메뉴 건너뛰기




Volumn 17, Issue 2, 2005, Pages 108-115

γδ T cell development - Having the strength to get there

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN;

EID: 14844334134     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.01.009     Document Type: Review
Times cited : (63)

References (70)
  • 1
    • 0029877562 scopus 로고    scopus 로고
    • Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice
    • W.R. Waters, and J.A. Harp Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice Infect Immun 64 1996 1854 1857
    • (1996) Infect Immun , vol.64 , pp. 1854-1857
    • Waters, W.R.1    Harp, J.A.2
  • 3
    • 0242442687 scopus 로고    scopus 로고
    • Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite
    • E. Ramsburg, R. Tigelaar, J. Craft, and A. Hayday Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite J Exp Med 198 2003 1403 1414
    • (2003) J Exp Med , vol.198 , pp. 1403-1414
    • Ramsburg, E.1    Tigelaar, R.2    Craft, J.3    Hayday, A.4
  • 4
    • 0037363585 scopus 로고    scopus 로고
    • Immunoregulation in the tissues by gammadelta T cells
    • A. Hayday, and R. Tigelaar Immunoregulation in the tissues by gammadelta T cells Nat Rev Immunol 3 2003 233 242
    • (2003) Nat Rev Immunol , vol.3 , pp. 233-242
    • Hayday, A.1    Tigelaar, R.2
  • 5
    • 0029864606 scopus 로고    scopus 로고
    • Gamma/delta and other unconventional T lymphocytes: What do they see and what do they do?
    • S.H. Kaufmann gamma/delta and other unconventional T lymphocytes: what do they see and what do they do? Proc Natl Acad Sci USA 93 1996 2272 2279
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2272-2279
    • Kaufmann, S.H.1
  • 6
    • 0035162229 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes: Exploring the Third Way in immunology
    • A. Hayday, E. Theodoridis, E. Ramsburg, and J. Shires Intraepithelial lymphocytes: exploring the Third Way in immunology Nat Immunol 2 2001 997 1003
    • (2001) Nat Immunol , vol.2 , pp. 997-1003
    • Hayday, A.1    Theodoridis, E.2    Ramsburg, E.3    Shires, J.4
  • 10
    • 0023872328 scopus 로고
    • Specificity and function of T cells bearing gamma delta receptors
    • C.A. Janeway Jr., B. Jones, and A. Hayday Specificity and function of T cells bearing gamma delta receptors Immunol Today 9 1988 73 76
    • (1988) Immunol Today , vol.9 , pp. 73-76
    • Janeway Jr., C.A.1    Jones, B.2    Hayday, A.3
  • 12
    • 0034091286 scopus 로고    scopus 로고
    • [gamma][delta] cells: A right time and a right place for a conserved third way of protection
    • A.C. Hayday [gamma][delta] cells: a right time and a right place for a conserved third way of protection Annu Rev Immunol 18 2000 975 1026
    • (2000) Annu Rev Immunol , vol.18 , pp. 975-1026
    • Hayday, A.C.1
  • 13
    • 0025062703 scopus 로고
    • A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells
    • K. Ikuta, T. Kina, I. MacNeil, N. Uchida, B. Peault, Y.H. Chien, and I.L. Weissman A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells Cell 62 1990 863 874
    • (1990) Cell , vol.62 , pp. 863-874
    • Ikuta, K.1    Kina, T.2    MacNeil, I.3    Uchida, N.4    Peault, B.5    Chien, Y.H.6    Weissman, I.L.7
  • 14
    • 0025171303 scopus 로고
    • A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: Evidence for controlled gene rearrangement and cytokine production
    • M.S. Krangel, H. Yssel, C. Brocklehurst, and H. Spits A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production J Exp Med 172 1990 847 859
    • (1990) J Exp Med , vol.172 , pp. 847-859
    • Krangel, M.S.1    Yssel, H.2    Brocklehurst, C.3    Spits, H.4
  • 15
    • 0033233269 scopus 로고    scopus 로고
    • Generation of human gammadelta T-cell repertoires
    • L.D. McVay, and S.R. Carding Generation of human gammadelta T-cell repertoires Crit Rev Immunol 19 1999 431 460
    • (1999) Crit Rev Immunol , vol.19 , pp. 431-460
    • McVay, L.D.1    Carding, S.R.2
  • 16
    • 4043114178 scopus 로고    scopus 로고
    • Early expression of a functional TCRbeta chain inhibits TCRgamma gene rearrangements without altering the frequency of TCRgammadelta lineage cells
    • D. Gerber, L. Boucontet, and P. Pereira Early expression of a functional TCRbeta chain inhibits TCRgamma gene rearrangements without altering the frequency of TCRgammadelta lineage cells J Immunol 173 2004 2516 2523 Mice expressing a rearranged TCRβ, TCRγ and TCRδ transgene in thymic precursors generate similar numbers of αβ cells as TCRβ-only transgenic mice, and similar numbers of γδ cells as TCRγ or TCRδ transgenic mice. The data suggest that γδ/αβ lineage determination displays a remarkable degree of TCR independence.
