Conversion of elderly to Alzheimer's dementia: Role of confluence of hypothermia and senescent stigmata - The plausible pathway

Journal of Alzheimer's Disease

Volumn 21, Issue 4, 2010, Pages 1039-1063

  Daulatzai, Mak Adam ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Aging; amyloid ; anesthesia; dementia; hypothermia; neurofibrillary tangles

Indexed keywords

ALCOHOL; AMITRIPTYLINE; AMYLOID BETA PROTEIN; ANESTHETIC AGENT; ANTIDEPRESSANT AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIPYRETIC AGENT; ATIPAMEZOLE; BACLOFEN; CAFFEINE; DESFLURANE; DESIPRAMINE; DIAZEPAM; FLUMAZENIL; HALOPERIDOL; HALOTHANE; ISOFLURANE; ISOPRENALINE; METERGOLINE; METHYLXANTHINE DERIVATIVE; MIANSERIN; MOCLOBEMIDE; NEUROLEPTIC AGENT; PROPRANOLOL; SEVOFLURANE; TAU PROTEIN; THEOPHYLLINE; UNINDEXED DRUG; ZIMELDINE;

AGING; ALZHEIMER DISEASE; ANESTHESIA; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN STEM; CEREBROVASCULAR DISEASE; COGNITION; COGNITIVE DEFECT; DELIRIUM; DEMENTIA; DEPRESSION; DIABETES MELLITUS; GENERAL ANESTHESIA; GLUCOSE METABOLISM; HUMAN; HYPOTHERMIA; HYPOXIA; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RISK FACTOR; SENESCENCE; THALAMOCORTICAL TRACT; THERMOREGULATION; THIAMINE DEFICIENCY; THYROID DISEASE;

EID: 78650504727     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-100267     Document Type: Article

References (227)

1. Daulatzai MA (2010) Early stages of pathogenesis in memory impairment during normal senescence and Alzheimer's disease. J Alzheimers Dis 20, 355-367.
2. Holtzman A, Simon EW (2000) Body temperature as a risk factor for Alzheimer's disease. Med Hypotheses 55, 440-444.
3. Roses AD (1997) Apolipoprotein E, a gene with complex biological interactions in the aging brain. Neurobiol Dis 4, 170-185
4. Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotas A, Perouansky M, Planel E, Silverstein JH, Wei H, Whit-tington RA, Xie Z, Zuo Z; First International Workshop on Anesthetics and Alzheimer's Disease (2009) Consensus Statement: First International Workshop on Anesthetics and Alzheimer's disease. AnesthAnalg 108, 1627-1630.
5. Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamu-ra M, Hayashi T, Yamaguchi H, Shimohama S, Lee H, Zhu X, Smith MA, Perry G (2010) Intraneuronal amyloid ft accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiol Disease 37, 731-737.
6. Ferrarelli F, Massimini M, Sarasso S, Casali A, Riedner BA, Angelini G, Tononi G, Pearce RA (2010) Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness. Proc Natl Acad Sci USA 107, 2681-2686.
7. Boyd-Kimball D, Sultana R, Mohmmad-Abdul H, Butter-field DA (2004) Rodent Abeta(1-42) exhibits oxidative stress properties similar to those of human Abeta(1-42): Implications for proposed mechanisms of toxicity. J Alzheimers Dis 6, 515-525.
8. Fox RH, Wood PM, Exton-Smith, AN (1973) Body temperature in the elderly. Br Med J 27, 200-206.
9. Keilsen L, Lambert D, Fabien D, Thebarge J, Ackerson T, Palomaki G, Turgeon W (1985) Screening for the hypothermia in the ambulatory elderly. The Maine experience. JAMA 254, 1781-1784.
10. Coudray-Lucas C, Prioux-Guyonneau M, Tassel A, Coq HM, Cohen Y, Wepierre J (1981) Influence of intoxication by anticholinesterase agents on core temperature in rats: relationships between hypothermia and acetylcholinesterase inhibition in different brain areas. Acta Pharmacol Toxicol (Copenh) 49, 215-222.
11. Coudray-Lucas C, Prioux-Guyonneau M, Sentenac H, Cohen Y, Wepierre J (1983) Brain catecholamine metabolism changes and hypothermia in intoxication by anti-cholinesterase agents. Acta Pharmacol Toxicol (Copenh) 52, 224-229.
12. Coimbra C, Wieloch T (1992) Hypothermia ameliorates neu-ronal survival when induced 2 hours after ischaemia in the rat. Acta Physiol Scand 146, 543-548.
13. Coimbra C, Wieloch T (1994) Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia. Acta Neu-ropathol 87,325-331.
14. Coimbra C, Drake M, Boris-Moller F, Wieloch T (1996) Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug. Evidence for chronic encephalopathic processes following ischemia. Stroke 27, 1578-1585.
15. Koerner IP, Brambrink AM (2006) Brain protection by anesthetic agents. Curr Opin Anaesthesiol 19, 481-486.
16. Matchett GA, Allard MW, Martin RD, Zhang JH (2009) Neu-roprotective effect of volatile anesthetic agents: molecular mechanisms. Neurol Res 31, 128-134.
17. Davis JD, Podolanczuk A, Donahue JE, Stopa E, Hennessey JV, Luo LG, Lim YP, Stern RA (2008) Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients. Curr Aging Sci 1, 175-181.
18. Okawa Y, Ishiguro K, Fujita SC (2003) Stress induced hyper- phosphorylation of tau in the mouse brain. FEBS Lett 535, 183-189.
19. Arendt T, Stieler J, Strijkstra AM, Hut RA, Rudiger J, Van der Zee EA, Harkany T, Holzer M, Hartig W (2003) Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. JNeurosci 23, 6972-6981.
