Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase

Cancer Letters

Volumn 205, Issue 2, 2004, Pages 155-160

  Brock, William A ^a   Milas, Luka ^a   Bergh, Sherry ^a   Lo, Ruth ^a   Szabó, Csaba ^b   Mason, Kathy A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b INOTEK CORPORATION   (United States)

Author keywords

Fibroblasts; Poly(ADP ribose) polymerase; Poly(ADP ribose) synthetase; Radiation; Radiosensitizer; Tumor cells

Indexed keywords

INO 1001; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL KILLING; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA REPAIR; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; FRACTIONATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIZATION; STATISTICAL SIGNIFICANCE;

RODENTIA;

EID: 1242271229     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2003.10.029     Document Type: Article

References (39)

1. Althaus F.R., Hilz H., Shall S. ADP-Ribosylation of Proteins. 1985;Springer, Berlin.
2. Jacobson M.K., Jacobson E.L. ADP-Ribose Transfer Reactions: Mechanisms and Biological Significance. 1989;Springer, New York.
3. Virag L., Salzman A.L., Szabo C. (ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J. Immunol. 161:1998;3753-3759.
4. Ha H.C., Snyder S.H. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc. Natl Acad. Sci USA. 96:1999;13978-13982.
5. Kaufmann S.H., Desnoyers S., Ottaviano Y., Davidson N.E., Poirier G.G. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 53:1993;3976-3985.
6. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., Earnshaw W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 371:1994;346-347.
7. de Murcia G., Menissier-de Murcia J. Poly(ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem. Sci. 19:1994;172-176.
8. Cleaver J.E., Morgan W.F. Poly(ADP-ribose)polymerase: a perplexing participant in cellular response to DNA breakage. Mutat. Res. 257:1991;1-18.
9. Lautier D., Lagueux J., Thibodeau J., Menard L., Poirier G.G. Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol. Cell Biochem. 122:1993;171-193.
10. Shall S. ADP-ribosylation reactions. Biochimie. 77:1995;313-318.
11. Lindahl T., Satoh M.S., Poirier G.G., Klungland A. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem. Sci. 20:1995;405-411.
12. Satoh M.S., Lindahl T. Role of poly(ADP-ribose) formation in DNA repair. Nature. 356:1992;356-358.
13. James M.R., Lehmann A. Role of poly(adenosine diphosphate ribose) in deoxyribonucleir acid repair in human fibroblasts. Biochemistry. 21:1982;4007-4013.
14. Zwelling L.A., Kerrigan D., Pommier Y. Inhibitors of poly(adenosine diphosphoribose) synthesis slow the resealing rate of X-ray induced DNA strand breaks. Biochem. Biophys. Res. Commun. 104:1982;897-902.
15. Ahnstrom G.L.M. Effects of 3-aminobenzamide on the rejoining of DNA strand breaks in mammalian cells exposed to methyl methanesulphonate; role of poly(ADP-ribose) polymerase. Mutat. Res. 194:1988;17-22.
16. Ding R., Pommier Y., Kang V.H., Smulson M. Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining. J. Biol. Chem. 267:1992;12804-12812.
17. Lunec J., George M., Hedges M., Cramp W.A., Whish W.J.D., Hunt B. Post-irradiation sensitization with the ADP-ribosyltransferase inhibitor 3-acetamidobenzamide. Br. J. Cancer. 49:1984;19-25.
18. Brown D.M., Evans J.W., Brown J.M. The influence of inhibitors of poly(ADP)polymerase on x-ray induced potentially lethal damage repair. Br. J. Cancer. 49:1984;27-34.
19. Ben-Hur E., Utsumi H., Elkind M.M. Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log phase Chinese hamster cells. Radiat. Res. 1984;97.
