CNS microvascular pericytes express macrophage-like function, cell surface integrin αM, and macrophage marker ED-2

Microvascular Research

Volumn 52, Issue 2, 1996, Pages 127-142

  Balabanov, Roumen ^a   Washington, Ruth ^a   Wagnerova, Jarmila ^a   Dore Duffy, Paula ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; ALPHA ACTIN; INTEGRIN;

ACTIN FILAMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL MEMBRANE PERMEABILITY; CELL SURFACE; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION; MACROPHAGE FUNCTION; MICROVASCULATURE; NERVE CELL NETWORK; NONHUMAN; PERICYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER;

ANIMALIA;

EID: 0030250260     PISSN: 00262862     EISSN: None     Source Type: Journal    
DOI: 10.1006/mvre.1996.0049     Document Type: Article

References (44)

1. Antonelli-Oldrige, A., Sanders, R. B., Smith, S. R., and D'Amore, P. (1989). An activated form of transforming growth factor β is produced by co-cultures of endothelial cells and pericytes. Proc. Natl. Acad. Sci. 86, 4544-4548.
2. Boado, R. J., and Pardridge, W. M. (1994). Differential expression of α-actin mRNA and immunoreactive protein in brain microvascular pericytes and smooth muscle cells. J. Neurosci. Res. 39, 430-435.
3. Bowman, P. D., Betz, A. L., Jerry, D. A., Wolinsky, J. S., Peuney, J. B., Shivers, R. R., and Goldstein, G. W. (1981). Primary culture of capillary endothelium from rat brain. In Vitro 17, 353-362.
4. Boya, J. (1976). An ultrastructural study of the relationship between pericytes and cerebral macrophages. Acta Anat. 95, 598-608.
5. Brown, J. (1991). Complement receptor and phagocytosis. Curr. Opin. Immunol. 3, 76-82.
6. Cancilla, P., Baker, P., Pollock, P., and Frommes, B. (1972). The reaction of pericytes of the central nervous system to exogenous protein. Lab. Invest. 26, 376-383.
7. Carson, M. P., and Haudenschild, C. C. (1986). Microvascular endothelium and pericytes: High yield, low passage cultures. In Vitro Cell Dev. Biol. 22, 344-354.
8. Crocker, D. J., Murad, T. M., and Geer, J. C. (1970). Role of the pericyte in wound healing: An ultrastructural study. Exp. Mol. Pathol. 13, 51-76.
9. D'Amore, P. A., and Thompson, R. W. (1987). Mechanisms of angiogenesis. Annu. Rev. Physiol. 49, 453-464.
10. Diaz-Flores, L., Gutierrez, R., Varela, H., Rancel, N., and Valladares, F. (1991). Microvascular pericytes: A review of their morphological and functional characteristics. Histol. Histopathol. 6, 269-286.
11. Dore-Duffy, P., Balabanov, R., Rafols, J., and Swanborg, R. (1996). The recovery phase of acute EAE in rats corresponds to development of endothelial cell unresponsiveness to interferon gamma-activation. J. Neurosci. Res. 44, 223-234.
12. Dore-Duffy, P., Washington, R., and Balabanov, R. (1994). Cytokine-mediated activation of cultured CNS microvessels: A system for examining antigenic modulation of CNS endothelial cells, and evidence for long-term expression of the adhesion protein E-selectin. J. Cereb. Blood Flow Metab. 14, 837-844.
13. + cells by murine brain microvessel endothelial cells and smooth muscle pericytes. J. Immunol. 151, 38-46.
14. Farrel, C. R., Stewart, R. A., Farrel, C. R., and Del Maestro, R. F. (1987). Pericytes in human cerebral microvasculature. Anat. Rec. 218, 466-469.
15. Giltin, J. D., and D'Amore, P. A. (1983). Culture of retinal capillary cells using selective growth media. Microvasc. Res. 24, 74-80.
16. Graeber, M., and Streit, W. (1990). Perivascular microglia defined. Trends Neurosci. 13, 336.
17. Graeber, M., Streit, W. J., and Kreutzberg, G. W. (1989). Identity of ED-2 positive perivascular cells in rat brain. J. Neurosci. Res. 22, 103-106.
18. Guilian, D., and Baker, T. (1986). Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6, 2163-2178.
19. Herman, I., and D'Amore, P. A. (1985). Microvascular pericytes contain muscle and nonmuscle actins. J. Cell Biol. 101, 43-45.
20. Hickey, W., and Kimura, H. (1988). Perivascular microglial cells of CNS are bone marrow-derived and present antigen in vivo. Science 230, 290-292.
