Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein

Current Biology

Volumn 10, Issue 20, 2000, Pages 1315-1318

  Ingham, P W ^a   Nystedt, S ^a,b   Nakano, Y ^a   Brown, W ^a   Stark, D ^a   Van den Heuvel, M ^a,c   Taylor, A M ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b LUND UNIVERSITY   (Sweden)

^c MRC Functional Genetics Unit   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034687244     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00755-7     Document Type: Article

References (25)

1. The world according to hedgehog
2. The Drosophila segment polarity gene patched encodes a protein with multiple potential membrane spanning domains
3. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
4. Conservation of the hedgehog/patched signaling pathway from flies to mice - Induction of a mouse patched gene by hedgehog
5. The Drosophila smoothened gene encodes a 7-pass membrane-protein, a putative receptor for the hedgehog signal
6. Smoothened encodes a serpentine protein required for hedgehog signaling
7. The tumor-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
8. Sonic hedgehog signaling by the patched-smoothened receptor complex
9. Role of the Drosophila patched gene in positional signalling
10. Dual roles for patched in sequestering and transducing hedgehog
11. Biochemical-evidence that Patched is the Hedgehog receptor
12. Characterization of two patched receptors for the vertebrate hedgehog protein family
13. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
14. Localised hedgehog activity controls spatially restricted transcription of wingless in the Drosophila embryo
15. Role of segment polarity gene in the definition and maintenance of cell states in the Drosophila embryo
16. Promoters to express cloned genes uniformly in Drosophila
17. Expression of engrailed proteins in arthropods, annelids, and chordates
18. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation
19. Antagonistic interaction between Wingless and Decapentaplegic responsible for dorsal-ventral pattern in the Drosophila leg
20. Dissecting the temporal requirements for homeotic gene function
21. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
22. Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
23. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi
24. Activating Smoothened mutations in sporadic basal-cell carcinoma