Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a Rho-dependent pathway

Journal of Immunology

Volumn 162, Issue 5, 1999, Pages 2964-2973

  Adamson, Peter ^a   Etienne, Sandrine ^b   Couraud, Pierre Olivier ^b   Calder, Virginia ^a   Greenwood, John ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CORTACTIN; CYTOCHALASIN D; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; RHO FACTOR;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CROSS LINKING; CYTOSKELETON; ENDOTHELIUM CELL; EXTRAVASATION; GENE ACTIVATION; LEUKOCYTE ADHERENCE; LYMPHOCYTE MIGRATION; MIGRATION INHIBITION; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ACTINS; ADENOSINE DIPHOSPHATE RIBOSE; ADP RIBOSE TRANSFERASES; ANIMALS; BOTULINUM TOXINS; BRAIN; CELL LINE; CELL MOVEMENT; CORTACTIN; CYTOCHALASIN D; ENDOTHELIUM, VASCULAR; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTES; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; PHOSPHORYLATION; RATS; RATS, INBRED LEW; RHOB GTP-BINDING PROTEIN;

EID: 0033105628     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Pryce, G., D. K. Male, I. Campbell, and J. Greenwood. 1997. Factors controlling T-cell migration across rat cerebral endothelium in vitro. J. Neuroimmunol. 75: 84.
2. Hickey, W. F., B. L. Hsu, and H. Kimura. 1991. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28:254.
3. Oppenheimer-Marks, N., L. S. Davis, and P. E. Lipsky. 1990. Human T-lymphocyte adhesion to endothelial cells and transendothelial cell migration: alteration of receptor use relates to the activation status of both the T-cell and the endothelial cell. J. Immunol. 145:140.
4. Greenwood, J., and V. Calder. 1993. Lymphocyte migration through cultured endothelial cell monolayers derived from the blood-retinal barrier. Immunology 80:401.
5. Osborn, L. 1990. Leukocyte adhesion to endothelium in inflammation. Cell 62:3.
6. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
7. Oppenheimer-Marks, N., L. S. Davis, D. T. Bogue, J. Ramberg, and P. E. Lipsky. 1991. Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes. J. Immunol. 147:2913.
8. Kavanaugh, A. F., E. Lightfoot, P. E. Lipsky, and N. Oppenheimer-Marks. 1991. Role of CD11/CD18 in adhesion and transendothelial migration of T cells. J. Immunol. 146:4149.
9. 1, integrin. Nature 356:63.
10. Male, D., J. Rahman, G. Pryce, T. Tamatani, and M. Miyasaka. 1994. Lymphocyte migration into the CNS modeled in vitro: roles of LFA-1, ICAM-1 and VLA-4. Immunology 81:366.
11. Greenwood, J., Y. Wang, and V. Calder. 1995. Lymphocyte adhesion and transendothelial migration in the CNS: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. Immunology 86:408.
12. lck. Cell 55:301.
13. Liao, F., H. S. Shin, and S. G. Rhee. 1992. Tyrosine phosphorylation of phospholipase C-γ 1 induced by cross-linking the high affinity or low affinity Fc receptor for IgG in U937 cells. Proc. Natl. Acad. Sci. USA 89:3659.
14. Doherty, P., and F. S. Walsh. 1992. Cell adhesion molecules, second messengers and axonal growth. Curr. Opin. Neurobiol. 2:595.
15. Rothlein, R., T. K. Kishimoto, and E. Mainolfi. 1994. Cross-linking of ICAM-1 induces co-signaling of an oxidative burst from mononuclear leukocytes. J. Immunol. 152:2488.
16. Chintana, C., S. A. Tibbetts, M. A. Chan, and S. H. Benedict. 1995. Cross-linking of ICAM-1 on T-cells induces transient tyrosine phosphorylation and inactivation of cdc2 kinase. J. Immunol. 155:5479.
17. van Horssen, M., S. Loman, G. T. Rijkers, S. E. Bloom, and A. C. Bloem. 1995. Co-ligation of ICAM-1 (CD54) and membrane IgM negatively affects B-cell receptor signaling. Eur. J. Immunol. 25:154.
18. Jackson, D. E., C. M. Ward, R. Wang, and P. J. Mewman. 1997. The protein tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. J. Biol. Chem. 272:6986.
