Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease

Annals of the New York Academy of Sciences

Volumn 802, Issue , 1996, Pages 6-15

  Tang, Ming Xin ^a,b   Maestre, Gladys ^b   Tsai, Wei Yann ^c   Liu, Xin Hua ^a   Feng, Lin ^b   Chung, Wai Yee ^b   Chun, Michael ^b   Schofield, Peter ^b   Stern, Yaakov ^a,b,c   Tycko, Benjamin ^b   Mayeux, Richard ^a,b  

^a and Epidemiology   (United States)

^b The New York Presbyterian Hospital   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4;

AGE; AGED; ALZHEIMER DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; ETHNIC GROUP; ETHNOLOGY; FEMALE; GENOTYPE; HEAD INJURY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; RISK; UNITED STATES;

EID: 8044235632     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb32593.x     Document Type: Conference Paper

References (51)

1. LANNFELT, L., L. LILIUS, M. NASTASE, M. VIITANEN, L. FRATIGLIONI, G. EGGERSTEN & L. BERGLAND. 1994. Lack of association between apolipoprotein E allele epsilon 4 and sporadic Alzheimer's disease. Neurosci. Lett. 169: 175-178.
2. MAESTRE, G., R. OTTMAN, Y. STERN, B. GURLAND, M. CHUN, M.-X. TANG, M. SHELANSKI, B. TYCKO & R. MAYEUX. 1995. Apolipoprotein-E and Alzheimer's disease: Ethnic variation in genotypic risks. Ann. Neurol. 37: 254-259.
3. POLVIKOSKI, T., R. SULKAVA, M. HALTIA, K. KAINULAINEN, A. VUORIO, A. VERKKONIEMI, L. NIINISTO, P. HALONEN & K. KONTULA. 1995. Apolipoprotien E, dementia and cortical depostion of β-amyloid protein. N. Engl. J. Med. 333: 1242-1247.
4. BROGAONKAR, D. S., L. C. SCHMIDIT, S. E. MARTIN, M. D. KANZER, L. EDELSOHN, J. GROWDON & L. A. FARRER. 1993. Linkage of late-onset Alzheimer's disease with apolipoprotein-E type 4 on chromosome 19. Lancet 342: 625.
5. CORDER, E. H., A. M. SAUNDERS, W. J. STRITTMATTER, D. E. SCHMECHEL, P. C. GASKEL, G. W. SMALL, A. D. ROSES, J. L. HAINES & M. PERICAK-VANCE. 1993. Gene dose of apolipoprotein-E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921-923.
6. CORDER, E. H., A. M. SAUNDER, N. J. RISCH, W. J. STRITTMATTER, D. E. SCHMECHEL, P. C. GASKEL & J. B. RIMMLER. 1994. Apolipoprotein E type 2 allele decreases the risk for late onset Alzheimer's disease. Nature Genet. 7: 180-184.
7. MAYEUX, R., Y. STERN, R. OTTMAN, T. K. TATEMICHI, M.-X. TANG, G. MAESTRE, C. NGAI, B. TYCKO & H. GINSBERG. 1993. The apolipoprotein ∈4 allele in patients with Alzheimer's disease. Ann. Neurol. 34: 752-754.
8. NOGUCHI, S., K. MURUKAMI & N. YAMADA. 1993. Apolipoprotein E genotype and Alzheimer's disease. Lancet 342: 737.
9. PAYAMI, H., J. KAYE, L. L. HESTON, T. BIRD & G. D. SCHELLENBERG. 1993. Apolipoprotein-E genotype and Alzheimer's disease. Lancet 342: 738.
10. POIRIER, J., J. DAVIGNON, D. BOUTHILLIER, S. KOGAN, P. BERTRAND & S. GAUTHIER. 1993. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342: 697-699.
11. ROSES, A. D., W. J. STRITTMATTER, M. A. PERICAK-VANCE, E. H. CORDER, A. M. SAUNDERS & D. E. SCHMECHEL. 1994. Clinical application of apolipoprotein E genotyping to Alzheimer's disease. Lancet 343: 1564-1565.
12. SAUNDERS, A. M., W. J. STRITTMATTER, D. SCHMECHEL, P. H. ST. GEORGE-HYSLOP, M. A. PERICAK-VANCE, S. H. JOO, B. L. ROSI & A. D. ROSES. 1993. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467-1472.
13. SAUNDERS, A. M., K. SCHMADER, J. C. S. BRIETNER, M. D. BENSON, W. T. BROWN, L. GOLDFARB, D. GOLDGABER & A. D. ROSES. 1993. Apolipoprotein-E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet 342: 710-711.
14. STRITTMATTER, W. J., A. M. SAUNDERS, D. SCHMECHEL, M. PERICAK-VANCE, J. ENGHILD, G. S. SALVESEN & A. D. ROSES. 1993. Apolipoprotein E: High-affinity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc. Natl. Acad. Sci. 90: 1977-1981.
