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Volumn 11, Issue 12, 2010, Pages 819-829

Triggers for genomic rearrangements: Insights into genomic, cellular and environmental influences

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

EID: 78549278708     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg2883     Document Type: Review
Times cited : (114)

References (116)
  • 1
    • 34547664096 scopus 로고    scopus 로고
    • Genomic disorders: Molecular mechanisms for rearrangements and conveyed phenotypes
    • Lupski, J. R. & Stankiewicz, P. Genomic disorders: molecular mechanisms for rearrangements and conveyed phenotypes. PLoS Genet. 1, e49 (2005).
    • (2005) PLoS Genet , vol.1
    • Lupski, J.R.1    Stankiewicz, P.2
  • 2
    • 72849159485 scopus 로고
    • Chromosome studies on normal and leukemic human leukocytes
    • Nowell, P. C. & Hungerford, D. A. Chromosome studies on normal and leukemic human leukocytes. J. Natl Cancer Inst. 25, 85-109 (1960).
    • (1960) J. Natl Cancer Inst. , vol.25 , pp. 85-109
    • Nowell, P.C.1    Hungerford, D.A.2
  • 3
    • 0000710215 scopus 로고
    • Chromosome studies in human leukemia. II. Chronic granulocytic leukemia
    • Nowell, P. C. & Hungerford, D. A. Chromosome studies in human leukemia. II. Chronic granulocytic leukemia. J. Natl Cancer Inst. 27, 1013-1035 (1961).
    • (1961) J. Natl Cancer Inst. , vol.27 , pp. 1013-1035
    • Nowell, P.C.1    Hungerford, D.A.2
  • 4
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley, J. D. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243, 290-293 (1973).
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 5
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker, B. J. et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med. 355, 2408-2417 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 2408-2417
    • Druker, B.J.1
  • 6
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D) J recombination
    • Bassing, C. H., Swat, W. & Alt, F. W. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109, S45-S55 (2002).
    • (2002) Cell , vol.109
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 7
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • Stavnezer, J., Guikema, J. E. & Schrader, C. E. Mechanism and regulation of class switch recombination. Annu. R ev. Immunol. 26, 261-292 (2008).
    • (2008) Annu. R Ev. Immunol. , vol.26 , pp. 261-292
    • Stavnezer, J.1    Guikema, J.E.2    Schrader, C.E.3
  • 8
    • 0027494095 scopus 로고
    • Interchange and intra-nuclear architecture
    • Savage, J. R. Interchange and intra-nuclear architecture. Environ. Mol. Mutagen. 22, 234-244 (1993).
    • (1993) Environ. Mol. Mutagen. , vol.22 , pp. 234-244
    • Savage, J.R.1
  • 9
    • 0038054340 scopus 로고    scopus 로고
    • Spatial proximity of translocation-prone gene loci in human lymphomas
    • Roix, J. J., McQueen, P. G., Munson, P. J., Parada, L. A. & Misteli, T. Spatial proximity of translocation-prone gene loci in human lymphomas. Nature Genet. 34, 287-291 (2003).
    • (2003) Nature Genet , vol.34 , pp. 287-291
    • Roix, J.J.1    McQueen, P.G.2    Munson, P.J.3    Parada, L.A.4    Misteli, T.5
  • 10
    • 0035233380 scopus 로고    scopus 로고
    • New approaches to lymphoma diagnosis
    • Harris, N. L. et al. New approaches to lymphoma diagnosis. Hematology 1, 194-220 (2001).
    • (2001) Hematology , vol.1 , pp. 194-220
    • Harris, N.L.1
  • 11
    • 0027331702 scopus 로고
    • PML/RARα fusion gene is expressed in both granuloid/macrophage and erythroid colonies in acute promyelocytic leukaemia
    • Takatsuki, H. et al. PML/RARα fusion gene is expressed in both granuloid/macrophage and erythroid colonies in acute promyelocytic leukaemia. B r. J. Haematol. 85, 477-482 (1993).
    • (1993) B R. J. Haematol. , vol.85 , pp. 477-482
    • Takatsuki, H.1
  • 12
    • 0028942312 scopus 로고
    • Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia
    • Turhan, A. G. et al. Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia. Blood 85, 2154-2161 (1995).
    • (1995) Blood , vol.85 , pp. 2154-2161
    • Turhan, A.G.1
  • 13
    • 0033557569 scopus 로고    scopus 로고
    • The nuclear topography of ABL, BCR, PML, and RARα genes: Evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation
    • Neves, H., Ramos, C., da Silva, M. G., Parreira, A. & Parreira, L. The nuclear topography of ABL, BCR, PML, and RARα genes: evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation. Blood 93, 1197-1207 (1999).