20. Hartig W, Stieler J, Boerema AS, Wolf J, Schmidt U, Weiss-fuss J, Bullmann T, Strijkstra AM, Arendt T (2007) Hibernation model of tau phosphorylation in hamsters: selective vulnerability of cholinergic basal forebrain neurons -implications for Alzheimer's disease. Eur J Neurosci 25, 69-80.
21. Kottke FJ, Phalen JS, Taylor CB, Visscher MB, Evans GT (1948) Effect of hypoxia on temperature regulation of mice, dogs, and men. Am J Physiol 153, 10-15.
22. Gautier H, Benora M, Schultz SA, Remmers JE (1991) Effect of hypoxia and cold acclimation on thermoregulation in the rat. Am J Physiol 71, 1355-1363.
23. Johnston CE, White MD, Wu M, Bristow GK, Giesbrecht GG (1996) Eucapnic hypoxia lowers human cold thermoreg-ulatory response and accelerates core cooling. J Appl Physiol 80, 422-429.
24. Rosenberg LB, Whang W, Shimbo D, Shah A, Shapiro PA, Davidson KW (2009) Exposure to tricyclic antidepressants is associated with an increased risk of incident CHD events in a population-based study. Int J Cardiol, in press.
25. Rowan PJ, Haas D, Campbell JA, Maclean DR, Davidson KW (2005) Depressive symptoms have an independent, gradient risk for coronary heart disease incidence in a random, population-based sample. Ann Epidemiol 15, 316-320.
26. Thurston RC, Kubzansky LD (2009) Women, loneliness, and incident coronary heart disease. Psychosom Med 71, 836842.
27. Dilsaver SC, Davidson RK (1989) Chronic treatment with amitriptyline produces subsensitivity to the hypothermic effects of yohimbine. Prog Neuropsychopharmacol Biol Psychiatry 13, 211-215.
28. Dilsaver SC, Davidson R, Majchrk M (1989) Chronic treatment with amitriptyline produces subsensitivity to the hy-pothermic effects ofclonidine. Prog Neuropsychopharmacol Biol Psychiatry 13, 297-302. (Pubitemid 19120557)
29. Gray JA, Goodwin GM, Heal DJ, Green AR (1987) Hypothermia induced by baclofen, a possible index of GABAB receptor function in mice, is enhanced by antidepressant drugs and ECS. Br J Pharmacol 92, 863-870.
30. Ginawi OT (2003) Possible involvement of opioid receptors in moclobemide-induced hypothermia in mice. Pharmacol Res 48, 237-240.
31. Durcan MJ, Morgan PF (1992) Opioid receptor mediation of the hypothermic response to caffeine. Eur J Pharmacol 224, 151-156.
32. Spiers DE, Fregly MJ, Barney CC (1986) Beta-adrenergic responsiveness in the rat following acute administration of ethanol. Pharmacology 32, 268-277.
33. Zarrindast MR, Heidari MR (1994) On the mechanisms by which theophylline changes core body temperature in mice. Eur J Pharmacol 257, 13-20.
34. Zarrindast MR, Tabatabai SA (1992) Involvement of dopamine receptor subtypes in mouse thermoregulation. Psy-chopharmacology (Berl) 107, 341-346.
35. Letenneur L (2004) Risk of dementia and alcohol and wine consumption: a review of recent results. Biol Res 37, 189193. (Pubitemid 39328256)
36. Harwood DG, Kalechstein A, Barker WW, Strauman S, St George-Hyslop P, Iglesias C, Loewenstein D, Duara R (2009) The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease. Int J Geriatr Psychiatry 25, 511-518.
37. Lomax P, Lee RJ (1982) Cold acclimation and resistance to ethanol induced hypothermia. Eur J Pharmacol 84, 87-91.
38. Turek VF, Ryabinin AE (2005) Ethanol versus lipopolysac-charide induced hypothermia: involvement of urocortin. Neuroscience 133, 1021-1028.
39. White AM (2003) What happened? Alcohol, memory blackouts, and the brain. Alcohol Res Health 27, 186-196.
40. White AM, Swartzwelder HS (2004) Hippocampal function during adolescence: a unique target of ethanol effects. Ann N YAcadSci 1021, 206-220.
41. Pyapali GK, Turner DA, Wilson WA, Swartzwelder HS S (1999) Age and dose-dependent effects of ethanol on the induction of hippocampal long-term potentiation. Alcohol 19, 107-111.
42. Roberto M, Nelson TE, Ur CL, Gruol DL (2002) Long-term potentiation in the rat hippocampus is reversibly depressed by chronic intermittent ethanol exposure. JNeurophysiol 87, 2385-2397.
43. Givens B, Williams JM, Gill TM (2000) Septohippocampal pathway as asite forthe memory-impairing effects of ethanol. Hippocampus 10, 111-121.
44. Biessels GJ, Kappelle LJ (2005) Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance ofthe brain or insulin-induced amyloid pathology? Biochem Soc Trans 33, 1041-1044.
45. Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S. (2006) Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study. Arch Neurol 63, 1551-1555.
46. Kopf D, Frolich L (2009) Risk of incident Alzheimer's disease in diabetic patients:a systematic review of prospective trials. J Alzheimers Dis 16, 677-685.
47. Scott AR, Bennett T, Macdonald IA (1987) Diabetes mellitus and thermoregulation. Can J Physiol Pharmacol 65, 13651376.
48. Irie F, Fitzpatrick AL, Lopez OL, Kuller LH, Peila R, Newman AB, Launer LJ (2008) Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study. Arch Neurol 65, 89-93.
49. Mafrica F, Fodale V (2008) Thyroid function, Alzheimer's disease and postoperative cognitive dysfunction: a tale of dangerous liaisons? J Alzheimers Dis 14, 95-105.
50. Ceresini G, Lauretani F, Maggio M, Ceda GP, Morganti S, Usberti E, Chezzi C, Valcavi R, Bandinelli S, Guralnik JM, Cappola AR, Valenti G, Ferrucci L (2009) Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study. J Am Geriatr Soc 57, 89-93.
