Cytotoxicity and cell-cycle effects of paclitaxel when used as a single agent and in combination with ionizing radiation

International Journal of Radiation Oncology Biology Physics

Volumn 37, Issue 4, 1997, Pages 885-895

  Gupta, Nalin ^a,b   Hu, Lily J ^a   Deen, Dennis F ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell cycle; Glioma; Paclitaxel; Radiation enhancer; X irradiation

Indexed keywords

PACLITAXEL;

ARTICLE; CELL CYCLE; CELL KILLING; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS; PRIORITY JOURNAL; RADIOSENSITIVITY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; CELL SURVIVAL; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; G1 PHASE; G2 PHASE; GLIOMA; HUMANS; MITOSIS; PACLITAXEL; RADIATION-SENSITIZING AGENTS; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0030887933     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(96)00535-4     Document Type: Article

References (41)

1. Baguley, B. C.; Marshall, E. S.; Whittaker, J. R.; Dotchin, M. C.; Nixon, J.; McCrystal, M. R.; Finlay, G. J.; Matthews, J. H. L.; Holdaway, K. M.; Zijl, P. V. Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer. Eur. J. Cancer 31A:230-237; 1995.
2. Bhalla, K.; Ibrado, A. M.; Tourkina, E.; Tang, C.; Mahoney, M. E.; Huang, Y. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia 7:563-568; 1994.
3. Cahan, M. A.; Walter, K. A.; Colvin, O. M.; Brem, H. Cytotoxicity of taxol against human and rat malignant brain tumors. Cancer Chemother. Pharmacol. 33:441-444; 1994.
4. Chen, G.; Jaffrezou, J. P.; Fleming, W. H.; Duran, G. E.; Sikic, B. I. Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection. Cancer Res. 54:4980-4987; 1994.
5. Choy, H.; Akerley, W.; Safran, H.; Clark, J.; Rege, V.; Papa, A.; Glantz, M.; Puthawala, Y.; Soderberg, C.; Leone, L. Phase I trial of outpatient weekly paclitaxel and concurrent radiation therapy for advanced non-small-cell lung cancer. J. Clin. Oncol. 12:2682-2686; 1994.
6. Choy, H.; Rodriguez, F.; Koester, S.; Hilsenbeck, S.; Von Hoff, D. Investigation of taxol as a potential radiation sensitizer. Cancer 71:3774-3778; 1993.
7. Diaz, J. F.; Andreu, J. M. Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: Reversibility, ligand stoichiometry, and competition. Biochemistry 32:2747-2755; 1993.
8. Donaldson, K. L.; Goolsby, G. L.; Wahl, A. F. Cytotoxicity of the anticancer agents cisplatin and taxol during cell proliferation and the cell cycle. Int. J. Cancer 57:847-855; 1994.
9. Finney, D. J. Statistical method in biological assay. 3rd ed. London: Charles Griffin; 1978.
10. Geard, C.; Jones, J. Radiation and Taxol effects on synchronized human cervical carcinoma cells. Int. J. Radiat. Oncol. Biol. Phys. 29:565-569; 1994.
11. Gorbsky, G. J. Kinetochores, microtubules and the metaphase checkpoint. Trends Cell Biol. 5:143-148; 1995.
12. Gupta, N.; Deen, D. F. Comments on the use of paclitaxel as a radiation sensitizer [letter]. Int. J. Radiat. Oncol. Biol. Phys. 33:239; 1995.
13. Hei, T. K.; Piao, C. Q.; Geard, C. R.; Hall, E. J. Taxol and ionizing radiation: Interaction and mechanisms. Int. J. Radiat. Oncol. Biol. Phys. 29:267-271; 1994.
14. Ho, J. T.; Deen, D. F. Prolonged hyperthermia eliminates mycoplasma from cultured human and rat brain tumor cell lines. Radiat. Res. 127:339-341; 1991.
15. Holmes, F. A.; Walter, R. S.; Theriault, R. L.; Forman, A. D.; Newton, L. K.; Raber, M. N.; Buzdar, A. U.; Frye, D. K.; Hortobagyi, G. N. Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J. Natl. Cancer Inst. 83:1797-1805; 1991.
16. Hoshino, T.; Ahn, D.; Prados, M.; Lamborn, K.; Wilson, C. Prognostic significance of the proliferative potential of intracranial gliomas measured by bromodeoxyuridine labeling. Int. J. Cancer 53:550-555; 1993.
17. Hoshino, T.; Ito, S.; Asai, A.; Shibuya, M.; Prados, M.; Dodson, B.; Davis, R.; Wilson, C. Cell kinetic analysis of human brain tumors by in situ double labeling with bromodeoxyuridine and iododeoxyuridine. Int. J. Cancer 50:1-5; 1992.
18. Jordan, M. A.; Margolis, R. L.; Himes, R. H.; Wilson, L. Identification of a distinct class of vinblastine binding sites on microtubules. J. Mol. Biol. 187:61-73; 1986.
