Serum soluble adhesion molecules in multiple sclerosis: Raised sVCAM-1, sICAM-1 and sE-selectin in primary progressive disease

Journal of Neurology

Volumn 246, Issue 2, 1999, Pages 87-92

  McDonnell, G V ^a   McMillan, S A ^a   Douglas, J P ^a   Droogan, A G ^a   Hawkins, S A ^b  

^a ROYAL VICTORIA HOSPITAL   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Multiple sclerosis; Primary progressive; Soluble E selectin; Soluble intercellular adhesion molecule 1; Soluble vascular cell adhesion molecule 1

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ARTICLE; BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD-BRAIN BARRIER; CHEMOTAXIS, LEUKOCYTE; DISEASE PROGRESSION; E-SELECTIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; EVALUATION STUDIES; FEMALE; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; L-SELECTIN; MALE; MENTAL DISORDERS; MIDDLE AGED; MULTIPLE SCLEROSIS; NERVOUS SYSTEM DISEASES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0032966616     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004150050313     Document Type: Article

References (29)

1. Calabresi PA, Tranquill LR, Dambrosia JM, Stone LA, Maloni H, Bash CN, Frank JA, McFarland HF (1997) Increases in soluble VCAM-1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon β-1b. Ann Neurol 41:669-674
2. 1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis. J Neurol Neurosurg Psychiatry 63:736-742
3. Dore-Duffy P, Newman W, Balabanov R, Lisak RP, Mainolfi E, Rothlein R, Peterson M (1995) Circulating soluble adhesion molecules in cerebrospinal fluid and serum of patients with multiple sclerosis: correlation with disease activity. Ann Neurol 37:55-62
4. Droogan AG, McMillan SA, Douglas JP, Hawkins SA (1996) Serum and cerebrospinal fluid levels of soluble adhesion molecules in multiple sclerosis: predominant intrathecal release of vascular cell adhesion molecule-1. J Neuroimmunol 64:185-191
5. Gearing JH, Newman W (1993) Circulating adhesion molecules in disease. Immunol Today 14:506-512
6. Giovannoni G, Thorpe JW, Kidd D, Kendall BE, Moseley IF, Thompson AJ, Keir G, Miller DH, Feldmann M, Thompson EJ (1996) Soluble E-selectin in multiple sclerosis: raised concentrations in patients with primary progressive disease. J Neurol Neurosurg Psychiatry 60:20-26
7. Giovannoni G, Lai M, Thorpe J, Kidd D, Chamoun V, Thompson AJ, Miller DH, Feldmann M, Thompson EJ (1997) Longitudinal study of soluble adhesion molecules in multiple sclerosis: correlation with gadolinium enhanced magnetic resonance imaging. Neurology 48:1557-1565
8. Hartung HP, Reiners K, Michels M, Hughes RAC, Heidenreich F, Zielasek J, Enders U, Toyka KV (1994) Serum levels of soluble E-selectin (ELAM-1) in immune-mediated neuropathies. Neurology 44:1153-1158
9. Hillert J, Gronning M, Nyland H, Link H, Olerup O (1992) An immunogenetic heterogeneity in multiple sclerosis. J Neurol Neurosurg Psychiatry 55:887-890
10. Kidd D, Barker GJ, Tofts PS, Gass A, Thompson AJ, McDonald WI, et al (1997) The transverse magnetic decay characteristics of long standing lesions and normal appearing white matter in MS. J Neurol 244:125-130
11. Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444-1452
12. Losseff NA, Webb SL, O'Riordan JI, Page R, Wang L, Barker GJ, et al (1996) Spinal cord atrophy and disability in multiple sclerosis: a new reproducible and sensitive MRI method with potential to monitor disease progression. Brain 119:701-708
13. Lublin FD, Reingold SC (1996) Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 46:907-911
14. McDonnell GV, Hawkins SA (1998) An epidemiologic study of multiple sclerosis in Northern Ireland. Neurology 50:423-428
15. McDonnell GV, McMillan SA, Douglas JP, Droogan AG, Hawkins SA (1998) Raised CSF levels of soluble adhesion molecules across the clinical spectrum of multiple sclerosis. J Neuroimmunol 85:186-192
16. McLean BN, Zeman AZJ, Barnes D, Thompson EJ (1993) Patterns of blood-brain barrier impairment and clinical features in multiple sclerosis. J Neurol Neurosurg Psychiatry 56:356-360
17. Olerup O, Hillert J, Fredrikson S, Olsson T, Kam-Hansen S, Moller E, Carlsson B, Wallin J (1989) Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities. Proc Natl Acad Sci USA 86:7113-7117
18. Pigott R, Dillon EP, Hemingway IH, Gearing AJH (1992) Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells. Biochem Biophys Res Commun 187:584-589
19. Poser CM, Paty DW, Scheinberg E, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227-231
20. Revesz T, Kidd D, Thompson AJ, Barnard RO, McDonald WI (1994) A comparison of the pathology of primary and secondary progressive multiple sclerosis. Brain 117:759-765
21. Rieckmann P, Nunke K, Burchardt M, Albrecht M, Wiltfang J, Ulrich M, Felgenhauer K (1993) Soluble intercellular adhesion molecule-1 in cerebrospinal fluid: an indicator for the inflammatory impairment of the blood brain barrier. J Neuroimmunol 47:133-140
22. Rieckmann P, Martin S, Weichselbraun I, Albrecht M, Kitze B, Weber T, Tumani H, Broocks A, Luer W, Helwig A, Poser S (1994) Serial analysis of circulating adhesion molecules and TNF receptor in serum from patients with multiple sclerosis: cICAM-1 is an indicator for relapse. Neurology 44:2367-2372
23. Rieckmann P, Altenhofen B, Riegel A, Baudewig J, Felgenhauer K (1997) Soluble adhesion molecules (sVCAM-1 and sICAM-1) in cerebrospinal fluid and serum correlate with MRI activity in multiple sclerosis. Ann Neurol 41:326-333
24. Schleiffebaum BO, Spertini O, Tedder TF (1992) Soluble L-selectin is present in human plasma at high levels and retains functional activity. J Cell Biol 119:229-238
25. Thompson AJ, Kermode AG, MacManus DG, Kingsley DPE, Kendall BE, Moseley IF, McDonald WI (1989) Pathogenesis of progressive multiple sclerosis. Lancet 333:1322-1323
26. Thompson AJ, Kermode AG, MacManus DG, Kendall BE, Kingsley DPE, Moseley IF, McDonald WI (1990) Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study. BMJ 300:631-634
27. Thompson AJ, Kermode AG, Wicks D, MacManus DG, Kendall BE, Kingsley DPE, McDonald WI (1991) Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol 29:53-62
28. Walker RWH, Thompson EJ, McDonald WI (1985) Cerebrospinal fluid in multiple sclerosis: relationships between immunoglobulins, leucocytes and clinical features. J Neurol 13:227-231
29. Weinshenker BG, Santrach P, Schaid D, Rodriguez M (1995) Association between class II major histocompatibility complex polymorphisms and the course of multiple sclerosis. Neurology 45:A384