Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck

Cancer Research

Volumn 59, Issue 8, 1999, Pages 1935-1940

  Huang, Shyh Min ^a   Bock, Jonathan M ^a   Harari, Paul M ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CELL PROLIFERATION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA;

ANTIBODIES, MONOCLONAL; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CELL SURVIVAL; G0 PHASE; G1 PHASE; HEAD AND NECK NEOPLASMS; HUMANS; RADIATION TOLERANCE; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 0033561522     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Fowler, J. F., and Lindstrom, M. J. Loss of local control with prolongation in radiotherapy. Int. J. Radiat. Oncol. Biol. Phys., 23: 457-467, 1992.
2. Harari, P. M., and Kinsella, T. J. Advances in radiation therapy for head and neck cancer. Curr. Opin. Oncol., 7: 248-254, 1995.
3. McGinn, C. J., Harari, P. M., Fowler, J. F., Ford, C. N., Pyle, G. M., and Kinsella, T. J. Dose intensification in curative head and neck cancer radiotherapy-linear quadratic analysis and preliminary assessment of clinical results. Int. J. Radiat. Oncol. Biol. Phys., 27: 363-369, 1993.
4. Huang, S., and Harari, P. M. Effects of anti-epidermal growth factor receptor monoclonal antibody 225 on proliferation, apoptosis and radiosensitivity in human squamous cell carcinomas of the head and neck. Proc. Am. Assoc. Cancer Res., 39: 64, 1998.
5. Khazaie, K., Schirrmacher, V., and Lichtner, R. B. EGF receptor in neoplasia and metastasis. Cancer Metastasis Rev., 12: 255-274, 1993.
6. Grandis, J. R., and Tweardy, D. J. Elevated levels of transforming growth factor a and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res., 53: 3579-3584, 1993.
7. Grandis, J. R., Melhem, M. F., Gooding, W. E., Day, R., Holst, V. A., Wagener, M. M., Drenning, S. D., and Tweardy, D. J. Levels of TGF-α and EGFR protein in head and neck squamous cell carcinoma and patient survival. J. Natl. Cancer Inst. (Bethesda), 90: 824-832, 1998.
8. Maurizi, M., Almadori, G., Ferrandina, G., Distefano, M., Romanini, M. E., Cadoni, G., Benedetti-Panici, P., Paludetti, G., Scambia, G., and Mancuso, S. Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. Br. J. Cancer, 74: 1253-1257, 1996.
9. Peter, R. U., Beetz, A., Ried, C., Michel, G., van Beuningen, D., and Ruzicka, T. Increased expression of the epidermal growth factor receptor in human epidermal keratinocytes after exposure to ionizing radiation. Radiat. Res., 136: 65-70, 1993.
10. Schmidt-Ullrich, R. K., Valerie, K. C., Chan, W., and McWilliams, D. Altered expression of epidermal growth factor receptor and estrogen receptor in MCF-7 cells after single and repeated radiation exposures. Int. J. Radiat. Oncol. Biol. Phys., 29: 813-819, 1994.
11. Schmidt-Ullrich, R. K., Mikkelsen, R. B., Dent, P., Todd, D. G., Valerie, K., Kavanagh, B. D., Contessa, J. N., Rorrer, W. K., and Chen, P. B. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene, 15: 1191-1197, 1997.
12. Kasid, U., Pirollo, K., Dritschilo, A., and Chang, E. Oncogenic basis of radiation resistance. Adv. Cancer Res., 61: 195-233, 1993.
13. Fan, Z., Masui, H., Altas, I., and Mendelsohn, J. Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res., 53: 4322-4328, 1993.
14. Fan, Z., Lu, Y., Wu, X., and Mendelsohn, J. Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J. Biol. Chem., 269: 27595-27602, 1994.
15. Prewett, M., Rockwell, P., Rockwell, R. F., Giorgio, N. A., Mendelsohn, J., Scher, H. I., and Goldstein, N. I. The biologic effects of C225, a chimeric monoclonal antibody to the EGFR, on human prostate carcinoma. J. Immunother., 19: 419-427, 1996.
16. Wu, X., Fan, Z., Masui, H., Rosen, N., and Mendelsohn, J. Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J. Clin. Invest., 95: 1897-1905, 1995.
17. 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene, 12: 1397-1403, 1996.
18. Mendelsohn, J., and Fan, Z. Epidermal growth factor receptor family and chemosensitization. J. Natl. Cancer Inst. (Bethesda), 89: 341-343, 1997.
19. Reid, S., Cross, R., and Snow, E. C. Combined Hoechst 33342 and merocyanine 540 staining to examine murine B cell cycle stage, viability and apoptosis. J. Immunol. Methods, 192: 43-54, 1996.
20. Pepper, C., Hoy, T., and Bentley, D. P. Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance. Br. J. Cancer, 76: 935-938, 1997.
21. 1 arrest in prostatic cancer cell line DU145. Cancer Res., 56: 3666-3669, 1996.
22. Coleman, C. N., and Stevenson, M. A. Biologic basis for radiation oncology. Oncology, 10: 399-411, 1996.
23. Wollman, R., Yahalom, J., Maxy, R., Pinto, J., and Fuks, Z. Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro. Int. J. Radiat. Oncol. Biol. Phys., 30: 91-98, 1994.
24. Kwok, T. T., and Sutherland, R. M. Enhancement of sensitivity of human squamous carcinoma cells to radiation by epidermal growth factor. J. Natl. Cancer Inst. (Bethesda), 81: 1020-1024, 1989.
25. Kwok, T. T., and Sutherland, R. M. Differences in EGF related radiosensitisation of human squamous carcinoma cells with high and low numbers of EGF receptors. Br. J. Cancer, 64: 251-254, 1991.
26. Bonner, J. A., Maihle, N. J., Folven, B. R., Christianson, T. J., and Spain, K. The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities. Int. J. Radiat. Oncol. Biol. Phys., 29: 243-247, 1994.
27. Bandyopadhyay, D., Mandal, M., Adam, L., Mendelsohn, J., and Kumar, R. Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J. Biol. Chem., 273: 1568-1573, 1998.
28. Kwok, T. T., and Sutherland, R. M. Cell cycle dependence of epidermal growth factor induced radiosensitization. Int. J. Radiat. Oncol. Biol. Phys., 22: 525-527, 1992.
29. Laderoute, K. R., Ausserer, W. A., Knapp, A. M., Grant, T. D., and Sutherland, R. M. Epidermal growth factor modifies cell cycle control in A431 human squamous carcinoma cells damaged by ionizing radiation. Cancer Res., 54: 1407-1411, 1994.
30. Meyn, R. E. Apoptosis and response to radiation: implications for radiation therapy. Oncology, 11: 349-356, 1997.
31. Dewey, W. C., Ling, C. C., and Meyn, R. E. Radiation-induced apoptosis: relevance to radiotherapy. Int. J. Radiat. Oncol. Biol. Phys., 33: 781-796, 1995.