    • (2004) J Immunol , vol.173 , pp. 2516-2523
    • Gerber, D.1    Boucontet, L.2    Pereira, P.3
  • 17
    • 0035911172 scopus 로고    scopus 로고
    • Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling
    • J. Kang, A. Volkmann, and D.H. Raulet Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling J Exp Med 193 2001 689 698
    • (2001) J Exp Med , vol.193 , pp. 689-698
    • Kang, J.1    Volkmann, A.2    Raulet, D.H.3
  • 18
    • 0032441260 scopus 로고    scopus 로고
    • Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: Role of receptor-associated chains and locus accessibility
    • S.K. Durum, S. Candeias, H. Nakajima, W.J. Leonard, A.M. Baird, L.J. Berg, and K. Muegge Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility J Exp Med 188 1998 2233 2241
    • (1998) J Exp Med , vol.188 , pp. 2233-2241
    • Durum, S.K.1    Candeias, S.2    Nakajima, H.3    Leonard, W.J.4    Baird, A.M.5    Berg, L.J.6    Muegge, K.7
  • 19
    • 0035652459 scopus 로고    scopus 로고
    • The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation
    • S.K. Ye, Y. Agata, H.C. Lee, H. Kurooka, T. Kitamura, A. Shimizu, T. Honjo, and K. Ikuta The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation Immunity 15 2001 813 823
    • (2001) Immunity , vol.15 , pp. 813-823
    • Ye, S.K.1    Agata, Y.2    Lee, H.C.3    Kurooka, H.4    Kitamura, T.5    Shimizu, A.6    Honjo, T.7    Ikuta, K.8
  • 20
    • 0035794296 scopus 로고    scopus 로고
    • Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination
    • Y. Agata, T. Katakai, S.K. Ye, M. Sugai, H. Gonda, T. Honjo, K. Ikuta, and A. Shimizu Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination J Exp Med 193 2001 873 880
    • (2001) J Exp Med , vol.193 , pp. 873-880
    • Agata, Y.1    Katakai, T.2    Ye, S.K.3    Sugai, M.4    Gonda, H.5    Honjo, T.6    Ikuta, K.7    Shimizu, A.8
  • 23
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    • U. von Freeden-Jeffry, P. Vieira, L.A. Lucian, T. McNeil, S.E. Burdach, and R. Murray Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine J Exp Med 181 1995 1519 1526
    • (1995) J Exp Med , vol.181 , pp. 1519-1526
    • Von Freeden-Jeffry, U.1    Vieira, P.2    Lucian, L.A.3    McNeil, T.4    Burdach, S.E.5    Murray, R.6
  • 24
    • 2942516896 scopus 로고    scopus 로고
    • Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages
    • H.E. Porritt, L.L. Rumfelt, S. Tabrizifard, T.M. Schmitt, J.C. Zuniga-Pflucker, and H.T. Petrie Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages Immunity 20 2004 735 745
    • (2004) Immunity , vol.20 , pp. 735-745
    • Porritt, H.E.1    Rumfelt, L.L.2    Tabrizifard, S.3    Schmitt, T.M.4    Zuniga-Pflucker, J.C.5    Petrie, H.T.6
  • 26
  • 30
    • 0141816703 scopus 로고    scopus 로고
    • Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a gammadelta T-cell fate in fetal thymus organ culture
    • M. Garcia-Peydro, V.G. de Yebenes, and M.L. Toribio Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a gammadelta T-cell fate in fetal thymus organ culture Blood 102 2003 2444 2451
    • (2003) Blood , vol.102 , pp. 2444-2451
    • Garcia-Peydro, M.1    De Yebenes, V.G.2    Toribio, M.L.3
  • 31
    • 0033491635 scopus 로고    scopus 로고
    • Alpha beta/gamma delta lineage commitment in the thymus of normal and genetically manipulated mice
    • H.J. Fehling, S. Gilfillan, and R. Ceredig Alpha beta/gamma delta lineage commitment in the thymus of normal and genetically manipulated mice Adv Immunol 71 1999 1 76
    • (1999) Adv Immunol , vol.71 , pp. 1-76
    • Fehling, H.J.1    Gilfillan, S.2    Ceredig, R.3
  • 32
    • 2442522357 scopus 로고    scopus 로고
    • Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
    • Lck promoter was used to conditionally delete RBP-J at the pro-T cell-pre-T cell (DN2-DN3) transition. This led to an arrest in αβ T cell development at the DN3 stage, and γδ cell numbers increased twofold.