    • (1999) Blood , vol.93 , pp. 1197-1207
    • Neves, H.1    Ramos, C.2    Da Silva, M.G.3    Parreira, A.4    Parreira, L.5
  • 14
    • 1842404178 scopus 로고    scopus 로고
    • Distribution of ABL and BCR genes in cell nuclei of normal and irradiated lymphocytes
    • Kozubek, S. et al. Distribution of ABL and BCR genes in cell nuclei of normal and irradiated lymphocytes. Blood 89, 4537-4545 (1997).
    • (1997) Blood , vol.89 , pp. 4537-4545
    • Kozubek, S.1
  • 15
    • 2642674401 scopus 로고    scopus 로고
    • Localisation and distance between ABL and BCR genes in interphase nuclei of bone marrow cells of control donors and patients with chronic myeloid leukaemia
    • Lukasova, E. et al. Localisation and distance between ABL and BCR genes in interphase nuclei of bone marrow cells of control donors and patients with chronic myeloid leukaemia. Hum. Genet. 100, 525-535 (1997).
    • (1997) Hum. Genet. , vol.100 , pp. 525-535
    • Lukasova, E.1
  • 16
    • 0025022463 scopus 로고
    • PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
    • Grieco, M. et al. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60, 557-563 (1990).
    • (1990) Cell , vol.60 , pp. 557-563
    • Grieco, M.1
  • 17
    • 0027955122 scopus 로고
    • Molecular characterization of RET/PTC3; A novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma
    • Santoro, M. et al. Molecular characterization of RET/PTC3; a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma. Oncogene 9, 509-516 (1994).
    • (1994) Oncogene , vol.9 , pp. 509-516
    • Santoro, M.1
  • 18
    • 0034613291 scopus 로고    scopus 로고
    • Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells
    • Nikiforova, M. N. et al. Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. Science 290, 138-141 (2000).
    • (2000) Science , vol.290 , pp. 138-141
    • Nikiforova, M.N.1
  • 19
    • 33646126725 scopus 로고    scopus 로고
    • Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements
    • Gandhi, M., Medvedovic, M., Stringer, J. R. & Nikiforov, Y. E. Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements. Oncogene 25, 2360-2366 (2006).
    • (2006) Oncogene , vol.25 , pp. 2360-2366
    • Gandhi, M.1    Medvedovic, M.2    Stringer, J.R.3    Nikiforov, Y.E.4
  • 20
    • 5444243359 scopus 로고    scopus 로고
    • Active genes dynamically colocalize to shared sites of ongoing transcription
    • Osborne, C. S. et al. Active genes dynamically colocalize to shared sites of ongoing transcription. Nature Genet. 36, 1065-1071 (2004).
    • (2004) Nature Genet , vol.36 , pp. 1065-1071
    • Osborne, C.S.1
  • 21
    • 73349090560 scopus 로고    scopus 로고
    • Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
    • Schoenfelder, S. et al. Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells. Nature Genet. 42, 53-61 (2010).
    • (2010) Nature Genet , vol.42 , pp. 53-61
    • Schoenfelder, S.1
  • 22
    • 58049208232 scopus 로고    scopus 로고
    • Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules
    • Hu, Q. et al. Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc. Natl Acad. Sci. USA 105, 19199-19204 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 19199-19204
    • Hu, Q.1
  • 23
    • 0037083376 scopus 로고    scopus 로고
    • Capturing chromosome conformation
    • Dekker, J., Rippe, K., Dekker, M. & Kleckner, N. Capturing chromosome conformation. Science 295, 1306-1311 (2002).
    • (2002) Science , vol.295 , pp. 1306-1311
    • Dekker, J.1    Rippe, K.2    Dekker, M.3    Kleckner, N.4
  • 24
    • 70449103609 scopus 로고    scopus 로고
    • An oestrogen-receptor-α-bound human chromatin interactome
    • Fullwood, M. J. et al. An oestrogen-receptor-α-bound human chromatin interactome. Nature 462, 58-64 (2009).
    • (2009) Nature , vol.462 , pp. 58-64
    • Fullwood, M.J.1
  • 25
    • 70349873824 scopus 로고    scopus 로고
    • Comprehensive mapping of long-range interactions reveals folding principles of the human genome
    • Lieberman-Aiden, E. et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326, 289-293 (2009).
    • (2009) Science , vol.326 , pp. 289-293
    • Lieberman-Aiden, E.1
  • 27
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • Tomlins, S. A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644-648 (2005).
    • (2005) Science , vol.310 , pp. 644-648
    • Tomlins, S.A.1
  • 28
    • 34547642493 scopus 로고    scopus 로고
    • Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
    • Tomlins, S. A. et al. Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature 448, 595-599 (2007).
    • (2007) Nature , vol.448 , pp. 595-599
    • Tomlins, S.A.1
  • 29
    • 33645750799 scopus 로고    scopus 로고
    • TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer
    • Tomlins, S. A. et al. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res. 66, 3396-3400 (2006).