19. Jordan, M. A.; Toso, R. T.; Thrower, D.; Wilson, L. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc. Natl. Acad. Sci. USA 90:9552-9556; 1993.
20. Kung, A. L.; Sherwood, S. W.; Schimke, R. T. Cell line-specific differences in the control of cell cycle progression in the absence of mitosis. Proc. Natl. Acad. Sci. USA 87:9553-9557; 1990.
21. Legha, S. S.; Ring, S.; Papadopoulos, N.; Raber, M.; Benjamin, R. S. A phase II trial of taxol in metastatic melanoma. Cancer 65:2478-2481; 1990.
22. Lehnert, M.; Emerson, S.; Dalton, W. S.; deGiuli, R.; Salmon, S. E. In vitro evaluation of chemosensitizers for clinical reversal of p-glycoprotein-associated taxol resistance. Monogr. Natl. Cancer Inst. 15:63-67; 1993.
23. Liebmann, J.; Cook, J. A.; Fisher, J.; Teague, D.; Mitchell, J. B. Changes in radiation survival curve parameters in human tumor and rodent cells exposed to paclitaxel (Taxol). Int. J. Radiat. Oncol. Biol. Phys. 29:559-564; 1994.
24. Liebmann, J. E.; Cook, J. A.; Lipschultz, C.; Teague, D.; Fisher, J.; Mitchell, J. B. Cytotoxic studies of paclitaxel (taxol) in human tumour cell lines. Br. J. Cancer 68:1104-1109; 1993.
25. McGuire, W. P.; Rowinski, E. K.; Grochow, L. B.; Longnecker, S. M.; Ettinger, D. S.; Armstrong, D. K.; Donehower, R. C. Taxol: A unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann. Intern. Med. 111:273-279; 1989.
26. Minotti, A. M.; Barlow, S. B.; Cabrai, F. Resistance to antimitotic drugs in Chinese hamster ovary cells correlates with changes in the level of polymerized tubulin. J. Biol. Chem. 266:3987-3994; 1991.
27. Parness, J.; Horwitz, S. B. Taxol binds to polymerized tubulin in vitro. J. Cell Biol. 91:479-487; 1981.
28. Roy, S. N.; Horwitz, S. B. A phosphoglycoprotein associated with taxol-resistance in J774.2 cells. Cancer Res. 45:3856-3863; 1985.
29. Rutka, J. T.; Giblin, J. R.; Dougherty, D. Y.; Liu, H. C.; McCulloch, J. R.; Bell, C. W.; Stern, R. S.; Wilson, C. B.; Rosenblum, M. L. Establishment and characterization of five cell lines derived from human malignant gliomas. Acta Neuropathol. (Berl.) 75:92-103; 1987.
30. Schiff, P. B.; Fant, J.; Horowitz, S. B. Promotion of microtubule assembly in vitro by taxol. Nature 277:665-667; 1979.
31. Schiff, P. B.; Horwitz, S. B. Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl. Acad. Sci. USA 77:1561-1565; 1980.
32. Seewaldt, V.; Greer, B.; Cain, J.; Figge, D.; Tamimi, H.; Brown, W.; Miller, S. Paclitaxel (Taxol) treatment for refractory ovarian cancer: phase II clinical trial. Am. J. Gynecol. Oncol. 170:1666-1670; 1994.
33. Sinclair, W. K. Cyclic X-ray responses in mammalian cells in vitro. Radiat. Res. 33:620-643; 1968.
34. Singer, W. D.; Jordan, M. A.; Wilson, L.; Himes, R. Binding of vinblastine to stabilized microtubules. Mol. Pharmacol. 36:366-370; 1989.
35. Steel, G. G.; Peckham, M. J. Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity. Int. J. Radiat. Oncol. Biol. Phys. 5:85-91; 1979.
36. Steren, A.; Sevin, B.; Perras, J.; Angioli, R.; Nguyen, H.; Guerra, L.; Koechli, O.; Averette, H. Taxol sensitizes human ovarian cancer cells to radiation. Gynecol. Oncol. 48:252-258; 1993.
37. Steren, A.; Sevin, B. U.; Perras, J.; Ramos, R.; Angioli, R.; Nguyen, H.; Koechli, O.; Averette, H. E. Taxol as a radiation sensitizer: A flow cytometric study. Gynecol. Oncol. 50:89-93; 1993.
38. Stromberg, J. S.; Lee, Y. J.; Armour, E. P.; Martinez, A. A.; Corry, P. M. Lack of radiosensitization after paclitaxel treatment of three human carcinoma cell lines. Cancer 75:2262-2268; 1995.
39. Thigpen, T.; Vance, R.; Puneky, L.; Khansur, T. Chemotherapy in advanced ovarian carcinoma: Current standards of care based on randomized trials. Gynecol. Oncol. 55:897-S107; 1994.
40. Tishler, R. B.; Geard, C. R.; Hall, E. J.; Schiff, P. B. Taxol sensitizes human astrocytoma cells to radiation. Cancer Res. 52:3495-3497; 1992.
41. Tishler, R. B.; Schiff, P. B.; Geard, C. R.; Hall, E. J. Taxol: A novel radiation sensitizer. Int. J. Radiat. Oncol. Biol. Phys. 22:613-617; 1992.