Molecular machinery of mitochondrial dynamics in yeast

Biological Chemistry

Volumn 388, Issue 9, 2007, Pages 917-926

  Merz, Sandra ^a   Hammermeister, Miriam ^a   Altmann, Katrin ^a   Dürr, Mark ^a   Westermann, Benedikt ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Actin cytoskeleton; Membrane division; Membrane fusion; Mitochondria; Organelle biogenesis; Saccharomyces cerevisiae

Indexed keywords

ACTIN;

APOPTOSIS; CELL DIFFERENTIATION; CELL DIVISION; CYTOSKELETON; EUKARYOTIC CELL; MEMBRANE FUSION; MITOCHONDRION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; YEAST;

MITOCHONDRIA; MITOCHONDRIAL PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 34547917607     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2007.110     Document Type: Review

References (108)

1. Aiken Hobbs, A.E., Srinivasan, M., McCaffery, J.M., and Jensen, R.E. (2001). Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. J. Cell Biol. 152, 401-410.
2. Altmann, K. and Westermann, B. (2005). Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Mol. Biol. Cell 16, 5410-5417.
3. Bereiter-Hahn, J. (1990). Behavior of mitochondria in the living cell. Int. Rev. Cytol. 122, 1-63.
4. Berger, K.L., Sogo, L.F., and Yaffe, M.P. (1997). Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J. Cell Biol. 136, 545-553.
5. Bleazard, W., McCaffery, J.M., King, E.J., Bale, S., Mozdy, A., Tieu, Q., Nunnari, J., and Shaw, J.M. (1999). The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat. Cell Biol. 1, 298-304.
6. Boldogh, I.R. and Pon, L.A. (2006). Interactions of mitochondria with the actin cytoskeleton. Biochim. Biophys. Acta 1763, 450-462.
7. Boldogh, I., Vojtov, N., Karmon, S., and Pon, L.A. (1998). Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. J. Cell Biol. 141, 1371-1381.
8. Boldogh, I.R., Yang, H.-C., Nowakowski, W.D., Karmon, S.L., Hays, L.G., Yates, J.R. III, and Pon, L.A. (2001). Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast. Proc. Natl. Acad. Sci. USA 98, 3162-3167.
9. Boldogh, I.R., Nowakowski, D.W., Yang, H.C., Chung, H., Karmon, S., Royes, P., and Pon, L.A. (2003). A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery. Mol. Biol. Cell 14, 4618-4627.
10. Boldogh, I.R., Ramcharan, S.L., Yang, H.C., and Pon, L.A. (2004). A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division. Mol. Biol. Cell 15, 3994-4002.
11. Burgess, S.M., Delannoy, M., and Jensen, R.E. (1994). MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J. Cell Biol. 126, 1375-1391.
12. Cerveny, K.L. and Jensen, R.E. (2003). The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria. Mol. Biol. Cell 14, 4126-4139.
13. Cerveny, K.L., McCaffery, J.M., and Jensen, R.E. (2001). Division of mitochondria requires a novel DNM1-interacting protein, Net2p. Mol. Biol. Cell 12, 309-321.
14. Cerveny, K.L., Studer, S.L., Jensen, R.E., and Sesaki, H. (2007). Yeast mitochondrial division and distribution require the cortical num1 protein. Dev. Cell 12, 363-375.
15. Chen, X.J. and Butow, R.A. (2005). The organization and inheritance of the mitochondrial genome. Nat. Rev. Genet. 6, 815-825.
16. Coonrod, E.M., Karren, M.A., and Shaw, J.M. (2007). Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion. Traffic 8, 500-511.
17. Dimmer, K.S., Fritz, S., Fuchs, F., Messerschmitt, M., Weinbach, N., Neupert, W., and Westermann, B. (2002). Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol. Biol. Cell 13, 847-853.
18. Dimmer, K.S., Jakobs, S., Vogel, F., Altmann, K., and Westermann, B. (2005). Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast. J. Cell Biol. 168, 103-115.