    • (2006) Cancer Res , vol.66 , pp. 3396-3400
    • Tomlins, S.A.1
  • 30
    • 39049170313 scopus 로고    scopus 로고
    • Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer
    • Helgeson, B. E. et al. Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer. Cancer Res. 68, 73-80 (2008).
    • (2008) Cancer Res , vol.68 , pp. 73-80
    • Helgeson, B.E.1
  • 31
    • 70849135782 scopus 로고    scopus 로고
    • Induced chromosomal proximity and gene fusions in prostate cancer
    • Mani, R. S. et al. Induced chromosomal proximity and gene fusions in prostate cancer. Science 326, 1230 (2009).
    • (2009) Science , vol.326 , pp. 1230
    • Mani, R.S.1
  • 32
    • 71249101060 scopus 로고    scopus 로고
    • Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    • A classic paper that describes the mechanisms underlying ETS gene fusions in prostate cancer
    • Lin, C. et al. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell 139, 1069-1083 (2009). A classic paper that describes the mechanisms underlying ETS gene fusions in prostate cancer.
    • (2009) Cell , vol.139 , pp. 1069-1083
    • Lin, C.1
  • 33
    • 34548210885 scopus 로고    scopus 로고
    • Myc dynamically and preferentially relocates to a transcription factory occupied by Igh
    • Osborne, C. S. et al. Myc dynamically and preferentially relocates to a transcription factory occupied by Igh. PLoS Biol. 5, e192 (2007).
    • (2007) PLoS Biol , vol.5
    • Osborne, C.S.1
  • 34
    • 0036795327 scopus 로고    scopus 로고
    • Conservation of relative chromosome positioning in normal and cancer cells
    • Parada, L. A., McQueen, P. G., Munson, P. J. & Misteli, T. Conservation of relative chromosome positioning in normal and cancer cells. Curr. Biol. 12, 1692-1697 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 1692-1697
    • Parada, L.A.1    McQueen, P.G.2    Munson, P.J.3    Misteli, T.4
  • 35
    • 67650001851 scopus 로고    scopus 로고
    • Complex human chromosomal and genomic rearrangements
    • Zhang, F., Carvalho, C. M. & Lupski, J. R. Complex human chromosomal and genomic rearrangements. Trends Genet. 25, 298-307 (2009).
    • (2009) Trends Genet , vol.25 , pp. 298-307
    • Zhang, F.1    Carvalho, C.M.2    Lupski, J.R.3
  • 36
    • 0028821932 scopus 로고
    • Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident
    • Fugazzola, L. et al. Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident. Cancer Res. 55, 5617-5620 (1995).
    • (1995) Cancer Res , vol.55 , pp. 5617-5620
    • Fugazzola, L.1
  • 37
    • 6244280442 scopus 로고
    • High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident
    • Klugbauer, S., Lengfelder, E., Demidchik, E. P. & Rabes, H. M. High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident. Oncogene 11, 2459-2467 (1995). (Pubitemid 26023813)
    • (1995) Oncogene , vol.11 , Issue.12 , pp. 2459-2467
    • Klugbauer, S.1    Lengfelder, E.2    Demidchik, E.P.3    Rabes, H.M.4
  • 38
    • 0030881411 scopus 로고    scopus 로고
    • Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis
    • Mizuno, T., Kyoizumi, S., Suzuki, T., Iwamoto, K. S. & Seyama, T. Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis. Oncogene 15, 1455-1460 (1997).
    • (1997) Oncogene , vol.15 , pp. 1455-1460
    • Mizuno, T.1    Kyoizumi, S.2    Suzuki, T.3    Iwamoto, K.S.4    Seyama, T.5
  • 39
    • 0027305591 scopus 로고
    • In vitro irradiation is able to cause RET oncogene rearrangement
    • Ito, T. et al. In vitro irradiation is able to cause RET oncogene rearrangement. Cancer Res. 53, 2940-2943 (1993).
    • (1993) Cancer Res , vol.53 , pp. 2940-2943
    • Ito, T.1
  • 40
    • 17844394699 scopus 로고    scopus 로고
    • Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to γ-radiation: A model of carcinogenic chromosomal rearrangement induced by ionizing radiation
    • Caudill, C. M., Zhu, Z., Ciampi, R., Stringer, J. R. & Nikiforov, Y. E. Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to γ-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation. J. Clin. Endocrinol. Metab. 90, 2364-2369 (2005).
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 2364-2369
    • Caudill, C.M.1    Zhu, Z.2    Ciampi, R.3    Stringer, J.R.4    Nikiforov, Y.E.5
  • 41
    • 0032005219 scopus 로고    scopus 로고
    • Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation
    • Deininger, M. W. et al. Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation. Cancer Res. 58, 421-425 (1998).
