Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis

Molecular Cancer Therapeutics

Volumn 5, Issue 3, 2006, Pages 564-574

  Noël, Georges ^a,b   Godon, Camille ^a   Fernet, Marie ^a   Giocanti, Nicole ^a   Mégnin Chanet, Frédérique ^a   Favaudon, Vincent ^a  

^a INSERM   (France)

^b CENTRE PAUL STRAUSS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 1,8 NAPHTHALIMIDE; CELL DNA; DOUBLE STRANDED DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CATALYSIS; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DIVISION; CELL GROWTH; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; DNA REPAIR; DNA REPLICATION; DNA SYNTHESIS; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; GAMMA RADIATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOSENSITIZATION;

1-NAPHTHYLAMINE; ANIMALS; CRICETINAE; DNA; DNA REPLICATION; HUMANS; MICE; MICE, KNOCKOUT; NAPHTHALIMIDES; NEOPLASMS; NUCLEIC ACID SYNTHESIS INHIBITORS; POLY(ADP-RIBOSE) POLYMERASES; QUINOLONES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; S PHASE; TUMOR CELLS, CULTURED;

EID: 33645469913     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-05-0418     Document Type: Article

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