19. 2+ mobilization. Eur. J. Immunol. 27:1530.
20. Durieu-Trautmann, O., N. Chaverot, S. Cazaubon, A. D. Strosberg, and P-O. Couraud. 1994. Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells. J. Biol. Chem. 269:12536.
21. Roux, F., O. Durieu-Trautmann, N. Foignant-Chaverot, M. Claire, P. Mailly, J. M. Bourre, A. D. Strosberg, and P-O. Couraud. 1994. Regulation of γ-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J. Cell. Physiol. 159:101.
22. Greenwood, J., G. Pryce, L. Devine, D. K. Male, W. L. C. dos Santos, V. L. Calder, and P. Adamson. 1996. SV40 large T immortalized cell lines of the rat blood-brain and blood-retinal barriers retain their phenolypic and immunological characteristics. J. Neuroimmunol. 71:51.
23. Etienne S., P. Adamson, J. Greenwood, A. D. Strosberg, S. Cazaubon, and P-O. Couraud. 1998. Rho-dependent signaling pathways coupled to ICAM-1 in microvascular brain endothelial cells. J. Immunol. 161:5755.
24. Abbott, N. J., C. C. W. Hughes, P. A. Revest, and J. Greenwood. 1992. Development and characterization of a rat brain capillary endothelial cell culture: towards an in vitro blood-brain barrier. J. Cell Sci. 103:23.
25. Greenwood, J. 1992. Characterization of a rat retinal endothelial cell culture and the expression of P-glycoprotein in brain and retinal endothelium. J. Neuroimmunol. 39:123.
26. + T cell lines with antigen and mitogen. Cell. Immunol. 159:220.
27. Hughes, C. C. W., D. K. Male, and P. L. Lantos. 1988. Adhesion of lymphocytes to cerebral microvascular cells: effects of interferon-γ, tumor necrosis factor and interleukin-1. Immunology 64:677.
28. Male, D., G. Pryce, C. Hughes, and P. Lantos. 1990. Lymphocyte migration into brain modeled in vitro: control by lymphocyte activation, cytokines, and antigen. Cell. Immunol. 127:1.
29. Wang, Y., V. Calder, J. Greenwood, and S. Lightman. 1993. Lymphocyte adhesion to cultured endothelial cells of the blood-retinal barrier. J. Neuroimmunol. 48:161.
30. ras upon T-cell activation. Nature 346:719.
31. Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389.
32. rho proteins. J. Biol. Chem. 267:20033.
33. Jahner, D., and T. Hunter. 1991. The ras related gene rhoB is an immediate early gene inducible by v-fps, epidermal growth factor and platelet derived growth factor in rat fibroblasts. Mol. Cell. Biol. 11:3682.
34. Nobes, C. D., and A. Hall. 1995. Rho, rac and cdc42 regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 81:53.
35. Aktories, K., S. Braun, S. Rosener, I. Just, and A. Hall. 1989. The rho gene product expressed in E. Coli is a substrate for botulinum ADP-ribosyltransferase C3. Biochem. Biophys. Res. Commun. 158:209.
36. Laudanna, C., J. J. Campbell, and E. C. Butcher. 1996. The role of rho in chemoattractant-activated leukocyte adhesion through integrins. Science 271: 981.
37. Huang C., Y. Ni, T. Wang, Y. Gao, G. C. Haudenschild, and X. Zhan. 1997. Down regulation of the filamentous actin cross-linking activity of cortactin by c-src mediated tyrosine phosphorylation. J. Biol. Chem. 272:13911.
38. Takaishi, K., T. Sasaki, T. Kameyama, S. Tsukita, S. Tsukita, and Y. Takai. 1995. Translocation of activated rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows. Oncogene 11:39.
39. Nusrat, A., M. Giry, J. R. Turner, S. P. Colgan, C.A. Parkos, D. Carnes, E. Lemichez, P. Boquet, and J. L. Madara. 1995. Rho protein regulates tight junctions and peripheral actin organization in polarized epithelia. Proc. Natl. Acad. Sci. USA 92:10629.
40. Schmalzing, G., H. P. Richter, A. Hansen, W. Schwartz, I. Just, and K. Aktories. 1995. Involvement of the GTP-binding protein rho in constitutive endocytosis in Xenopus laevia oocytes. J. Cell. Biol. 130:1319.