Remarkable roles of proteolysis on and beyond the cell surface

Current Opinion in Cell Biology

Volumn 12, Issue 5, 2000, Pages 606-612

  Blobel, Carl P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; MATRILYSIN; METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA; ZINC;

ALZHEIMER DISEASE; ARTHRITIS; AUTOCRINE EFFECT; BONE DEVELOPMENT; CELL FUNCTION; CELL MIGRATION; CELL SURFACE; CYTOKINE PRODUCTION; EXTRACELLULAR MATRIX; GENE CONTROL; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; TUMOR PROMOTION;

EID: 0033817591     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00139-3     Document Type: Review

References (59)

1. The metzincins topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases
2. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
3. Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5
4. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
5. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase 1
6. Metalloprotease-disintegrins: Modular proteins capable of promoting cell-cell interactions and triggering signals by protein ectodomain shedding
7. ADAMs: Focus on the protease domain
8. The ADAM gene family: Surface proteins with an adhesion and protease activity packed into a single molecule
9. An essential role for ectodomain shedding in mammalian development
10. Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor
11. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
12. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis
13. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption
14. A metalloprotease disintegrin that releases tumour-necrosis factor-α from cells
15. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the alzheimer amyloid protein precursor
16. Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing
17. Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3
18. LIN-12/Notch signaling: Lessons from worms and flies
19. KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis
20. A Notch affair
21. The Notch1 receptor is cleaved constitutively by a furin-like convertase
22. Roles for proteolysis and trafficking in notch maturation and signal transduction
23. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
24. Presenilin is required for activity and nuclear access of Notch in Drosophila
25. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
26. Nuclear access and action of notch in vivo
27. Notch signalling. A short cut to the nucleus
28. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch
29. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
30. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
31. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α
32. Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases
33. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
34. ECM and cell surface proteolysis: Regulating cellular ecology
35. Matrix metalloproteinases: Biologic activity and clinical implications
36. Cancer biology: Extracellular proteinases in malignancy
37. Matrix metalloproteinases in inflammatory demyelination: Targets for treatment
38. Matrix metalloproteinases and the development of cancer
39. In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy
40. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
41. The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter
42. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
43. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
44. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
45. Purification and Cloning of amyloid precursor protein beta-secretase from human brain
46. Identification of a novel aspartic protease (Asp 2) as beta-secretase
47. Expression analysis of BACE2 in brain and peripheral tissues
48. The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans
49. Control of cell migration during Caenorhabditis elegans development
50. Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans
51. A metalloprotease prepares the way
52. Purification and cloning of aggrecanase-1: A member of the ADAMTS family of proteins
53. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
54. Structure of human pro-matrix metalloproteinase-2: Activation mechanism revealed
55. Tumor targeting with a selective gelatinase inhibitor
56. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
57. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
58. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane