LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation

Neuron

Volumn 64, Issue 6, 2009, Pages 791-798

  Ko, Jaewon ^a   Fuccillo, Marc V ^a   Malenka, Robert C ^a   Südhof, Thomas C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CELLBIO; MOLNERO; SIGNALING

Indexed keywords

ALPHA NEUREXIN; BETA NEUREXIN; LEUCINE RICH REPEAT TRANSMEMBRANE PROTEIN 2; MEMBRANE PROTEIN; NEUREXIN; NEUROLIGIN 1; RNA; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; EXCITATORY JUNCTION POTENTIAL; NERVE CELL DIFFERENTIATION; NONHUMAN; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA SPLICING;

ALTERNATIVE SPLICING; ANIMALS; CELL ADHESION; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CERCOPITHECUS AETHIOPS; COS CELLS; EXCITATORY POSTSYNAPTIC POTENTIALS; HUMANS; LIGANDS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NEURAL CELL ADHESION MOLECULES; NEURAL PATHWAYS; PROTEIN BINDING; RATS; RECOMBINANT PROTEINS; RNA SPLICE SITES; SIGNAL TRANSDUCTION; SYNAPSES; TRANSFECTION;

EID: 72149130256     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2009.12.012     Document Type: Article

References (32)

1. Biederer T., Sara Y., Mozhayeva M., Atasoy D., Liu X., Kavalali E.T., and Südhof T.C. SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297 (2002) 1525-1531
2. Bierut L.J., Madden P.A., Breslau N., Johnson E.O., Hatsukami D., Pomerleau O.F., Swan G.E., Rutter J., Bertelsen S., Fox L., et al. Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum. Mol. Genet. 16 (2007) 24-35
3. Brose N. Synaptogenic proteins and synaptic organizers: "many hands make light work.". Neuron 61 (2009) 650-652
4. Boucard A.A., Chubykin A.A., Comoletti D., Taylor P., and Südhof T.C. A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to α- and β-neurexins. Neuron 48 (2005) 229-236
5. Chubykin A.A., Liu X., Comoletti D., Tsigelny I., Taylor P., and Südhof T.C. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J. Biol. Chem. 280 (2005) 22365-22374
6. Chubykin A.A., Atasoy D., Etherton M.R., Brose N., Kavalali E.T., Gibson J.R., and Südhof T.C. Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron 54 (2007) 919-931
7. Francks C., Maegawa S., Laurén J., Abrahams B.S., Velayos-Baeza A., Medland S.E., Colella S., Groszer M., McAuley E.Z., Caffrey T.M., et al. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol. Psychiatry 12 (2007) 1129-1139, 1057
8. Graf E.R., Zhang X., Jin S.X., Linhoff M.W., and Craig A.M. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 (2004) 1013-1026
9. Hata Y., Davletov B., Petrenko A.G., Jahn R., and Südhof T.C. Interaction of synaptotagmin with the cytoplasmic domains of neurexins. Neuron 10 (1993) 307-315
10. Ichtchenko K., Hata Y., Nguyen T., Ullrich B., Missler M., Moomaw C., and Südhof T.C. Neuroligin 1: a splice site-specific ligand for β-neurexins. Cell 81 (1995) 435-443
11. Kattenstroth G., Tantalaki E., Südhof T.C., Gottmann K., and Missler M. Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins. Proc. Natl. Acad. Sci. USA 101 (2004) 2607-2612
12. Kim S., Burette A., Chung H.S., Kwon S.K., Woo J., Lee H.W., Kim K., Kim H., Weinberg R.J., and Kim E. NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation. Nat. Neurosci. 9 (2006) 1294-1301
13. Kim H.G., Kishikawa S., Higgins A.W., Seong I.S., Donovan D.J., Shen Y., Lally E., Weiss L.A., Najm J., Kutsche K., et al. Disruption of neurexin 1 associated with autism spectrum disorder. Am. J. Hum. Genet. 82 (2008) 199-207
14. Kirov G., Rujescu D., Ingason A., Collier D.A., O'Donovan M.C., and Owen M.J. Neurexin 1 (NRXN1) deletions in schizophrenia. Schizophr. Bull. 35 (2009) 851-854
15. Ko J., Zhang C., Arac D., Boucard A.A., Brunger A.T., and Südhof T.C. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 (2009) 3244-3255
16. Lauren J., Airaksinen M.S., Saarma M., and Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics 81 (2003) 411-421
17. Linhoff M.W., Laurén J., Cassidy R.M., Dobie F.A., Takahashi H., Nygaard H.B., Airaksinen M.S., Strittmatter S.M., and Craig A.M. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 61 (2009) 734-749
18. Ludwig K.U., Mattheisen M., Mühleisen T.W., Roeske D., Schmäl C., Breuer R., Schulte-Körne G., Müller-Myhsok B., Nöthen M.M., Hoffmann P., et al. Supporting evidence for LRRTM1 imprinting effects in schizophrenia. Mol. Psychiatry 14 (2009) 743-745
19. 2+ channels to synaptic vesicle exocytosis. Nature 423 (2003) 939-948
20. Nguyen T., and Südhof T.C. Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. J. Biol. Chem. 272 (1997) 26032-26039
21. Nose A., Mahajan V.B., and Goodman C.S. Connectin: a homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila. Cell 70 (1992) 553-567
22. Reissner C., Klose M., Fairless R., and Missler M. Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components. Proc. Natl. Acad. Sci. USA 105 (2008) 15124-15129
23. Rujescu D., Ingason A., Cichon S., Pietiläinen O.P., Barnes M.R., Toulopoulou T., Picchioni M., Vassos E., Ettinger U., Bramon E., et al., GROUP Investigators. Disruption of the neurexin 1 gene is associated with schizophrenia. Hum. Mol. Genet. 18 (2009) 988-996
24. Scheiffele P., Fan J., Choih J., Fetter R., and Serafini T. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101 (2000) 657-669
25. Südhof T.C. Neuroligins and neurexins link synaptic function to cognitive disease. Nature 455 (2008) 903-911
26. Sugita S., Saito F., Tang J., Satz J., Campbell K., and Südhof T.C. A stoichiometric complex of neurexins and dystroglycan in brain. J. Cell Biol. 154 (2001) 435-445
27. Tabuchi K., Blundell J., Etherton M.R., Hammer R.E., Liu X., Powell C.M., and Südhof T.C. A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318 (2007) 71-76
28. Torres R., Firestein B.L., Dong H., Staudinger J., Olson E.N., Huganir R.L., Bredt D.S., Gale N.W., and Yancopoulos G.D. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron 21 (1998) 1453-1463
29. Ushkaryov Y.A., Petrenko A.G., Geppert M., and Südhof T.C. Neurexins: synaptic cell surface proteins related to the α-latrotoxin receptor and laminin. Science 257 (1992) 50-56
30. Ushkaryov Y.A., Hata Y., Ichtchenko K., Moomaw C., Afendis S., Slaughter C.A., and Südhof T.C. Conserved domain structure of β-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins. J. Biol. Chem. 269 (1994) 11987-11992
31. Varoqueaux F., Aramuni G., Rawson R.L., Mohrmann R., Missler M., Gottmann K., Zhang W., Südhof T.C., and Brose N. Neuroligins determine synapse maturation and function. Neuron 51 (2006) 741-754
32. 2+ channels. J. Neurosci. 25 (2005) 4330-4342