Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization

Journal of Biological Chemistry

Volumn 280, Issue 26, 2005, Pages 25060-25070

  Neuspiel, Margaret ^a   Zunino, Rodolfo ^a   Gangaraju, Sandhya ^a   Rippstein, Peter ^a   McBride, Heidi ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELLS; ENZYME INHIBITION; FREE RADICALS; FUSION REACTIONS; HYDROLYSIS; MEMBRANES;

CELL DEATH; EUKARYOTES; MITOCHONDRIAL FUSION; NUCLEOTIDE EXCHANGE;

ENZYMES;

CYTOCHROME C; FREE RADICAL; GUANOSINE TRIPHOSPHATASE; MITOFUSIN 1; MITOFUSIN 2; MUTANT PROTEIN; NUCLEOTIDE; OUTER MEMBRANE PROTEIN; PROTEIN BAX; RADICAL; STAUROSPORINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CELL ORGANELLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME RELEASE; EUKARYOTE; HETEROKARYON; HYDROLYSIS; MEMBRANE FUSION; MITOCHONDRIAL MEMBRANE; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEADY STATE; STIMULATION; WILD TYPE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BINDING SITES; COS CELLS; CYTOCHROMES C; DNA, COMPLEMENTARY; FLUORESCENT DYES; FREE RADICALS; GENES, DOMINANT; GTP PHOSPHOHYDROLASES; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; STAUROSPORINE; TIME FACTORS; TRANSFECTION;

EUKARYOTA;

EID: 21644455319     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501599200     Document Type: Article

References (54)

1. Santel, A., and Fuller, M. T. (2001) J. Cell Sci. 114, 867-874
2. Rojo, M., Legros, F., Chateau, D., and Lombes, A. (2002) J. Cell Sci. 115, 1663-1674
3. Santel, A., Frank, S., Gaume, B., Herrler, M., Youle, R. J., and Fuller, M. T. (2003) J. Cell Sci. 116, 2763-2774
4. Legros, F., Lombes, A., Frachon, P., and Rojo, M. (2002) Mol. Biol. Cell 13, 4343-4354
5. Eura, Y., Ishihara, N., Yokota, S., and Mihara, K. (2003) J. Biochem. (Tokyo) 134, 333-344
6. Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., and Chan, D. C. (2003) J. Cell Biol. 160, 189-200
7. Koshiba, T., Detmer, S. A., Kaiser, J. T., Chen, H., McCaffery, J. M., and Chan, D. C. (2004) Science 305, 858-862
8. Fritz, S., Rapaport, D., Klanner, E., Neupert, W., and Westermann, B. (2001) J. Cell Biol. 152, 683-692
9. Ishihara, N., Eura, Y., and Mihara, K. (2004) J. Cell Sci. 117, 6535-6546
10. Cipolat, S., Martins de Brito, O., Dal Zilio, B., and Scorrano, L. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 15927-15932
11. Sesaki, H., and Jensen, R. E. (2001) J. Cell Biol. 152, 1123-1134
12. Wong, E. D., Wagner, J. A., Scott, S. V., Okreglak, V., Holewinske, T. J., Cassidy-Stone, A., and Nunnari, J. (2003) J. Cell Biol. 160, 303-311
13. Sesaki, H., and Jensen, R. E. (2004) J. Biol. Chem. 279, 28298-28303
14. Sesaki, H., Southard, S. M., Hobbs, A. E., and Jensen, R. E. (2003) Biochem. Biophys. Res. Commun. 308, 276-283
15. McQuibban, G. A., Saurya, S., and Freeman, M. (2003) Nature 423, 537-541
16. Herlan, M., Vogel, F., Bornhovd, C., Neupert, W., and Reichert, A. S. (2003) J. Biol. Chem. 278, 27781-27788
17. Fritz, S., Weinbach, N., and Westermann, B. (2003) Mol. Biol. Cell 14, 2303-2313
18. Dimmer, K. S., Fritz, S., Fuchs, F., Messerschmitt, M., Weinbach, N., Neupert, W., and Westermann, B. (2002) Mol. Biol. Cell 13, 847-853
19. Kijima, K., Numakura, C., Izumino, H., Umetsu, K., Nezu, A., Shiiki, T., Ogawa, M., Ishizaki, Y., Kitamura, T., Shozawa, Y., and Hayasaka, K. (2005) Hum. Genet. 116, 23-27
20. Zuchner, S., Mersiyanova, I. V., Muglia, M., Bissar-Tadmouri, N., Rochelle, J., Dadali, E. L., Zappia, M., Nelis, E., Patitucci, A., Senderek, J., Parman, Y., Evgrafov, O., Jonghe, P. D., Takahashi, Y., Tsuji, S., Pericak-Vance, M. A., Quattrone, A., Battologlu, E., Polyakov, A. V., Timmerman, V., Schroder, J. M., and Vance, J. M. (2004) Nat. Genet. 36, 449-451
21. Chen, K. H., Guo, X., Ma, D., Guo, Y., Li, Q., Yang, D., Li, P., Qiu, X., Wen, S., Xiao, R. P., and Tang, J. (2004) Nat. Cell Biol. 6, 872-883
22. Yoon, Y., Krueger, E. W., Oswald, B. J., and McNiven, M. A. (2003) Mol. Cell. Biol. 23, 5409-5420
23. James, D. I., Parone, P. A., Mattenberger, Y., and Martinou, J. C. (2003) J. Biol. Chem. 278, 36373-36379
24. Stojanovski, D., Koutsopoulos, O. S., Okamoto, K., and Ryan, M. T. (2004) J. Cell Sci. 117, 1201-1210
25. Lee, Y. J., Jeong, S. Y., Karbowski, M., Smith, C. L., and Youle, R. J. (2004) Mol. Biol. Cell 15, 5001-5011
26. Breckenridge, D. G., Stojanovic, M., Marcellus, R. C., and Shore, G. C. (2003) J. Cell Biol. 160, 1115-1127
27. Olichon, A., Baricault, L., Gas, N., Guillou, E., Valette, A., Belenguer, P., and Lenaers, G. (2003) J. Biol. Chem. 278, 7743-7746
28. Sugioka, R., Shimizu, S., and Tsujimoto, Y. (2004) J. Biol. Chem. 279, 52726-52734
29. Harder, Z., Zunino, R., and McBride, H. (2004) Curr. Biol. 14, 340-345
30. Christoforidis, S., and Zerial, M. (2001) Methods Enzymol. 329, 120-132
31. Barbacid, M. (1987) Annu. Rev. Biochem. 56, 779-827
32. Franken, S. M., Scheidig, A. J., Krengel, U., Rensland, H., Lautwein, A., Geyer, M., Scheffzek, K., Goody, R. S., Kalbitzer, H. R., and Pai, E. F. (1993) Biochemistry 32, 8411-8420
33. Futatsugi, N., and Tsuda, M. (2001) Biophys. J. 81, 3483-3488
34. Vetter, I. R., and Wittinghofer, A. (2001) Science 294, 1299-1304
35. Bucci, C., Parton, R. G., Mather, I. H., Stunnenberg, H., Simons, K., Hoflack, B., and Zerial, M. (1992) Cell 70, 715-728
36. Scheidig, A. J., Franken, S. M., Corrie, J. E., Reid, G. P., Wittinghofer, A., Pai, E. F., and Goody, R. S. (1995) J. Mol. Biol. 253, 132-150
37. Richter, M. F., Schwemmle, M., Herrmann, C., Wittinghofer, A., and Staeheli, P. (1995) J. Biol. Chem. 270, 13512-13517
38. Rybin, V., Ullrich, O., Rubino, M., Alexandrov, K., Simon, I., Seabra, M. C., Goody, R., and Zerial, M. (1996) Nature 383, 266-269
39. Simon, I., Zerial, M., and Goody, R. S. (1996) J. Biol. Chem. 271, 20470-20478
40. Karbowski, M., Lee, Y. J., Gaume, B., Jeong, S. Y., Frank, S., Nechushtan, A., Santel, A., Fuller, M., Smith, C. L., and Youle, R. J. (2002) J. Cell Biol. 159, 931-938
41. Desagher, S., Osen-Sand, A., Nichols, A., Eskes, R., Montessuit, S., Lauper, S., Maundrell, K., Antonsson, B., and Martinou, J. C. (1999) J. Cell Biol. 144, 891-901
42. Wei, M. C., Zong, W. X., Cheng, E. H., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., and Korsmeyer, S. J. (2001) Science 292, 727-730
43. Pavlov, E. V., Priault, M., Pietkiewicz, D., Cheng, E. H., Antonsson, B., Manon, S., Korsmeyer, S. J., Mannella, C. A., and Kinnally, K. W. (2001) J. Cell Biol. 155, 725-731
44. Yoon, Y., Pitts, K. R., and McNiven, M. A. (2001) Mol. Biol. Cell 12, 2894-2905
45. Smirnova, E., Shurland, D.-L., Ryazantsev, S. N., and van der Bliek, A. M. (1998) J. Cell Biol. 143, 351-358
46. Smirnova, E., Griparic, L., Shurland, D. L., and van Der Bliek, A. M. (2001) Mol. Biol. Cell 12, 2245-2256
47. Frank, S., Gaume, B., Bergmann-Leitner, E. S., Leitner, W. W., Robert, E. G., Catez, F., Smith, C. L., and Youle, R. J. (2001) Dev. Cell 1, 515-525
48. Collins, T. J., Berridge, M. J., Lipp, P., and Bootman, M. D. (2002) EMBO J. 21, 1616-1627
49. De Giorgi, F., Lartigue, L., and Ichas, F. (2000) Cell Calcium 28, 365-370
50. Huser, J., and Blatter, L. A. (1999) Biochem. J. 343, 311-317
51. Bach, D., Pich, S., Soriano, F. X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J. R., Lloberas, J., Camps, M., Zierath, J. R., Rabasa-Lhoret, R., Wallberg-Henriksson, H., Laville, M., Palacin, M., Vidal, H., Rivera, F., Brand, M., and Zorzano, A. (2003) J. Biol. Chem. 278, 17190-17197
52. Karbowski, M., Arnoult, D., Chen, H., Chan, D. C., Smith, C. L., and Youle, R. J. (2004) J. Cell Biol. 164, 493-499
53. Karbowski, M., and Youle, R. J. (2003) Cell Death Differ. 10, 870-880
54. Bossy-Wetzel, E., Barsoum, M. J., Godzik, A., Schwarzenbacher, R., and Lipton, S. A. (2003) Curr. Opin. Cell Biol. 15, 706-716