    • (1998) Cancer Res , vol.58 , pp. 421-425
    • Deininger, M.W.1
  • 42
    • 62549130381 scopus 로고    scopus 로고
    • Live cell microscopy analysis of radiation-induced DNA double-strand break motion
    • Jakob, B., Splinter, J., Durante, M. & Taucher-Scholz, G. Live cell microscopy analysis of radiation-induced DNA double-strand break motion. Proc. Natl Acad. Sci. USA 106, 3172-3177 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3172-3177
    • Jakob, B.1    Splinter, J.2    Durante, M.3    Taucher-Scholz, G.4
  • 43
    • 0030292802 scopus 로고    scopus 로고
    • Insight into sites
    • Savage, J. R. Insight into sites. Mutat. Res. 366, 81-95 (1996).
    • (1996) Mutat. Res. , vol.366 , pp. 81-95
    • Savage, J.R.1
  • 44
    • 77951060421 scopus 로고    scopus 로고
    • DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells
    • Gandhi, M., Dillon, L. W., Pramanik, S., Nikiforov, Y. E. & Wang, Y. H. DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells. Oncogene 29, 2272-2280 (2010).
    • (2010) Oncogene , vol.29 , pp. 2272-2280
    • Gandhi, M.1    Dillon, L.W.2    Pramanik, S.3    Nikiforov, Y.E.4    Wang, Y.H.5
  • 45
    • 0034712748 scopus 로고    scopus 로고
    • Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
    • Strick, R., Strissel, P. L., Borgers, S., Smith, S. L. & Rowley, J. D. Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc. Natl Acad. Sci. USA 97, 4790-4795 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 4790-4795
    • Strick, R.1    Strissel, P.L.2    Borgers, S.3    Smith, S.L.4    Rowley, J.D.5
  • 46
    • 17944364716 scopus 로고    scopus 로고
    • Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia
    • Blanco, J. G. et al. Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia. Proc. Natl Acad. Sci. USA 98, 10338-10343 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 10338-10343
    • Blanco, J.G.1
  • 47
    • 0027096062 scopus 로고
    • Oxidants are a major contributor to aging
    • Ames, B. N. & Shigenaga, M. K. Oxidants are a major contributor to aging. Ann. NY Acad. Sci. 663, 85-96 (1992).
    • (1992) Ann. NY Acad. Sci. , vol.663 , pp. 85-96
    • Ames, B.N.1    Shigenaga, M.K.2
  • 48
    • 0036012789 scopus 로고    scopus 로고
    • ATM deficiency and oxidative stress: A new dimension of defective response to DNA damage
    • Barzilai, A., Rotman, G. & Shiloh, Y. ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair 1, 3-25 (2002).
    • (2002) DNA Repair , vol.1 , pp. 3-25
    • Barzilai, A.1    Rotman, G.2    Shiloh, Y.3
  • 49
    • 0037022534 scopus 로고    scopus 로고
    • Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants
    • Karanjawala, Z. E., Murphy, N., Hinton, D. R., Hsieh, C. L. & Lieber, M. R. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr. Biol. 12, 397-402 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 397-402
    • Karanjawala, Z.E.1    Murphy, N.2    Hinton, D.R.3    Hsieh, C.L.4    Lieber, M.R.5
  • 50
    • 0021965942 scopus 로고
    • Induction of superoxide dismutase, chromosomal aberrations and sister-chromatid exchanges by paraquat in Chinese hamster fibroblasts
    • Nicotera, T. M., Block, A. W., Gibas, Z. & Sandberg, A. A. Induction of superoxide dismutase, chromosomal aberrations and sister-chromatid exchanges by paraquat in Chinese hamster fibroblasts. Mutat. Res. 151, 263-268 (1985).
    • (1985) Mutat. Res. , vol.151 , pp. 263-268
    • Nicotera, T.M.1    Block, A.W.2    Gibas, Z.3    Sandberg, A.A.4
  • 51
    • 14644425402 scopus 로고    scopus 로고
    • A biological network in Saccharomyces cerevisiae prevents the deleterious effects of endogenous oxidative DNA damage
    • Huang, M. E. & Kolodner, R. D. A biological network in Saccharomyces cerevisiae prevents the deleterious effects of endogenous oxidative DNA damage. Mol. Cell 17, 709-720 (2005).
    • (2005) Mol. Cell , vol.17 , pp. 709-720
    • Huang, M.E.1    Kolodner, R.D.2
  • 52
    • 34547459934 scopus 로고    scopus 로고
    • Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death
    • Ragu, S. et al. Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death. Proc. Natl Acad. Sci. USA 104, 9747-9752 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 9747-9752
    • Ragu, S.1
  • 53
    • 0036469913 scopus 로고    scopus 로고
    • The connection between transcription and genomic instability
    • Aguilera, A. The connection between transcription and genomic instability. EMBO J. 21, 195-201 (2002).
    • (2002) EMBO J , vol.21 , pp. 195-201
    • Aguilera, A.1
  • 54
    • 70449522304 scopus 로고    scopus 로고
    • Topoisomerase i suppresses genomic instability by preventing interference between replication and transcription
    • Tuduri, S. et al. Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription. Nature Cell Biol. 11, 1315-1324 (2009).
