Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant

Nature Immunology

Volumn 7, Issue 8, 2006, Pages 843-850

  Lewis, Julia M ^a   Girardi, Michael ^a   Roberts, Scott J ^a   Barbee, Susannah D ^b   Hayday, Adrian C ^b   Tigelaar, Robert E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL SELECTION; CONTROLLED STUDY; DENDRITIC CELL; EPIDERMIS CELL; GENETIC DISORDER; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SKIN DISEASE; SKIN EPITHELIUM; STEM CELL; STROMA; T LYMPHOCYTE; THYMUS;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; DENDRITIC CELLS; FLOW CYTOMETRY; MICE; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SKIN; STEM CELLS; STROMAL CELLS; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 33746178062     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1363     Document Type: Article

References (50)

1. Hayday, A., Theodoridis, E., Ramsburg, E. & Shires, J. Intraepithelial lymphocytes: Exploring the Third Way in immunology. Nat. Immunol. 2, 997-1003 (2001).
2. Born, W. et al. Immunoregulatory functions of γδ T cells. Adv. Immunol. 71, 77-144 (1999).
3. Hayday, A. & Tigelaar, R. Immunoregulation in the tissues by γδ T cells. Nat. Rev. Immunol. 3, 233-242 (2003).
4. Rocha, B., Guy-Grand, D. & Vassalli, P. Extrathymic T cell differentiation. Curr. Opin. Immunol. 7, 235-242 (1995).
5. + cells. Science 305, 248-251 (2004).
6. Lambolez, F. et al. The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs. Nat. Immunol. 7, 76-82 (2006).
7. + dendritic epidermal cells. Cell 55, 837-847 (1988).
8. Mallick-Wood, C.A. et al. Conservation of T cell receptor conformation in epidermal 2cδ cells with disrupted primary Vγ gene usage. Science 279, 1729-1733 (1998).
9. Janeway, C.A., Jr., Jones, B. & Hayday, A. Specificity and function of T cells bearing γδ receptors. Immunol. Today 9, 73-76 (1988).
10. + T cells are positively selected in the thymus by agonist self-peptides. Immunity 16, 355-364 (2002).
11. Yamagata, T., Mathis, D. & Benoist, C. Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells. Nat. Immunol. 5, 597-605 (2004).
12. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001).
13. Asarnow, D.M., Cado, D. & Raulet, D.H. Selection is not required to produce invariant T-cell receptor γ-gene junctional sequences. Nature 361, 158-160 (1993).
14. Itohara, S. et al. T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes. Cell 72, 337-348 (1993).
15. Kyes, S., Pao, W. & Hayday, A. Influence of site of expression on the fetal γδ T-cell receptor repertoire. Proc. Natl. Acad. Sci. USA 88, 7830-7833 (1991).
16. Passoni, L. et al. Intrathymic delta selection events in γδ cell development. Immunity 7, 83-95 (1997).
17. Ferrero, I., Wilson, A., Beermann, F., Held, W. & MacDonald, H.R. T cell receptor specificity is critical for the development of epidermal γβ T cells. J. Exp. Med. 194, 1473-1483 (2001).
18. Xiong, N., Kang, C. & Raulet, D.H. Positive selection of dendritic epidermal γδ T cell precursors in the fetal thymus determines expression of skin-homing receptors. Immunity 21, 121-131 (2004).
19. Tigelaar, R.E. & Lewis, J.M. Immunobiology of mouse dendritic epidermal T cells: A decade later, some answers, but still more questions. J. Invest. Dermatol. 105, 43S-49S (1995).
20. Hara, H. et al. Development of dendritic epidermal T cells with a skewed diversity of γδ TCRs in Vδ1-deficient mice. J. Immunol. 165, 3695-3705 (2000).
21. Moore, T.A., von Freeden-Jeffry, U., Murray, R. & Zlotnik, A. Inhibition of γδ T cell development and early thymocyte maturation in IL-7-/- mice. J. Immunol. 157, 2366-2373 (1996).
22. De Creus, A. et al. Developmental and functional defects of thymic and epidermal Vγ3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice. J. Immunol. 168, 6486-6493 (2002).
23. + T cells to different stages of chemically induced skin cancer. J. Exp. Med. 198, 747-755 (2003).
24. Girardi, M. et al. Resident skin-specific γδ T cells provide local, nonredundant regulation of cutaneous inflammation. J. Exp. Med. 195, 855-867 (2002).
