-
1
-
-
31544444123
-
Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer
-
Powers H.J. Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer. J Nutr 135 (2005) 2960S-2966S
-
(2005)
J Nutr
, vol.135
-
-
Powers, H.J.1
-
2
-
-
23844445571
-
Thymidylate synthase structure, function and implication in drug discovery
-
Costi M.P., Ferrari S., Venturelli A., Calo S., Tondi D., and Barlocco D. Thymidylate synthase structure, function and implication in drug discovery. Curr Med Chem 12 (2005) 2241-2258
-
(2005)
Curr Med Chem
, vol.12
, pp. 2241-2258
-
-
Costi, M.P.1
Ferrari, S.2
Venturelli, A.3
Calo, S.4
Tondi, D.5
Barlocco, D.6
-
3
-
-
0025611018
-
Metabolism and mechanism of action of 5-fluorouracil
-
Parker W.B., and Cheng Y.C. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther 48 (1990) 381-395
-
(1990)
Pharmacol Ther
, vol.48
, pp. 381-395
-
-
Parker, W.B.1
Cheng, Y.C.2
-
4
-
-
0031725620
-
Thymine metabolism and thymineless death in prokaryotes and eukaryotes
-
Ahmad S.I., Kirk S.H., and Eisenstark A. Thymine metabolism and thymineless death in prokaryotes and eukaryotes. Ann Rev Microbiol 52 (1998) 591-625
-
(1998)
Ann Rev Microbiol
, vol.52
, pp. 591-625
-
-
Ahmad, S.I.1
Kirk, S.H.2
Eisenstark, A.3
-
5
-
-
0028250942
-
Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy
-
Eriksson S., Arner E., Spasokoukotskaja T., Wang L., Karlsson A., Brosjo O., et al. Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy. Adv Enzyme Regul 34 (1994) 13-25
-
(1994)
Adv Enzyme Regul
, vol.34
, pp. 13-25
-
-
Eriksson, S.1
Arner, E.2
Spasokoukotskaja, T.3
Wang, L.4
Karlsson, A.5
Brosjo, O.6
-
6
-
-
33745096901
-
Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers
-
Basten G.P., Duthie S.J., Pirie L., Vaughan N., Hill M.H., and Powers H.J. Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Br J Cancer 94 (2006) 1942-1947
-
(2006)
Br J Cancer
, vol.94
, pp. 1942-1947
-
-
Basten, G.P.1
Duthie, S.J.2
Pirie, L.3
Vaughan, N.4
Hill, M.H.5
Powers, H.J.6
-
7
-
-
0034234531
-
Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon
-
Kim Y.I., Shirwadkar S., Choi S.W., Puchyr M., Wang Y., and Mason J.B. Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon. Gastroenterology 119 (2000) 151-161
-
(2000)
Gastroenterology
, vol.119
, pp. 151-161
-
-
Kim, Y.I.1
Shirwadkar, S.2
Choi, S.W.3
Puchyr, M.4
Wang, Y.5
Mason, J.B.6
-
8
-
-
33845326730
-
Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene
-
Crott J.W., Liu Z., Choi S.W., and Mason J.B. Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene. Mutat Res 626 (2007) 171-179
-
(2007)
Mutat Res
, vol.626
, pp. 171-179
-
-
Crott, J.W.1
Liu, Z.2
Choi, S.W.3
Mason, J.B.4
-
9
-
-
33751260923
-
Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c
-
Knock E., Deng L., Wu Q., Leclerc D., Wang X.L., and Rozen R. Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c. Cancer Res 66 (2006) 10349-10356
-
(2006)
Cancer Res
, vol.66
, pp. 10349-10356
-
-
Knock, E.1
Deng, L.2
Wu, Q.3
Leclerc, D.4
Wang, X.L.5
Rozen, R.6
-
10
-
-
14044252841
-
Gene-nutrient interactions in one-carbon metabolism
-
Friso S., and Choi S.W. Gene-nutrient interactions in one-carbon metabolism. Curr Drug Metab 6 (2005) 37-46
-
(2005)
Curr Drug Metab
, vol.6
, pp. 37-46
-
-
Friso, S.1
Choi, S.W.2
-
11
-
-
0021343975
-
Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil
-
