메뉴 건너뛰기




Volumn 161, Issue 2, 2010, Pages 288-307

New insights into the molecular mechanisms of general anaesthetics

Author keywords

GABA receptor; general anaesthetics; glycine receptor; membrane; NMDA receptor; pressure reversal

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; ANESTHETIC AGENT; CHLOROFORM; DESFLURANE; ENFLURANE; ETHER; ETOMIDATE; GLYCINE RECEPTOR; HALOTHANE; ISOFLURANE; METHOXYFLURANE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PENTOBARBITAL; POTASSIUM CHANNEL; PROPOFOL; SEVOFLURANE;

EID: 77956042806     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00891.x     Document Type: Review
Times cited : (84)

References (179)
  • 2
    • 40949095655 scopus 로고    scopus 로고
    • Guide to Receptors and Channels, 3rd edition (2008 revision)
    • Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels, 3rd edition (2008 revision). Br J Pharmacol 153 (Suppl. 2 S1 S209.
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL. 2
    • Alexander, S.P.H.1    Mathie, A.2    Peters, J.A.3
  • 3
    • 34547598476 scopus 로고    scopus 로고
    • Thalamic microinjection of nicotine reverses sevoflurane-induced loss of right reflex in the rat
    • Alkire MT, McReynolds JR, Hahn EL, Trivedi AN (2007). Thalamic microinjection of nicotine reverses sevoflurane-induced loss of right reflex in the rat. Anesthesiology 107 : 264 272.
    • (2007) Anesthesiology , vol.107 , pp. 264-272
    • Alkire, M.T.1    McReynolds, J.R.2    Hahn, E.L.3    Trivedi, A.N.4
  • 4
    • 34547120249 scopus 로고    scopus 로고
    • Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels
    • Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R et al. (2009). Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels. J Biol Chem 282 : 20977 20990.
    • (2009) J Biol Chem , vol.282 , pp. 20977-20990
    • Andres-Enguix, I.1    Caley, A.2    Yustos, R.3    Schumacher, M.A.4    Spanu, P.D.5    Dickinson, R.6
  • 8
    • 0035816642 scopus 로고    scopus 로고
    • Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function
    • Beckstead MJ, Phelan R, Mihic SJ (2001). Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function. J Biol Chem 276 : 24959 24964.
    • (2001) J Biol Chem , vol.276 , pp. 24959-24964
    • Beckstead, M.J.1    Phelan, R.2    Mihic, S.J.3
  • 9
    • 0036733135 scopus 로고    scopus 로고
    • Anesthetic and ethanol effects on spontaneously opening glycine receptor channels
    • Beckstead MJ, Phelan R, Trudell JR, Bianchini MJ, Mihic SJ (2002). Anesthetic and ethanol effects on spontaneously opening glycine receptor channels. J Neurochem 82 : 1343 1351.
    • (2002) J Neurochem , vol.82 , pp. 1343-1351
    • Beckstead, M.J.1    Phelan, R.2    Trudell, J.R.3    Bianchini, M.J.4    Mihic, S.J.5
  • 12
    • 0023024238 scopus 로고
    • Isoflurance effects in rat hippocampal cortex: A quantitative evaluation of different cellular sites of action
    • Berg-Johnsen J, Langmoen I (1986). Isoflurance effects in rat hippocampal cortex: a quantitative evaluation of different cellular sites of action. Acta Physiol Scand 128 : 613 618.
    • (1986) Acta Physiol Scand , vol.128 , pp. 613-618
    • Berg-Johnsen, J.1    Langmoen, I.2
  • 13
    • 0023628325 scopus 로고
    • Isoflurance hyperpolarizes neurones in rat and human cerebral cortex
    • Berg-Johnsen J, Langmoen I (1987). Isoflurance hyperpolarizes neurones in rat and human cerebral cortex. Acta Physiol Scand 130 : 679 685.
    • (1987) Acta Physiol Scand , vol.130 , pp. 679-685
    • Berg-Johnsen, J.1    Langmoen, I.2
  • 14
    • 26344446799 scopus 로고    scopus 로고
    • The interaction of halothane with the binding site of a functional protein, cholesterol oxidase
    • Bertaccini E, Trudell J, Brick P, Lieb WR, Franks NP (1998). The interaction of halothane with the binding site of a functional protein, cholesterol oxidase. Anesthesiology 89 : A98.
    • (1998) Anesthesiology , vol.89 , pp. 98
    • Bertaccini, E.1    Trudell, J.2    Brick, P.3    Lieb, W.R.4    Franks, N.P.5
  • 15
    • 0034624021 scopus 로고    scopus 로고
    • Binding of the general anesthetics propofol and halothane to human serum albumin
    • Bhattacharya AA, Curry S, Franks NP (2000). Binding of the general anesthetics propofol and halothane to human serum albumin. J Biol Chem 275 : 38731 38738.
    • (2000) J Biol Chem , vol.275 , pp. 38731-38738
    • Bhattacharya, A.A.1    Curry, S.2    Franks, N.P.3
  • 16
    • 4143077106 scopus 로고    scopus 로고
    • A conductances in anesthetic suppression of intrinsic neuronal excitability
    • A conductances in anesthetic suppression of intrinsic neuronal excitability. J Neurophysiol 92 : 1658 1667.
    • (2004) J Neurophysiol , vol.92 , pp. 1658-1667
    • Bieda, M.C.1    MacIver, M.B.2
  • 17
    • 34547242440 scopus 로고    scopus 로고
    • Coarse graining of nonbonded degrees of freedom
    • 4 pages
    • Bock H, Gubbins KE, Klapp SHL (2007). Coarse graining of nonbonded degrees of freedom. Phys Rev Lett 98 : 267801 (4 pages).
    • (2007) Phys Rev Lett , vol.98 , pp. 267801
    • Bock, H.1    Gubbins, K.E.2    Klapp, S.H.L.3
  • 19
    • 0031027931 scopus 로고    scopus 로고
    • The lateral pressure profile in membranes: A physical mechanism of general anesthesia
    • Cantor R (1997). The lateral pressure profile in membranes: a physical mechanism of general anesthesia. Biochemistry 36 : 2339 2344.
    • (1997) Biochemistry , vol.36 , pp. 2339-2344
    • Cantor, R.1
  • 20
    • 0035028750 scopus 로고    scopus 로고
    • Breaking the Meyer-Overton rule: Predicted effects of varying stiffness and interfacial activity on the intrinsic potency of anesthetics
    • Cantor R (2001). Breaking the Meyer-Overton rule: predicted effects of varying stiffness and interfacial activity on the intrinsic potency of anesthetics. Biophys J 80 : 2284 2297.
    • (2001) Biophys J , vol.80 , pp. 2284-2297
    • Cantor, R.1
  • 22
    • 2942663892 scopus 로고    scopus 로고
    • Revisiting lipid-general anesthetic interactions (II): Halothane location and changes in lipid bilayer microenvironment monitored by fluorescence
    • Carnini A, Phillips HA, Shamrakov LG, Cramb DT (2004). Revisiting lipid-general anesthetic interactions (II): halothane location and changes in lipid bilayer microenvironment monitored by fluorescence. Can J Chem 82 : 1139 1149.