51. Davis JD, Podolanczuk A, Donahue JE, Stopa E, Hennessey JV, Luo LG, Lim YP, Stern RA (2008) Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients. Curr Aging Sci 1, 175-181.
52. Tan ZS, Beiser A, Vasan RS, Au R, Auerbach S, Kiel DP, Wolf PA, Seshadri S (2008) Thyroid function and the risk of Alzheimer disease: the Framingham Study. Arch Intern Med 168, 1514-1520.
53. Panza F, Solfrizzi V, Colacicco AM, D'Introno A, Capurso C, Palasciano R, Todarello O, Capurso S, Pellicani V, Capurso A (2006) Cerebrovascular disease in the elderly: lipoprotein metabolism and cognitive decline. Aging Clin Exp Res 18, 144-148.
54. Meert AP, Berghmans T, Sculier JP (2006) Hypothermia and Hodgkin's disease: case report and review of the literature. Acta Clin Belg 61, 252-254.
55. Planel E, Miyasaka T, Launey T, Chui DH, Tanemura K, Sato S, Murayama O, Ishiguro K, Tatebayashi Y, Takashima A (2004) Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease. J Neurosci 24, 2401-2411.
56. Planel E, Richter KEG, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, Nelson RB, Lau L-F, Duff KE (2007) Anesthesia leads to tau hyper-phosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci 27, 3090-3097.
57. Planel E, Brettville A. Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE (2009) Acceleration and persistence of neurofibrillary pathology in a mouse model oftaupathy following anesthesia. FASEBJ 23, 2595-2604.
58. Planel E, Yasutake K, Fujita SC, Ishiguro K (2001) Inhibition of protein phosphatase 2A overrides Tau protein kinase I/glycogen synthase kinase 3ft and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse. J Biol Chem 276, 3429834306.
59. Avila J, Diaz-Nido J (2004) Tangling with hypothermia. Nat Med 10, 460-461.
60. Fukui K, Takatsu H, Shinkai T, Suzuki S, Abe K, Ura-no S (2005) Appearance of amyloid beta like substances and delayed-type apoptosis in rat hippocampus CA1 region through aging and oxidative stress. J Alzheimers Dis 8, 299309.
61. Calingasan NY, Gandy SE, Baker H, Sheu KF, Kim KS, Wisniewski HM, Gibson GE (1995) Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency. Brain Res 677, 50-60.
62. Zhang Q, Ding H, Li W, Fan Z, Sun A, Luo J, Ke ZJ (2009) Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism. Brain Res 1264, 111-118.
63. Yanagisawa M, Planel E, Ishiguro K, Fujita SC (1999) Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease. FEBSLett 461, 329-333.
64. Peers C, Pearson HA, Boyle JP (2007) Hypoxia and Alzheimer's disease. Essays Biochem 43, 153-164.
65. Peers C, Dallas ML, Boycott HE, Scragg JL, Pearson HA, Boyle JP (2009) Hypoxia and neurodegeneration. Ann N Y AcadSci 1177, 169-177.
66. Sun X, He G, Qing H, Zhou W, Dobie F, Cai F, Staufenbiel M, Huang LE, Song W (2006) Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. Proc Natl AcadSci USA 103, 18727-18732.
67. Alafuzoff I, Aho L, Helisalmi S, Mannermaa A, Soininen H (2009) Beta-amyloid deposition in brains of subjects with diabetes. Neuropathol Appl Neurobiol 35, 60-68.
68. S Roriz-Filho J, Sa-Roriz TM, Rosset I, Camozzato AL, Santos AC, Chaves ML, Moriguti JC, Roriz-Cruz M (2009) (Pre)diabetes, brain aging, and cognition. Biochim Biophys Acta 1792, 432-443.
69. Sonnen JA, Larson EB, Brickell K, Crane PK, Woltjer R, Montine TJ, Craft S (2009) Different patterns of cerebral injury in dementia with or without diabetes. Arch Neurol 66, 315-322.
70. Lee RKK, Araki W, Wurtman RJ (1997) Stimulation of amy-loid precursor protein synthesis by adrenergic receptors coupled to isn't in document cAMP isn't in document formation. Proc Natl Acad Sci USA 94, 5422-5426.
71. Lee RKK, Knapp S, Wurtman RJ (1999) Prostaglandin E2 stimulates amyloid precursor protein gene expression: inhibition by immunosuppressants. J Neurosci 19, 940-947.
72. Johnson T, Monk T, Rasmussen LS, Abildstrom H, Houx P, Korttila K, Kuipers HM, Hanning CD, Siersma VD, Kristensen D, Canet J, Ibanaz MT, Moller JT (2002) Postoperative cognitive dysfunction in middle-aged patients. Anesthe-siology 96, 1351-1357.
73. Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, Rabbit P, Jolles J, Larsen K, Hanning CD, Langeron O, Johnson T, Lauven PM, Kristensen PA, Biedler A, van Beem H, Fraidakis O, Silverstein JH, Beneken JE, Gravenstein JS (1998) Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International study of post-operative cognitive dys function. Lancet 351, 857-861.
74. Ancelin ML, de Roquefeuil G, Ledesert B, Bonnel F, Cheminal JC, Ritchie K (2001) Exposure to anaesthetic agents, cognitive functioning and depressive symptomology in the elderly. BrJPsychiatr 178, 360-366.
75. BohnenN, Warner MA, Kokmen E, Kurland LT (1994) Early and midlife exposure to anesthesia and age of onset of Alzheimer's disease. Int J Neurosci 77, 181-185.
76. Bohnen N, Warner MA, Kokmen E, Beard CM, Kurland LT (1994) Alzheimer's disease and cumulative exposure to anesthesia: A case-control study. J Am Geriatr Soc 42, 198201. (Pubitemid 24057360)
77. MuravchickS, Smith DS (1995) Parkinsonian symptoms during emergence from general anesthesia. Anesthesiology 82, 305-307.
