Holey barrier: Claudins and the regulation of brain endothelial permeability

Journal of Cell Biology

Volumn 161, Issue 3, 2003, Pages 459-460

  Matter, Karl ^a   Balda, Maria S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Blood brain barrier; Occludin; Paracellular permeability; Tight junction

Indexed keywords

CLAUDIN 5; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

BLOOD BRAIN BARRIER; DIFFUSION; ENDOTHELIUM; KNOCKOUT MOUSE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; TIGHT JUNCTION;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL MEMBRANE; DRUG DESIGN; ENDOTHELIUM, VASCULAR; HUMANS; MEMBRANE PROTEINS; MICE; PROTEIN ENGINEERING; TIGHT JUNCTIONS;

EID: 0038273906     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200304039     Document Type: Review

References (18)

1. Abbott, N.J. 2002. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 200:629-638.
2. Anderson, J.M. 2001. Molecular structure of tight junctions and their role in epithelial transport. News Physiol. Sci. 16:126-130.
3. Balda, M.S., and K. Matter. 2000. Transmembrane proteins of tight junctions. Semin. Cell Dev. Biol. 11:281-289.
4. Benais-Pont, G., A. Punn, C. Flores-Maldonado, J. Eckert, G. Raposo, T.P. Fleming, M. Cereijido, M.S. Balda, and K. Matter. 2003. Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability. J. Cell Biol. 160:729-740.
5. Cereijido, M., L. González-Mariscal, and G. Contreras. 1989. Tight junction: barrier between higher organisms and environment. News Physiol. Sci. 4:72-74.
6. Claude, P. 1978. Morphological factors influencing transepithelial permeability: a model for the resistance of the zonula occludens. J. Membr. Biol. 39:219-232.
7. Dejana, E., M.G. Lampugnani, O. Martinez-Estrada, and G. Bazzoni. 2000. The molecular organization of endothelial junctions and their functional role in vascular morphogenesis and permeability. Int. J. Dev. Biol. 44:743-748.
8. Furuse, M., T. Hirase, M. Itoh, A. Nagafuchi, S. Yonemura, S. Tsukita, and S. Tsukita. 1993. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol. 123:1777-1788.
9. Furuse, M., M. Hata, K. Furuse, Y. Yoshida, A. Haratake, Y. Sugitani, T. Noda, A. Kubo, and S. Tsukita. 2002. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J. Cell Biol. 156:1099-1111.
10. Hirase, T., S. Kwashima, E.Y. Wong, T. Ueyama, Y. Rikitake, S. Tsukita, M. Yokoyama, and J.M. Staddon. 2001. Regulation of tight junction permeability and occludin phosphorylation by RhoA-p160ROCK-dependent and -independent mechanisms. J. Biol. Chem. 276:10423-10431.
11. Matter, K., and M.S. Balda. 2003. Signalling to and from tight junctions. Nat. Rev. Mol. Cell Biol. 4:225-236.
12. Nitta, T., M. Hata, S. Gotoh, Y. Seo, H. Sasaki, N. Hashimoto, M. Furuse, and S. Tsukita. 2003. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J. Cell Biol. 161:653-660.
13. Simon, D.B., Y. Lu, K.A. Choate, H. Velazquez, E. Al-Sabban, M. Praga, G. Casari, A. Bettinelli, G. Colussi, J. Rodriguez-Soriano, et al. 1999. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science. 285:103-106.
14. Sonoda, N., M. Furuse, H. Sasaki, S. Yonemura, J. Katahira, Y. Horiguchi, and S. Tsukita. 1999. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: evidence for direct involvement of claudins in tight junction barrier. J. Cell Biol. 147:195-204.
15. Tsukita, S., M. Furuse, and M. Itoh. 2001. Multifunctional strands in tight junctions. Nat. Rev. Mol. Cell Biol. 2:285-293.
16. Turksen, K., and T.-C. Troy. 2002. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development. 129:1775-1784.
17. Wolburg, H., and A. Lippoldt. 2002. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul. Pharmacol. 38:323-337.
18. Wong, V., and B.M. Gumbiner. 1997. A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J. Cell Biol. 136: 399-409.