    • (2004) Can J Chem , vol.82 , pp. 1139-1149
    • Carnini, A.1    Phillips, H.A.2    Shamrakov, L.G.3    Cramb, D.T.4
  • 23
    • 34548383003 scopus 로고    scopus 로고
    • Simulations of biomolecule unbinding from proteins using DL-POLY
    • Chau P-L (2006). Simulations of biomolecule unbinding from proteins using DL-POLY. Mol Simul 32 : 953 961.
    • (2006) Mol Simul , vol.32 , pp. 953-961
    • Chau, P.-L.1
  • 24
    • 34147125991 scopus 로고    scopus 로고
    • A possible mechanism for pressure reversal of general anaesthetics from molecular simulations
    • Chau P-L, Hoang P, Picaud S, Jedlovszky P (2007). A possible mechanism for pressure reversal of general anaesthetics from molecular simulations. Chem Phys Lett 438 : 294 297.
    • (2007) Chem Phys Lett , vol.438 , pp. 294-297
    • Chau, P.-L.1    Hoang, P.2    Picaud, S.3    Jedlovszky, P.4
  • 25
    • 67349285718 scopus 로고    scopus 로고
    • Pressure reversal of general anaesthetics: A possible mechanism from molecular dynamics simulations
    • Chau P-L, Jedlovszky P, Hoang P, Picaud S (2009). Pressure reversal of general anaesthetics: a possible mechanism from molecular dynamics simulations. J Mol Liq 147 : 128 134.
    • (2009) J Mol Liq , vol.147 , pp. 128-134
    • Chau, P.-L.1    Jedlovszky, P.2    Hoang, P.3    Picaud, S.4
  • 27
    • 44849099307 scopus 로고    scopus 로고
    • Four-α-helix bundle with designed anesthetic binding pockets. Part I: Halothane effects on structure and dynamics
    • Cui T, Bondarenko V, Ma D, Canlas C, Brandon NR, Johansson JS et al. (2008). Four-α-helix bundle with designed anesthetic binding pockets. Part I: halothane effects on structure and dynamics. Biophys J 94 : 4464 4472.
    • (2008) Biophys J , vol.94 , pp. 4464-4472
    • Cui, T.1    Bondarenko, V.2    Ma, D.3    Canlas, C.4    Brandon, N.R.5    Johansson, J.S.6
  • 28
    • 0014221607 scopus 로고
    • Inhibition of spinal neurons by glycine
    • Curtis DR, Hosli L, Johnston GA (1967). Inhibition of spinal neurons by glycine. Nature 215 : 1502 1503.
    • (1967) Nature , vol.215 , pp. 1502-1503
    • Curtis, D.R.1    Hosli, L.2    Johnston, G.A.3
  • 29
    • 0014390175 scopus 로고
    • A pharmacological study of the depression of spinal neurones by glycine and related amino acids
    • Curtis DR, Hosli L, Johnston GA (1968). A pharmacological study of the depression of spinal neurones by glycine and related amino acids. Exp Brain Res 5 : 235 258.
    • (1968) Exp Brain Res , vol.5 , pp. 235-258
    • Curtis, D.R.1    Hosli, L.2    Johnston, G.A.3
  • 31
    • 84859000686 scopus 로고    scopus 로고
    • γ-Amino butyric acid type A receptor mutations at β2 N265 alter etomidate efficacy while preserving basal and agonist-dependent activity
    • Desai R, Ruesch D, Forman SA (2009). γ-Amino butyric acid type A receptor mutations at β2 N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology 107 : 264 272.
    • (2009) Anesthesiology , vol.107 , pp. 264-272
    • Desai, R.1    Ruesch, D.2    Forman, S.A.3
  • 32
    • 0028307274 scopus 로고
    • Can the stereoselective effects of the anesthetic isoflurane be accounted for by lipid solubility?
    • Dickinson R, Franks NP, Lieb WR (1994). Can the stereoselective effects of the anesthetic isoflurane be accounted for by lipid solubility? Biophys J 66 : 2019 2023.
    • (1994) Biophys J , vol.66 , pp. 2019-2023
    • Dickinson, R.1    Franks, N.P.2    Lieb, W.R.3
  • 33
    • 38449123896 scopus 로고    scopus 로고
    • Competitve inhibition at the glycine site of the N-methyl-d-aspartate receptor by the anesthetics xenon and isoflurane
    • Dickinson R, Petersen BK, Banks P, Simillis C, Martin JCS, Valenzuela CA et al. (2007). Competitve inhibition at the glycine site of the N-methyl-d-aspartate receptor by the anesthetics xenon and isoflurane. Anesthesiology 107 : 756 767.
    • (2007) Anesthesiology , vol.107 , pp. 756-767
    • Dickinson, R.1    Petersen, B.K.2    Banks, P.3    Simillis, C.4    Martin, J.C.S.5    Valenzuela, C.A.6
  • 34
    • 0028080354 scopus 로고
    • Evidence for direct actions of general anesthetics on an ion-channel protein - A new look at a unified mechanism of action
    • Dilger JP, Vidal AM, Mody HI, Liu Y (1994). Evidence for direct actions of general anesthetics on an ion-channel protein - a new look at a unified mechanism of action. Anesthesiology 81 : 431 442.
    • (1994) Anesthesiology , vol.81 , pp. 431-442
    • Dilger, J.P.1    Vidal, A.M.2    Mody, H.I.3    Liu, Y.4
  • 35
    • 33747598041 scopus 로고    scopus 로고
    • A receptor α subunits that regulate the agonist action of pentobarbital
    • A receptor α subunits that regulate the agonist action of pentobarbital. J Pharmacol Exp Ther 318 : 1094 1101.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1094-1101
    • Drafts, B.C.1    Fisher, J.L.2
  • 38
    • 0037171769 scopus 로고    scopus 로고
    • Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics
    • Eckenhoff RG, Knoll FJ, Greenblatt EP, Dailey WP (2002). Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics. J Med Chem 45 : 1879 1886.
    • (2002) J Med Chem , vol.45 , pp. 1879-1886
    • Eckenhoff, R.G.1    Knoll, F.J.2    Greenblatt, E.P.3    Dailey, W.P.4
  • 39
    • 0001205583 scopus 로고
    • Encephalitis lethargica
    • von Economo C (1917). Encephalitis lethargica. Wien Klin Wochenschr 30 : 581 585.
    • (1917) Wien Klin Wochenschr , vol.30 , pp. 581-585
    • Von Economo, C.1
  • 40
    • 34347183249 scopus 로고
    • Schlaftheorie
    • von Economo C (1929). Schlaftheorie. Ergeb Physiol 28 : 312 339.
    • (1929) Ergeb Physiol , vol.28 , pp. 312-339
    • Von Economo, C.1
  • 41
    • 27544460357 scopus 로고    scopus 로고
    • A receptor extracellular and transmembrane domains: Important insights in pharmacology and function
    • A receptor extracellular and transmembrane domains: important insights in pharmacology and function. Mol Pharmacol 68 : 1291 1300.
    • (2005) Mol Pharmacol , vol.68 , pp. 1291-1300
    • Ernst, M.1    Bruckner, S.2    Boresch, S.3    Sieghart, W.4
  • 42
    • 0033537884 scopus 로고    scopus 로고
    • Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer
    • Farrar SJ, Whiting PJ, Bonnert TP, McKernan RM (1999). Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer. J Biol Chem 274 : 10100 10104.
