Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns

Molecular Therapy

Volumn 10, Issue 5, 2004, Pages 874-881

  Laufs, Stephanie ^a   Nagy, K Zsuzsanna ^a   Giordano, Frank A ^a   Hotz Wagenblatt, Agnes ^a   Zeller, W Jens ^a   Fruehauf, Stefan ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Favored integration; Insertional mutagenesis; Ligation mediated PCR; NOD SCID mouse assay; Peripheral blood progenitor cells; Retroviral vector transduction

Indexed keywords

CELL CYCLE PROTEIN; CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; PROTEIN KINASE; PROTEINASE; REGULATOR PROTEIN; RETROVIRUS VECTOR; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL CYCLE; CELL POPULATION; CHIMERA; CONTROLLED STUDY; CPG ISLAND; DONOR; EXON; FEMALE; GENE INSERTION; GENE SEQUENCE; GENE TARGETING; GENETIC ANALYSIS; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN GENOME; INTRON; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD STEM CELL; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROVIRUS; SCID MOUSE; SIGNAL TRANSDUCTION; STEREOSPECIFICITY; TRANSCRIPTION INITIATION SITE; UNINDEXED SEQUENCE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS DNA CELL DNA INTERACTION; VIRUS INTERFERENCE;

ALU ELEMENTS; ANIMALS; CHROMOSOMES, HUMAN; CPG ISLANDS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTRONS; MICE; MICE, INBRED NOD; MICE, SCID; MUTAGENESIS, INSERTIONAL; RETROVIRIDAE; TRANSCRIPTION INITIATION SITE; VIRUS INTEGRATION;

INSERTION SEQUENCES;

EID: 7044228128     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.08.001     Document Type: Article

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