Regulation of cytokine receptors by golgi N-glycan processing and endocytosis

Science

Volumn 306, Issue 5693, 2004, Pages 120-124

  Partridge, Emily A ^a,c   Le Roy, Christine ^a   Di Guglielmo, Gianni M ^a   Pawling, Judy ^a   Cheung, Pam ^a,b   Granovsky, Maria ^a,b   Nabi, Ivan R ^c   Wrana, Jeffrey L ^a,b   Dennis, James W ^a,b,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKING; ENZYMES; GROWTH KINETICS; SUBSTITUTION REACTIONS; SURFACE REACTIONS;

CYTOKINE RECEPTORS; ENDOCYTOSIS; LIGAND; SURFACE RETENTION;

CELLS;

BETA1,6 N ACETYLGLUCOSAMINYLTRANSFERASE V; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GALECTIN 3; GLYCAN; N ACETYLGLUCOSAMINYLTRANSFERASE; N ACETYLLACTOSAMINE; PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG; ALPHA 1,6 MANNOSYLGLYCOPROTEIN BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; ALPHA-1,6-MANNOSYLGLYCOPROTEIN BETA 1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE; CYTOKINE RECEPTOR; GROWTH PROMOTOR; POLY N ACETYLLACTOSAMINE; POLY-N-ACETYLLACTOSAMINE; POLYSACCHARIDE;

BIOLOGY;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CELL DIFFERENTIATION; CELL MOTILITY; CELL SURFACE; CONTROLLED STUDY; ENDOCYTOSIS; EPITHELIUM CELL; EXTRAVASATION; LEUKOCYTE ACTIVATION; MESENCHYME; METASTASIS; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROCESSING; RECEPTOR BINDING; RECEPTOR DENSITY; RECEPTOR OCCUPANCY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL MEMBRANE; CELL MOTION; CELL TRANSFORMATION; ENZYMOLOGY; EXPERIMENTAL NEOPLASM; GENE VECTOR; GENETICS; GLYCOSYLATION; GOLGI COMPLEX; METABOLISM; PATHOLOGY; PERITONEUM MACROPHAGE; PHYSIOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALIA;

ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; ENDOCYTOSIS; GALECTIN 3; GENETIC VECTORS; GLYCOSYLATION; GOLGI APPARATUS; GROWTH SUBSTANCES; MACROPHAGES, PERITONEAL; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, TRANSGENIC; N-ACETYLGLUCOSAMINYLTRANSFERASES; NEOPLASM METASTASIS; PHAGOCYTOSIS; POLYSACCHARIDES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CYTOKINE; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION;

EID: 6044239186     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1102109     Document Type: Article

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28. This research was supported by grants from the Canadian Institute for Health Research (CIHR) and a U.S. Army Breast Cancer Research grant to J.W.D. and a CIHR studentship to E.P. The authors thank A. Raz for Gal-3 antibodies and J. Hudson and C. Swallow for helpful discussion.