78. Eckenhoff RG, Johansson JS, Wei H, Carnini A, Kang B, Wei W, Pidikiti R, Keller JM, Eckenhoff MF (2004) Inhaled anesthetic enhancement ofamyloid-beta oligomerization and cytotoxicity. Anesthesiology 101, 703-709.
79. Carnini A, Lear JD, Eckenhoff RG (2007) Inhaled anesthetic modulation of amyloid beta(1-40) assembly and growth. Curr Alzheimer Res 4, 233-241.
80. Xie Z, Tanzi RE (2006) Alzheimer's disease and postoperative cognitive dysfunction. Exp Gerontol 41, 346-359.
81. Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE (2006) Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci 61, 1300-1306.
82. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE (2006) The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology 104, 988-994.
83. Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE (2007) The inhalation anesthetic isoflurane [99] induces a vicious cycle ofapoptosis and amyloid beta-protein accumulation. J Neurosci 27, 1247-1254.
84. Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z (2008) The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions. J Biol Chem 283, 11866-11875.
85. Selnes OA, Grega MA, Bailey MM, Pham LD, Zeger SL, Baumgartner WA, McKhann GM (2008) Cognition 6 years after surgical or medical therapy for coronary artery disease. Ann Neurol 63,581-590.
86. Wu CL, Hsu W, Richman JM, Raja SN (2004) Postoperative cognitive function as an outcome of regional anesthesia and analgesia. Reg Anesth Pain Med 29, 257-268.
87. Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M (2007) Postoperative impairment ofcognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology 106, 436-443.
88. Wei H, Liang G, Yang H, Wang Q, Hawkins B, Madesh M, Wang S, Eckenhoff RG (2008) The common inhalation-al anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors. Anesthesiology 108, 251-260.
89. Yang H, Liang G, Hawkins BJ, Madesh M, Pierwola A, Wei H (2008) Inhalational anesthetics induce cell damage by disruption ofintracellular calcium homeostasis with different potencies. Anesthesiology 109, 243-250.
90. Severson JA (1984) Neurotransmitter receptors and aging. J Am Geriatr Soc 32, 24-27.
91. Kokmen E, Beard CM, O'Brien PC, Kurland LT (1996) Epidemiology of dementia in Rochester, Minnesota. Mayo Clin Proc 71, 275-282.
92. Rasmussen LS, Larsen K, Houx P, SkovgaardLT, Hanning CD, Moller JT (2001) The assessment of postoperative cognitive function. Acta Anaesthesiol 45, 275-289.
93. Riis J, Lomholt, B, Haxholdt O, Kehlet H, Valentin N, Danielsen U, Dyrberg V (1983) Immediate and long-term mental recovery from general versus epidural anesthesia in elderly patients. Acta Anaesthesiol Scand 27, 44-49.
94. Rasmussen LS, Siersma VD (2004) Postoperative cognitive dysfunction: true deterioration versus random variation. Acta Anaesthesiol Scand 48, 1137-1143.
95. Rasmussen LS, Johnson T, Kuipers HM, Kristensen D, Siers-ma VD, Vila P, Jolles J, Papaioannou A, Abildstrom H, Silver-stein JH, Bonal JA, Raeder J, Nielsen IK, Korttila K, Munoz L, Dodds C, Hanning CD, Moller JT; ISPOCD2 (International Study of Postoperative Cognitive Dysfunction) Investigators (2003) Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand 47, 260-266.
96. McKhann GM, Goldsborough MA, Borowicz Jr. LM, Selnes OA, Mellits ED, Enger C, Quaskey SA, Baumgartner WA, Cameron DE, Stuart RS, Gardner TJ (1997) Cognitive outcome after coronary artery bypass: a one-year prospective study. Ann Thorac Surg 63, 510-515. (Pubitemid 27084582)
97. Bekker AY, Weeks EJ (2003) Cognitive function after anaesthesia in the elderly. Best Pract Res Clin Anaesthesiol 17, 259-272.
98. Wilson RE, Li Y, Aggarwal NT, McCann JJ, Gilley DW, Bienias JL, Barnes LL, Evans DA (2006) Cognitive decline and survival in Alzheimer's disease. Int J Geriatr Psychiatry 21, 356-362.
99. Dodds C, Allison J (1998) Postoperative cognitive deficit in the elderly surgical patient. Br J Anaesthesiol 81, 449-462.
100. Olin K, Eriksdotter-Jonhagen K, Jansson A, Herrington MK, Kristiansson M, Permert J (2005) Postoperative delirium in elderly patients after major abdominal surgery. Br J Surg 92, 1559-1564.
101. Benoit, AG, Campbell BI, Tanner JR, Staley JD, Wallbridge HR, Biehl DR, Bradley BD, Louridas G, Guzman RP, Fromm RA (2005) Risk factors and prevalence of perioperative cognitive dysfunction in abdominal aneurysm patients. J Vasc Surg 42, 884-890.
102. Bo M, Massaia M, Speme S, Cappa G, Strumia K, Cerrato P, Ponzio F, Poli L (2006) Risk of cognitive decline in older patients after carotid endarterectomy: an observational study. J Am Geriatr Soc 54, 932-936.
103. Abildstrom H, Rasmussen LS, Rentowl P, Hanning CD, Ras-mussen H, Kristensen PA, Moller JT (2000) Cognitive dysfunction 1-2 years after non-cardiac surgery in the elderly. ISPOCD group. International study of post-operative cognitive dysfunction. Acta Anaesthesiol Scand 44, 1246-1251.
104. Bedford PD (1955) Adverse cerebral effects of anaesthesia on old people. Lancet 269, 259-263.
105. Gustafson Y, Berggren D, Brannstrom B, Bucht G, Norberg A, Hansson LI, Winblad B (1988) Acute confusional states in elderly patients treated for femoral neck fracture. J Am Geriatr Soc 36, 525-530.