    • (2009) Nature Cell Biol , vol.11 , pp. 1315-1324
    • Tuduri, S.1
  • 55
    • 0021278143 scopus 로고
    • DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
    • Glover, T. W., Berger, C., Coyle, J. & Echo, B. DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum. Genet. 67, 136-142 (1984).
    • (1984) Hum. Genet. , vol.67 , pp. 136-142
    • Glover, T.W.1    Berger, C.2    Coyle, J.3    Echo, B.4
  • 56
    • 61549098717 scopus 로고    scopus 로고
    • Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants
    • Arlt, M. F. et al. Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants. Am. J. Hum. Genet. 84, 339-350 (2009).
    • (2009) Am. J. Hum. Genet. , vol.84 , pp. 339-350
    • Arlt, M.F.1
  • 57
    • 70350776635 scopus 로고    scopus 로고
    • Rare pathogenic microdeletions and tandem duplications are microhomology-mediated and stimulated by local genomic architecture
    • Vissers, L. E. et al. Rare pathogenic microdeletions and tandem duplications are microhomology-mediated and stimulated by local genomic architecture. Hum. Mol. Genet. 18, 3579-3593 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 3579-3593
    • Vissers, L.E.1
  • 58
    • 0037074013 scopus 로고    scopus 로고
    • ATR regulates fragile site stability
    • Casper, A. M., Nghiem, P., Arlt, M. F. & Glover, T. W. ATR regulates fragile site stability. Cell 111, 779-789 (2002).
    • (2002) Cell , vol.111 , pp. 779-789
    • Casper, A.M.1    Nghiem, P.2    Arlt, M.F.3    Glover, T.W.4
  • 59
    • 0037178723 scopus 로고    scopus 로고
    • ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
    • Cha, R. S. & Kleckner, N. ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 297, 602-606 (2002).
    • (2002) Science , vol.297 , pp. 602-606
    • Cha, R.S.1    Kleckner, N.2
  • 60
    • 0037178740 scopus 로고    scopus 로고
    • Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
    • Sogo, J. M., Lopes, M. & Foiani, M. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 297, 599-602 (2002).
    • (2002) Science , vol.297 , pp. 599-602
    • Sogo, J.M.1    Lopes, M.2    Foiani, M.3
  • 62
    • 67649878596 scopus 로고    scopus 로고
    • The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans
    • Zhang, F. et al. The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans. Nature Genet. 41, 849-853 (2009).
    • (2009) Nature Genet , vol.41 , pp. 849-853
    • Zhang, F.1
  • 63
    • 59249105978 scopus 로고    scopus 로고
    • A microhomology-mediated break-induced replication model for the origin of human copy number variation
    • Hastings, P. J., Ira, G. & Lupski, J. R. A microhomology-mediated break-induced replication model for the origin of human copy number variation. PLoS Genet. 5, e1000327 (2009).
    • (2009) PLoS Genet , vol.5
    • Hastings, P.J.1    Ira, G.2    Lupski, J.R.3
  • 64
    • 37349109667 scopus 로고    scopus 로고
    • A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders
    • Lee, J. A., Carvalho, C. M. & Lupski, J. R. A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders. Cell 131, 1235-1247 (2007).
    • (2007) Cell , vol.131 , pp. 1235-1247
    • Lee, J.A.1    Carvalho, C.M.2    Lupski, J.R.3
  • 65
    • 33745255099 scopus 로고    scopus 로고
    • A topoisomerase IIβ-mediated dsDNA break required for regulated transcription
    • Ju, B. G. et al. A topoisomerase IIβ-mediated dsDNA break required for regulated transcription. Science 312, 1798-1802 (2006).
    • (2006) Science , vol.312 , pp. 1798-1802
    • Ju, B.G.1
  • 66
    • 77955069195 scopus 로고    scopus 로고
    • Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
    • Haffner, M. C. et al. Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nature Genet. 42, 668-675 (2010).
    • (2010) Nature Genet , vol.42 , pp. 668-675
    • Haffner, M.C.1
  • 67
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422, 726-730 (2003).
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1
  • 68
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham, P., Bransteitter, R., Petruska, J. & Goodman, M. F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424, 103-107 (2003).
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 69
    • 0034284120 scopus 로고    scopus 로고
    • Loss of drug-stimulated topoisomerase II DNA breaks in living cells is different at two unrelated loci
    • Binaschi, M., Borgnetto, M. E. & Capranico, G. Loss of drug-stimulated topoisomerase II DNA breaks in living cells is different at two unrelated loci. Nucleic Acids Res. 28, 3289-3293 (2000).
    • (2000) Nucleic Acids Res , vol.28 , pp. 3289-3293
    • Binaschi, M.1    Borgnetto, M.E.2    Capranico, G.3
  • 70
    • 33747873409 scopus 로고    scopus 로고
    • Chromatin structural elements and chromosomal translocations in leukemia
    • Zhang, Y. & Rowley, J. D. Chromatin structural elements and chromosomal translocations in leukemia. DNA Repair 5, 1282-1297 (2006).
