Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane

Anesthesia and Analgesia

Volumn 109, Issue 6, 2009, Pages 1816-1822

  Rau, Vinuta ^a   Iyer, Sangeetha V ^b   Oh, Irene ^a   Chandra, Dev ^b   Harrison, Neil ^c   Eger, Edmond I ^a   Fanselow, Michael S ^d   Homanics, Gregg E ^b   Sonner, James M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A ALPHA 4 RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR; ISOFLURANE; UNCLASSIFIED DRUG;

AMNESIA; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DECLARATIVE MEMORY; FEAR; FEMALE; GENE INACTIVATION; HIPPOCAMPUS; HYPNOSIS; IMMOBILIZATION; KNOCKOUT MOUSE; MALE; MOUSE; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RIGHTING REFLEX; WILD TYPE;

EID: 73949111037     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3181bf6ae6     Document Type: Article

References (30)

1. Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci 2004;5:709-720
2. Campagna JA, Miller KW, Forman SA. Mechanisms of actions of inhaled anesthetics. N Engl J Med 2003;348:2110-2124
3. Eger EI II, Koblin DD, Harris RA, Kendig JJ, Pohorille A, Halsey MJ, Trudell JR. Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites. Anesth Analg 1997;84:915-918
4. Bonin RP, Orser BA. GABA(A) receptor subtypes underlying general anesthesia. Pharmacol Biochem Behav 2008;90:105-112
5. Sieghart W, Sperk G. Subunit composition, distribution and function of GABA(A) receptor subtypes. Curr Top Med Chem 2002;2:795-816
6. Farrant M, Nusser Z. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci 2005;6:215-229
7. Mody I, Pearce RA. Diversity of inhibitory neurotransmission through GABA(A) receptors. Trends Neurosci 2004;27:569-575
8. Sonner JM, Cascio M, Xing Y, Fanselow MS, Kralic JE, Morrow AL, Korpi ER, Hardy S, Sloat B, Eger EI II, Homanics GE. Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear. Mol Pharmacol 2005;68:61-68
9. Caraiscos VB, Newell JG, You-Ten KE, Elliott EM, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane. J Neurosci 2004;24:8454-8458
10. Belelli D, Peden DR, Rosahl TW, Wafford KA, Lambert JJ. Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics. J Neurosci 2005;25:11513-11520
11. Sun C, Sieghart W, Kapur J. Distribution of alpha1, alpha4, gamma2, and delta subunits of GABAA receptors in hippocampal granule cells. Brain Res 2004;1029:207-216
12. Khan ZU, Gutierrez A, Mehta AK, Miralles CP, De Blas AL. The alpha 4 subunit of the GABAA receptors from rat brain and retina. Neuropharmacology 1996;35:1315-1322
13. Sur C, Farrar SJ, Kerby J, Whiting PJ, Atack JR, McKernan RM. Preferential coassembly of alpha4 and delta subunits of the gamma-aminobutyric acidA receptor in rat thalamus. Mol Pharmacol 1999;56:110-115
14. Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE. GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc Natl Acad Sci USA 2006;103:15230-15235
15. Jia F, Yue M, Chandra D, Homanics GE, Goldstein PA, Harrison NL. Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus. J Pharmacol Exp Ther 2008;324:1127-1135
16. Fanselow MS. Conditioned and unconditional components of post-shock freezing. Pavlov J Biol Sci 1980;15:177-182
17. Fanselow MS. Neural organization of the defensive behavior system responsible for fear. Psychon Bull Rev 1994;1:429-438
18. Homanics GE, Ferguson C, Quinlan JJ, Daggett J, Snyder K, Lagenaur C, Mi ZP, Wang XH, Grayson DR, Firestone LL. Gene knockout of the alpha6 subunit of the gammaaminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol Pharmacol 1997;51:588-596
19. Waud D. On biologic assays involving quantal responses. J Pharmacol Exp Ther 1972;183:577-697
20. Alifimoff JK, Firestone LL, Miller KW. Anesthetic potencies of secondary alcohol enantiomers. Anesthesiology 1987;66:55-59
21. Mazze RI, Rice SA, Baden JM. Halothane, isoflurane, and enflurane MAC in pregnant and nonpregnant female and male mice and rats. Anesthesiology 1985;62:339-341
22. Flood P, Sonner JM, Gong D, Coates KM. Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex. Anesthesiology 2002;97:902-905
23. Maren S, Fanselow MS. The amygdala and fear conditioning: has the nut been cracked? Neuron 1996;16:237-240
24. Kim JJ, Fanselow MS. Modality-specific retrograde amnesia of fear. Science 1992;256:675-677
25. Phillips RG, LeDoux JE. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 1992;106:274-285
26. Prenosil GA, Schneider Gasser EM, Rudolph U, Keist R, Fritschy JM, Vogt KE. Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons. J Neurophysiol 2006;96:846-857
27. Nusser Z, Sieghart W, Somogyi P. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci 1998;18:1693-1703
28. Raines DE, Claycomb RJ, Forman SA. Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition. Anesth Analg 2003;96:112-118
29. Zhang Y, Sonner JM, Eger EI II, Stabernack CR, Laster MJ, Raines DE, Harris RA. Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane. Anesth Analg 2004;99:85-90
30. Kim J, Atherley R, Werner DF, Homanics GE, Carstens E, Antognini JF. Isoflurane depression of spinal nociceptive processing and minimum alveolar anesthetic concentration are not attenuated in mice expressing isoflurane resistant gamma-aminobutyric acid type-A receptors. Neurosci Lett 2007;420:209-212