25. Girardi, M., Lewis, J.M., Filler, R.B., Hayday, A.C. & Tigelaar, R.E. Environmentally responsive and reversible regulation of epidermal barrier function by γδ T cells. J. Invest. Dermatol. 126, 808-814 (2006).
26. Bauer, S. et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285, 727-729 (1999).
27. Dandekar, A.A., O'Malley, K. & Perlman, S. Important roles for γ interferon and NKG2D in γδ T-cell-induced demyelination in T-cell receptor β-deficient mice infected with a coronavirus. J. Virol. 79, 9388-9396 (2005).
28. Nitahara, A. et al. NKG2D ligation without T cell receptor engagement triggers both cytotoxicity and cytokine production in dendritic epidermal T cells. J. Invest. Dermatol. 126, 1052-1058 (2006).
29. + dendritic epidermal cells of adult mice from fetal thymic precursors. Nature 344, 68-70 (1990).
30. + fetal murine thymocytes home to the skin and give rise to proliferating dendritic epidermal T cells. J. Immunol. 146, 2536-2543 (1991).
31. Ikuta, K. et al. A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 62, 863-874 (1990).
32. Leclercq, G., Plum, J., Nandi, D., De Smedt, M. & Allison, J.P. Intrathymic differentiation of Vγ3 T cells. J. Exp. Med. 178, 309-315 (1993).
33. Tatsumi, Y., Pena, J.C., Matis, L., Deluca, D. & Bluestone, J.A. Development of T cell receptor-γδ cells. Phenotypic and functional correlations of T cell receptor-γδ thymocyte maturation. J. Immunol. 151, 3030-3041 (1993).
34. Van Beneden, K. et al. Expression of inhibitory receptors Ly49E and CD94/ NKG2 on fetal thymic and adult epidermal TCR Vγ3 lymphocytes. J. Immunol. 168, 3295-3302 (2002).
35. Girardi, M. & Hayday, A.C. Immunosurveillance by γδ T cells: Focus on the murine system. Chem. Immunol. Allergy 86, 136-150 (2005).
36. Kabelitz, D., Marischen, L., Oberg, H.H., Holtmeier, W. & Wesch, D. Epithelial defence by γδ T cells. Int. Arch. Allergy Immunol. 137, 73-81 (2005).
37. Kronenberg, M. & Rudensky, A. Regulation of immunity by self-reactive T cells. Nature 435, 598-604 (2005).
38. Wang, H. & Clarks, S.H. Positive selection focuses the VH12 B-cell repertoire towards a single B1 specificity with survival function. Immunol. Rev. 197, 51-59 (2004).
39. Montecino-Rodriguez, E., Leathers, H. & Dorshkind, K. Identification of a B-1 B cell-specified progenitor. Nat. Immunol. 7, 293-301 (2006).
40. Baumgarth, N., Tung, J.W. & Herzenberg, L.A. Inherent specificities in natural antibodies: A key to immune defense against pathogen invasion. Springer Semin. Immunopathol. 26, 347-362 (2005).
41. Parker, W. et al. Specificity and function of 'natural' antibodies in immunodeficient subjects: Clues to B cell lineage and development. J. Clin. Immunol. 17, 311-321 (1997).
42. Paloczi, K., Batai, A., Gopcsa, L., Ezsi, R. & Petranyi, G.G. Immunophenotypic characterisation of cord blood B-lymphocytes. Bone Marrow Transplant 4, S89-S91 (1998).
43. Pereira, P., Gerber, D., Huang, S.Y. & Tonegawa, S. Ontogenic development and tissue distribution of Vγ1-expressing γδ T lymphocytes in normal mice. J. Exp. Med. 182, 1921-1930 (1995).
44. Goodman, T., LeCorre, R. & Lefrancois, L. A T-cell receptor γδ-specific monoclonal antibody detects a Vγ5 region polymorphism. Immunogenetics 35, 65-68 (1992).
45. + γδ T cells elicited by inflammation. J. Leukoc. Biol. 75, 68-75 (2004).
46. Itohara, S. et al. Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia. Nature 343, 754-757 (1990).
47. Findly, R.C., Roberts, S.J. & Hayday, A.C. Dynamic response of murine gut intraepithelial T cells after infection by the coccidian parasite Eimeria. Eur. J. Immunol. 23, 2557-2564 (1993).
48. Jenkinson, E.J. & Owen, J.J. T-cell differentiation in thymus organ cultures. Semin. Immunol. 2, 51-58 (1990).
49. Jenkinson, E.J., Anderson, G. & Owen, J.J. Studies on T cell maturation on defined thymic stromal cell populations in vitro. J. Exp. Med. 176, 845-853 (1992).
50. Goldman, J.P., Spencer, D.M. & Raulet, D.H. Ordered rearrangement of variable region genes of the T cell receptor γ locus correlates with transcription at the unrearranged genes. J. Exp. Med. 177, 729-739 (1993).