106. O'Keeffe ST, Ni Chonchubhair A (1994) Postoperative delirium in the elderly. Br J Anaesth 73, 673-687.
107. Cully DJ, Yukhananov RY, Baxter MG, Crosby G (2003) Memory effects of general anesthesia persist for weeks in young and aged rats. Anesth Analg 96, 104-106.
108. Rees DI, Gaines GYIII (1985) Anesthetic considerations for patients with Alzheimer's disease. Tex Med 81, 45-48.
109. Bone I, Rosen M (2000) Alzheimer's disease and anaesthesia. Anaesthesia 55, 592-593.
110. Ritchie K, Polge C, de Roquefeuil G, Djakovic M, Ledesert B (1997) Impact of anesthesia on the cognitive functioning of the elderly. Int Psychogeriatr 9, 309-326.
111. van Groen T, Puurunen K, Maki HM, Sivenius J, Jolkkonen J (2005) Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats. Stroke 36, 1551-1556.
112. Eckenhoff RG, Eckenhoff M F (2007) Anesthesia, amyloid and Alzheimer's. Cell science Rev 4, 78-96.
113. Culley DJ, Baxter MG, Crosby CA, Yukhananov R, Crosby G (2004) Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats. Anesth Analg 99, 1393-1397. (Pubitemid 39407286)
114. Culley DJ, Yukhananov RY, Baxter MG, Crosby G (2003) Memory effects of general anesthesia persist for weeks in young and aged rats. Anesth Analg 96, 104-109.
115. Culley DJ, Baxter MG, Yukhananov RY, Crosby G (2004) Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology 100, 309-314. (Pubitemid 38133698)
116. Futterer CD, Maurer MH, Schmitt A, Feldmann RE Jr, Kuschinsky W, Waschke KF (2004) Alterations in rat brain proteins after desflurane anesthesia. Anesthesiology 100, 302-308.
117. Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcanto-nio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z (2009) The common inhalational anesthetic sevo?urane induces apopto-sis and increases beta-amyloid protein levels. Arch Neurol 66, 620-631.
118. Mandal PK, Fodale V (2009) Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization. Biochem Biophys Res Commun 379, 716-720.
119. Mandal PK, Fodale V (2009) Smaller Molecular-sized Anesthetics Oligomerize Aft Peptide Simulating Alzheimer's Disease: a Relevant Issue. Europ JAnesthesiol 46, 805-806.
120. Mandal PK, Simplaceanu V, Fodale V (2010) Intravenous Anesthetic Diazepam does not induce Amyloid beta-peptide Oligomerization but Diazepam Co-administered with Halothane Oligomerizes Amyloid Beta-peptide: An NMR study. J Alzheimers Dis 20, 127-134.
121. Mandal PK, Bhavesh NS, Chauhan VS, Fodale V (2010) NMR investigations ofAft peptide interactions with propofol at clinically relevant concentrations with and without aqueous halothane solution. J Alzheimers Dis 21, 1303-1309.
122. Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z (2008) Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci 28, 4551-4560.
123. Bianchi SL, Tran T, Liu C, Lin S, Li Y, Keller JM, Eckenhoff RG, Eckenhoff MF (2008) Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics. Neurobiol Aging 29, 1002-1010.
124. Eckenhoff R, Zheng W, Kelz M (2008) From anesthetic mechanisms research to drug discovery. Clin Pharmacol Ther 84, 144-148.
125. Kuehn BM (2007) Anesthesia-Alzheimer disease link probed. JAMA 297, 1760.
126. Alvarez G, Murioz-Montariio JR, Satmstegui J, Avila J, Bogonez E, Diaz-Nido J (2002) Regulation of tau phosphory-lation and protection against beta-amyloid induced neurode-generation by lithium. Possible implications for Alzheimer's disease. Bipolar Disord 4, 153-165.
127. Lorio G, Avila J, Diaz-Nido J (2001) Modifications of tau protein during neuronal cell death. J Alzheimers Dis 3, 563575.
128. Giannakopoulos P, Herrmann FR, Bussiere T, Bouras C, Ko-vari E, Perl DP, Morrison JH, Gold G, Hof PR (2003) Tangle and neuron numbers, but not amyloid load predict cognitive status in Alzheimer's disease. Neurology 60, 1495-1500.
129. Avila J (2006) Tau phosphorylation and aggregation in Alzheimer's disease pathology. FEBS Lett 580, 2922-2927.
130. Bretteville A, Planel E (2008) Tau aggregates: toxic, inert, or protective species? J Alzheimers Dis 14, 431-436.
131. Trojanowski JQ, Lee VM (1994) Paired helical filament tau in Alzheimer's disease. The kinase connection. Am J Pathol 144, 449-453.
132. Johansson C, Skoog I (1996) A population-based study on the association between dementia and hip fractures in 85-year olds. Aging (Milano) 3, 189-196.
133. Lim C, Duflou J (2008) Hypothermia fatalities in a temperate climate: Sydney, Australia. Pathology 40, 46-51.
134. Jaiswal MK, Mallick BN (2009) Prazosin modulates rapid eye movement sleep deprivation-induced changes in body temperature in rats. J Sleep Res 18, 349-356.
135. Sullivan F, Hutchinson M, Bahandeka S, Moore RE (1987) Chronic hypothermia in multiple sclerosis. J Neurol Neuro-surgPsychiatry 50, 813-815.
136. Sehara Y (2009) Hypothermia with Osborn waves in Parkinson's disease. Intern Med 48, 615-618.
137. Hama K, Miwa H, Kondo T (2009) Life-threatening hypothermia in Parkinson's disease. Mov Disord 24, 945-946.
138. Sacco RL, Chong JY, Prabhakaran S, Elkind MS (2007) Experimental treatments for acute ischaemic stroke. Lancet 369, 331-341.
139. Burk J, Burggraf D, Vosko M, Dichgans M, Hamann GF (2008) Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. Brain Res 1226, 248-255.
