Analysis of the human neurexin genes: Alternative splicing and the generation of protein diversity

Genomics

Volumn 79, Issue 4, 2002, Pages 587-597

  Rowen, Lee ^a   Young, Janet ^a   Birditt, Brian ^a   Kaur, Amardeep ^a   Madan, Anup ^a   Philipps, Dana L ^b   Qin, Shizhen ^d   Minx, Patrick ^d   Wilson, Richard K ^c   Hood, Leroy ^c   Graveley, Brenton R ^c  

^a INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alternative splicing; Large genes; Neurexins

Indexed keywords

CELL ADHESION MOLECULE; NEUREXIN;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ARTICLE; DNA FLANKING REGION; GENE LOCATION; GENETIC ANALYSIS; GENETIC REGULATION; HUMAN; HUMAN CELL; INTRON; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN METABOLISM;

MAMMALIA;

EID: 0036210068     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2002.6734     Document Type: Article

References (40)

1. Neurexins: Three genes and 1001 products
2. The making of neurexins
3. Neurexins: Synaptic cell surface proteins related to the α-latrotoxin receptor and laminin
4. Neurexins are functional α-latrotoxin receptors
5. Polypeptide composition of the α-latrotoxin receptor. High affinity binding protein consists of a family of related high molecular weight polypeptides complexed to a low molecular weight protein
6. Structure and evolution of neurexophilin
7. Neurexophilin binding to α-neurexins. A single LNS domain functions as an independently folding ligand-binding unit
8. Neurexin I a is a major α-latrotoxin receptor that cooperates in α-latrotoxin action
9. Neuroligin 1: A splice site-specific ligand for β-neurexins
10. Structures, alternative splicing, and neurexin binding of multiple neuroligins
11. Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses
12. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons
13. Neurexin III a: Extensive alternative splicing generates membrane-bound and soluble forms
14. Cartography of neurexins: More than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons
15. Deciphering genomes through automated large-scale sequencing
16. Initial sequencing and analysis of the human genome
17. Expression of neurexin 1 a splice variants in sympathetic neurons: Selective changes during differentiation and in response to neurotrophins
18. MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data
19. Silencing is golden: Negative regulation in the control of neuronal gene transcription
20. Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing
21. Splicing of precursors to mRNAs by the spliceosomes
22. The neuronal RNA binding protein Nova-1 recognizes specfic RNA targets in vitro and in vivo
23. Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability
24. The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain
25. Sequence-specific RNA binding by a Nova KH domain: Implications for paraneoplastic disease and the fragile X syndrome
26. Alternative RNA splicing in the nervous system
27. Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB
28. Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing
29. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
30. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine ract binding protein
31. Protein diversity from alternative splicing: A challenge for bioinformatics and post-genome biology
32. Alternative splicing: Increasing diversity in the proteomic world
33. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system
34. The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia
35. The sequence of the human genome
36. Progression of the cell cycle through mitosis leads to abortion of nascent transcripts
37. Loss of gene function through rapid mitotic cycles in the Drosophila embryo
38. A physical map of human chromosome 14
39. Multiple-complete-digest restriction fragment mapping: Generating sequence-ready maps for large-scale DNA sequencing
40. Integration of cytogenetic landmarks into the draft sequence of the human genome