20. Ben-Hur E. Involvement of poly(ADP-ribose) in the radiation response of mammalian cells. Int. J. Radiat. Biol. 46:1984;659-671.
21. 2O and inhibitors of poly(ADP-ribose) synthetase in cultured mammalian L5178Y cells. Radiat. Res. 98:1984;574-582.
22. Thraves P., Mossman K.L., Brennan T., Dritschilo A. Radiosensitization of human fibroblasts by 3-aminobensamide in Chinese hamster V79 cells exposed to X-rays. Radiat. Res. 104:1985;119-127.
23. Kelland L.R., Burgess L., Steel G.G. Radiation damage repair capacity of a human germ cell tumour cell line: inhibition by 3-aminobenzamide. Int. J. Radiat. Biol. 51:1987;227-241.
24. Arundel-Suto C.M., Scavone S.V., Turner W.R., Suto M.J., Sebolt-Leopold J.S. Effects of PD128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in Chinese hamster V79 cells. Radiat. Res. 126:1991;367-371.
25. Wang Z.Q., Auer B., Stingl L., Berghammer H., Haidacher E., Schweiger M., Wagner E.F. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Develop. 9:1995;510-520.
26. Menissier-de Murcia J., Niedergang C., Trucco C., Ricoul M., Dutrillaux B., Mark M. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl Acad. Sci USA. 94:1997;7303-7307.
27. Wang Z.Q., Stingl L., Jantsch M., Los M., Schulze-Osthoff K., Wagner E.F. PARP is important for genomic stability but dispensable in apoptosis. Genes Dev. 11:1997;2347-2358.
28. Southan G., Szabo C. Inhibitors of poly(ADP-ribose) polymerase. Current Med. Chem. 10:2003;321-340.
29. Komjati K., Jagtap P., Baloglu E., VanDuzer J., Salzman A.L., Szabo C. Poly(ADP-ribose) polymerase inhibition in stroke: establishment of the therapeutic window of intervention and delineation of its role in the pathogenesis of white matter damage. Fed. Am. Soc. Exp. Biol. J. 16:2002;A599. (abstr).
30. Shimoda K., Murakami K., Traber L.L., Cox R.A., Hawkins H.K., Schmalstieg F.C. Effect of poly(ADP-ribose) synthetase inhibition on burn and smoke inhalation injury in the sheep. Am. J. Physiol. 2003;. (in press).
31. Kahn T.A., Ruel M., Bianchi C., Voisine P., Li J., Baker J., et al. Poly-ADP-Ribose synthetase inhibition improves postischemic myocardial function after cardiopulmonary bypass. J. Am. Coll. Surg. 2003.
32. Geara F.B., Peters L.J., Ang K.K., Wike J.L., Brock W.A. Radiosensitivity measurements of keratinocytes and fibroblasts from radiotherapy patients. Int. J. Radiat. Oncol. Biol. Phys. 24:1992;287-293.
33. Fertil B., Malaise E.P. Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy. Int. J. Radiat. Biol. 7:1981;621-629.
34. Hall E.J. Radiobiology for the Radiologist. 5th edition: 2000;Lippincott Williams and Wilkins, Philadelphia, PA.
35. Burgman P., Konings A.W.T. Effect of inhibitors of poly(ADP-ribose) polymerase on the radiation response of HeLa S3 cells. Int. J. Radiat. Biol. 119:1989;380-386.
36. Ben-Hur E., Utsumi H., Elkind M.M. Inhibitors of poly(ADP-ribose) synthesis enhance radiation response by differentially affecting repair of potentially lethal vs. sublethal damage. Br. J. Cancer. 49:(Suppl. VI):1984;39-42.
37. Huet J., Laval F. Influence of poly(ADP-ribose) synthesis inhibitors on the repair of sublethal and potentially lethal damage in γ-irradiated mammalian cells. Int. J. Radiat. Biol. 47:1985;655-662.
38. Kumar A., Kiefer J., Schneider E., Crompton N.E.A. Enhanced cell killing, inhibition of recovery from potentially lethal damage and increased mutation frequency by 3-aminobenzamide in Chinese hamster V79 cells exposed to X-rays. Radiat. Res. 47:1985;103-112.
39. Weltin D., Holl V., Hyun J.W., Dufour P., Marchal J., Bischoff P. Effect of 6(5H)-phenanthridinone, a poly(ADP-ribose)polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells. Int. J. Radiat. Biol. 72:1997;685-692.