메뉴 건너뛰기




Volumn 118, Issue 14, 2005, Pages 3049-3059

The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells

Author keywords

Apoptosis; Drp1; hFis1; Mitochondrial morphology; Mitofusin; shRNA

Indexed keywords

DYNAMIN; HYBRID PROTEIN; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; PROTEIN MTP18; RNA; UNCLASSIFIED DRUG;

EID: 23844539004     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02415     Document Type: Article
Times cited : (201)

References (47)
  • 3
    • 2142758117 scopus 로고    scopus 로고
    • Mitochondrial dynamics in mammals
    • Chen, H. and Chan, D. C. (2004). Mitochondrial dynamics in mammals. Curr. Top. Dev. Biol. 59, 119-144.
    • (2004) Curr. Top. Dev. Biol. , vol.59 , pp. 119-144
    • Chen, H.1    Chan, D.C.2
  • 4
    • 0037455575 scopus 로고    scopus 로고
    • Mitofusins Mfnl and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
    • Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E. and Chan, D. C. (2003). Mitofusins Mfnl and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 160, 189-200.
    • (2003) J. Cell Biol. , vol.160 , pp. 189-200
    • Chen, H.1    Detmer, S.A.2    Ewald, A.J.3    Griffin, E.E.4    Fraser, S.E.5    Chan, D.C.6
  • 5
    • 0037440004 scopus 로고    scopus 로고
    • Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA
    • Czauderna, F., Fechtner, M., Aygun, H., Arnold, W., Klippel, A., Giese, K. and Kaufmann, J. (2003). Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA. Nucleic Acids Res. 31, 670-682.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 670-682
    • Czauderna, F.1    Fechtner, M.2    Aygun, H.3    Arnold, W.4    Klippel, A.5    Giese, K.6    Kaufmann, J.7
  • 7
    • 3242677639 scopus 로고    scopus 로고
    • siRNAs: Applications in functional genomics and potential as therapeutics
    • Dorsett, Y. and Tuschl, T. (2004). siRNAs: applications in functional genomics and potential as therapeutics. Nat. Rev. Drug Discov. 3, 318-329.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 318-329
    • Dorsett, Y.1    Tuschl, T.2
  • 8
    • 0142058391 scopus 로고    scopus 로고
    • Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion
    • Eura, Y., Ishihara, N., Yokota, S. and Mihara, K. (2003). Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. J. Biochem. 134, 333-344.
    • (2003) J. Biochem. , vol.134 , pp. 333-344
    • Eura, Y.1    Ishihara, N.2    Yokota, S.3    Mihara, K.4
  • 9
    • 0036654694 scopus 로고    scopus 로고
    • A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth
    • Fantin, V. R., Berardi, M. J., Scorrano, L., Korsmeyer, S. J. and Leder, P. (2002). A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell 2, 29-42.
    • (2002) Cancer Cell , vol.2 , pp. 29-42
    • Fantin, V.R.1    Berardi, M.J.2    Scorrano, L.3    Korsmeyer, S.J.4    Leder, P.5
  • 11
    • 2542487188 scopus 로고    scopus 로고
    • Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1
    • Frieden, M., James, D., Castelbou, C., Danckaert, A., Martinou, J. C. and Demaurex, N. (2004). Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1. J. Biol. Chem. 279, 22704-22714.
    • (2004) J. Biol. Chem. , vol.279 , pp. 22704-22714
    • Frieden, M.1    James, D.2    Castelbou, C.3    Danckaert, A.4    Martinou, J.C.5    Demaurex, N.6
  • 12
    • 2442421118 scopus 로고    scopus 로고
    • Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria
    • Griparic, L., van der Wel, N. N., Orozco, I. J., Peters, P, J. and van der Bliek, A. M. (2004). Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria. J. Biol. Chem. 279, 18792-18798.
    • (2004) J. Biol. Chem. , vol.279 , pp. 18792-18798
    • Griparic, L.1    van der Wel, N.N.2    Orozco, I.J.3    Peters, P.J.4    van der Bliek, A.M.5
  • 13
    • 0031440879 scopus 로고    scopus 로고
    • Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase
    • Hales, K. G. and Fuller, M. T. (1997). Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Cell 90, 121-129.
    • (1997) Cell , vol.90 , pp. 121-129
    • Hales, K.G.1    Fuller, M.T.2
  • 14
    • 1542380494 scopus 로고    scopus 로고
    • Sumol conjugates mitochondrial substrates and participates in mitochondrial fission
    • Harder, Z., Zunino, R. and McBride, H. (2004). Sumol conjugates mitochondrial substrates and participates in mitochondrial fission. Curr. Biol. 14, 340-345.
    • (2004) Curr. Biol. , vol.14 , pp. 340-345
    • Harder, Z.1    Zunino, R.2    McBride, H.3
  • 15
    • 0042526632 scopus 로고    scopus 로고
    • Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA
    • Herlan, M., Vogel, F., Bornhovd, C., Neupert, W. and Reichert, A. S. (2003). Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J. Biol. Chem. 278, 27781-27788.
    • (2003) J. Biol. Chem. , vol.278 , pp. 27781-27788
    • Herlan, M.1    Vogel, F.2    Bornhovd, C.3    Neupert, W.4    Reichert, A.S.5
  • 16
    • 0141592470 scopus 로고    scopus 로고
    • hFis1, a novel component of the mammalian mitochondrial fission machinery
    • James, D. I., Parone, P. A., Mattenberger, Y. and Martinou, J. C. (2003). hFis1, a novel component of the mammalian mitochondrial fission machinery. J. Biol. Chem. 278, 36373-36379.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36373-36379
    • James, D.I.1    Parone, P.A.2    Mattenberger, Y.3    Martinou, J.C.4
  • 17
    • 0043166392 scopus 로고    scopus 로고
    • Dynamics of mitochondrial morphology in healthy cells and during apoptosis
    • Karbowski, M. and Youle, R. J. (2003). Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ. 10, 870-880.
    • (2003) Cell Death Differ. , vol.10 , pp. 870-880
    • Karbowski, M.1    Youle, R.J.2
  • 19
    • 0031708412 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
    • Klippel, A., Escobedo, M. A., Wachowicz, M. S., Apell, G., Brown, T. W., Giedlin, M. A., Kavanaugh, W. M. and Williams, L. T. (1998). Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol. Cell. Biol. 18, 5699-5711.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 5699-5711
    • Klippel, A.1    Escobedo, M.A.2    Wachowicz, M.S.3    Apell, G.4    Brown, T.W.5    Giedlin, M.A.6    Kavanaugh, W.M.7    Williams, L.T.8
  • 20
    • 0033231549 scopus 로고    scopus 로고
    • C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane
    • Labrousse, A. M., Zappaterra, M. D., Rube, D. A. and van der Bliek, A. M. (1999). C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol. Cell 4, 815-826.
    • (1999) Mol. Cell , vol.4 , pp. 815-826
    • Labrousse, A.M.1    Zappaterra, M.D.2    Rube, D.A.3    van der Bliek, A.M.4
  • 21
    • 0038700756 scopus 로고    scopus 로고
    • Mitochondrial membrane remodelling regulated by a conserved rhomboid protease
    • McQuibban, G. A., Saurya, S. and Freeman, M. (2003). Mitochondrial membrane remodelling regulated by a conserved rhomboid protease. Nature 423, 537-541.
    • (2003) Nature , vol.423 , pp. 537-541
    • McQuibban, G.A.1    Saurya, S.2    Freeman, M.3
  • 23
    • 0038024175 scopus 로고    scopus 로고
    • A fuzzy mitochondrial fusion apparatus comes into focus
    • Mozdy, A. D. and Shaw, J. M. (2003). A fuzzy mitochondrial fusion apparatus comes into focus. Nat. Rev. Mol. Cell Biol. 4, 468-478.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 468-478
    • Mozdy, A.D.1    Shaw, J.M.2
  • 24
    • 0034676096 scopus 로고    scopus 로고
    • Dnmlp GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p
    • Mozdy, A. D., McCaffery, J. M. and Shaw, J. M. (2000). Dnmlp GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J. Cell Biol. 151, 367-380.
    • (2000) J. Cell Biol. , vol.151 , pp. 367-380
    • Mozdy, A.D.1    McCaffery, J.M.2    Shaw, J.M.3
  • 25
    • 0030969942 scopus 로고    scopus 로고
    • Protein import into mitochondria
    • Neupert, W. (1997). Protein import into mitochondria. Annu. Rev. Biochem. 66, 863-917.
    • (1997) Annu. Rev. Biochem. , vol.66 , pp. 863-917
    • Neupert, W.1
  • 27
    • 0037424239 scopus 로고    scopus 로고
    • Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