    • (2006) DNA Repair , vol.5 , pp. 1282-1297
    • Zhang, Y.1    Rowley, J.D.2
  • 71
    • 65249165421 scopus 로고    scopus 로고
    • Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma
    • Mathas, S. et al. Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc. Natl Acad. Sci. USA 106, 5831-5836 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 5831-5836
    • Mathas, S.1
  • 72
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber, M. R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu. Re v . Biochem. 79, 181-211 (2010).
    • (2010) Annu. Re v . Biochem. , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 73
    • 0034621854 scopus 로고    scopus 로고
    • Frequent chromosomal translocations induced by DNA double-strand breaks
    • Richardson, C. & Jasin, M. Frequent chromosomal translocations induced by DNA double-strand breaks. Nature 405, 697-700(2000).
    • (2000) Nature , vol.405 , pp. 697-700
    • Richardson, C.1    Jasin, M.2
  • 74
    • 77950462986 scopus 로고    scopus 로고
    • Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4- ligase IV during chromosomal translocation formation
    • Simsek, D. & Jasin, M. Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4- ligase IV during chromosomal translocation formation. Nature Struct. Mol. Biol. 17, 410-416 (2010).
    • (2010) Nature Struct. Mol. Biol. , vol.17 , pp. 410-416
    • Simsek, D.1    Jasin, M.2
  • 75
    • 77649267656 scopus 로고    scopus 로고
    • Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70
    • Boboila, C. et al. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc. Natl Acad. Sci. USA 107, 3034-3039 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 3034-3039
    • Boboila, C.1
  • 76
    • 34748863465 scopus 로고    scopus 로고
    • IgH class switching and translocations use a robust non-classical end-joining pathway
    • Yan, C. T. et al. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449, 478-482 (2007).
    • (2007) Nature , vol.449 , pp. 478-482
    • Yan, C.T.1
  • 77
    • 77149176004 scopus 로고    scopus 로고
    • Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
    • Boboila, C. et al. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J. Exp. Med. 207, 417-427 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 417-427
    • Boboila, C.1
  • 78
    • 77950466186 scopus 로고    scopus 로고
    • NHEJ and its backup pathways in chromosomal translocations
    • Lieber, M. R. NHEJ and its backup pathways in chromosomal translocations. Nature Struct. Mol. Biol. 17, 393-395 (2010).
    • (2010) Nature Struct. Mol. Biol. , vol.17 , pp. 393-395
    • Lieber, M.R.1
  • 79
    • 77649131406 scopus 로고    scopus 로고
    • Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
    • Moynahan, M. E. & Jasin, M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nature R e v. Mol. Cell Biol. 11, 196-207 (2010).
    • (2010) Nature R e V. Mol. Cell Biol. , vol.11 , pp. 196-207
    • Moynahan, M.E.1    Jasin, M.2
  • 80
    • 77649191573 scopus 로고    scopus 로고
    • Genome destabilization by homologous recombination in the germ line
    • Sasaki, M., Lange, J. & Keeney, S. Genome destabilization by homologous recombination in the germ line. Nature Rev. Mol. Cell Biol. 11, 182-195 (2010).
    • (2010) Nature Rev. Mol. Cell Biol. , vol.11 , pp. 182-195
    • Sasaki, M.1    Lange, J.2    Keeney, S.3
  • 81
    • 47249095041 scopus 로고    scopus 로고
    • Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks
    • Mansour, W. Y. et al. Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks. Nucleic acids research 36, 4088-4098 (2008).
    • (2008) Nucleic Acids Research , vol.36 , pp. 4088-4098
    • Mansour, W.Y.1
  • 82
    • 0036468807 scopus 로고    scopus 로고
    • Genome architecture, rearrangements and genomic disorders
    • Stankiewicz, P. & Lupski, J. R. Genome architecture, rearrangements and genomic disorders. Trends Genet. 18, 74-82 (2002).
    • (2002) Trends Genet , vol.18 , pp. 74-82
    • Stankiewicz, P.1    Lupski, J.R.2
  • 83
    • 0022379447 scopus 로고
    • The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
    • Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E. & Croce, C. M. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229, 1390-1393 (1985).
    • (1985) Science , vol.229 , pp. 1390-1393
    • Tsujimoto, Y.1    Gorham, J.2    Cossman, J.3    Jaffe, E.4    Croce, C.M.5
  • 84
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563 (2000).
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1
  • 85
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
    • Revy, P. et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102, 565-575 (2000).
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1
  • 86
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu, M. et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 274, 18470-18476 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 18470-18476
    • Muramatsu, M.1
  • 87
    • 4644257592 scopus 로고    scopus 로고
    • AID is required for c-myc/IgH chromosome translocations in vivo
    • Ramiro, A. R. et al. AID is required for c-myc/IgH chromosome translocations in vivo. Cell 11 8, 431-438 (2004).