19. Drubin, D.G., Jones, H.D., and Wertman, K.F. (1993). Actin structure and function: roles in mitochondrial organization and morphogenesis in budding yeast and identification of the phalloidin binding site. Mol. Biol. Cell 4, 1277-1294.
20. Dürr, M., Escobar-Henriques, M., Merz, S., Geimer, S., Langer, T., and Westermann, B. (2006). Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast. Mol. Biol. Cell 17, 3745-3755.
21. Egner, A., Jakobs, S., and Hell, S.W. (2002). Fast 100 nm resolution 3D-microscope reveals structural plasticity of mitochondria in live yeast. Proc. Natl. Acad. Sci. USA 99, 3370-3375.
22. Escobar-Henriques, M., Westermann, B., and Langer, T. (2006). Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome- independent turnover of Fzo1. J. Cell Biol. 173, 645-650.
23. Fannjiang, Y., Cheng, W.C., Lee, S.J., Qi, B., Pevsner, J., Mc-Caffery, J.M., Hill, R.B., Basanez, G., and Hardwick, J.M. (2004). Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev. 18, 2785-2797.
24. Farkasovsky, M. and Küntzel, H. (1995). Yeast Num1p associates with the mother cell cortex during S/G2 phase and affects microtubular functions. J. Cell Biol. 131, 1003-1014.
25. Fehrenbacher, K.L., Yang, H.C., Gay, A.C., Huckaba, T.M., and Pon, L.A. (2004). Live cell imaging of mitochondrial movement along actin cables in budding yeast. Curr. Biol. 14, 1996-2004.
26. Fehrenbacher, K.L., Boldogh, I.R., and Pon, L.A. (2005). A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast. Mol. Biol. Cell 16, 5094-5102.
27. Fekkes, P., Shepard, K.A., and Yaffe, M.P. (2000). Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J. Cell Biol. 151, 333-340.
28. Frazier, A.E., Kiu, C., Stojanovski, D., Hoogenraad, N.J., and Ryan, M.T. (2006). Mitochondrial morphology and distribution in mammalian cells. Biol. Chem. 387, 1551-1558.
29. Frederick, R.L., McCaffery, J.M., Cunningham, K.W., Okamoto, K., and Shaw, J.M. (2004). Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J. Cell Biol. 167, 87-98.
30. Fritz, S., Rapaport, D., Klanner, E., Neupert, W., and Westermann, B. (2001). Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion. J. Cell Biol. 152, 683-692.
31. Fritz, S., Weinbach, N., and Westermann, B. (2003). Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. Mol. Biol. Cell 14, 2303-2313.
32. Fuchs, F., Prokisch, H., Neupert, W., and Westermann, B. (2002). Interaction of mitochondria with microtubules in the filamentous fungus Neurospora crassa. J. Cell Sci. 115, 1931-1937.
33. Garcia-Rodriguez, L.J., Gay, A.C., and Pon, L.A. (2007). Puf3p, a Pumilio family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeast. J. Cell Biol. 176, 197-207.
34. Gerber, A.P., Herschlag, D., and Brown, P.O. (2004). Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol. 2, E79.
35. Gorsich, S.W. and Shaw, J.M. (2004). Importance of mitochondrial dynamics during meiosis and sporulation. Mol. Biol. Cell 15, 4369-4381.
36. Griffin, E.E., Graumann, J., and Chan, D.C. (2005). The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. J. Cell Biol. 170, 237-248.
37. Hales, K.G. and Fuller, M.T. (1997). Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Cell 90, 121-129.
38. Heath-Engel, H.M. and Shore, G.C. (2006). Mitochondrial membrane dynamics, cristae remodelling and apoptosis. Biochim. Biophys. Acta 1763, 549-560.
39. Herlan, M., Vogel, F., Bornhövd, C., Neupert, W., and Reichert, A.S. (2003). Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J. Biol. Chem. 278, 27781-27788.
40. Herlan, M., Bornhövd, C., Hell, K., Neupert, W., and Reichert, A.S. (2004). Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. J. Cell Biol. 165, 167-173.
41. Hermann, G.J., King, E.J., and Shaw, J.M. (1997). The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton. J. Cell Biol. 137, 141-153.