    • Olichon, A., Baricault, L., Gas, N., Guillou, E., Valette, A., Belenguer, P. and Lenaers, G. (2003). Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J. Biol. Chem. 278, 7743-7746.
    • (2003) J. Biol. Chem. , vol.278 , pp. 7743-7746
    • Olichon, A.1    Baricault, L.2    Gas, N.3    Guillou, E.4    Valette, A.5    Belenguer, P.6    Lenaers, G.7
  • 28
    • 0032734577 scopus 로고    scopus 로고
    • The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells
    • Pitts, K. R., Yoon, Y., Krueger, E. W. and McNiven, M. A. (1999). The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. Mol. Biol. Cell 10, 4403-4417.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 4403-4417
    • Pitts, K.R.1    Yoon, Y.2    Krueger, E.W.3    McNiven, M.A.4
  • 29
    • 0035057837 scopus 로고    scopus 로고
    • Control of mitochondrial morphology by a human mitofusin
    • Santel, A. and Fuller, M. T. (2001). Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 114, 867-874.
    • (2001) J. Cell Sci. , vol.114 , pp. 867-874
    • Santel, A.1    Fuller, M.T.2
  • 30
    • 0038783254 scopus 로고    scopus 로고
    • Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells
    • Santel, A., Frank, S., Gaume, B., Herrler, M., Youle, R. J. and Fuller, M. T. (2003). Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J. Cell Sci. 116, 2763-2774.
    • (2003) J. Cell Sci. , vol.116 , pp. 2763-2774
    • Santel, A.1    Frank, S.2    Gaume, B.3    Herrler, M.4    Youle, R.J.5    Fuller, M.T.6
  • 31
    • 0037427529 scopus 로고    scopus 로고
    • Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria
    • Satoh, M., Hamamoto, T., Seo, N., Kagawa, Y. and Endo, H. (2003). Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria. Biochem. Biophys. Res. Com. 300, 482-493.
    • (2003) Biochem. Biophys. Res. Com. , vol.300 , pp. 482-493
    • Satoh, M.1    Hamamoto, T.2    Seo, N.3    Kagawa, Y.4    Endo, H.5
  • 32
  • 33
    • 0041765777 scopus 로고    scopus 로고
    • Staying in aerobic shape: How the structural integrity of mitochondria and mitochondrial DNA is maintained
    • Scott, S. V., Cassidy-Stone, A., Meeusen, S. L. and Nunnari, J. (2003). Staying in aerobic shape: how the structural integrity of mitochondria and mitochondrial DNA is maintained. Curr. Opin. Cell Biol. 15, 482-488.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 482-488
    • Scott, S.V.1    Cassidy-Stone, A.2    Meeusen, S.L.3    Nunnari, J.4
  • 34
    • 0033571410 scopus 로고    scopus 로고
    • Division versus fusion: Dnmlp and Fzolp antagonistically regulate mitochondrial shape
    • Sesaki, H. and Jensen, R. E. (1999). Division versus fusion: Dnmlp and Fzolp antagonistically regulate mitochondrial shape. J. Cell Biol. 147, 699-706.
    • (1999) J. Cell Biol. , vol.147 , pp. 699-706
    • Sesaki, H.1    Jensen, R.E.2
  • 35
    • 0036536714 scopus 로고    scopus 로고
    • Mitochondrial dynamics and division in budding yeast
    • Shaw, J. M. and Nunnari, J. (2002). Mitochondrial dynamics and division in budding yeast. Trends Cell Biol. 12, 178-184.
    • (2002) Trends Cell Biol. , vol.12 , pp. 178-184
    • Shaw, J.M.1    Nunnari, J.2
  • 36
    • 0037213559 scopus 로고    scopus 로고
    • Mammalian RNAi for the masses
    • Shi, Y. (2003). Mammalian RNAi for the masses. Trends Genet. 19, 9-12.
    • (2003) Trends Genet. , vol.19 , pp. 9-12
    • Shi, Y.1
  • 37
    • 0032547754 scopus 로고    scopus 로고
    • A human dynamin-related protein controls the distribution of mitochondria
    • Smirnova, E., Shurland, D. L., Ryazantsev, S. N. and van der Bliek, A. M. (1998). A human dynamin-related protein controls the distribution of mitochondria. J. Cell Biol. 143, 351-358.
    • (1998) J. Cell Biol. , vol.143 , pp. 351-358
    • Smirnova, E.1    Shurland, D.L.2    Ryazantsev, S.N.3    van der Bliek, A.M.4
  • 38
    • 0035166814 scopus 로고    scopus 로고
    • Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
    • Smirnova, E., Griparic, L., Shurland, D. L. and van der Bliek, A. M. (2001). Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol. Biol. Cell 12, 2245-2256.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2245-2256