21. Jeynes, B. (1984). Reaction of granular pericytes in a rabbit cerebrovascular ischemia model. Stroke 16, 121-125.
22. Joyce, N. C., Haire, M. F., and Palade, G. E. (1985). Contractile proteins in pericytes: Immunoperoxidase localization of tropomyosin. J. Cell Biol. 100, 1379-1386.
23. Kelley, C. H., D'Amore, P., Hechtman, H., and Shepro, D. (1987). Microvascular pericyte contractility in vitro: Comparison with other cells of the vascular wall. J. Cell Biol. 104, 483-490.
24. Kida, S., Steart, P. V., Zhang, E-T., and Weller, R. O. (1993). Perivascular cells act as scavengers in the cerebral perivascular spaces and remain distinct from pericytes, microglia and macrophages. Acta Neuropathol. 85, 646-652.
25. Kristensson, K., and Orson, Y. (1973). Accumulation of protein tracers in pericytes of the central nervous system following systematic injection in immature mice. Acta Neurol. Scand. 48, 189-194.
26. Mato, M., Ookawara, S., and Kurihara, K. (1980). Uptake of exogenous substances and marked enfolding of these fluorescent granular pericytes in cerebral fine vessels. Am. J. Anat. 157, 329-332.
27. Maxwell, D., and Kruger, L. (1965). Small blood vessels and the origins of phagocytosis in rat cerebral cortex following heavy particle irradiation. Exp. Neurol. 12, 33-54.
28. + T cell proliferation in vitro. J. Immunol. 154, 151-161.
29. Nels, V., and Drenckhahn, D. (1991). Heterogeneity of microvascular pericytes for smooth muscle type alpha actin. J. Cell. Biol. 113, 147-154.
30. Newcomb, P. M., and Herman, I. M. (1993). Pericyte growth and contractile phenotype: Modulation by endothelial-synthesized matrix and comparison with aortic smooth muscle. J. Cell Physiol. 155, 385-393.
31. Pardridge, W. M., Buciar, J. Y., and Touretellote, W. W. (1989). Human brain microvascular DR-antigen. J. Neurosci. Res. 23, 336-341.
32. Paterson, P. Y., and Swanborg, R. H. (1988). Demyelinating diseases of the central and peripheral nervous systems. In "Immunological Diseases," 4th ed. (M. Samster, Ed.), pp. 1877-1916. Little Brown, Boston.
33. Peters, A., Josephson, K., and Vincent, S. (1991). Effect of aging on the neuroglial cells and pericyte within area 17 of the rhesus monkey cerebral cortex. Anat. Rec. 229, 384-398.
34. Saliagen, G., Moore, S., Farby, Z., Schelper, R., and Hart, M. N. (1989). Purification of murine endothelial cultures by flow cytometry using fluorescein labeled Griffonia simpliciforia agglutinin. Am. J. Pathol. 134, 1227-1232.
35. Sanguedorge, M. V., Capo, C. A., Bouguard, R., and Mege, J. L. (1992). Zymosan stimulated tumor necrosis factor production by human monocytes. J. Immunol. 148, 2229-2236.
36. Shepro, D., and Morel, N. (1993). Pericyte physiology. FASEB 7, 1031-1038.
37. Sims, D. E. (1991). Recent advances in pericyte biology - Implications for health and diseases. Can. J. Cardiol. 7, 431-443.
38. Spatz, M., Dodson, R. F., and Bembry, J. (1983). Cerebrovascular muscle culture: Isolation, growth and morphological characterization. Brain Res. 280, 387-391.
39. Steinham, J. A., Wilson, J., Sanders, G. S., and Steward, C. (1982). Phagocytosis: Flow cytometric quantitation with fluorescent microspheres. Science 215, 64-66.
40. Streit, W. J., and Graber, M. B. (1993). Heterogeneity of microglial and perivascular cell population: Insights gained from the facial nucleus paradigm. Glia 7, 68-74.
41. Streit, W. J., and Kreutzberg, G. W. (1987). Lectin binding by resting and reactive microglia. J. Neurocytol. 16, 249-260.
42. Tagani, M., Jubota, A., Nara, Y., and Yamori, Y. (1991). Detailed disease processes of cerebral pericytes and astrocytes in stroke-prone rats SPR. Clin. Exp. Hypertens. Theory Pract. 13, 1069-1075.
43. VanDuers, B. (1976). Observation on the blood-brain barrier in hypertensive rats, with particular reference of phagocytic pericytes. J. Ultrastruct. Res. 56, 65-77.
44. Verbeek, M. M., Otte-Holler, I., Wesseling, P., Ruiter, D. J., and de Waal, R. M. W. (1994). Induction of α-smooth muscle actin expression in cultured human brain pericytes by transforming growth factor-β1. Am. J. Pathol. 144, 372-382.