Berger S.H., and Hakala M.T. Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil. Mol Pharmacol 25 (1984) 303-309
-
(1984)
Mol Pharmacol
, vol.25
, pp. 303-309
-
-
Berger, S.H.1
Hakala, M.T.2
-
12
-
-
0018124757
-
The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine
-
Jackson R.C. The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine. J Biol Chem 253 (1978) 7440-7446
-
(1978)
J Biol Chem
, vol.253
, pp. 7440-7446
-
-
Jackson, R.C.1
-
13
-
-
0035217760
-
The role of dUTPase and uracil-DNA repair in cancer chemotherapy
-
Ladner R.D. The role of dUTPase and uracil-DNA repair in cancer chemotherapy. Curr Protein Pept Sci 2 (2001) 361-370
-
(2001)
Curr Protein Pept Sci
, vol.2
, pp. 361-370
-
-
Ladner, R.D.1
-
14
-
-
0017740439
-
Excision repair of uracil incorporated in DNA as a result of a defect in dUTPase
-
Tye B.K., and Lehman I.R. Excision repair of uracil incorporated in DNA as a result of a defect in dUTPase. J Mol Biol 117 (1977) 293-306
-
(1977)
J Mol Biol
, vol.117
, pp. 293-306
-
-
Tye, B.K.1
Lehman, I.R.2
-
15
-
-
0022506923
-
DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate
-
Ingraham H.A., Dickey L., and Goulian M. DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate. Biochemistry 25 (1986) 3225-3230
-
(1986)
Biochemistry
, vol.25
, pp. 3225-3230
-
-
Ingraham, H.A.1
Dickey, L.2
Goulian, M.3
-
16
-
-
0023655202
-
Deoxyribonucleoside triphosphate imbalance 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death
-
Yoshioka A., Tanaka S., Hiraoka O., Koyama Y., Hirota Y., Ayusawa D., et al. Deoxyribonucleoside triphosphate imbalance 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J Biol Chem 262 (1987) 8235-8241
-
(1987)
J Biol Chem
, vol.262
, pp. 8235-8241
-
-
Yoshioka, A.1
Tanaka, S.2
Hiraoka, O.3
Koyama, Y.4
Hirota, Y.5
Ayusawa, D.6
-
17
-
-
0023678551
-
A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells
-
Ayusawa D., Arai H., Wataya Y., and Seno T. A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells. Mutat Res 200 (1988) 221-230
-
(1988)
Mutat Res
, vol.200
, pp. 221-230
-
-
Ayusawa, D.1
Arai, H.2
Wataya, Y.3
Seno, T.4
-
18
-
-
0026483281
-
Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity
-
Canman C.E., Tang H.Y., Normolle D.P., Lawrence T.S., and Maybaum J. Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity. Proc Natl Acad Sci USA 89 (1992) 10474-10478
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10474-10478
-
-
Canman, C.E.1
Tang, H.Y.2
Normolle, D.P.3
Lawrence, T.S.4
Maybaum, J.5
-
19
-
-
26944498660
-
Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency
-
Li L., Connor E.E., Berger S.H., and Wyatt M.D. Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency. Biochem Pharmacol 70 (2005) 1458-1468
-
(2005)
Biochem Pharmacol
, vol.70
, pp. 1458-1468
-
-
Li, L.1
Connor, E.E.2
Berger, S.H.3
Wyatt, M.D.4
-
20
-
-
0028982818
-
Ratio of 2′-deoxyadenosine-5′-triphosphate/thymidine-5′-triphosphate influences the commitment of human colon carcinoma cells to thymineless death
-
Houghton J.A., Tillman D.M., and Harwood F.G. Ratio of 2′-deoxyadenosine-5′-triphosphate/thymidine-5′-triphosphate influences the commitment of human colon carcinoma cells to thymineless death. Clin Cancer Res 1 (1995) 723-730
-
(1995)
Clin Cancer Res
, vol.1
, pp. 723-730
-
-
Houghton, J.A.1
Tillman, D.M.2
Harwood, F.G.3
-
21
-
-
0029841372
-
DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells
-
Matsui S.I., Arredondo M.A., Wrzosek C., and Rustum Y.M. DNA damage and p53 induction do not cause ZD1694-induced cell cycle arrest in human colon carcinoma cells. Cancer Res 56 (1996) 4715-4723
-
(1996)
Cancer Res
, vol.56
, pp. 4715-4723
-
-
Matsui, S.I.1
Arredondo, M.A.2
Wrzosek, C.3
Rustum, Y.M.4
-
22
-
-
0027482012
-
Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate
-
Canman C.E., Lawrence T.S., Shewach D.S., Tang H.Y., and Maybaum J. Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate. Cancer Res 53 (1993) 5219-5224
-
(1993)
Cancer Res
, vol.53
, pp. 5219-5224
-
-
Canman, C.E.1
Lawrence, T.S.2
Shewach, D.S.3
Tang, H.Y.4
Maybaum, J.5
-
23
-
-
0028223117
-
Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase
-
Canman C.E., Radany E.H., Parsels L.A., Davis M.A., Lawrence T.S., and Maybaum J. Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase. Cancer Res 54 (1994) 2296-2298
-
(1994)
Cancer Res
, vol.54
, pp. 2296-2298
-
-
Canman, C.E.1
Radany, E.H.2
Parsels, L.A.3
Davis, M.A.4
Lawrence, T.S.5
Maybaum, J.6
-
24
-
-
4944241573
-
Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition
-
Koehler S.E., and Ladner R.D. Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. Mol Pharmacol 66 (2004) 620-626
-
(2004)
Mol Pharmacol
, vol.66
, pp. 620-626
-
-
Koehler, S.E.1
Ladner, R.D.2
-
25
-
-
0035800492
-
The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition
-
Webley S.D., Welsh S.J., Jackman A.L., and Aherne G.W. The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition. Br J Cancer 85 (2001) 446-452
-
(2001)
Br J Cancer
, vol.85
, pp. 446-452
-
-
Webley, S.D.1
Welsh, S.J.2
Jackman, A.L.3
Aherne, G.W.4
-
26
-
-
0004228157
-
-
ASM Press, Washington, D.C.
-
Friedberg E.C., Walker G.C., Siede W., Wood R.D., Schultz R.A., and Ellenberger T. DNA repair and mutagenesis (2006), ASM Press, Washington, D.C.
-
(2006)
DNA repair and mutagenesis
-
-
Friedberg, E.C.1
Walker, G.C.2
Siede, W.3
Wood, R.D.4
Schultz, R.A.5
Ellenberger, T.6
-
27
-
-
0037115911
-
Uracil in DNA-occurrence, consequences and repair
-
Krokan H.E., Drablos F., and Slupphaug G. Uracil in DNA-occurrence, consequences and repair. Oncogene 21 (2002) 8935-8948
-
(2002)
Oncogene
, vol.21
, pp. 8935-8948
-
-
Krokan, H.E.1
Drablos, F.2
Slupphaug, G.3
-
28
-
-
0033636312
-
Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication
-
Nilsen H., Rosewell I., Robins P., Skjelbred C.F., Andersen S., Slupphaug G., et al. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication. Mol Cell 5 (2000) 1059-1065
-
(2000)
Mol Cell
, vol.5
, pp. 1059-1065
-
-
Nilsen, H.1
Rosewell, I.2
Robins, P.3
Skjelbred, C.F.4
Andersen, S.5
Slupphaug, G.6
-
29
-
-
0033168183
-
Post-replicative base excision repair in replication foci
-
Otterlei M., Warbrick E., Nagelhus T.A., Haug T., Slupphaug G., Akbari M., et al. Post-replicative base excision repair in replication foci. EMBO J 18 (1999) 3834-3844
-
(1999)
EMBO J
, vol.18
, pp. 3834-3844
-
-
Otterlei, M.1
Warbrick, E.2
Nagelhus, T.A.3
Haug, T.4
Slupphaug, G.5
Akbari, M.6
-
30
-
-
0041639515
-
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
-
Nilsen H., Stamp G., Andersen S., Hrivnak G., Krokan H.E., Lindahl T., et al. Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene 22 (2003) 5381-5386
-
(2003)
Oncogene
, vol.22
