Protection of hematopoietic cells from O6-alkylation damage by O6-methylguanine DNA methyltransferase gene transfer: Studies with different O6-alkylating agents and retroviral backbones

European Journal of Haematology

Volumn 67, Issue 1, 2001, Pages 2-13

  Jansen, Michael ^a   Bardenheuer, Walter ^a   Sorg, Ursula Regina ^a   Seeber, Siegfried ^a   Flasshove, Michael ^a   Moritz, Thomas ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Chloroethylnitrosoureas; DNA repair; Gene therapy; O6 methylguanine DNA methyltransferase; Retrovirus

Indexed keywords

ALKYLATING AGENT; CARMUSTINE; CHLOROETHYLNITROSOUREA; LOMUSTINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; N2 ZIP PGK MGMT; NIMUSTINE; RECOMBINANT DNA; SF1 MGMT; TEMOZOLOMIDE; TETRAZINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS VECTOR;

ALKYLATION; ANIMAL CELL; ARTICLE; BLOOD TOXICITY; BONE MARROW CELL; CELL DAMAGE; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME BINDING; GENE OVEREXPRESSION; GENE TRANSFER; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; TECHNOLOGY;

ALKYLATING AGENTS; ALKYLATION; ANIMALS; CARMUSTINE; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; DACARBAZINE; DNA DAMAGE; DNA, COMPLEMENTARY; DRUG RESISTANCE; GENETIC VECTORS; HEMATOPOIETIC STEM CELLS; HUMANS; LOMUSTINE; MICE; MOLONEY MURINE LEUKEMIA VIRUS; NIMUSTINE; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RECOMBINANT FUSION PROTEINS; RETROVIRIDAE; SARCOMA VIRUSES, MURINE; SPLEEN FOCUS-FORMING VIRUSES; TERMINAL REPEAT SEQUENCES; TRANSFECTION;

EID: 0034883452     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2001.067001002.x     Document Type: Article

References (50)

1. Introduction: Dose-intensive therapy for adult malignancies
2. Transfer of drug resistance genes into hematopoietic progenitors to improve chemotherapy tolerance
3. Establishing chemoresistance in hematopoietic progenitor cells
4. Transfer of drug resistance genes to hemotopoietic precursors
5. 6 -alkylguanine-DNA alkyltransferase and BCNU treated defined length synthetic oligodeoxynucleotides
6. DNA alkylation by the haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair or removal
7. 6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
8. 6-methylguanine-DNA methyltransferase
9. 6 alkylguanine-DNA alkyltransferase activity in human myeloid cells
10. 6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues
11. 6-benzylguanine plus BCNU
12. The nitrosoureas: Carmustine (BCNU) and lomustine (CCNU)
13. Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo
14. 6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents
15. 6-alkylguanine-DNA-alkyltransferase
16. Human alkyltransferase-transinduced murine myeloid progenitors are enriched in vivo by BCNU treatment of transplanted mice
17. Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors
18. Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent
19. 6-methylguanine DNA methyltransferase complementary DNA
20. Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction
21. Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells
22. Versatile retroviral vectors for potential use in gene therapy
23. Dominant selection of hematopoietic progenitor cells with retroviral MDR1 co-expression vectors
24. + peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer
25. High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing fluorescence protein
26. 6-methylguanine-DNA methyltransferase in HeLa cells
27. Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: Acceleration of recovery of peripheral blood neutrophils and platelets
28. Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor
29. + hematopoietic cells
30. Properties of haematopoietic stem cells surviving 5-fluorouracil treatment: Evidence for a pre-CFU-S cell?
31. Rapid, efficient DNA extraction for PCR from cells or blood
32. Transfer of the cytidine deaminase cDNA into hematopoietic cells
33. DNA repair: Enzymatic mechanisms and relevance to drug response
34. DNA repair mechanisms associated with cellular resistance to antitumor drugs: Potential novel targets
35. Relevance of DNA repair to carcinogenesis and cancer therapy
36. Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
37. 6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs
38. 6-Benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow
39. 6-benzylguanine and temozolomide
40. 6-benzylguanine, and an alkyltransferase-expressing retroviral vector
41. Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11
42. Hematopoietic stem cell deficit of transplanted bone marrow previously exposed to cytotoxic agents
43. Type and position of promoter elements in retroviral vectors have substantial effects on the expression level of an enhanced green fluorescent protein reporter gene
44. 6-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection
45. Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice
46. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells
47. Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors
48. 6-methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy
49. 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts
50. New concepts in the treatment of breast cancer using high-dose chemotherapy