The common inhalational anesthetic sevoflurane induces apoptosis and increases β-amyloid protein levels

Archives of Neurology

Volumn 66, Issue 5, 2009, Pages 620-631

  Dong, Yuanlin ^a   Zhang, Guohua ^a,b   Zhang, Bin ^a,c   Moir, Robert D ^a   Xia, Weiming ^d   Marcantonio, Edward R ^d   Culley, Deborah J ^e   Crosby, Gregory ^e   Tanzi, Rudolph E ^a   Xie, Zhongcong ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CARBOBENZOXYVALYLALANYLASPARTIC ACID; CASPASE 3; CASPASE INHIBITOR; GAMMA SECRETASE INHIBITOR; SEVOFLURANE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHALATION ANESTHESIA; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANESTHETICS, INHALATION; ANIMALS; APOPTOSIS; BRAIN; CASPASE 3; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HUMANS; METHYL ETHERS; MICE; MICE, INBRED C57BL; SENILE PLAQUES; UP-REGULATION;

EID: 66249148382     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2009.48     Document Type: Article

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