, pp. 5381-5386
-
-
Nilsen, H.1
Stamp, G.2
Andersen, S.3
Hrivnak, G.4
Krokan, H.E.5
Lindahl, T.6
-
31
-
-
0033575886
-
The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
-
Hendrich B., Hardeland U., Ng H.H., Jiricny J., and Bird A. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature 401 (1999) 301-304
-
(1999)
Nature
, vol.401
, pp. 301-304
-
-
Hendrich, B.1
Hardeland, U.2
Ng, H.H.3
Jiricny, J.4
Bird, A.5
-
32
-
-
0037135130
-
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice
-
Millar C.B., Guy J., Sansom O.J., Selfridge J., MacDougall E., Hendrich B., et al. Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science 297 (2002) 403-405
-
(2002)
Science
, vol.297
, pp. 403-405
-
-
Millar, C.B.1
Guy, J.2
Sansom, O.J.3
Selfridge, J.4
MacDougall, E.5
Hendrich, B.6
-
33
-
-
0037069366
-
Mbd4 inactivation increases C to T transition mutations and promotes gastrointestinal tumor formation
-
Wong E., Yang K., Kuraguchi M., Werling U., Avdievich E., Fan K., et al. Mbd4 inactivation increases C to T transition mutations and promotes gastrointestinal tumor formation. Proc Natl Acad Sci USA 99 (2002) 14937-14942
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14937-14942
-
-
Wong, E.1
Yang, K.2
Kuraguchi, M.3
Werling, U.4
Avdievich, E.5
Fan, K.6
-
34
-
-
0033599013
-
Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency
-
Bader S., Walker M., Hendrich B., Bird A., Bird C., Hooper M., et al. Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. Oncogene 18 (1999) 8044-8047
-
(1999)
Oncogene
, vol.18
, pp. 8044-8047
-
-
Bader, S.1
Walker, M.2
Hendrich, B.3
Bird, A.4
Bird, C.5
Hooper, M.6
-
35
-
-
0032743063
-
The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability
-
Riccio A., Aaltonen L.A., Godwin A.K., Loukola A., Percesepe A., Salovaara R., et al. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. Nat Genet 23 (1999) 266-268
-
(1999)
Nat Genet
, vol.23
, pp. 266-268
-
-
Riccio, A.1
Aaltonen, L.A.2
Godwin, A.K.3
Loukola, A.4
Percesepe, A.5
Salovaara, R.6
-
36
-
-
33847663262
-
The enigmatic thymine DNA glycosylase
-
Cortazar D., Kunz C., Saito Y., Steinacher R., and Schar P. The enigmatic thymine DNA glycosylase. DNA Repair (Amst) 6 (2007) 489-504
-
(2007)
DNA Repair (Amst)
, vol.6
, pp. 489-504
-
-
Cortazar, D.1
Kunz, C.2
Saito, Y.3
Steinacher, R.4
Schar, P.5
-
37
-
-
33845726097
-
Methylating agents and DNA repair responses: methylated bases and sources of strand breaks
-
Wyatt M.D., and Pittman D.L. Methylating agents and DNA repair responses: methylated bases and sources of strand breaks. Chem Res Toxicol 19 (2006) 1580-1594
-
(2006)
Chem Res Toxicol
, vol.19
, pp. 1580-1594
-
-
Wyatt, M.D.1
Pittman, D.L.2
-
38
-
-
0030979178
-
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage
-
Blount B.C., Mack M.M., Wehr C.M., MacGregor J.T., Hiatt R.A., Wang G., et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94 (1997) 3290-3295
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3290-3295
-
-
Blount, B.C.1
Mack, M.M.2
Wehr, C.M.3
MacGregor, J.T.4
Hiatt, R.A.5
Wang, G.6
-
39
-
-
2942521401
-
Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes
-
Mashiyama S.T., Courtemanche C., Elson-Schwab I., Crott J., Lee B.L., Ong C.N., et al. Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes. Anal Biochem 330 (2004) 58-69
-
(2004)
Anal Biochem
, vol.330