    • (1999) J Biol Chem , vol.274 , pp. 10100-10104
    • Farrar, S.J.1    Whiting, P.J.2    Bonnert, T.P.3    McKernan, R.M.4
  • 43
    • 0036198191 scopus 로고    scopus 로고
    • Nuclear overhauser enhancement spectroscopy cross-relaxation rates and ethanol distribution across membranes
    • Feller SE, Brown CA, Nizza DT, Gawrisch K (2002). Nuclear overhauser enhancement spectroscopy cross-relaxation rates and ethanol distribution across membranes. Biophys J 82 : 1396 1404.
    • (2002) Biophys J , vol.82 , pp. 1396-1404
    • Feller, S.E.1    Brown, C.A.2    Nizza, D.T.3    Gawrisch, K.4
  • 46
    • 0028848223 scopus 로고
    • A discrete site for general anesthetics on a postsynaptic receptor
    • Forman SA, Miller KW, Yellen G (1995). A discrete site for general anesthetics on a postsynaptic receptor. Mol Pharmacol 48 : 574 581.
    • (1995) Mol Pharmacol , vol.48 , pp. 574-581
    • Forman, S.A.1    Miller, K.W.2    Yellen, G.3
  • 47
    • 0021211620 scopus 로고
    • Do general anesthetics act by competitive binding to specific receptors?
    • Franks NP, Lieb WR (1984). Do general anesthetics act by competitive binding to specific receptors? Nature 310 : 599 601.
    • (1984) Nature , vol.310 , pp. 599-601
    • Franks, N.P.1    Lieb, W.R.2
  • 48
    • 42349089480 scopus 로고    scopus 로고
    • General anaesthesia: From molecular targets to neuronal pathways of sleep and arousal
    • Franks NP (2008). General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 9 : 370 386.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 370-386
    • Franks, N.P.1
  • 51
    • 58749112562 scopus 로고    scopus 로고
    • The influence of 1-alkanols and external pressure on the lateral pressure profiles of lipid bilayers
    • Griepernau B, Böckmann RA (2008). The influence of 1-alkanols and external pressure on the lateral pressure profiles of lipid bilayers. Biophys J 95 : 5766 5778.
    • (2008) Biophys J , vol.95 , pp. 5766-5778
    • Griepernau, B.1    Böckmann, R.A.2
  • 53
    • 0025986811 scopus 로고
    • The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurons
    • Hales TG, Lambert JJ (1991). The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurons. Br J Pharmacol 104 : 619 628.
    • (1991) Br J Pharmacol , vol.104 , pp. 619-628
    • Hales, T.G.1    Lambert, J.J.2
  • 55
    • 0020199656 scopus 로고
    • Effects of high pressure on the central nervous system
    • Halsey MJ (1982). Effects of high pressure on the central nervous system. Physiol Rev 62 : 1341 1377.
    • (1982) Physiol Rev , vol.62 , pp. 1341-1377
    • Halsey, M.J.1
  • 56
    • 0016865543 scopus 로고
    • Pressure reversal of narcosis produced by anaesthetics, narcotics and tranquillisers
    • Halsey MJ, Wardley-Smith B (1975). Pressure reversal of narcosis produced by anaesthetics, narcotics and tranquillisers. Nature 257 : 811 813.
    • (1975) Nature , vol.257 , pp. 811-813
    • Halsey, M.J.1    Wardley-Smith, B.2
  • 57
    • 0030049370 scopus 로고    scopus 로고
    • The human glycine receptor β-subunit: Primary structure, functional characterisation and chromosomal localisation of the human and murine genes
    • Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR et al. (1996). The human glycine receptor β-subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes. Mol Brain Res 35 : 211 219.
    • (1996) Mol Brain Res , vol.35 , pp. 211-219
    • Handford, C.A.1    Lynch, J.W.2    Baker, E.3    Webb, G.C.4    Ford, J.H.5    Sutherland, G.R.6
  • 58
    • 0026763799 scopus 로고
    • Isoflurane anesthesia is stereoselective
    • Harris B, Moody E, Skolnick P (1992). Isoflurane anesthesia is stereoselective. Eur J Pharmacol 217 : 215 216.
    • (1992) Eur J Pharmacol , vol.217 , pp. 215-216
    • Harris, B.1    Moody, E.2    Skolnick, P.3
  • 59
    • 0028233768 scopus 로고
    • Effects of halothane and propofol on purified brain protein kinase C activation
    • Hemmings HC, Adamo AIB (1994). Effects of halothane and propofol on purified brain protein kinase C activation. Anesthesiology 81 : 147 155.
    • (1994) Anesthesiology , vol.81 , pp. 147-155
    • Hemmings, H.C.1    Adamo, A.I.B.2
  • 63
    • 0035033098 scopus 로고    scopus 로고
    • Modulation of NMDA receptor function by ketamine and magnesium. Part II: Interactions with volatile anesthetics
    • Hollmann MW, Liu H-T, Hoenemann CW, Liu W-H, Durieux ME (2001). Modulation of NMDA receptor function by ketamine and magnesium. Part II: interactions with volatile anesthetics. Anesth Analg 92 : 1182 1191.
    • (2001) Anesth Analg , vol.92 , pp. 1182-1191
    • Hollmann, M.W.1    Liu, H.-T.2    Hoenemann, C.W.3    Liu, W.-H.4    Durieux, M.E.5
  • 64
    • 0030615289 scopus 로고    scopus 로고
    • Gene knockout of the α6 subunit of the γ-aminobutyric acid type a receptor: Lack of effect on responses to ethanol, pentobarbital, and general anaesthetics
    • Homanics GE, Ferguson C, Quinlan JL, Daggett J, Snyder K, Lagenaur C et al. (1997). Gene knockout of the α6 subunit of the γ-aminobutyric acid type a receptor: lack of effect on responses to ethanol, pentobarbital, and general anaesthetics. Mol Pharmacol 51 : 588 596.
    • (1997) Mol Pharmacol , vol.51 , pp. 588-596
    • Homanics, G.E.1    Ferguson, C.2    Quinlan, J.L.3    Daggett, J.4    Snyder, K.5    Lagenaur, C.6
  • 67
    • 0345269286 scopus 로고    scopus 로고
    • 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5- carboxylate: A derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels
    • Husain SS, Ziebell MR, Ruesch D, Hong F, Arevalo E, Kosterlitz JA et al. (2003). 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5- carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem 46 : 1257 1265.
    • (2003) J Med Chem , vol.46 , pp. 1257-1265
    • Husain, S.S.1    Ziebell, M.R.2    Ruesch, D.3    Hong, F.4    Arevalo, E.5    Kosterlitz, J.A.6
  • 68
    • 38849208542 scopus 로고    scopus 로고
    • MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility
    • Irifune M, Katayama S, Takarada T, Shimizu Y, Endo C, Takata T et al. (2007). MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility. Can J Anesth 54 : 998 1005.
    • (2007) Can J Anesth , vol.54 , pp. 998-1005
    • Irifune, M.1    Katayama, S.2    Takarada, T.3    Shimizu, Y.4    Endo, C.5    Takata, T.6
  • 70
    • 0036754362 scopus 로고    scopus 로고
    • A receptor α1 subunit: Implications for modulation by inhaled anesthetics and ion channel structure
    • A receptor α1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. Neuropharmacology 43 : 669 678.
