2-(3-Methyl-3H-diaziren-3-yl) ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: A derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels

Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2003, Pages 1257-1265

  Shaukat Husain, S ^a   Ziebell, Michael R ^b   Ruesch, Dirk ^a   Hong, Filbert ^b   Arevalo, Enrique ^a,b   Kosterlitz, Jonathan A ^a   Olsen, Richard W ^c   Forman, Stuart A ^a   Cohen, Jonathan B ^b   Miller, Keith W ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ACETYLCHOLINE; ANESTHETIC AGENT; AZIETOMIDATE [2 (3 METHYL 3H DIAZIREN 3 YL)ETHYL 1 (1 PHENYLETHYL) 1H IMIDAZOLE 5 CARBOXYLATE; AZIRINE DERIVATIVE; CONVULSANT AGENT; ETOMIDATE; ETOMIDATE 2 (3 METHYL 3H DIAZIREN 3 YL)ETHYL 1 (1 PHENYLETHYL) 1H IMIDAZOLE 5 CARBOXYLATE; IMIDAZOLE DERIVATIVE; ION CHANNEL; LIGAND; NICOTINIC RECEPTOR; TERT BUTYLBICYCLOPHOSPHOROTHIOATE S 35; TRITIUM; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; DESENSITIZATION; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; ION CURRENT; MEMBRANE BINDING; NONHUMAN; PHOTOAFFINITY LABELING; STEREOCHEMISTRY; STEREOSPECIFICITY; TADPOLE; TORPEDO;

ALLOSTERIC REGULATION; ANESTHETICS, GENERAL; ANIMALS; BINDING SITES; ETOMIDATE; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; IMIDAZOLES; ION CHANNEL GATING; LARVA; LIGANDS; MICE; OOCYTES; PATCH-CLAMP TECHNIQUES; PHOTOAFFINITY LABELS; RECEPTORS, GABA-A; RECEPTORS, NICOTINIC; REFLEX; STEREOISOMERISM; TORPEDO; XENOPUS;

EID: 0345269286     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020465v     Document Type: Article

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