140. Lee SH, Kim YH, Kim YJ, Yoon BW (2008) Atorvastatin enhances hypothermia-induced neuroprotection after stroke. J Neurol Sci 275, 64-68.
141. Nagy Z, Esiri MM, Jobst KA, Morris JH, King EM, McDonald B, Joachim C, Litchfield S, Barnetson L, Smith AD (1997) The effects of additional pathology on the cognitive deficit in Alzheimer disease. J Neuropathol Exp Neurol 56, 165-170.
142. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR (1997) Brain infarction and the clinical expression of Alzheimer disease: The Nun Study. JAMA 277, 813-817.
143. Jendroska K, Hoffmann OM, Patt S (1997) Amyloid beta peptide and precursor protein (APP) in mild and severe brain ischemia. Ann NY AcadSci 826, 401-405.
144. Kalaria RN (2000) The role of cerebral ischemia in Alzheimer's disease. Neurobiol Aging 21, 321-330.
145. Veselis RA, Reinsel RA, Feschenko VA, Wronski M (1997) The comparative amnestic effects of midazolam, propofol, thiopental, and fentanyl at equisedative concentrations. Anes-thesiology 87, 749-764.
146. Veselis RA, Reinsel RA, Beattie BJ, Mawlawi OR, Feschenko VA, DiResta GR, Larson SM, Blasberg RG (1997) Midazolam changes cerebral bloodflow in discrete brain regions: An H2(15)O positron emission tomography study. Anesthesiology 87, 1106-1117.
147. Veselis RA, Reinsel RA, Distrian AM, Feshchenko VA, Beat-tie BJ (2000) Asymmetric dose-related effects of midazolam on regional cerebral blood flow. In Memory and Awareness in Anaesthesia IV: Proceedings of the Fourth International Symposium on Memory and Awareness in Anaesthesia. Jordan C, Vaughan DJA, Newton DEF, Eds. Imperial College Press, London, pp. 287-303.
148. Veselis RA, Reinsel RA, Tsakanikas D, Gutzler M, Fes-chenko VA, Dnistrian AM (2000) Conscious sedation with propofol: Preliminary observations using positron emission tomographic imaging. In Memory and Awareness in Anesthesia IV: Proceedings of the Fourth International Symposium on Memory and Awareness in Anaesthesia. Jordan C, Vaugh-an DJA, Newton DEF, Eds. Imperial College Press, London, pp. 232-247.
149. Veselis RA, Reinsel RA, Feschenko VA, Dnistrian AM (2002) A neuroanatomical construct for the amnesic effects of propofol. Anesthesiology 97, 329-337.
150. Hiltunen M, Makinen P, Peraniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J (2009) Focal cerebral ischemia in rats alters APP processing and expression of Aft peptide degrading enzymes in the thalamus. Neurobiol Dis 35, 103113.
151. Jevtovic-Todorovic V, Todorovic S, Mennerick S, Powell S, Dikranian K, Benshoff N, Zorumski CF, Olney JW (1998) Nitrous oxide (laughing gas) is an NMDA antagonist, neuro-protectant and neurotoxin. Nat Med 4, 460-463.
152. Jevtovic-Todorovic V, WozniakD, Benshoff N, Olney J (2001) A comparative evaluation of the neurotoxic properties of ketamine and nitrous oxide. Brain Res 895, 264-267.
153. Jevtovic-Todorovic V, Carter LB (2005) The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain. Neurobiol Aging 26, 947-956.
154. Leung JM, Sands LP, Vaurio LE, Wang Y (2006) Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients. Br J Anaesthesiol 96, 754-760.
155. Hole A, Terjesen T, Breivik H (1980) Epidural versus general anaesthesia for total hip arthroplasty in elderly patients. Acta Anaesthesiol Scand 24, 279-287.
156. Jankowski CJ (2004) Postoperative delirium in elderly orthopedic surgical patients. Anesthesiology 101, A40.
157. Alkire MT, Gruver R, Miller J, McReynolds JR, Hahn EL, Cahill L (2008) Neuroimaging analysis of an anesthetic gas that blocks human emotional memory. Proc Natl Acad Sci U SA 105, 1722-1727.
158. Alkire MT, Haier RJ, Fallon JH (2000) Toward a unified theory of narcosis: Brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthesia-induced unconsciousness. Conscious Cogn 9, 370-386.
159. Henon H, Pasquier F, Leys D (2006) Poststroke dementia. Cerebrovasc Dis 22, 61-70.
160. Mielke MM, Rosenberg PB, Tschanz J, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PV, Green RC, Welsh-Bohmer KA, Breitner JC, Munger R, Lyketsos CG (2007) Vascular factors predict rate of progression in Alzheimer disease. Neurology 69, 1850-1858.
161. Rasmussen LS (2006) Postoperative cognitive dysfunction: incidence and prevention. Best Pract Res Clin Anaesthesiol 20, 315-330.
162. Palotas A, Juhasz A, Janka Z, Bahn S, Kalman J (2007) Alzheimer-specific biomarker changes following heart surgery. Eur J Neurol 14(Suppl 1), 318.
163. Reiman EM, Caselli RJ, Yun LS (1996) Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 334, 752-758.
164. Chandra V, Kokmen E, Schoenberg BS, Beard CM (1989) Head trauma with loss of consciousness as a risk factor for Alzheimer's disease. Neurology 39, 1576-1578.
165. Gedye A, Beattie BL, Tuokko H, Horton A, Korsarek E (1989) Severe head injury hastens age of onset of Alzheimer's disease. J Am Geriatr Soc 37, 970-973.
166. Graves AB, White E, Koepsell TD (1990) The association between head trauma and Alzheimer's disease. Am J Epidemiol 131, 491-501.
167. Molgaard, CA, Stanford EP, Morton DJ, Ryden LA, Schubert KR, Golbeck AL (1990) Epidemiology of head trauma and neurocognitive impairment in a multi-ethnic population. Neuroepidemiology 9, 233-242.