    • (2004) Immunity , vol.20 , pp. 611-622
    • Tanigaki, K.1    Tsuji, M.2    Yamamoto, N.3    Han, H.4    Tsukada, J.5    Inoue, H.6    Kubo, M.7    Honjo, T.8
  • 33
    • 0035979234 scopus 로고    scopus 로고
    • Presenilin-dependent gamma-secretase activity modulates thymocyte development
    • P. Doerfler, M.S. Shearman, and R.M. Perlmutter Presenilin-dependent gamma-secretase activity modulates thymocyte development Proc Natl Acad Sci USA 98 2001 9312 9317
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9312-9317
    • Doerfler, P.1    Shearman, M.S.2    Perlmutter, R.M.3
  • 34
    • 0036070308 scopus 로고    scopus 로고
    • Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta lineage thymocytes
    • A. Wolfer, A. Wilson, M. Nemir, H.R. MacDonald, and F. Radtke Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta lineage thymocytes Immunity 16 2002 869 879
    • (2002) Immunity , vol.16 , pp. 869-879
    • Wolfer, A.1    Wilson, A.2    Nemir, M.3    MacDonald, H.R.4    Radtke, F.5
  • 35
    • 0034671940 scopus 로고    scopus 로고
    • MHC recognition in thymic development: Distinct, parallel pathways for survival and lineage commitment
    • D. Chang, P. Valdez, T. Ho, and E. Robey MHC recognition in thymic development: distinct, parallel pathways for survival and lineage commitment J Immunol 165 2000 6710 6715
    • (2000) J Immunol , vol.165 , pp. 6710-6715
    • Chang, D.1    Valdez, P.2    Ho, T.3    Robey, E.4
  • 37
    • 0029311234 scopus 로고
    • Alpha beta and gamma delta T cells can share a late common precursor
    • E.C. Dudley, M. Girardi, M.J. Owen, and A.C. Hayday Alpha beta and gamma delta T cells can share a late common precursor Curr Biol 5 1995 659 669
    • (1995) Curr Biol , vol.5 , pp. 659-669
    • Dudley, E.C.1    Girardi, M.2    Owen, M.J.3    Hayday, A.C.4
  • 38
    • 0037306064 scopus 로고    scopus 로고
    • An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors
    • S.M. Hayes, E.W. Shores, and P.E. Love An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors Immunol Rev 191 2003 28 37 This review compares and contrasts subunit composition of TCRγδ, TCRαβ and the pre-TCR with emphasis on functional consequences. Furthermore, the authors report that reducing the signalling potential of TCRγδ in a TCRγδ transgenic strain, by replacement of the TCRζ chain with a mutant TCRζ chain lacking ITAM motifs, resulted in decreased generation of γδ cells, but increased production of αβ-committed thymocytes. A 'signalling potential' model for γδ/αβ lineage commitment is proposed.