42. Hermann, G.J., Thatcher, J.W., Mills, J.P., Hales, K.G., Fuller, M.T., Nunnari, J., and Shaw, J.M. (1998). Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J. Cell Biol. 143, 359-373.
43. Hoffmann, H.-P. and Avers, C.J. (1973). Mitochondrion of yeast: ultrastructural evidence for one giant, branched organelle per cell. Science 181, 749-750.
44. Honda, S. and Hirose, S. (2003). Stage-specific enhanced expression of mitochondrial fusion and fission factors during spermatogenesis in rat testis. Biochem. Biophys. Res. Commun. 311, 424-432.
45. Ingerman, E., Perkins, E.M., Marino, M., Mears, J.A., McCaffery, J.M., Hinshaw, J.E., and Nunnari, J. (2005). Dnm1 forms spirals that are structurally tailored to fit mitochondria. J. Cell Biol. 170, 1021-1027.
46. Itoh, T., Watabe, A., Toh-e, A., and Matsui, Y. (2002). Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae. Mol. Cell. Biol. 22, 7744-7757.
47. Itoh, T., Toh, E.A., and Matsui, Y. (2004). Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast. EMBO J. 23, 2520-2530.
48. Jakobs, S., Martini, N., Schauss, A.C., Egner, A., Westermann, B., and Hell, S.W. (2003). Spatial and temporal dynamics of budding yeast mitochondria lacking the division component Fis1p. J. Cell Sci. 116, 2005-2014.
49. Jones, B.A. and Fangman, W.L. (1992). Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin. Genes Dev. 6, 380-389.
50. Kondo-Okamoto, N., Shaw, J.M., and Okamoto, K. (2003). Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation. J. Biol. Chem. 278, 48997-49005.
51. Kondo-Okamoto, N., Ohkuni, K., Kitagawa, K., McCaffery, J.M., Shaw, J.M., and Okamoto, K. (2006). The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast. Mol. Biol. Cell 17, 3756-3767.
52. Koshiba, T., Detmer, S.A., Kaiser, J.T., Chen, H., McCaffery, J.M., and Chan, D.C. (2004). Structural basis of mitochondrial tethering by mitofusin complexes. Science 305, 858-862.
53. Labrousse, A.M., Zappaterra, M.D., Rube, D.A., and van der Bliek, A.M. (1999). C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol. Cell 4, 815-826.
54. Lazzarino, D.A., Boldogh, I., Smith, M.G., Rosand, J., and Pon, L.A. (1994). Yeast mitochondria contain ATP-sensitive, reversible actin-binding activity. Mol. Biol. Cell 5, 807-818.
55. Legesse-Miller, A., Massol, R.H., and Kirchhausen, T. (2003). Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. Mol. Biol. Cell 14, 1953-1963.
56. McQuibban, G.A., Saurya, S., and Freeman, M. (2003). Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature 423, 537-541.
57. Meeusen, S. and Nunnari, J. (2003). Evidence for a two membrane-spanning autonomous mitochondrial DNA replisome. J. Cell Biol. 163, 503-510.
58. Meeusen, S., McCaffery, J.M., and Nunnari, J. (2004). Mitochondrial fusion intermediates revealed in vitro. Science 305, 1747-1752.
59. Meeusen, S., DeVay, R., Block, J., Cassidy-Stone, A., Wayson, S., McCaffery, J.M., and Nunnari, J. (2006). Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1. Cell 127, 383-395.
60. Meisinger, C., Pfannschmidt, S., Rissler, M., Milenkovic, D., Becker, T., Stojanovski, D., Youngman, M.J., Jensen, R.E., Chacinska, A., Guiard, B., et al. (2007). The morphology proteins Mdm12/Mmm1 function in the major β-barrel assembly pathway of mitochondria. EMBO J. 26, 2229-2239.
61. Meisinger, C., Rissler, M., Chacinska, A., Szklarz, L.K., Milenkovic, D., Kozjak, V., Schönfisch, B., Lohaus, C., Meyer, H.E., Yaffe, M.P., et al. (2004). The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev. Cell 7, 61-71.
62. Meisinger, C., Wiedemann, N., Rissler, M., Strub, A., Milenkovic, D., Schönfisch, B., Müller, H., Kozjak, V., and Pfanner, N. (2006). Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10. J. Biol. Chem. 281, 22819-22826.