168. Nicoll JA, Roberts GW, Graham DI (1995) Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. Nature Med 1, 135-137.
169. Roses AD, Saunders, AM (1995) Head injury, amyloid ft and Alzheimer's disease. Nature Med 1, 603-604.
170. Xu, PT, Schmechel D, Rothrock-Christian, T (1996) Human apolipoprotein E2, E3 and E4 isoform-specific transgenic mice: Human-like pattern of neuronal immunoreactivity in central nervous system not observed in wild type mice. Neu-robiol Dis 3, 229-245.
171. Horsburgh K, Nicoll JAR (1996) Selected cellular alterations in amyloid precursor protein and apolipoprotein E following transient cerebral ischaemia in the rat. Alzheimers Res 1, 169-176.
172. Jofre-Monseny L, Minihane AM, Rimbach G (2008) Impact of apoE genotype on oxidative stress, inflammation and disease risk. MolNutr Food Res 52, 131-145. (Pubitemid 351211806)
173. Rasmusson DX, Brandt J, Martin DB Folstein MF (1995) Head injury as a risk factor in Alzheimer's disease. Brain Inj 9,213-219.
174. Mayeux R, Ottman R, Maestre G (1995) Synergistic effects of traumatic head injury and apolipoprotein-e4 in patients with Alzheimer's disease. Neurology 45, 555-557.
175. Tang MX, Maestre G, Tsai WY (1996) Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Ann NY Acad Sci 802, 6-15.
176. Ely EW, Girard TD, Shintani AK, Jackson JC, Gordon SM, Thomason JW, Pun BT, Canonico AE, Light RW, Pandhari-pande P, Laskowitz DT (2007) Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med 35, 112-117.
177. Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR (2007) Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology 107, 406-411.
178. Sieber FE (2009) Postoperative delirium in the elderly surgical patient. Anesthesiol Clin 27, 451-464.
179. Chortkoff BS, Gonsowski CT, Bennett HL, Levinson B, Crankshaw DP, Dutton RC, Ionescu P, Block RI, Eger EL II (1995) Subanesthetic concentrations of desflurane and propofol suppress recall ofemotionally charged information. Anesth Analg 81, 728-736.
180. Chortkoff BS, Eger ELII, Crankshaw DP, Gonsowski CT, Dutton RC, Ionescu P (1995) Concentrations of desflurane and propofol that suppress response to command in humans. Anesth Analg 81, 737-743.
181. Campagna JA, Miller KW, Forman SA (2003) Mechanisms of actions of inhaled anesthetics. N Engl J Med 348, 21102124.
182. Rampil IJ, Mason P, Singh H (1993) Anesthetic potency (MAC) is independent of forebrain structure in rats. Anesthesiology 78, 707-712.
183. Rampil IJ (1994) Anesthetic potency is not altered after hy-pothermic spinal cord transection in rats. Anesthesiology 80, 606-610.
184. Rampil IJ (2000) Mechanisms and sites of action of general anaesthetics. In Memory and Awareness in Anesthesia IV: Proceedings of the Fourth International Symposium on Memory and Awareness in Anaesthesia. Jordan C, Vaughan DJA, Newton DEF, Eds. Imperial College Press, London, pp. 223-231.
185. McFarlane C, Warner DS, Dexter F, Ludwig PA (1994) Minimum alveolar concentration for halothane in the rat is resistant to effects of forebrain ischemia and reperfusion. Anes-thesiology 81, 1206-1211.
186. Antognini JF, Carstens EE (2002) In vivo characterization of clinical anesthesia and its components. British J Anaesth 89, 156-166.
187. Antognini JF, Jinks SL, Atherley RJ, Clayton C, Carstens EE (2003) Spinal anesthesia indirectly depresses cortical activity associated with electrical stimulation of the reticular formation. Br J Anaesth 91, 233-238.
188. Antognini JF, Jinks SL, Carstens EE, Atherley RJ (2004) Preserved reticular neuronal activity during selective delivery of supra-clinical isoflurane concentrations to brain in goats and its association with spontaneous movement. Neurosci Lett 361, 94-97.
189. Baars BJ (1995) Tutorial commentary: Surprisingly small sub cortical structures are needed for the state of waking consciousness, while cortical projection areas seem to provide perceptual contents of consciousness. Conscious Cogn 4, 159-162.
190. Newman J (1997) Putting the puzzle together: I. Towards a general theory of the neural correlates of consciousness. J Consciousness Studies 4, 46-66.
191. Wolf S (2008) Consciousness and Neuronal Synchronization. Chapter 1, Section 1 -Basics. In The Neurology of Con-sciousness, Laureys S, Tononi G, Eds. Elsevier, Amsterdam, pp. 43-52.
192. Tononi G (2004) An information integration theory of consciousness. BMC Neurosci 5, 42-62.
193. Van Dort CJ, Baghdoyan HA, Lydic R (2008) Neurochemical modulators of sleep and anesthetic states. Int Anesthesiol Clin 46, 75-104.
194. Veselis RA, Reinsel RA, Beattie BJ, Mawlawi OR, Fes-hchenko VA, DiResta GR, Larson SM, Blasberg RG (1997) Midazolam changes cerebral blood flow in discrete brain regions: an H2(15)O positron emission tomography study. Anesthesiology 87, 1106-1117.
195. Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M (2002) The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci 5, 979-984.
196. Ori C, Dam M, Pizzolato G, Battistin L, Giron G (1986) Effects of isoflurane anesthesia on local cerebral glucose utilization in the rat. Anesthesiology 65, 152-156.
197. Ito M, Miyaoka M, Ishii S (1984) Alterations in local cerebral glucose utilization during various anesthesia -the effect of urethane and a review. No To Shinkei 36, 111-119.
