An isoflurane- and alcohol-insensitive mutant GABAA receptor α1 subunit with near-normal apparent affinity for GABA: Characterization in heterologous systems and production of knockin mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 1, 2006, Pages 208-218

  Borghese, C M ^a   Werner, D F ^b   Topf, N ^c   Baron, N V ^c   Henderson, L A ^a   Boehm II, S L ^d   Blednov, Y A ^a   Saad, A ^e   Dai, S ^e   Pearce, R A ^e   Harris, R A ^a   Homanics, G E ^b   Harrison, N L ^c  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d BINGHAMTON UNIVERSITY   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALANINE; ALCOHOL; HISTIDINE; INHALATION ANESTHETIC AGENT; ISOFLURANE; LEUCINE; SERINE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LINE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPERACTIVITY; KNOCKOUT MOUSE; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; WILD TYPE; XENOPUS LAEVIS;

ANIMALS; CELLS, CULTURED; ETHANOL; FEMALE; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; HUMANS; ISOFLURANE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MUTATION; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS; ZINC;

EID: 33749009598     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.104406     Document Type: Article

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