., 61: 1508-1516, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 1508-1516
    • Lin, X.1    Ramamurthi, K.2    Mishima, M.3    Kondo, A.4    Christen, R.D.5    Howell, S.B.6
  • 57
    • 0030741503 scopus 로고    scopus 로고
    • hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents
    • Brown, R., Hirst, G. L., Gallagher, G. M., McIlwrath, A. J., Margison, G. P., van der Zee, A. G., and Anthoney, D. A. hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents. Oncogene, 15: 45-52, 1997.
    • (1997) Oncogene , vol.15 , pp. 45-52
    • Brown, R.1    Hirst, G.L.2    Gallagher, G.M.3    McIlwrath, A.J.4    Margison, G.P.5    Van der Zee, A.G.6    Anthoney, D.A.7
  • 58
    • 0027269844 scopus 로고
    • Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction
    • Fang, W., and Modrich, P. Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. J. Biol. Chem., 268: 11838-11844, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11838-11844
    • Fang, W.1    Modrich, P.2
  • 60
    • 0033561529 scopus 로고    scopus 로고
    • The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells
    • Berry, S. E., Garces, C., Hwang, H., Kunugi, K., Meyers, M., Davis, T. W., Boothman, D. A., and Kinsella, T. J. The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells. Cancer Res., 59: 1840-1845, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 1840-1845
    • Berry, S.E.1    Garces, C.2    Hwang, H.3    Kunugi, K.4    Meyers, M.5    Davis, T.W.6    Boothman, D.A.7    Kinsella, T.J.8
  • 61
    • 0034667429 scopus 로고    scopus 로고
    • Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: MSH2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the dThd analogues and 6-thioguanine
    • Berry, S. E., Davis, T. W., Schupp, J. E., Hwang, H., Wind, N., and Kinsella, T. J. Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: MSH2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the dThd analogues and 6-thioguanine. Cancer Res., 60: 5773-5780, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 5773-5780
    • Berry, S.E.1    Davis, T.W.2    Schupp, J.E.3    Hwang, H.4    Wind, N.5    Kinsella, T.J.6
  • 62
    • 0017728872 scopus 로고
    • The effects of incorporation of 5-halogenated deoxyuridines into the DNA of eukaryotic cells
    • Goz, B. The effects of incorporation of 5-halogenated deoxyuridines into the DNA of eukaryotic cells. Pharmacol. Rev., 29: 249-272, 1978.
    • (1978) Pharmacol. Rev. , vol.29 , pp. 249-272
    • Goz, B.1
  • 63
    • 0026593802 scopus 로고
    • Decrease in TTP pools mediated by 5-bromo-2′-deoxycytidine exposure in a human glioblastoma cell line
    • Shewach, D. S., Ellero, J., Maneini, W. R., and Ensminger, W. D. Decrease in TTP pools mediated by 5-bromo-2′-deoxycytidine exposure in a human glioblastoma cell line. Biochem. Pharmacol., 43: 1579-1585, 1992.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 1579-1585
    • Shewach, D.S.1    Ellero, J.2    Maneini, W.R.3    Ensminger, W.D.4
  • 64
    • 0033647208 scopus 로고    scopus 로고
    • Characterization of MLH1 and MSH2 DNA mismatch repair proteins in the cell lines of the NCI anticancer drug screen
    • Taverna, P., Liu, L., Hanson, A. J., Monks, A., and Gerson, S. L. Characterization of MLH1 and MSH2 DNA mismatch repair proteins in the cell lines of the NCI anticancer drug screen. Cancer Chemother. Pharmacol., 46: 507-516, 2000.
    • (2000) Cancer Chemother. Pharmacol. , vol.46 , pp. 507-516
    • Taverna, P.1    Liu, L.2    Hanson, A.J.3    Monks, A.4    Gerson, S.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.