    • Smirnova, E.1    Griparic, L.2    Shurland, D.L.3    van der Bliek, A.M.4
  • 39
    • 1842479419 scopus 로고    scopus 로고
    • Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology
    • Stojanovski, D., Koutsopoulos, O. S., Okamoto, K. and Ryan, M. T. (2004). Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. J. Cell Sci. 117, 1201-1210.
    • (2004) J. Cell Sci. , vol.117 , pp. 1201-1210
    • Stojanovski, D.1    Koutsopoulos, O.S.2    Okamoto, K.3    Ryan, M.T.4
  • 40
    • 0242579164 scopus 로고    scopus 로고
    • The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle
    • Suzuki, M., Jeong, S. Y., Karbowski, M., Youle, R. J. and Tjandra, N. (2003). The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J. Mol. Biol. 334, 445-458.
    • (2003) J. Mol. Biol. , vol.334 , pp. 445-458
    • Suzuki, M.1    Jeong, S.Y.2    Karbowski, M.3    Youle, R.J.4    Tjandra, N.5
  • 41
    • 0034676101 scopus 로고    scopus 로고
    • Mdvlp is a WD repeat protein that interacts with the dynamin-related GTPase, Dnmlp, to trigger mitochondrial division
    • Tieu, Q. and Nunnari, J. (2000). Mdvlp is a WD repeat protein that interacts with the dynamin-related GTPase, Dnmlp, to trigger mitochondrial division. J. Cell Biol. 151, 353-366.
    • (2000) J. Cell Biol. , vol.151 , pp. 353-366
    • Tieu, Q.1    Nunnari, J.2
  • 42
    • 0036322806 scopus 로고    scopus 로고
    • The WD repeat protein, Mdvlp, functions as a molecular adaptor by interacting with Dnmlp and Fis1p during mitochondrial fission
    • Tieu, Q., Okreglak, V., Naylor, K. and Nunnari, J. (2002). The WD repeat protein, Mdvlp, functions as a molecular adaptor by interacting with Dnmlp and Fis1p during mitochondrial fission. J. Cell Biol. 158, 445-452.
    • (2002) J. Cell Biol. , vol.158 , pp. 445-452
    • Tieu, Q.1    Okreglak, V.2    Naylor, K.3    Nunnari, J.4
  • 43
    • 3843125367 scopus 로고    scopus 로고
    • Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis
    • Tondera, D., Santel, A., Schwarzer, R., Dames, S., Giese, K., Klippel, A. and Kaufmann, J. (2004). Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis. J. Biol. Chem. 279, 31544-31555.
    • (2004) J. Biol. Chem. , vol.279 , pp. 31544-31555
    • Tondera, D.1    Santel, A.2    Schwarzer, R.3    Dames, S.4    Giese, K.5    Klippel, A.6    Kaufmann, J.7
  • 44
    • 0034676095 scopus 로고    scopus 로고
    • The dynamin-related GTPase, Mgmlp, is an intermembrane space protein required for maintenance of fusion competent mitochondria
    • Wong, E. D., Wagner, J. A., Gorsich, S. W., McCaffery, J. M., Shaw, J. M. and Nunnari, J. (2000). The dynamin-related GTPase, Mgmlp, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J. Cell Biol. 151, 341-352.
    • (2000) J. Cell Biol. , vol.151 , pp. 341-352
    • Wong, E.D.1    Wagner, J.A.2    Gorsich, S.W.3    McCaffery, J.M.4    Shaw, J.M.5    Nunnari, J.6
  • 45
    • 0037415638 scopus 로고    scopus 로고
    • The intramitochondrial dynamin-related GTPase, Mgmlp, is a component of a protein complex that mediates mitochondrial fusion
    • Wong, E. D., Wagner, J. A., Scott, S. V., Okreglak, V., Holewinske, T. J., Cassidy-Stone, A. and Nunnari, J. (2003). The intramitochondrial dynamin-related GTPase, Mgmlp, is a component of a protein complex that mediates mitochondrial fusion. J. Cell Biol. 160, 303-311.
    • (2003) J. Cell Biol. , vol.160 , pp. 303-311
    • Wong, E.D.1    Wagner, J.A.2    Scott, S.V.3    Okreglak, V.4    Holewinske, T.J.5    Cassidy-Stone, A.6    Nunnari, J.7
  • 46
    • 0043092647 scopus 로고    scopus 로고
    • The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1
    • Yoon, Y., Krueger, E. W., Oswald, B. J. and McNiven, M. A. (2003). The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol. Cell. Biol. 23, 5409-5420.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 5409-5420
    • Yoon, Y.1    Krueger, E.W.2    Oswald, B.J.3    McNiven, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.