The aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe

Cell Cycle

Volumn 8, Issue 19, 2009, Pages 3172-3181

  Tao, Yungan ^a,b,c   Leteur, Céline ^a,c   Calderaro, Julien ^e   Girdler, Fiona ^f   Zhang, Ping ^a,b,c   Frascogna, Valérie ^a,c   Varna, Mariana ^e   Opolon, Paule ^c,d   Castedo, Maria ^c,e   Bourhis, Jean ^a,b,c   Kroemer, Guido ^c,e   Deutsch, Eric ^a,b,c  

^a UPRES EA27 10 Laboratoire Radiosensibilité des Tumeurs et Tissus Sains   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d CNRS   (France)

^e INSERM   (France)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Aurora B; Cell death; Checkpoint; Mitotic catastrophe; Radiation

Indexed keywords

2 [[3 [4 [5 [2 (3 FLUOROANILINO) 2 OXOETHYL] 1H PYRAZOL 3 YLAMINO] 7 QUINAZOLINYLOXY]PROPYL](ETHYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE; CASPASE; CHECKPOINT KINASE 1; HISTONE H2A; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN BAX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CELL; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HCT116; CELL STRAIN HT29; CELL SUBPOPULATION; CELL SURVIVAL; COLON CANCER; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IONIZING RADIATION; MICRONUCLEUS; MITOSIS; MOUSE; NONHUMAN; POLYPLOIDY; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; RADIOSENSITIZATION; TREATMENT RESPONSE; TUMOR XENOGRAFT;

EID: 70349904767     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.19.9729     Document Type: Article

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