, pp. 58-69
-
-
Mashiyama, S.T.1
Courtemanche, C.2
Elson-Schwab, I.3
Crott, J.4
Lee, B.L.5
Ong, C.N.6
-
40
-
-
0031763502
-
DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro
-
Duthie S.J., and Hawdon A. DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. Faseb J 12 (1998) 1491-1497
-
(1998)
Faseb J
, vol.12
, pp. 1491-1497
-
-
Duthie, S.J.1
Hawdon, A.2
-
41
-
-
0033635671
-
Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells
-
Duthie S.J., Narayanan S., Blum S., Pirie L., and Brand G.M. Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer 37 (2000) 245-251
-
(2000)
Nutr Cancer
, vol.37
, pp. 245-251
-
-
Duthie, S.J.1
Narayanan, S.2
Blum, S.3
Pirie, L.4
Brand, G.M.5
-
42
-
-
33847057392
-
5-Fluorouracil incorporated into DNA is excised by the smug1 DNA glycosylase to reduce drug cytotoxicity
-
An Q., Robins P., Lindahl T., and Barnes D.E. 5-Fluorouracil incorporated into DNA is excised by the smug1 DNA glycosylase to reduce drug cytotoxicity. Cancer Res 67 (2007) 940-945
-
(2007)
Cancer Res
, vol.67
, pp. 940-945
-
-
An, Q.1
Robins, P.2
Lindahl, T.3
Barnes, D.E.4
-
43
-
-
33749014429
-
Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase
-
Fischer J.A., Muller-Weeks S., and Caradonna S.J. Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase. Cancer Res 66 (2006) 8829-8837
-
(2006)
Cancer Res
, vol.66
, pp. 8829-8837
-
-
Fischer, J.A.1
Muller-Weeks, S.2
Caradonna, S.J.3
-
44
-
-
7044278257
-
The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity
-
Cortellino S., Turner D., Masciullo V., Schepis F., Albino D., Daniel R., et al. The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc Natl Acad Sci USA 100 (2003) 15071-15076
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15071-15076
-
-
Cortellino, S.1
Turner, D.2
Masciullo, V.3
Schepis, F.4
Albino, D.5
Daniel, R.6
-
45
-
-
36549061567
-
5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems
-
Fischer F., Baerenfaller K., and Jiricny J. 5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems. Gastroenterology 133 (2007) 1858-1868
-
(2007)
Gastroenterology
, vol.133
, pp. 1858-1868
-
-
Fischer, F.1
Baerenfaller, K.2
Jiricny, J.3
-
46
-
-
14044264185
-
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage
-
Meyers M., Wagner M.W., Mazurek A., Schmutte C., Fishel R., and Boothman D.A. DNA mismatch repair-dependent response to fluoropyrimidine-generated damage. J Biol Chem 280 (2005) 5516-5526
-
(2005)
J Biol Chem
, vol.280
, pp. 5516-5526
-
-
Meyers, M.1
Wagner, M.W.2
Mazurek, A.3
Schmutte, C.4
Fishel, R.5
Boothman, D.A.6
-
47
-
-
0031691145
-
Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells
-
Parsels L.A., Parsels J.D., Wagner L.M., Loney T.L., Radany E.H., and Maybaum J. Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells. Cancer Chemother Pharmacol 42 (1998) 357-362
-
(1998)
Cancer Chemother Pharmacol
, vol.42
, pp. 357-362
-
-
Parsels, L.A.1
Parsels, J.D.2
Wagner, L.M.3
Loney, T.L.4
Radany, E.H.5
Maybaum, J.6
-
48
-
-
0033811850
-
Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331
-
Webley S.D., Hardcastle A., Ladner R.D., Jackman A.L., and Aherne G.W. Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331. Br J Cancer 83 (2000) 792-799
-
(2000)
Br J Cancer
, vol.83
, pp. 792-799
-
-
Webley, S.D.1
Hardcastle, A.2
Ladner, R.D.3
Jackman, A.L.4
Aherne, G.W.5
-
49
-
-
16244423009
-
Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts
-
Andersen S., Heine T., Sneve R., König I., Krokan H.E., Epe B., et al. Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis 26 (2005) 547-555
-
(2005)
Carcinogenesis
, vol.26
, pp. 547-555
-
-
Andersen, S.1
Heine, T.2
Sneve, R.3
König, I.4
Krokan, H.E.5
Epe, B.6
-
50
-
-
4444318490
-
Involvement of base excision repair in response to therapy targeted at thymidylate synthase
-
Li L., Berger S.H., and Wyatt M.D. Involvement of base excision repair in response to therapy targeted at thymidylate synthase. Mol Cancer Ther 3 (2004) 747-753
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 747-753
-
-
Li, L.1
Berger, S.H.2
Wyatt, M.D.3
-
51
-
-
37549072672
-
Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase
-
Luo Y., Walla M., and Wyatt M.D. Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase. DNA Repair 8 (2008) 162-169
-
(2008)
DNA Repair
, vol.8
, pp. 162-169
-
-
Luo, Y.1
Walla, M.2
Wyatt, M.D.3
-
52
-
-
0037304541
-
Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition
-
Welsh S.J., Hobbs S., and Aherne G.W. Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition. Eur J Cancer 39 (2003) 378-387
-
(2003)
Eur J Cancer
, vol.39
, pp. 378-387
-
-
Welsh, S.J.1
Hobbs, S.2
Aherne, G.W.3
-
53
-
-
4344701997
-
Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency
-
Cabelof D.C., Raffoul J.J., Nakamura J., Kapoor D., Abdalla H., and Heydari A.R. Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency. J Biol Chem 279 (2004) 36504-36513
-
(2004)
J Biol Chem
, vol.279
, pp. 36504-36513
-
-
Cabelof, D.C.1
Raffoul, J.J.2
Nakamura, J.3
Kapoor, D.4
Abdalla, H.5
Heydari, A.R.6
-
54
-
-
29144487060
-
AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation
-
Dornfeld K., and Johnson M. AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation. Nucleic Acids Res 33 (2005) 6644-6653
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 6644-6653
-
-
Dornfeld, K.1
Johnson, M.2
-
55
-
-
31644442238
-
Linking uracil base excision repair and 5-fluorouracil toxicity in yeast
-
Seiple L., Jaruga P., Dizdaroglu M., and Stivers J.T. Linking uracil base excision repair and 5-fluorouracil toxicity in yeast. Nucleic Acids Res 34 (2006) 140-151
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 140-151
-
-
Seiple, L.1
Jaruga, P.2
Dizdaroglu, M.3
Stivers, J.T.4
-
56
-
-
0036731991
-
dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae
-
Tinkelenberg B.A., Hansbury M.J., and Ladner R.D. dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae. Cancer Res 62 (2002) 4909-4915
-
(2002)
Cancer Res
, vol.62
, pp. 4909-4915
-
-
Tinkelenberg, B.A.1
Hansbury, M.J.2
Ladner, R.D.3
-
57
-
-
0026711129
-
Multiple mutant of Escherichia coli synthesizing virtually thymineless DNA during limited growth
-
el-Hajj H.H., Wang L., and Weiss B. Multiple mutant of Escherichia coli synthesizing virtually thymineless DNA during limited growth. J Bacteriol 174 (1992) 4450-4456
-
(1992)
J Bacteriol
, vol.174
, pp. 4450-4456
-
-
el-Hajj, H.H.1
Wang, L.2
Weiss, B.3
-
58
-
-
0027426749
-
dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae
-
Gadsden M.H., McIntosh E.M., Game J.C., Wilson P.J., and Haynes R.H. dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. Embo J 12 (1993) 4425-4431
-
(1993)
Embo J
, vol.12
, pp. 4425-4431
-
-
Gadsden, M.H.1