63. Messerschmitt, M., Jakobs, S., Vogel, F., Fritz, S., Dimmer, K.S., Neupert, W., and Westermann, B. (2003). The inner membrane protein Mdm33 controls mitochondrial morphology in yeast. J. Cell Biol. 160, 553-564.
64. Miyakawa, I., Aoi, H., Sando, N., and Kuroiwa, T. (1984). Fluorescence microscopic studies of mitochondrial nucleoids during meiosis and sporulation in the yeast, Saccharomyces cerevisiae. J. Cell Sci. 66, 21-38.
65. Mozdy, A., McCaffery, J.M., and Shaw, J.M. (2000). Dnm1p GTPase-mediated mitochondrial fusion is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol. 151, 367-379.
66. Mullins, R.D. and Pollard, T.D. (1999). Structure and function of the Arp2/3 complex. Curr. Opin. Struct. Biol. 9, 244-249.
67. Naylor, K., Ingerman, E., Okreglak, V., Marino, M., Hinshaw, J.E., and Nunnari, J. (2006). Mdv1 interacts with assembled Dnm1 to promote mitochondrial division. J. Biol. Chem. 281, 2177-2183.
68. Neutzner, A. and Youle, R.J. (2005). Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae. J. Biol. Chem. 280, 18598-18603.
69. Nunnari, J., Marshall, W.F., Straight, A., Murray, A., Sedat, J.W., and Walter, P. (1997). Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol. Biol. Cell 8, 1233-1242.
70. Okamoto, K. and Shaw, J.M. (2005). Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu. Rev. Genet. 39, 503-536.
71. Otsuga, D., Keegan, B.R., Brisch, E., Thatcher, J.W., Hermann, G.J., Bleazard, W., and Shaw, J.M. (1998). The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast. J. Cell Biol. 143, 333-349.
72. Parone, P.A. and Martinou, J.C. (2006). Mitochondrial fission and apoptosis: an ongoing trial. Biochim. Biophys. Acta 1763, 522-530.
73. Petroski, M.D. and Deshaies, R.J. (2005). Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 6, 9-20.
74. Pozniakovsky, A.I., Knorre, D.A., Markova, O.V., Hyman, A.A., Skulachev, V.P., and Severin, F.F. (2005). Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast. J. Cell Biol. 168, 257-269.
75. Praefcke, G.J. and McMahon, H.T. (2004). The dynamin superfamily: universal membrane tubulation and fission molecules? Nat. Rev. Mol. Cell Biol. 5, 133-147.
76. Prokisch, H., Neupert, W., and Westermann, B. (2000). Role of MMM1 in maintaining mitochondrial morphology in Neurospora crassa. Mol. Biol. Cell 11, 2961-2971.
77. Pruyne, D., Legesse-Miller, A., Gao, L., Dong, Y., and Bretscher, A. (2004). Mechanisms of polarized growth and organelle segregation in yeast. Annu. Rev. Cell Dev. Biol. 20, 559-591.
78. Rapaport, D., Brunner, M., Neupert, W., and Westermann, B. (1998). Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J. Biol. Chem. 273, 20150-20155.
79. Reck-Peterson, S.L., Provance, D.W. Jr., Mooseker, M.S., and Mercer, J.A. (2000). Class V myosins. Biochim. Biophys. Acta 1496, 36-51.
80. Rojo, M., Legros, F., Chateau, D., and Lombes, A. (2002). Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J. Cell Sci. 115, 1663-1674.
81. Sato, A., Nakada, K., and Hayashi, J. (2006). Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA. Biochim. Biophys. Acta 1763, 473-481.
82. Schauss, A.C., Bewersdorf, J., and Jakobs, S. (2006). Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface. J. Cell Sci. 119, 3098-3106.
83. Scheckhuber, C.Q., Erjavec, N., Tinazli, A., Hamann, A., Nyström, T., and Osiewacz, H.D. (2007). Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat. Cell Biol. 9, 99-105.
84. Sesaki, H. and Jensen, R.E. (1999). Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J. Cell Biol. 147, 699-706.
85. Sesaki, H. and Jensen, R.E. (2001). UGO1 encodes an outer membrane protein required for mitochondrial fusion. J. Cell Biol. 152, 1123-1134.
86. Sesaki, H. and Jensen, R.E. (2004). Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J. Biol. Chem. 279, 28298-28303.
