Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics

Molecular Cell

Volumn 21, Issue 6, 2006, Pages 761-773

  Delivani, Petrina ^a   Adrain, Colin ^a   Taylor, Rebecca C ^a   Duriez, Patrick J ^a   Martin, Seamus J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN CED 9; PROTEIN EGL 1; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL FUSION; ENZYME REGULATION; HUMAN; HUMAN CELL; MAMMAL CELL; MITOCHONDRION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL LINE; CRICETINAE; CYTOCHROMES C; HUMANS; MEMBRANE PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REPRESSOR PROTEINS; TRANSFECTION;

MAMMALIA;

EID: 33644859410     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2006.01.034     Document Type: Article

References (25)

1. F. Chen, B.M. Hersh, B. Conradt, Z. Zhou, D. Riemer, Y. Gruenbaum, and H.R. Horvitz Translocation of Caenorhabditis elegans CED-4 to nuclear membranes during programmed cell death Science 287 2000 1485 1489
2. A.M. Chinnaiyan, K. O'Rourke, B.R. Lane, and V.M. Dixit Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death Science 275 1997 1122 1126
3. S. Cipolat, O. Martins de Brito, B. Dal Zilio, and L. Scorrano OPA1 requires mitofusin 1 to promote mitochondrial fusion Proc. Natl. Acad. Sci. USA 101 2004 15927 15932
4. A. Claude, and E.F. Fullam An electron microscope study of isolated mitochondria J. Exp. Med. 81 1945 51 65
5. T.J. Collins, M.J. Berridge, P. Lipp, and M.D. Bootman Mitochondria are morphologically and functionally heterogeneous within cells EMBO J. 21 2002 1616 1627
6. B. Conradt, and H.R. Horvitz The Caenorhabditis elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9 Cell 93 1998 519 529
7. S. Desagher, and J.C. Martinou Mitochondria as the central control point of apoptosis Trends Cell Biol. 10 2000 369 377
8. S. Frank, B. Gaume, E.S. Bergmann-Leitner, W.W. Leitner, E.G. Robert, F. Catez, C.L. Smith, and R.J. Youle The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis Dev. Cell 1 2001 515 525
9. M.O. Hengartner, R.E. Ellis, and H.R. Horvitz Caenorhabditis elegans gene ced-9 protects cells from programmed cell death Nature 356 1992 494 499
10. R. Jagasia, P. Grote, B. Westermann, and B. Conradt DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in Caenorhabditis elegans Nature 433 2005 754 760
11. D.I. James, P.A. Parone, Y. Mattenberger, and J.C. Martinou hFis1, a novel component of the mammalian mitochondrial fission machinery J. Biol. Chem. 278 2003 36373 36379
12. M. Karbowski, and R.J. Youle Dynamics of mitochondrial morphology in healthy cells and during apoptosis Cell Death Differ. 10 2003 870 880
13. M. Karbowski, Y.J. Lee, B. Gaume, S.Y. Jeong, S. Frank, A. Nechushtan, A. Santel, M. Fuller, C.L. Smith, and R.J. Youle Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis J. Cell Biol. 159 2002 931 938
14. T. Koshiba, S.A. Detmer, J.T. Kaiser, H. Chen, J.M. McCaffery, and D.C. Chan Structural basis of mitochondrial tethering by mitofusin complexes Science 305 2004 858 862
15. T. Kuwana, M.R. Mackey, G. Perkins, M.H. Ellisman, M. Latterich, R. Schneiter, D.R. Green, and D.D. Newmeyer Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane Cell 111 2002 331 342
16. Y.J. Lee, S.Y. Jeong, M. Karbowski, C.L. Smith, and R.J. Youle Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis Mol. Biol. Cell 15 2004 5001 5011
17. K. Moriishi, D.C. Huang, S. Cory, and J.M. Adams Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1 Proc. Natl. Acad. Sci. USA 96 1999 9683 9688
18. A. Nechushtan, C.L. Smith, I. Lamensdorf, S.H. Yoon, and R.J. Youle Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis J. Cell Biol. 153 2001 1265 1276
19. D.D. Newmeyer, and S. Ferguson-Miller Mitochondria: releasing power for life and unleashing the machineries of death Cell 112 2003 481 490
20. A. Olichon, L. Baricault, N. Gas, E. Guillou, A. Valette, P. Belenguer, and G. Lenaers Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis J. Biol. Chem. 278 2003 7743 7746
21. A. Santel, S. Frank, B. Gaume, M. Herrler, R.J. Youle, and M.T. Fuller Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells J. Cell Sci. 116 2003 2763 2774
22. L. Scorrano, M. Ashiya, K. Buttle, S. Weiler, S.A. Oakes, C.A. Mannella, and S.J. Korsmeyer A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis Dev. Cell 2 2002 55 67
23. A. Strasser The role of BH3-only proteins in the immune system Nat. Rev. Immunol. 5 2005 189 200
24. D.L. Vaux, I.L. Weissman, and S.K. Kim Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2 Science 258 1992 1955 1957
25. M.C. Wei, W.X. Zong, E.H. Cheng, T. Lindsten, V. Panoutsakopoulou, A.J. Ross, K.A. Roth, G.R. MacGregor, C.B. Thompson, and S.J. Korsmeyer Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death Science 292 2001 727 730