McIntosh, E.M.2
Game, J.C.3
Wilson, P.J.4
Haynes, R.H.5
-
59
-
-
4644318236
-
5-Fluoro-2′-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells
-
Parsels L.A., Parsels J.D., Tai D.C., Coughlin D.J., and Maybaum J. 5-Fluoro-2′-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells. Cancer Res 64 (2004) 6588-6594
-
(2004)
Cancer Res
, vol.64
, pp. 6588-6594
-
-
Parsels, L.A.1
Parsels, J.D.2
Tai, D.C.3
Coughlin, D.J.4
Maybaum, J.5
-
60
-
-
33748292931
-
Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil
-
Robinson H.M., Jones R., Walker M., Zachos G., Brown R., Cassidy J., et al. Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil. Oncogene 25 (2006) 5359-5369
-
(2006)
Oncogene
, vol.25
, pp. 5359-5369
-
-
Robinson, H.M.1
Jones, R.2
Walker, M.3
Zachos, G.4
Brown, R.5
Cassidy, J.6
-
61
-
-
33748364583
-
Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy
-
Xiao Z., Xue J., Sowin T.J., and Zhang H. Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy. Mol Cancer Ther 5 (2006) 1935-1943
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1935-1943
-
-
Xiao, Z.1
Xue, J.2
Sowin, T.J.3
Zhang, H.4
-
62
-
-
0018340479
-
Production of sister chromatid exchanges by various cancer chemotherapeutic agents
-
Banerjee A., and Benedict W.F. Production of sister chromatid exchanges by various cancer chemotherapeutic agents. Cancer Res 39 (1979) 797-799
-
(1979)
Cancer Res
, vol.39
, pp. 797-799
-
-
Banerjee, A.1
Benedict, W.F.2
-
63
-
-
0022800531
-
Induction, by thymidylate stress, of genetic recombination as evidenced by deletion of a transferred genetic marker in mouse FM3A cells
-
Ayusawa D., Koyama H., Shimizu K., Kaneda S., Takeishi K., and Seno T. Induction, by thymidylate stress, of genetic recombination as evidenced by deletion of a transferred genetic marker in mouse FM3A cells. Mol Cell Biol 6 (1986) 3463-3469
-
(1986)
Mol Cell Biol
, vol.6
, pp. 3463-3469
-
-
Ayusawa, D.1
Koyama, H.2
Shimizu, K.3
Kaneda, S.4
Takeishi, K.5
Seno, T.6
-
64
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 411 (2001) 366-374
-
(2001)
Nature
, vol.411
, pp. 366-374
-
-
Hoeijmakers, J.H.1
-
65
-
-
0036900120
-
Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair
-
table of contents
-
Symington L.S. Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev 66 (2002) 630-670 table of contents
-
(2002)
Microbiol Mol Biol Rev
, vol.66
, pp. 630-670
-
-
Symington, L.S.1
-
66
-
-
0027937868
-
Thymine starvation-induced structural-changes in Escherichia-coli DNA-detection by pulsed-field gel-electrophoresis and evidence for involvement of homologous recombination
-
Nakayama K., Kusano K., Irino N., and Nakayama H. Thymine starvation-induced structural-changes in Escherichia-coli DNA-detection by pulsed-field gel-electrophoresis and evidence for involvement of homologous recombination. J Mol Biol 243 (1994) 611-620
-
(1994)
J Mol Biol
, vol.243
, pp. 611-620
-
-
Nakayama, K.1
Kusano, K.2
Irino, N.3
Nakayama, H.4
-
67
-
-
0020028533
-
DNA repair and the genetic effects of thymidylate stress in yeast
-
Kunz B.A., and Haynes R.H. DNA repair and the genetic effects of thymidylate stress in yeast. Mutat Res 93 (1982) 353-375
-
(1982)
Mutat Res
, vol.93
, pp. 353-375
-
-
Kunz, B.A.1
Haynes, R.H.2
-
68
-
-
0030850047
-
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
-
Scully R., Chen J., Ochs R.L., Keegan K., Hoekstra M., Feunteun J., et al. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90 (1997) 425-435
-
(1997)
Cell
, vol.90
, pp. 425-435
-
-
Scully, R.1
Chen, J.2
Ochs, R.L.3
Keegan, K.4
Hoekstra, M.5
Feunteun, J.6
-
69
-
-
0030933762
-
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
-
Sharan S.K., Morimatsu M., Albrecht U., Lim D.S., Regel E., Dinh C., et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386 (1997) 804-810
-
(1997)
Nature
, vol.386
, pp. 804-810
-
-
Sharan, S.K.1
Morimatsu, M.2
Albrecht, U.3
Lim, D.S.4
Regel, E.5
Dinh, C.6
-
70
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan M.B., and Bartek J. Cell-cycle checkpoints and cancer. Nature 432 (2004) 316-323
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
71
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald III E.R., Hurov K.E., Luo J., et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316 (2007) 1160-1166
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald III, E.R.4
Hurov, K.E.5
Luo, J.6
-
72
-
-
34547950170
-
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment
-
Olson E., Nievera C.J., Lee A.Y., Chen L., and Wu X. The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem 282 (2007) 22939-22952
-
(2007)
J Biol Chem
, vol.282
, pp. 22939-22952
-
-
Olson, E.1
Nievera, C.J.2
Lee, A.Y.3
Chen, L.4
Wu, X.5
-
73
-
-
36949026476
-
BRCA2: a universal recombinase regulator
-
Thorslund T., and West S.C. BRCA2: a universal recombinase regulator. Oncogene 26 (2007) 7720-7730
-
(2007)
Oncogene
, vol.26
, pp. 7720-7730
-
-
Thorslund, T.1
West, S.C.2
-
74
-
-
34247481285
-
Targeting checkpoint kinase 1 in cancer therapeutics
-
Tse A.N., Carvajal R., and Schwartz G.K. Targeting checkpoint kinase 1 in cancer therapeutics. Clin Cancer Res 13 (2007) 1955-1960
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1955-1960
-
-
Tse, A.N.1
Carvajal, R.2
Schwartz, G.K.3
-
75
-
-
13944266820
-
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
-
Sorensen C.S., Hansen L.T., Dziegielewski J., Syljuasen R.G., Lundin C., Bartek J., et al. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 7 (2005) 195-201
-
(2005)
Nat Cell Biol
, vol.7
, pp. 195-201
-
-
Sorensen, C.S.1
Hansen, L.T.2
Dziegielewski, J.3
Syljuasen, R.G.4
Lundin, C.5
Bartek, J.6
-
76
-
-
20244388673
-
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
-
Syljuasen R.G., Sorensen C.S., Hansen L.T., Fugger K., Lundin C., Johansson F., et al. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol 25 (2005) 3553-3562
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3553-3562
-
-
Syljuasen, R.G.1
Sorensen, C.S.2
Hansen, L.T.3
Fugger, K.4
Lundin, C.5
Johansson, F.6
-
77
-
-
0031670310
-
UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner
-
Hsueh C.T., Kelsen D., and Schwartz G.K. UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner. Clin Cancer Res 4 (1998) 2201-2206
-
(1998)
Clin Cancer Res
, vol.4
, pp. 2201-2206
-
-
Hsueh, C.T.1
Kelsen, D.2
Schwartz, G.K.3
-
78
-
-
34248158210
-
Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival
-
Wilsker D., and Bunz F. Loss of ataxia telangiectasia mutated- and Rad3-related function potentiates the effects of chemotherapeutic drugs on cancer cell survival. Mol Cancer Ther 6 (2007) 1406-1413
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1406-1413
-
-
Wilsker, D.1
Bunz, F.2
|