87. Sesaki, H., Southard, S.M., Hobbs, A.E., and Jensen, R.E. (2003). Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion. Biochem. Biophys. Res. Commun. 308, 276-283.
88. Sesaki, H., Dunn, C.D., Iijima, M., Shepard, K.A., Yaffe, M.P., Machamer, C.E., and Jensen, R.E. (2006). Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J. Cell Biol. 173, 651-658.
89. Shepard, K.A. and Yaffe, M.P. (1999). The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. J. Cell Biol. 144, 711-720.
90. Simon, V.R., Karmon, S.L., and Pon, L.A. (1997). Mitochondrial inheritance: cell cycle and actin cable dependence of polarized mitochondrial movements in Saccharomyces cerevisiae. Cell Motil. Cytoskel. 37, 199-210.
91. Simon, V.R., Swayne, T.C., and Pon, L.A. (1995). Actin-dependent mitochondrial motility in mitotic yeast and cell-free systems: identification of a motor activity on the mitochondrial surface. J. Cell Biol. 130, 345-354.
92. Sogo, L.F. and Yaffe, M.P. (1994). Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J. Cell Biol. 130, 1361-1373.
93. Steinberg, G. and Schliwa, M. (1993). Organelle movements in the wild type and wall-less fzg3-1 mutants of Neurospora crassa are mediated by cytoplasmic microtubules. J. Cell Sci. 106, 555-564.
94. Stevens, B. (1981). Mitochondrial structure. In: The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance, E.W. Strathern, E.W. Jones and J.R. Broach, eds. (Cold Spring Harbor, NY, USA: Cold Spring Harbor Laboratory Press), pp. 471-504.
95. Stevens, J.M., Galyov, E.E., and Stevens, M.P. (2006). Actin-dependent movement of bacterial pathogens. Nat. Rev. Microbiol. 4, 91-101.
96. Stojanovski, D., Rissler, M., Pfanner, N., and Meisinger, C. (2006). Mitochondrial morphology and protein import - a tight connection? Biochim. Biophys. Acta 1763, 414-421.
97. 2+ signaling. Biochim. Biophys. Acta 1763, 442-449.
98. Tieu, Q. and Nunnari, J. (2000). Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. J. Cell Biol. 151, 353-365.
99. Tieu, Q., Okreglak, V., Naylor, K., and Nunnari, J. (2002). The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission. J. Cell Biol. 158, 445-452.
100. Visser, W., van Spronsen, E.A., Nanninga, N., Pronk, J.T., Gijs Kuenen, J., and van Dijken, J.P. (1995). Effects of growth conditions on mitochondrial morphology in Saccharomyces cerevisiae. Antonie Van Leeuwenhoek 67, 243-253.
101. Westermann, B. (2003). Mitochondrial membrane fusion. Biochim. Biophys. Acta 1641, 195-202.
102. Westermann, B. and Neupert, W. (2000). Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae. Yeast 16, 1421-1427.
103. Westermann, B. and Prokisch, H. (2002). Mitochondrial dynamics in filamentous fungi. Fungal Genet. Biol. 36, 91-97.
104. Wong, E.D., Wagner, J.A., Gorsich, S.W., McCaffery, J.M., Shaw, J.M., and Nunnari, J. (2000). The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J. Cell Biol. 151, 341-352.
105. Wong, E.D., Wagner, J.A., Scott, S.V., Okreglak, V., Holewinske, T.J., Cassidy-Stone, A., and Nunnari, J. (2003). The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion. J. Cell Biol. 160, 303-311.
106. Yaffe, M.P., Harata, D., Verde, F., Eddison, M., Toda, T., and Nurse, P. (1996). Microtubules mediate mitochondrial distribution in fission yeast. Proc. Natl. Acad. Sci. USA 93, 11664-11668.
107. Yang, H.C., Palazzo, A., Swayne, T.C., and Pon, L.A. (1999). A retention mechanism for distribution of mitochondria during cell division in budding yeast. Curr. Biol. 9, 1111-1114.
108. Youngman, M.J., Aiken Hobbs, A.E., Burgess, S.M., Srinivasan, M., and Jensen, R.E. (2004). Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids. J. Cell Biol. 164, 677-688.