    • (2002) Neuropharmacology , vol.43 , pp. 669-678
    • Jenkins, J.1    Andreasen, A.2    Trudell, J.R.3    Harrison, N.L.4
  • 72
    • 50449085293 scopus 로고    scopus 로고
    • Resolving voltage-dependent structural changes of a membrane photoreceptor by surface-enhanced IR difference spectroscopy
    • Jiang X, Zaitseva E, Schmidt M, Siebert F, Engelhard M, Schlesinger R et al. (2008). Resolving voltage-dependent structural changes of a membrane photoreceptor by surface-enhanced IR difference spectroscopy. Proc Natl Acad Sci USA 105 : 12113 12117.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 12113-12117
    • Jiang, X.1    Zaitseva, E.2    Schmidt, M.3    Siebert, F.4    Engelhard, M.5    Schlesinger, R.6
  • 73
    • 0003015547 scopus 로고
    • Hydrostatic pressure reversal of narcosis in tadpoles
    • Johnson FH, Flagler EA (1950). Hydrostatic pressure reversal of narcosis in tadpoles. Science 112 : 91 92.
    • (1950) Science , vol.112 , pp. 91-92
    • Johnson, F.H.1    Flagler, E.A.2
  • 74
    • 0344219573 scopus 로고
    • Activity of narcotized amphibian larvae under hydrostatic pressure
    • Johnson FH, Flagler EA (1951). Activity of narcotized amphibian larvae under hydrostatic pressure. J Cell Comp Physiol 37 : 15 25.
    • (1951) J Cell Comp Physiol , vol.37 , pp. 15-25
    • Johnson, F.H.1    Flagler, E.A.2
  • 75
    • 27144454353 scopus 로고    scopus 로고
    • From waking to sleeping: Neuronal and chemical substrates
    • Jones BE (2005). From waking to sleeping: neuronal and chemical substrates. Trends Pharmacol Sci 26 : 578 586.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 578-586
    • Jones, B.E.1
  • 76
    • 0027359048 scopus 로고
    • Effect of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons
    • Jones MV, Harrison NL (1993). Effect of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons. J Neurophysiol 70 : 1339 1349.
    • (1993) J Neurophysiol , vol.70 , pp. 1339-1349
    • Jones, M.V.1    Harrison, N.L.2
  • 77
    • 33846040820 scopus 로고    scopus 로고
    • Effects of an amphipathic α-helical peptide on lateral pressure and water penetration in phosphatidylcholine and monoolein mixed membranes
    • Kamo T, Nakano N, Kuroda Y, Handa T (2006). Effects of an amphipathic α-helical peptide on lateral pressure and water penetration in phosphatidylcholine and monoolein mixed membranes. J Phys Chem B 110 : 24987 24992.
    • (2006) J Phys Chem B , vol.110 , pp. 24987-24992
    • Kamo, T.1    Nakano, N.2    Kuroda, Y.3    Handa, T.4
  • 78
    • 0017157301 scopus 로고
    • Neuromuscular function at hyperbaric pressures: Pressure-anesthetic interactions
    • Kendig JJ, Cohen EN (1976). Neuromuscular function at hyperbaric pressures: pressure-anesthetic interactions. Am J Physiol Cell Physiol 230 : 1244 1248.
    • (1976) Am J Physiol Cell Physiol , vol.230 , pp. 1244-1248
    • Kendig, J.J.1    Cohen, E.N.2
  • 79
    • 0016710801 scopus 로고
    • Effects of pressure and anesthetics on conduction and synaptic transmission
    • Kendig JJ, Trudell JR, Cohen EN (1975). Effects of pressure and anesthetics on conduction and synaptic transmission. J Pharmacol Exp Ther 195 : 216 224.
    • (1975) J Pharmacol Exp Ther , vol.195 , pp. 216-224
    • Kendig, J.J.1    Trudell, J.R.2    Cohen, E.N.3
  • 80
    • 0037215587 scopus 로고    scopus 로고
    • Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neurons
    • Kitamura A, Marszalec W, Yeh JZ, Narahashi T (2003). Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neurons. J Pharmacol Exp Ther 304 : 162 171.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 162-171
    • Kitamura, A.1    Marszalec, W.2    Yeh, J.Z.3    Narahashi, T.4
  • 81
    • 0036790255 scopus 로고    scopus 로고
    • Effects of the nonimmobilizer hexafluroethane on the model membrane dimyristoylphosphatidyl-choline
    • Koubi L, Tarek M, Bandyopadhyay S, Klein ML, Scharf D (2002). Effects of the nonimmobilizer hexafluroethane on the model membrane dimyristoylphosphatidyl-choline. Anesthesiology 97 : 848 855.
    • (2002) Anesthesiology , vol.97 , pp. 848-855
    • Koubi, L.1    Tarek, M.2    Bandyopadhyay, S.3    Klein, M.L.4    Scharf, D.5
  • 82
    • 0034023885 scopus 로고    scopus 로고
    • A and glycine receptors and the effects of TM2 and TM3 mutations
    • A and glycine receptors and the effects of TM2 and TM3 mutations. Br J Pharmacol 129 : 731 743.
    • (2000) Br J Pharmacol , vol.129 , pp. 731-743
    • Krasowski, M.D.1    Harrison, N.L.2
  • 83
    • 0031967619 scopus 로고    scopus 로고
    • Propofol and other intravenous anesthetics have sites of action on the γ-aminobutyric acid type A receptor distinct from that for isoflurane
    • Krasowski MD, Koltchine VV, Rick CE, Ye Q, Finn SE, Harrison NL (1998). Propofol and other intravenous anesthetics have sites of action on the γ-aminobutyric acid type A receptor distinct from that for isoflurane. Mol Pharmacol 53 : 530 538.
    • (1998) Mol Pharmacol , vol.53 , pp. 530-538
    • Krasowski, M.D.1    Koltchine, V.V.2    Rick, C.E.3    Ye, Q.4    Finn, S.E.5    Harrison, N.L.6
  • 85
    • 0032523002 scopus 로고    scopus 로고
    • Evidence for a tetrameric structure of recombinant NMDA receptors
    • Laube B, Kuhse J, Betz H (1998). Evidence for a tetrameric structure of recombinant NMDA receptors. J Neurosci 18 : 2954 2961.
    • (1998) J Neurosci , vol.18 , pp. 2954-2961
    • Laube, B.1    Kuhse, J.2    Betz, H.3
  • 89
    • 0022557289 scopus 로고
    • The effects of anaesthetics and high pressure on the responses of the rat superior cervical ganglion in vitro
    • Little HJ, Thomas DL (1986). The effects of anaesthetics and high pressure on the responses of the rat superior cervical ganglion in vitro. J Physiol 374 : 387 399.
    • (1986) J Physiol , vol.374 , pp. 387-399
    • Little, H.J.1    Thomas, D.L.2
  • 90
    • 9244228006 scopus 로고    scopus 로고
    • Potent activation of the human tandem pore domain K channel tresk with clinical concentrations of volatile anesthetics
    • Liu C, Au JD, Zou HL, Cotten JF, Yost CS (2004). Potent activation of the human tandem pore domain K channel tresk with clinical concentrations of volatile anesthetics. Anesth Analg 99 : 1715 1722.
    • (2004) Anesth Analg , vol.99 , pp. 1715-1722
    • Liu, C.1    Au, J.D.2    Zou, H.L.3    Cotten, J.F.4    Yost, C.S.5
  • 91
    • 68049123307 scopus 로고    scopus 로고
    • Mechanism of interaction between the general anesthetic halothane and a model ion channel protein, II: Fluorescence and vibrational spectroscopy using a cyanophenylalanine probe
    • Liu J, Strzalka J, Tronin A, Johansson JS, Blaise JK (2009). Mechanism of interaction between the general anesthetic halothane and a model ion channel protein, II: fluorescence and vibrational spectroscopy using a cyanophenylalanine probe. Biophys J 96 : 4176 4187.
    • (2009) Biophys J , vol.96 , pp. 4176-4187
    • Liu, J.1    Strzalka, J.2    Tronin, A.3    Johansson, J.S.4    Blaise, J.K.5
  • 92
    • 70350322975 scopus 로고    scopus 로고
    • In-plane and out-of-plane infrared difference spectroscopy unravels tilting of helices and structural changes in a membrane protein upon substrate binding
    • Lórenz-Fonfría VA, Granell M, León X, Leblanc G, Padros E (2009). In-plane and out-of-plane infrared difference spectroscopy unravels tilting of helices and structural changes in a membrane protein upon substrate binding. J Am Chem Soc 131 : 15094 15095.
    • (2009) J Am Chem Soc , vol.131 , pp. 15094-15095
    • Lórenz-Fonfría, V.A.1    Granell, M.2    León, X.3    Leblanc, G.4    Padros, E.5
  • 93
    • 28044444302 scopus 로고    scopus 로고
    • Sleep, anesthesiology, and the neurobiology of arousal state control
    • Lydic R, Baghdoyan HA (2005). Sleep, anesthesiology, and the neurobiology of arousal state control. Anesthesiology 103 : 1268 1295.
    • (2005) Anesthesiology , vol.103 , pp. 1268-1295
    • Lydic, R.1    Baghdoyan, H.A.2
  • 95
    • 44849083478 scopus 로고    scopus 로고
    • Four-α-helix bundle with designed anesthetic binding pockets. Part I: Structural and dynamical analyses
    • Ma D, Brandon NR, Cui T, Bondarenko V, Canlas C, Johansson JS et al. (2008). Four-α-helix bundle with designed anesthetic binding pockets. Part I: structural and dynamical analyses. Biophys J 94 : 4454 4463.
    • (2008) Biophys J , vol.94 , pp. 4454-4463
    • Ma, D.1    Brandon, N.R.2    Cui, T.3    Bondarenko, V.4    Canlas, C.5    Johansson, J.S.6
  • 96
    • 33745648972 scopus 로고    scopus 로고
    • Limbic system participates in mediating the effects of general anesthetics
    • Ma J, Leung LS (2006). Limbic system participates in mediating the effects of general anesthetics. Neuropsychopharmacology 31 : 1177 1192.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1177-1192
    • Ma, J.1    Leung, L.S.2
  • 97
    • 17444446483 scopus 로고    scopus 로고
    • The septohippocampal system participates in general anesthesia
    • Ma J, Shen B, Stewart LS, Herrick IA, Leung LS (2002). The septohippocampal system participates in general anesthesia. J Neurosci 22 : RC200.
    • (2002) J Neurosci , vol.22 , pp. 200
    • Ma, J.1    Shen, B.2    Stewart, L.S.3    Herrick, I.A.4    Leung, L.S.5
  • 99
    • 0034255021 scopus 로고    scopus 로고
    • Specific binding sites for alcohols and anesthetics on ligand-gated ion channels
    • Mascia MP, Trudell JR, Harris RA (2000). Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci USA 97 : 9305 9310.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9305-9310
    • Mascia, M.P.1    Trudell, J.R.2    Harris, R.A.3
  • 100
    • 0027934191 scopus 로고
    • Structural analysis of mouse glycine receptor α-subunit genes. Identification and chromosomal localization of a novel variant, α4
    • Matzenbach B, Maulet Y, Sefton L, Avner P, Guenet JL, Betz H (1994). Structural analysis of mouse glycine receptor α-subunit genes. Identification and chromosomal localization of a novel variant, α4. J Biol Chem 269 : 2607 2612.
    • (1994) J Biol Chem , vol.269 , pp. 2607-2612
    • Matzenbach, B.1    Maulet, Y.2    Sefton, L.3    Avner, P.4    Guenet, J.L.5    Betz, H.6
  • 104
    • 0015874085 scopus 로고
    • The pressure reversal of general anesthesia and the critical volume hypothesis
    • Miller KW, Paton WDM, Smith RA, Smith EB (1973). The pressure reversal of general anesthesia and the critical volume hypothesis. Mol Pharmacol 9 : 131 143.
    • (1973) Mol Pharmacol , vol.9 , pp. 131-143
    • Miller, K.W.1    Paton, W.D.M.2    Smith, R.A.3    Smith, E.B.4
  • 105
    • 35448998854 scopus 로고    scopus 로고
    • Exploring ligand recognition and ion flow in comparative models of the human GABA type A receptor
    • Mokrab Y, Bavro VN, Mizuguchi K, Martin IL, Todorov NP, Dunn SMJ et al. (2007). Exploring ligand recognition and ion flow in comparative models of the human GABA type A receptor. J Mol Graph Model 26 : 760 774.
    • (2007) J Mol Graph Model , vol.26 , pp. 760-774
    • Mokrab, Y.1    Bavro, V.N.2    Mizuguchi, K.3    Martin, I.L.4    Todorov, N.P.5    Dunn, S.M.J.6
  • 108
    • 0000995939 scopus 로고
    • Some physical mechanisms in narcosis
    • Mullins LJ (1954). Some physical mechanisms in narcosis. Chem Rev 54 : 289 323.
    • (1954) Chem Rev , vol.54 , pp. 289-323
    • Mullins, L.J.1
  • 113
    • 4344649800 scopus 로고    scopus 로고
    • Potential impact of an X-ray free electron laser on structural biology
    • Neutze R, Huldt G, Hajdu J, van der Spoel D (2004). Potential impact of an X-ray free electron laser on structural biology. Radiat Phys Chem 71 : 905 916.
    • (2004) Radiat Phys Chem , vol.71 , pp. 905-916
    • Neutze, R.1    Huldt, G.2    Hajdu, J.3    Van Der Spoel, D.4
  • 114
    • 61549110188 scopus 로고    scopus 로고
    • Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors
    • Nguyen HT, Li KY, daGraca RL, Delphin E, Xiong M, Ye JH (2009). Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors. Anesthesiology 110 : 326 332.
    • (2009) Anesthesiology , vol.110 , pp. 326-332
    • Nguyen, H.T.1    Li, K.Y.2    Dagraca, R.L.3    Delphin, E.4    Xiong, M.5    Ye, J.H.6
  • 115
    • 0019981853 scopus 로고
    • General anesthetics hyperpolarize neurons in the vertebrate central nervous system
    • Nicoll RA, Madison DV (1982). General anesthetics hyperpolarize neurons in the vertebrate central nervous system. Science 217 : 1055 1057.
    • (1982) Science , vol.217 , pp. 1055-1057
    • Nicoll, R.A.1    Madison, D.V.2
  • 116
    • 0041324605 scopus 로고    scopus 로고
    • The actions of sevoflurane and desflurane on the γ-aminobutyric acid receptor type A - Effects of TM2 mutations in the α- And β-subunits
    • Nishikawa K, Harrison NL (2003). The actions of sevoflurane and desflurane on the γ-aminobutyric acid receptor type A - effects of TM2 mutations in the α- and β-subunits. Anesthesiology 99 : 678 684.
    • (2003) Anesthesiology , vol.99 , pp. 678-684
    • Nishikawa, K.1    Harrison, N.L.2
  • 118
    • 34447639568 scopus 로고    scopus 로고
    • Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol
    • Ollila OHS, Rog T, Karttunen M, Vattulainen I (2007). Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane functionality: comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol. J Struct Biol 159 : 311 323.
    • (2007) J Struct Biol , vol.159 , pp. 311-323
    • Ollila, O.H.S.1    Rog, T.2    Karttunen, M.3    Vattulainen, I.4
  • 121
    • 33846920665 scopus 로고    scopus 로고
    • NMDA receptor subunits: Function and pharmacology
    • Paoletti P, Neyton J (2007). NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 7 : 39 47.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 39-47
    • Paoletti, P.1    Neyton, J.2
  • 124
    • 21244467594 scopus 로고    scopus 로고
    • Concentration effects of volatile anesthetics on the properties of model membranes: A coarse-grain approach
    • Pickholz M, Saiz L, Klein ML (2005). Concentration effects of volatile anesthetics on the properties of model membranes: a coarse-grain approach. Biophys J 88 : 1524 1534.
    • (2005) Biophys J , vol.88 , pp. 1524-1534
    • Pickholz, M.1    Saiz, L.2    Klein, M.L.3
  • 125
    • 2342598499 scopus 로고    scopus 로고
    • Neurotransmission in central cardiovascular control: 10 suggestions for microinjections
    • Pilowsky PM (2004). Neurotransmission in central cardiovascular control: 10 suggestions for microinjections. Hypertension 43 : 945 946.
    • (2004) Hypertension , vol.43 , pp. 945-946
    • Pilowsky, P.M.1
  • 127
    • 0033557760 scopus 로고    scopus 로고
    • 2rmL) and Drosophila (RDL) GABA receptors by a single amino acid residue
    • 2rmL) and Drosophila (RDL) GABA receptors by a single amino acid residue. J Physiol 515 : 3 18.
    • (1999) J Physiol , vol.515 , pp. 3-18
    • Pistis, M.1    Belelli, D.2    McGurk, D.A.3    Japj, L.4
  • 129
    • 0034703007 scopus 로고    scopus 로고
    • Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic
    • Pratt MB, Husain SS, Miller KW, Cohen JB (2000). Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic. J Biol Chem 275 : 29441 29451.
    • (2000) J Biol Chem , vol.275 , pp. 29441-29451
    • Pratt, M.B.1    Husain, S.S.2    Miller, K.W.3    Cohen, J.B.4
  • 130
    • 0030722469 scopus 로고    scopus 로고
    • Stoichiometry of recombinant N-methyl-d-aspartate receptor channels inferred from single-channel current patterns
    • Premkumar LS, Auerbach A (1997). Stoichiometry of recombinant N-methyl-d-aspartate receptor channels inferred from single-channel current patterns. J Gen Physiol 110 : 485 502.
    • (1997) J Gen Physiol , vol.110 , pp. 485-502
    • Premkumar, L.S.1    Auerbach, A.2
  • 131
    • 73949111037 scopus 로고    scopus 로고
    • γ-Aminobutyric acid type A receptor α4 subunit knockout mice are resistant to the amnestic effect of isoflurane
    • Rau V, Iyer SV, Oh I, Chandra D, Harrison N, Eger EI et al. (2009). γ-Aminobutyric acid type A receptor α4 subunit knockout mice are resistant to the amnestic effect of isoflurane. Anesth Analg 109 : 1816 1822.
    • (2009) Anesth Analg , vol.109 , pp. 1816-1822
    • Rau, V.1    Iyer, S.V.2    Oh, I.3    Chandra, D.4    Harrison, N.5    Eger, E.I.6
  • 134
    • 44849140144 scopus 로고    scopus 로고
    • Bubbles, gating, and anesthetics in ion channels
    • Roth R, Gillespie D, Nonner W, Eisenberg RE (2008). Bubbles, gating, and anesthetics in ion channels. Biophys J 94 : 4282 4298.
    • (2008) Biophys J , vol.94 , pp. 4282-4298
    • Roth, R.1    Gillespie, D.2    Nonner, W.3    Eisenberg, R.E.4
  • 135
    • 0017162201 scopus 로고
    • Pressure antagonism of anaesthetic-induced conduction failure in frog peripheral nerve
    • Roth SH, Smith RA, Paton WDM (1976). Pressure antagonism of anaesthetic-induced conduction failure in frog peripheral nerve. Br J Anaesth 48 : 621 628.
    • (1976) Br J Anaesth , vol.48 , pp. 621-628
    • Roth, S.H.1    Smith, R.A.2    Paton, W.D.M.3
  • 136
    • 0017684533 scopus 로고
    • Halothane binds in the adenine-specific niche of crystalline adenylate kinase
    • Sachsenheimer W, Pai EF, Schulz GE, Schirmer RH (1977). Halothane binds in the adenine-specific niche of crystalline adenylate kinase. FEBS Lett 79 : 310 312.
    • (1977) FEBS Lett , vol.79 , pp. 310-312
    • Sachsenheimer, W.1    Pai, E.F.2    Schulz, G.E.3    Schirmer, R.H.4
  • 137
    • 0035576935 scopus 로고    scopus 로고
    • The sleep switch: Hypothalamic control of sleep and wakefulness
    • Saper CB, Chou TC, Scammell TE (2001). The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 24 : 726 731.
    • (2001) Trends Neurosci , vol.24 , pp. 726-731
    • Saper, C.B.1    Chou, T.C.2    Scammell, T.E.3
  • 139
    • 0013842370 scopus 로고
    • Binding of xenon to sperm whale myoglobin
    • Schoenborn B, Watson HC, Kendrew JC (1965). Binding of xenon to sperm whale myoglobin. Nature 207 : 28 30.
    • (1965) Nature , vol.207 , pp. 28-30
    • Schoenborn, B.1    Watson, H.C.2    Kendrew, J.C.3
  • 141
    • 0020559609 scopus 로고
    • Anesthetic antagonism of the effects of high hydrostatic pressure on locomotory activity of the brine shrimp Artemia
    • Simon SA, Parmentier JL, Bennett PB (1983). Anesthetic antagonism of the effects of high hydrostatic pressure on locomotory activity of the brine shrimp Artemia. Comp Biochem Physiol 75A : 193 199.
    • (1983) Comp Biochem Physiol , vol.75 , pp. 193-199
    • Simon, S.A.1    Parmentier, J.L.2    Bennett, P.B.3
  • 143
    • 72049124287 scopus 로고    scopus 로고
    • X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
    • Sobolevsky AI, Rosconi MP, Gouaux E (2009). X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature 462 : 745 756.
    • (2009) Nature , vol.462 , pp. 745-756
    • Sobolevsky, A.I.1    Rosconi, M.P.2    Gouaux, E.3
  • 144
    • 33646178159 scopus 로고    scopus 로고
    • Differential modulation of human N-methyl-d-aspartate receptors by structurally diverse general anesthetics
    • Solt K, Eger EI, Raines DE (2006). Differential modulation of human N-methyl-d-aspartate receptors by structurally diverse general anesthetics. Anesth Analg 102 : 1407 1411.
    • (2006) Anesth Analg , vol.102 , pp. 1407-1411
    • Solt, K.1    Eger, E.I.2    Raines, D.E.3
  • 145
    • 33845949948 scopus 로고    scopus 로고
    • Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning and the right reflex in mice engineered to express α1 γ-aminobutyric acid type A receptors unresponsive to isoflurane
    • Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA et al. (2007). Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning and the right reflex in mice engineered to express α1 γ-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology 106 : 107 113.
    • (2007) Anesthesiology , vol.106 , pp. 107-113
    • Sonner, J.M.1    Werner, D.F.2    Elsen, F.P.3    Xing, Y.4    Liao, M.5    Harris, R.A.6
  • 146
    • 0034029603 scopus 로고    scopus 로고
    • Constrating synaptic actions of the inhalational general anesthetics isoflurane and xenon
    • de Sousa SLM, Dickinson R, Lieb WR, Franks NP (2000). Constrating synaptic actions of the inhalational general anesthetics isoflurane and xenon. Anesthesiology 92 : 1055 1066.
    • (2000) Anesthesiology , vol.92 , pp. 1055-1066
    • De Sousa, S.L.M.1    Dickinson, R.2    Lieb, W.R.3    Franks, N.P.4
  • 147
    • 68049124979 scopus 로고    scopus 로고
    • Mechanism of interaction between the general anesthetic halothane and a model ion channel protein, I: Structural investigations via X-ray reflectivity from langmuir monolayers
    • Strzalka J, Liu J, Tronin A, Churbanova IY, Johansson JS, Blaise JK (2009). Mechanism of interaction between the general anesthetic halothane and a model ion channel protein, I: structural investigations via X-ray reflectivity from langmuir monolayers. Biophys J 96 : 4164 4175.
    • (2009) Biophys J , vol.96 , pp. 4164-4175
    • Strzalka, J.1    Liu, J.2    Tronin, A.3    Churbanova, I.Y.4    Johansson, J.S.5    Blaise, J.K.6
  • 148
    • 0026518089 scopus 로고
    • Halothane-induced hyperpolarization and depression of postsynaptic potentials of guinea pig thalamic neurons in vitro
    • Sugiyama K, Muteki T, Shimoji K (1992). Halothane-induced hyperpolarization and depression of postsynaptic potentials of guinea pig thalamic neurons in vitro. Brain Res 576 : 97 103.
    • (1992) Brain Res , vol.576 , pp. 97-103
    • Sugiyama, K.1    Muteki, T.2    Shimoji, K.3
  • 149
    • 23044471767 scopus 로고    scopus 로고
    • Movement suppression during anesthesia: Neural projections from the mesopontine tegmentum to areas involved in motor control
    • Sukhotinsky I, Hopkins DA, Lu J, Saper CB, Devor M (2005). Movement suppression during anesthesia: neural projections from the mesopontine tegmentum to areas involved in motor control. J Comp Neurol 489 : 425 448.
    • (2005) J Comp Neurol , vol.489 , pp. 425-448
    • Sukhotinsky, I.1    Hopkins, D.A.2    Lu, J.3    Saper, C.B.4    Devor, M.5
  • 150
    • 33751174766 scopus 로고    scopus 로고
    • Projections from the mesopontine tegmental anesthesia area to regions involved in pain modulation
    • Sukhotinsky I, Reiner K, Govrin-Lippmann R, Belenky M, Lu J, Hopkins DA et al. (2007a). Projections from the mesopontine tegmental anesthesia area to regions involved in pain modulation. J Chem Neuroanat 32 : 159 178.
    • (2007) J Chem Neuroanat , vol.32 , pp. 159-178
    • Sukhotinsky, I.1    Reiner, K.2    Govrin-Lippmann, R.3    Belenky, M.4    Lu, J.5    Hopkins, D.A.6
  • 152
    • 0037058912 scopus 로고    scopus 로고
    • Large-scale molecular dynamics simulations of general anesthetic effects on the ion channel in the fully hydrated membrane: The implication of molecular mechanisms of general anesthesia
    • Tang P, Xu Y (2002). Large-scale molecular dynamics simulations of general anesthetic effects on the ion channel in the fully hydrated membrane: the implication of molecular mechanisms of general anesthesia. Proc Natl Acad Sci USA 99 : 16035 16040.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16035-16040
    • Tang, P.1    Xu, Y.2
  • 154
    • 0032228279 scopus 로고    scopus 로고
    • Sensing isothermal changes in the lateral pressure in model membranes using di-pyrenyl phosphatidylcholine
    • Templer RH, Castle SJ, Curran AR, Rumbles G, Klug DR (1998). Sensing isothermal changes in the lateral pressure in model membranes using di-pyrenyl phosphatidylcholine. Faraday Discuss 111 : 41 53.
    • (1998) Faraday Discuss , vol.111 , pp. 41-53
    • Templer, R.H.1    Castle, S.J.2    Curran, A.R.3    Rumbles, G.4    Klug, D.R.5
  • 155
    • 42649132203 scopus 로고    scopus 로고
    • Influence of ethanol on lipid membranes: From lateral pressure profiles to dynamics and partitioning
    • Terama E, Ollila OHS, Salonen A, Rowat AC, Trandum C, Westh P et al. (2008). Influence of ethanol on lipid membranes: from lateral pressure profiles to dynamics and partitioning. J Phys Chem B 112 : 4131 4139.
    • (2008) J Phys Chem B , vol.112 , pp. 4131-4139
    • Terama, E.1    Ollila, O.H.S.2    Salonen, A.3    Rowat, A.C.4    Trandum, C.5    Westh, P.6
  • 156
    • 0031910550 scopus 로고    scopus 로고
    • Stereo-selective effects of etomidate optical isomers on γ-aminobutyric acid type A receptors and animals
    • Tomlin SL, Jenkins A, Lieb WR, Franks NP (1998). Stereo-selective effects of etomidate optical isomers on γ-aminobutyric acid type A receptors and animals. Anesthesiology 88 : 708 717.
    • (1998) Anesthesiology , vol.88 , pp. 708-717
    • Tomlin, S.L.1    Jenkins, A.2    Lieb, W.R.3    Franks, N.P.4
  • 157
    • 0026471603 scopus 로고
    • The general anesthetic potency of propofol and its dependence on hydrostatic pressure
    • Tonner PH, Poppers DM, Miller KW (1992). The general anesthetic potency of propofol and its dependence on hydrostatic pressure. Anesthesiology 77 : 926 931.
    • (1992) Anesthesiology , vol.77 , pp. 926-931
    • Tonner, P.H.1    Poppers, D.M.2    Miller, K.W.3
  • 158
    • 0015936087 scopus 로고
    • The effect of two inhalation anesthetics on the order of spin-labeled phospholipid vesicles
    • Trudell JR, Hubbell WL, Cohen EN (1973a). The effect of two inhalation anesthetics on the order of spin-labeled phospholipid vesicles. Biochim Biophys Acta Biomembr 291 : 321 327.
    • (1973) Biochim Biophys Acta Biomembr , vol.291 , pp. 321-327
    • Trudell, J.R.1    Hubbell, W.L.2    Cohen, E.N.3
  • 159
    • 0015936158 scopus 로고
    • Pressure reversal of inhalation anesthetic-induced disorder in spin-labeled phospholipid vesicles
    • Trudell JR, Hubbell WL, Cohen EN (1973b). Pressure reversal of inhalation anesthetic-induced disorder in spin-labeled phospholipid vesicles. Biochim Biophys Acta Biomembr 291 : 328 334.
    • (1973) Biochim Biophys Acta Biomembr , vol.291 , pp. 328-334
    • Trudell, J.R.1    Hubbell, W.L.2    Cohen, E.N.3
  • 160
    • 0002599020 scopus 로고
    • The antagonistic effect of an inhalation anesthetic and high pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers
    • Trudell JR, Payan DG, Chin JH, Cohen EN (1975). The antagonistic effect of an inhalation anesthetic and high pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers. Proc Natl Acad Sci USA 72 : 210 213.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 210-213
    • Trudell, J.R.1    Payan, D.G.2    Chin, J.H.3    Cohen, E.N.4
  • 161
    • 0031755264 scopus 로고    scopus 로고
    • Effects of anesthetics on the structure of a phospholipid bilayer
    • Tu K, Tarek M, Klein ML, Scharf D (1998). Effects of anesthetics on the structure of a phospholipid bilayer. Biophys J 75 : 2123 2134.
    • (1998) Biophys J , vol.75 , pp. 2123-2134
    • Tu, K.1    Tarek, M.2    Klein, M.L.3    Scharf, D.4
  • 165
    • 13444271681 scopus 로고    scopus 로고
    • Refined structure of the nicotinic acetylcholine receptor at 4-Å resolution
    • Unwin N (2005). Refined structure of the nicotinic acetylcholine receptor at 4-Å resolution. J Mol Biol 346 : 967 989.
    • (2005) J Mol Biol , vol.346 , pp. 967-989
    • Unwin, N.1
  • 166
    • 44849120711 scopus 로고    scopus 로고
    • Interaction of anesthetics with open and closed conformations of a potassium channel studied via molecular dynamics and normal mode analysis
    • Vemparala S, Domene C, Klein ML (2008). Interaction of anesthetics with open and closed conformations of a potassium channel studied via molecular dynamics and normal mode analysis. Biophys J 94 : 4260 4269.
    • (2008) Biophys J , vol.94 , pp. 4260-4269
    • Vemparala, S.1    Domene, C.2    Klein, M.L.3
  • 167
    • 33749517506 scopus 로고    scopus 로고
    • Partitioning of anesthetics into a lipid bilayer and their interaction with membrane-bound peptide bundles
    • Vemparala S, Saiz L, Eckenhoff RG, Klein ML (2006). Partitioning of anesthetics into a lipid bilayer and their interaction with membrane-bound peptide bundles. Biophys J 91 : 2815 2825.
    • (2006) Biophys J , vol.91 , pp. 2815-2825
    • Vemparala, S.1    Saiz, L.2    Eckenhoff, R.G.3    Klein, M.L.4
  • 169
    • 0038178996 scopus 로고    scopus 로고
    • A receptor subtypes in the brain: A paradigm for CNS drug discovery?
    • A receptor subtypes in the brain: a paradigm for CNS drug discovery? Drug Discov Today 8 : 445 450.
    • (2003) Drug Discov Today , vol.8 , pp. 445-450
    • Whiting, P.J.1
  • 170
    • 0029071823 scopus 로고
    • Structural conservation of ion conduction pathways in K channel and glutamate receptors
    • Wood MW, van Dongen HMA, van Dongen AMJ (1995). Structural conservation of ion conduction pathways in K channel and glutamate receptors. Proc Natl Acad Sci USA 92 : 4882 4886.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4882-4886
    • Wood, M.W.1    Van Dongen, H.M.A.2    Van Dongen, A.M.J.3
  • 171
    • 0033551765 scopus 로고    scopus 로고
    • Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors
    • Yamakura T, Mihic SJ, Harris RA (1999). Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors. J Biol Chem 274 : 23006 23012.
    • (1999) J Biol Chem , vol.274 , pp. 23006-23012
    • Yamakura, T.1    Mihic, S.J.2    Harris, R.A.3
  • 172
    • 11444270685 scopus 로고    scopus 로고
    • Isoflurane modulation of neuronal nicotinic acetylcholine receptors expressed in human embryonic kidney cells
    • Yamashita M, Mori T, Nagata K, Yeh JZ, Narahashi T (2005). Isoflurane modulation of neuronal nicotinic acetylcholine receptors expressed in human embryonic kidney cells. Anesthesiology 102 : 76 84.
    • (2005) Anesthesiology , vol.102 , pp. 76-84
    • Yamashita, M.1    Mori, T.2    Nagata, K.3    Yeh, J.Z.4    Narahashi, T.5
  • 173
    • 66549105346 scopus 로고    scopus 로고
    • Glycine receptors contribute to hypnosis induced by ethanol
    • Ye JH, Sokol KA, Bhavsar U (2009). Glycine receptors contribute to hypnosis induced by ethanol. Alcohol Clin Exp Res 33 : 1069 1074.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 1069-1074
    • Ye, J.H.1    Sokol, K.A.2    Bhavsar, U.3
  • 174
    • 0032488831 scopus 로고    scopus 로고
    • Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position α267
    • Ye Q, Koltchine VV, Mihic SJ, Mascia MP, Wick MJ, Finn SE et al. (1998). Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position α267. J BiolChem 273 : 3314 3319.
    • (1998) J BiolChem , vol.273 , pp. 3314-3319
    • Ye, Q.1    Koltchine, V.V.2    Mihic, S.J.3    Mascia, M.P.4    Wick, M.J.5    Finn, S.E.6
  • 175
    • 0024390051 scopus 로고
    • 400 MHz two-dimensional nuclear overhauser spectroscopy on anesthetic interaction with lipid bilayer
    • Yokono S, Ogli K, Miura S, Ueda I (1989). 400 MHz two-dimensional nuclear overhauser spectroscopy on anesthetic interaction with lipid bilayer. Biochim Biophys Acta 982 : 300 302.
    • (1989) Biochim Biophys Acta , vol.982 , pp. 300-302
    • Yokono, S.1    Ogli, K.2    Miura, S.3    Ueda, I.4
  • 176
    • 0014849024 scopus 로고
    • Interaction between halothane and hydrostatic pressure
    • Youngson AF, MacDonald AG (1975). Interaction between halothane and hydrostatic pressure. Br J Anaesth 42 : 801 802.
    • (1975) Br J Anaesth , vol.42 , pp. 801-802
    • Youngson, A.F.1    MacDonald, A.G.2
  • 179
    • 68049133058 scopus 로고    scopus 로고
    • Mechanism of interaction between the general anesthetic halothane and a model ion channel protein, III: Molecular dynamics simulation incorporating a cyanophenylalanine spectroscopic probe
    • Zou H, Liu J, Blaise JK (2009). Mechanism of interaction between the general anesthetic halothane and a model ion channel protein, III: molecular dynamics simulation incorporating a cyanophenylalanine spectroscopic probe. Biophys J 96 : 4188 4199.
    • (2009) Biophys J , vol.96 , pp. 4188-4199
    • Zou, H.1    Liu, J.2    Blaise, J.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.