    • (2004) Cell , vol.11 , Issue.8 , pp. 431-438
    • Ramiro, A.R.1
  • 88
    • 33644643189 scopus 로고    scopus 로고
    • Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
    • Ramiro, A. R. et al. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440, 105-109 (2006).
    • (2006) Nature , vol.440 , pp. 105-109
    • Ramiro, A.R.1
  • 89
    • 57149146036 scopus 로고    scopus 로고
    • AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
    • Robbiani, D. F. et al. AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell 135, 1028-1038 (2008).
    • (2008) Cell , vol.135 , pp. 1028-1038
    • Robbiani, D.F.1
  • 90
    • 70449641054 scopus 로고    scopus 로고
    • AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations
    • Robbiani, D. F. et al. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol. Cell 36, 631-641 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 631-641
    • Robbiani, D.F.1
  • 91
    • 39149099085 scopus 로고    scopus 로고
    • Tw o levels of protection for the B cell genome during somatic hypermutation
    • Liu, M. et al. Tw o levels of protection for the B cell genome during somatic hypermutation. Nature 451, 841-845 (2008).
    • (2008) Nature , vol.451 , pp. 841-845
    • Liu, M.1
  • 93
    • 33748623634 scopus 로고    scopus 로고
    • Common fragile sites as targets for chromosome rearrangements
    • Arlt, M. F., Durkin, S. G., Ragland, R. L. & Glover, T. W. Common fragile sites as targets for chromosome rearrangements. DNA Repair 5, 1126-1135 (2006).
    • (2006) DNA Repair , vol.5 , pp. 1126-1135
    • Arlt, M.F.1    Durkin, S.G.2    Ragland, R.L.3    Glover, T.W.4
  • 94
    • 34249907843 scopus 로고    scopus 로고
    • Non-B DNA conformations, mutagenesis and disease
    • Wells, R. D. Non-B DNA conformations, mutagenesis and disease. Trends Biochem. Sci. 32, 271-278 (2007).
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 271-278
    • Wells, R.D.1
  • 95
    • 33646359685 scopus 로고    scopus 로고
    • DNA structures at chromosomal translocation sites
    • Raghavan, S. C. & Lieber, M. R. DNA structures at chromosomal translocation sites. Bioessays 28, 480-494 (2006).
    • (2006) Bioessays , vol.28 , pp. 480-494
    • Raghavan, S.C.1    Lieber, M.R.2
  • 97
    • 33644543741 scopus 로고    scopus 로고
    • Z-DNA-forming sequences generate large-scale deletions in mammalian cells
    • Wang, G., Christensen, L. A. & Vasquez, K. M. Z-DNA-forming sequences generate large-scale deletions in mammalian cells. Proc. Natl Acad. Sci. USA 103, 2677-2682 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 2677-2682
    • Wang, G.1    Christensen, L.A.2    Vasquez, K.M.3
  • 98
    • 0034790435 scopus 로고    scopus 로고
    • Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males
    • Kurahashi, H. & Emanuel, B. S. Unexpectedly high rate of De novo constitutional t(11;22) translocations in sperm from normal males. Nature Genet. 29, 139-140 (2001).
    • (2001) Nature Genet , vol.29 , pp. 139-140
    • Kurahashi, H.1    Emanuel, B.S.2
  • 99
    • 33144472660 scopus 로고    scopus 로고
    • Genetic variation affects de novo translocation frequency
    • Kato, T. et al. Genetic variation affects De novo translocation frequency. Science 311, 971 (2006).
    • (2006) Science , vol.311 , pp. 971
    • Kato, T.1
  • 100
    • 1542287213 scopus 로고    scopus 로고
    • A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex
    • Raghavan, S. C., Swanson, P. C., Wu, X., Hsieh, C. L. & Lieber, M. R. A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature 428, 88-93 (2004).
    • (2004) Nature , vol.428 , pp. 88-93
    • Raghavan, S.C.1    Swanson, P.C.2    Wu, X.3    Hsieh, C.L.4    Lieber, M.R.5
  • 101
    • 57349185631 scopus 로고    scopus 로고
    • Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity
    • Tsai, A. G. et al. Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell 135, 1130-1142 (2008).
    • (2008) Cell , vol.135 , pp. 1130-1142
    • Tsai, A.G.1
  • 102
    • 77953889472 scopus 로고    scopus 로고
    • Natural mutagenesis of human genomes by endogenous retrotransposons
    • Iskow, R. C. et al. Natural mutagenesis of human genomes by endogenous retrotransposons. Cell 141, 1253-1261 (2010).
    • (2010) Cell , vol.141 , pp. 1253-1261
    • Iskow, R.C.1
  • 103
    • 77953892366 scopus 로고    scopus 로고
    • Mobile interspersed repeats are major structural variants in the human genome
    • Huang, C. R. et al. Mobile interspersed repeats are major structural variants in the human genome. Cell 141, 1171-1182 (2010).
