Non physiological overexpression of low-density lipoprotein receptors causes pathological intracellular lipid accumulation and the formation of cholesterol and cholesteryl ester crystals in vitro

Journal of Molecular Medicine

Volumn 77, Issue 10, 1999, Pages 735-743

  Heeren, Jörg ^a   Steinwaerder, Dirk S ^b   Schnieders, Frank ^c   Cichon, Günther ^c   Strauss, Michael ^c   Beisiegel, Ulrike ^a,d,e  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c HUMBOLDT UNIVERSITY   (Germany)

^d UNIVERSITY OF HAMBURG   (Germany)

^e Clinical Research Group   (Germany)

Author keywords

Cholesterol deposition; Familial hypercholesterolemia; Gene therapy; Low density lipoprotein receptor; Regulated gene expression

Indexed keywords

CHOLESTEROL; COMPLEMENTARY DNA; IODINE 125; LOW DENSITY LIPOPROTEIN RECEPTOR;

ARTICLE; CHOLESTEROL METABOLISM; FAMILIAL HYPERCHOLESTEROLEMIA; GENE OVEREXPRESSION; GENE THERAPY; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; LIVER CELL; PROMOTER REGION; THIN LAYER CHROMATOGRAPHY;

ADENOVIRUSES, HUMAN; ANIMALS; AVIAN SARCOMA VIRUSES; CARCINOMA, HEPATOCELLULAR; CATTLE; CHOLESTEROL; CHOLESTEROL ESTERS; CRYSTALLIZATION; GENE EXPRESSION REGULATION; GENE THERAPY; GENES, SYNTHETIC; GROWTH HORMONE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; INTRACELLULAR FLUID; LIPID METABOLISM; LIVER NEOPLASMS; PROMOTER REGIONS (GENETICS); RECEPTORS, LDL; RECOMBINANT FUSION PROTEINS; SELECTION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032751795     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001099900045     Document Type: Article

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