198. Lenz C, Rebel A, van Ackern K, Kuschinsky W, Waschke KF (1998) Local cerebral blood flow, local cerebral glucose utilization, and flow-metabolism coupling during sevoflurane versus isoflurane anesthesia in rats. Anesthesiology 89, 14801488. (Pubitemid 29001587)
199. Lenz C, Frietsch T, Futterer C, Rebel A, van Ackern K, Kuschinsky W, Waschke KF (1999) Local coupling of cerebral blood flow to cerebral glucose metabolism during in-halational anesthesia in rats: desflurane versus isoflurane. Anesthesiology 91, 1720-1723.
200. Guillery RW, Sherman SM (2002) Thalamic relay functions and their role in corticocortical communica-tion:generalizations from the visual system. Neuron 33, 163175.
201. Gajraj RJ, Doi M, Mantzaridis H, Kenny GN (1998) Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness. Br J Anaesth 80, 46-52.
202. Dutton RC, Rampil IJ, Eger EL II (2000) Inhaled nonim-mobilizers do not alter the middle latency auditory-evoked response of rats. Anesth Analg 90, 213-217.
203. Llinas RR, Steriade M (2006) Bursting of thalamic neurons and states of vigilance. J Neurophysiol 95, 3297-3308.
204. McCormick DA, Bal T (1997) Sleep and arousal: thalamocortical mechanisms. Annu Rev Neurosci 20, 185-215.
205. McCormick DA, Pape HC (1990) Properties of a hyperpo-larization activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J Physiol 431, 291-318.
206. Tononi G, Massimini M (2008) Why does consciousness fade in early sleep? Ann NY Acad Sci 1129, 330-334.
207. Savaki HE, Desban M, Glowinski J, Besson MJ (1983) Local cerebral glucose consumption in the rat. I. Effects of halothane anesthesia. J Comp Neurol 213, 36-45.
208. Savaki HE, Desban M, Glowinski J, Besson MJ (1983) Local cerebral glucose consumption in the rat. II. Effects of unilateral substantia nigra stimulation in conscious and in halothane-anesthetized animals. J Comp Neurol 213, 46-65.
209. Maurice T, Lockhart BP, Privat A (1996) Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction. Brain Res 706, 181-193.
210. Mikulec AA, Pittson S, Amagasu SM, Monroe FA, MacIver MB (1998) Halothane depresses action potential conduction in hippocampal axons. Brain Res 796, 231-238.
211. Study RE (1994) Isoflurane inhibits multiple voltage-gated calcium currents in hippocampal pyramidal neurons. Anes-thesiology 81, 104-116.
212. Pittson S, Himmel AM, MacIver MB (2004) Multiple synap-tic and membrane sites ofanesthetic action in the CA1 region of rat hippocampal slices. BMC Neurosci 3, 52.
213. Topulos GP, Lansing RW, Banzett RB (1993) The experience of complete neuromuscular blockade in awake humans. J Clin Anesth 5, 369-374.
214. Pike KE, Savage G, Villemagne VL, Ng S, Moss SA, Maruff P, Mathis CA, Klunk WE, Masters CL, Rowe CC (2007) Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain 130, 2837-2844.
215. Bourgeat P, Chetelat G, Villemagne VL, Fripp J, Raniga P, Pike K, Acosta O, Szoeke C, Ourselin S, Ames D, Ellis KA, Martins RN, Masters CL, Rowe CC, Salvado O (2010) Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology 74, 121-127.
216. Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ (2009) Alzheimer's Disease Neuroimaging Initiative. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain 132, 1310-1323.
217. Kemppainen NM, Aalto S, Wilson IA, Nagren K, Helin S, Brack A, Oikonen V, Kailajarvi M, Scheinin M, Viitanen M, Parkkola R, Rinne JO (2007) PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment. Neurology 68, 1603-1606.
218. Urbanc B, Betnel M, Cruz L, Bitan G, Teplow DB (2010) Elucidation ofAmyloid beta-Protein Oligomerization Mechanisms: Discrete Molecular Dynamics Study. J Am Chem Soc 132, 4266-42680.
219. Rhein V, Song X, Wiesner A, Ittner LM, Baysang G, Meier F, Ozmen L, Bluethmann H, Drtjse S, Brandt U, Savaskan E, Czech C, Gotz J, Eckert A (2009) Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci USA 106, 20057-20062.
220. Ribe EM, Perez M, Puig B, Gich I, Lim F, Cuadrado M, Sesma T, Catena S, Sanchez B, Nieto M, Gomez-Ramos P, Moran MA, Cabodevilla F, Samaranch L, Ortiz L, Perez A, Ferrer I, Avila J, Gomez-Isla T (2005) Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice. Neurobiol Dis 20, 814-822.
221. Sahara N, Lewis J, DeTure M, McGowan E, Dickson DW, Hutton M, Yen SH (2002) Assembly of tau in transgenic animals expressing P301Ltau: alteration of phosphorylation and solubility. JNeurochem 83, 1498-1508.
222. Thornberry NA(1998) Caspases: keymediators ofapoptosis. Chem Biol 5, R97-R103.
223. Velliquette RA, O'Connor T, Vassar R (2005) Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis. J Neurosci 25, 10874-10883.
224. Nordborg C, Johansson BB (1996) Secondary thalamic lesions after ligation of the middle cerebral artery: an ultra-structural study. Acta Neuropathol 91, 61-66.
225. Fujie W, Kirino T, Tomukai N, Iwasawa T, Tamura A (1990) Progressive shrinkage ofthe thalamus following middle cerebral artery occlusion in rats. Stroke 21, 1485-1488. (Pubitemid 20339720)
226. Dijkhuizen RM, Knollema S, van der Worp HB, Ter Horst GJ, De Wildt DJ, Berkelbach van der Sprenkel JW, Tulleken KA, Nicolay K (1998) Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: evidence for region-specific sensitivity and delayed damage. Stroke 29, 695-704.
227. Carmichael ST, Tatsukawa K, Katsman D, Tsuyuguchi N, Kornblum HI (2004) Evolution ofdiaschisis in a focal stroke model. Stroke 35, 758-763.