Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

Molecular Therapy

Volumn 9, Issue 1, 2004, Pages 5-13

  Baum, Christopher ^a,b   von Kalle, Christof ^b   Staal, Frank J T ^c   Li, Zhixiong ^a   Fehse, Boris ^d   Schmidt, Manfred ^e   Weerkamp, Floor ^c   Karlsson, Stefan ^f   Wagemaker, Gerard ^c   Williams, David A ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e UNIVERSITY OF FREIBURG   (Germany)

^f LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

RETROVIRUS VECTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER PREVENTION; CANCER RISK; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INSERTION; GENE MUTATION; GENE THERAPY; GENE TRANSFER; GENETIC MANIPULATION; HEMATOPOIETIC CELL; HUMAN; LEUKEMOGENESIS; MUTAGENESIS; NONHUMAN; PATHOGENESIS; PROTO ONCOGENE; RETROVIRUS; REVIEW; SOMATIC CELL; TRANSGENE; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

UNIDENTIFIED RETROVIRUS;

EID: 10744233606     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2003.10.013     Document Type: Review

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