15. STRITTMATTER, W. J., K. H. WEISGRABER, D. HUANG, L. M. DONG, G. S. SALVESEN, M. PERICAK-VANCE, D. SCHMECHEL & A. D. ROSES. 1993. Binding of human apolipoprotein E to β-A4 peptide: Isoform-specific effects and implications for late-onset Alzheimer's disease. Proc. Natl. Acad. Sci. 90: 8098-8102.
16. CHARTIER-HARDLIN, M.-C, M. PARFITT, S. LEGARIN, J. PEREZ-TUR, T. BROUSSEAU, A. EVANS, C. BER, et al. 1994. Apolipoprotein E, ∈4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: Analysis of the 19q13.2 chromosomal region. Human Mol. Gen. 3: 569-574.
17. KUUSISTO, J., K. KOIVISTO, K. KERVINEN, L. MYKKANEN, E. L. HELKALA, M. VANHANEN & T. HANNIEN. 1994. Association of apolipoprotein-E phenotypes with late onset Alzheimer's disease: Population based study. Br. Med. J. 309: 636-638.
18. SORBI, S., B. NACMIAS, P. FORLEO, S. LATORRACA, I. GOBBINI, L. BRACCO, S. PIACENTINI & L. AMADUCCI. 1994. ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease. Neurosci. Lett. 177: 100-102.
19. LIDDELL, M., J. WILLIAMS, A. BAYER, F. KAISER & M. OWEN. 1994. Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease. J. Med. Genet. 31: 197-200.
20. HENDRIE, H. C., K. S. HALL, S. HUI, F. W. UNVERZAGT, C. E. YU, D. K. LAHIRI & A. SAHOTA. 1995. Apolipoprotein-E genotypes and Alzheimer's disease in a community study of elderly African-Americans. Ann. Neurol. 37: 118-120.
21. ROSES, A. D. 1995. Apolipoprotein E genotyping in the differential diagnosis, not prediction of Alzheimer's disease. Ann. Neurol. 38: 6-14.
22. PAYAMI, H., K. R. MONTEE, J. KAYE, E. M. WUSMAN, T. BIRD, C.-E. YU, L. L. HESTON & G. D. SCHELLENBERG. 1994. Apolipoprotein-E genotype and Alzheimer's disease. JAMA 271: 1316-1317.
23. MAYEUX, R., R. OTTMAN, G. MAESTRE, C. NGAI, M.-X. TANG, H. GINSBERG, M. CHUN, B. TYCKO & M. S. SHELANSKI. 1995. Synergistic effects of traumatic head injury and apolipoprotein-∈4 in patients with Alzheimer's disease. Neurology 45: 555-557.
24. OSUNTOKUN, B. O., A. SAHOTA, A. O. OGUNNIYI, O. GUREJE, O. BAIEYWU, A. ADEYINKA & S. O. OLUWOLE. 1995. Lack of an association between apolipoprotein E ∈4 and Alzheimer's disease in elderly Nigerians. Ann. Neurol. 38: 463-465.
25. KAMBOH, M. I., D. K. SANGHERA, R. E. FERRELL & S. T. DEKOSKY. 1995. APOE*4-associated Alzheimer's disease risk is modified by α1-antichymotrysin polymorphism. Nature Genet. 10: 486-488.
26. TANG, M.-X., G. MAESTRE, W.-Y. TSAI, X.-H. LIU, L. FENG, W.-Y. CHUNG, M. CHUN, P. SCHOFIELD, Y. STERN, B. TYCKO & R. MAYEUX. 1996. Relative risk of Alzheimer's disease and age-at-onset based on APOE genotypes among elderly African-Americans, Caucasians and Hispanics in New York City. Am. J. Hum. Genet. 58: 554-574.
27. AMERICAN PSYCHIATRIC ASSOCIATION. 1987. Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised. American Psychiatric Association. Washington, DC. pp. 205-224.
28. MCKHANN, G., D. DRACHMAN, M. FOLSTEIN, R. KATZMAN, D. PRICE & E. M. STADLAN. 1984. Clinical diagnosis of Alzheimer's disease: Report of NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944.
29. PITTMAN, J., H. ANDREWS, T. TATEMICHI, B. LINK, E. STRUENING, Y. STERN & R. MAYEUX. 1992. Diagnosis of dementia in a heterogenous population: A comparison of paradigm-based diagnosis and physician's diagnosis. Arch. Neurol. 49: 461-467.
30. STERN, Y., H. ANDREWS, J. PITTMAN, M. SANO, T. TATEMICHI, R. LANTIGUA & R. MAYEUX. 1992. Diagnosis of dementia in a heterogenous population: Development of a neuropsychological paradigm and quantified correction for education. Arch. Neurol. 49: 453-460.
31. SCHOFIELD, P. W., M.-X. TANG, K. MARDER, K. BELL, G. DOONEIEF, R. LANTIGUA, D. WILDER & R. MAYEUX. 1995. Consistency of clinical diagnosis in a community-based longitudinal study of dementia and Alzheimer's disease. Neurology 45: 2159-2164.
32. TURNBULL, B. W. 1974. Nonparametric estimation of survivorship function with doubly censored data. J. Am. Stat. Assoc. 69: 169-174.
33. CUPPLES, L. A., N. J. RISCH, L. A. FARRER & R. H. MYERS. 1991. Estimation of age at onset with missing information of onset. Am. J. Hum. Genet. 49: 76-87.
34. TANG, M.-X., W.-Y. TSAI, K. MARDER & R. MAYEUX. 1995. Linear rank tests for doubly censored data. Stat. Med. 14: 2555-2563.
35. CENSUS OF POPULATION AND HOUSING. 1991. 1990: Summary Tape File 1 Technical Documentation Prepared by Bureau of Census. Census Bureau. Washington, DC.
36. HIXSON, J. & D. VERNIER. 1991. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhAI. J. Lipid Res. 31: 545-548.
37. MAYEUX, R., R. OTTMAN, M.-X. TANG, L. NOBOA-BAUZA, K. MARDER, B. GURLAND & Y. STERN. 1993. Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community-dwelling elderly persons and their first-degree relatives. Ann. Neurol. 33: 494-501.
38. DAVIGNON, J., R. E. GREGG & C. F. SING. 1988. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8: 1-21.
39. HALLMAN, D. M., E. BOERWINKLE, N. SAHA, C. SANDHOLZER, H. J. MENZEL, A. CSAZAR & G. UTERMANN. 1991. The apolipoprotein E polymorphism: A comparison of allele frequencies and effects in nine populations. Am. J. Hum. Genet. 49: 338-349.
40. KAMBOH, M. I., B. SEPEHRNIA & R. E. FERRELL. 1989. Genetic studies of human apolipoproteins. VI. Common polymorphism of apolipoprotein E in blacks. Dis. Markers 7: 49-55.
41. SEPEHRNIA, B., M. I. KAMBOH, L. L. ADAMS-CAMPBELL, C. H. BUNKER, M. NWANKWO, P. P. MAJUMDER & R. E. FERRELL. 1989. Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of lipoproteins in Nigerian blacks. Am. J. Hum. Genet. 45: 586-591.
42. SANDHOLZER, C., R. DELPORT, H. VERMAAK & G. UTERMANN. 1995. High frequency of the apo epsilon 4 allele in Khoi San from South Africa. Hum. Genet. 95: 46-48.
43. ZEKRAOUI, L., G. LUCOTTE & A. RAISONNIER. 1995. Apolipoprotein E genotypes in Africa: Alleleic frequencies and ethnic groups. Paper presented at the Ibsen Foundation Meeting. Paris, France, May 29.
44. SCHACHTER, F., L. FAURE-DELANEF, F. GUENOT, H. ROUGER, P. FROGUEL, L. LESUEURGINOT & D. COHEN. 1994. Genetic associations with human longevity at the APOE and ACE loci. Nature Genet. 6: 29-32.
45. KERVINEN, K., M. J. SAVOLAINEN, J. SALOKANNEL, A. HYNNINEN, J. HEIKKINEN, C. EHNHOLM, M. J. KOISTINEN & Y. A. KESANIEMI. 1994. Apolipoprotein E and B polymorphics-longevity factors assessed in nonagenarians. Atherosclerosis 105: 89-95.
46. LOUHIJA, J., H. E. MIETTINEN, K. KONTULA, M. J. TIKKANEN, T. A. MIETTINEN & R. S. TILVIS. 1994. Aging and genetic variation of plasma apolipoprotiens. Relative loss of the apolipoprotein E4 phenotype in centenarians. Arterioscler. Thromb. 14: 1084-1089.
47. EICHNER, J. E., L. H. KULLER, T. J. ORCHARD, G. A. GRANDITS, L. M. MCCALLUM, R. E. FERRELL & J. D. NEATON. 1993. Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease. Am. J. Cardiol. 71: 160-165.
48. WILSON, P. W., R. H. MYERS, M. G. LARSON, J. M. ORDOVAS, P. A. WOLF & E. J. SCHAEFER. 1994. Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study. JAMA 272: 1666-1671.
49. LUC, G., J. M. BARD & D. ARVEILER. 1994. Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM Study. Arterioscler. Thromb. 14: 1412-1419.
50. STENGARD, J. H., K. E. ZERBA, J. PEKKANEN, C. EHNHOLM, A. NISSINEN & C. F. SING. 1995. Apolipoprotein E polymorphis predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation 91: 265-269.
51. GARJRA, B., J. K. CANDLISH, N. SAHA, J. W. MAK & J. S. TAY. 1994. Effect of apolipoprotein E variants on plasma lipids and apolipoproteins in the Orang Asli ('aborigines') of Malaysia. Human Heredity 44: 209-213.