    • (2010) Cell , vol.141 , pp. 1171-1182
    • Huang, C.R.1
  • 104
    • 77953880842 scopus 로고    scopus 로고
    • LINE-1 retrotransposition activity in human genomes
    • Beck, C. R. et al. LINE-1 retrotransposition activity in human genomes. Cell 141, 1159-1170 (2010).
    • (2010) Cell , vol.141 , pp. 1159-1170
    • Beck, C.R.1
  • 105
    • 77955160719 scopus 로고    scopus 로고
    • High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes
    • doi: 10.1101/gr.106419.110)
    • Ewing, A. D. & Kazazian, H. H. Jr. High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes. Genome Res. (doi: 10.1101/gr.106419.110) (2010).
    • (2010) Genome Res
    • Ewing, A.D.1    Kazazian Jr., H.H.2
  • 106
    • 4644220954 scopus 로고    scopus 로고
    • MLL: A histone methyltransferase disrupted in leukemia
    • Hess, J. L. MLL: a histone methyltransferase disrupted in leukemia. Trends Mol. Med. 10, 500-507 (2004).
    • (2004) Trends Mol. Med. , vol.10 , pp. 500-507
    • Hess, J.L.1
  • 107
    • 0029962292 scopus 로고    scopus 로고
    • A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element
    • Reiter, L. T. et al. A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element. Nature Genet. 12, 288-297 (1996).
    • (1996) Nature Genet , vol.12 , pp. 288-297
    • Reiter, L.T.1
  • 108
    • 35349024178 scopus 로고    scopus 로고
    • A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement
    • Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. & Desiderio, S. A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity 27, 561-571 (2007).
    • (2007) Immunity , vol.27 , pp. 561-571
    • Liu, Y.1    Subrahmanyam, R.2    Chakraborty, T.3    Sen, R.4    Desiderio, S.5
  • 109
    • 37249041657 scopus 로고    scopus 로고
    • RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D) J recombination
    • Matthews, A. G. et al. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature 450, 1106-1110 (2007).
    • (2007) Nature , vol.450 , pp. 1106-1110
    • Matthews, A.G.1
  • 110
    • 66749124789 scopus 로고    scopus 로고
    • H3K4me3 stimulates the V(D) J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: Implications for translocations
    • Shimazaki, N., Tsai, A. G. & Lieber, M. R. H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations. Mol. Cell 34, 535-544 (2009).
    • (2009) Mol. Cell , vol.34 , pp. 535-544
    • Shimazaki, N.1    Tsai, A.G.2    Lieber, M.R.3
  • 111
    • 76749123506 scopus 로고    scopus 로고
    • Genetics. Genetic control of hotspots
    • Cheung, V. G., Sherman, S. L. & Feingold, E. Genetics. Genetic control of hotspots. Science 327, 791-792 (2010).
    • (2010) Science , vol.327 , pp. 791-792
    • Cheung, V.G.1    Sherman, S.L.2    Feingold, E.3
  • 112
    • 77957579303 scopus 로고    scopus 로고
    • PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans
    • Berg I. L., et al. PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans. Nature Genet. 42: 859-863: 2010.
    • (2010) Nature Genet , vol.42 , pp. 859-863
    • Berg, I.L.1
  • 113
    • 0037452770 scopus 로고    scopus 로고
    • Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: A potential mechanism for position-effect variegation
    • Ng, H. H., Ciccone, D. N., Morshead, K. B., Oettinger, M. A. & Struhl, K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc. Natl Acad. Sci. USA 100, 1820-1825 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 1820-1825
    • Ng, H.H.1    Ciccone, D.N.2    Morshead, K.B.3    Oettinger, M.A.4    Struhl, K.5
  • 114
    • 35348988679 scopus 로고    scopus 로고
    • Paired-end mapping reveals extensive structural variation in the human genome
    • Korbel, J. O. et al. Paired-end mapping reveals extensive structural variation in the human genome. Science 318, 420-426 (2007).
    • (2007) Science , vol.318 , pp. 420-426
    • Korbel, J.O.1
  • 115
    • 77952586314 scopus 로고    scopus 로고
    • The 1000 Genomes Project: New opportunities for research and social challenges
    • Via, M., Gignoux, C. & Burchard, E. G. The 1000 Genomes Project: new opportunities for research and social challenges. Genome Med. 2, 3 (2010).
    • (2010) Genome Med , vol.2 , pp. 3
    • Via, M.1    Gignoux, C.2    Burchard, E.G.3
  • 116
    • 31044432090 scopus 로고    scopus 로고
    • XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
    • Ahnesorg, P., Smith, P. & Jackson, S. P. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124, 301-313 (2006).
    • (2006) Cell , vol.124 , pp. 301-313
    • Ahnesorg, P.1    Smith, P.2    Jackson, S.P.3


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