    • (2003) Immunol Rev , vol.191 , pp. 28-37
    • Hayes, S.M.1    Shores, E.W.2    Love, P.E.3
  • 41
    • 0035335975 scopus 로고    scopus 로고
    • Early TCR alpha beta expression promotes maturation of T cells expressing Fc epsilon RI gamma containing TCR/CD3 complexes
    • K. Petersson, and F. Ivars Early TCR alpha beta expression promotes maturation of T cells expressing Fc epsilon RI gamma containing TCR/CD3 complexes J Immunol 166 2001 6616 6624
    • (2001) J Immunol , vol.166 , pp. 6616-6624
    • Petersson, K.1    Ivars, F.2
  • 43
    • 0034781509 scopus 로고    scopus 로고
    • P38 MAP kinase activity modulates alpha beta T cell development
    • T. Mulroy, and J. Sen p38 MAP kinase activity modulates alpha beta T cell development Eur J Immunol 31 2001 3056 3063
    • (2001) Eur J Immunol , vol.31 , pp. 3056-3063
    • Mulroy, T.1    Sen, J.2
  • 46
    • 0030273082 scopus 로고    scopus 로고
    • The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells
    • L. Bruno, H.J. Fehling, and H. von Boehmer The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells Immunity 5 1996 343 352
    • (1996) Immunity , vol.5 , pp. 343-352
    • Bruno, L.1    Fehling, H.J.2    Von Boehmer, H.3
  • 47
    • 0034698734 scopus 로고    scopus 로고
    • Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells
    • K. Terrence, C.P. Pavlovich, E.O. Matechak, and B.J. Fowlkes Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells J Exp Med 192 2000 537 548
    • (2000) J Exp Med , vol.192 , pp. 537-548
    • Terrence, K.1    Pavlovich, C.P.2    Matechak, E.O.3    Fowlkes, B.J.4
  • 48
    • 2942726387 scopus 로고    scopus 로고
    • Delayed and restricted expression limits putative instructional opportunities of Vgamma1.1/Vgamma2 gammadelta TCR in alphabeta/gammadelta lineage choice in the thymus
    • A. Krotkova, E. Smith, G. Nerz, I. Falk, and K. Eichmann Delayed and restricted expression limits putative instructional opportunities of Vgamma1.1/Vgamma2 gammadelta TCR in alphabeta/gammadelta lineage choice in the thymus J Immunol 173 2004 25 32 This study demonstrates the different kinetics of expression for TCRβ and TCRγδ proteins in early thymocyte differentiation. DN3 thymocytes express TCRβ, but not TCRγδ, and show no selection for in-frame TCRγ and TCRδ rearrangements. These data impose limits on the degree to which TCRγδ can compete with the pre-TCR for instructional opportunities.
    • (2004) J Immunol , vol.173 , pp. 25-32
    • Krotkova, A.1    Smith, E.2    Nerz, G.3    Falk, I.4    Eichmann, K.5
  • 49
    • 0036070307 scopus 로고    scopus 로고
    • Distinct structure and signaling potential of the gamma delta TCR complex
    • S.M. Hayes, and P.E. Love Distinct structure and signaling potential of the gamma delta TCR complex Immunity 16 2002 827 838
    • (2002) Immunity , vol.16 , pp. 827-838
    • Hayes, S.M.1    Love, P.E.2
  • 50
    • 0022289842 scopus 로고
    • Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats
    • K.A. Wharton, K.M. Johansen, T. Xu, and S. Artavanis-Tsakonas Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats Cell 43 1985 567 581
    • (1985) Cell , vol.43 , pp. 567-581
    • Wharton, K.A.1    Johansen, K.M.2    Xu, T.3    Artavanis-Tsakonas, S.4
  • 51
    • 0346496018 scopus 로고    scopus 로고
    • An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    • G. Eberl, S. Marmon, M.J. Sunshine, P.D. Rennert, Y. Choi, and D.R. Littman An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells Nat Immunol 5 2004 64 73
    • (2004) Nat Immunol , vol.5 , pp. 64-73
    • Eberl, G.1    Marmon, S.2    Sunshine, M.J.3    Rennert, P.D.4    Choi, Y.5    Littman, D.R.6
  • 52
    • 0033621534 scopus 로고    scopus 로고
    • A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule
    • M.P. Crowley, A.M. Fahrer, N. Baumgarth, J. Hampl, I. Gutgemann, L. Teyton, and Y. Chien A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule Science 287 2000 314 316
    • (2000) Science , vol.287 , pp. 314-316
    • Crowley, M.P.1    Fahrer, A.M.2    Baumgarth, N.3    Hampl, J.4    Gutgemann, I.5    Teyton, L.6    Chien, Y.7
  • 53
    • 0032590211 scopus 로고    scopus 로고
    • Autospecific gammadelta thymocytes that escape negative selection find sanctuary in the intestine
    • T. Lin, H. Yoshida, G. Matsuzaki, S.R. Guehler, K. Nomoto, T.A. Barrett, and D.R. Green Autospecific gammadelta thymocytes that escape negative selection find sanctuary in the intestine J Clin Invest 104 1999 1297 1305
    • (1999) J Clin Invest , vol.104 , pp. 1297-1305
    • Lin, T.1    Yoshida, H.2    Matsuzaki, G.3    Guehler, S.R.4    Nomoto, K.5    Barrett, T.A.6    Green, D.R.7
  • 54
    • 2942640089 scopus 로고    scopus 로고
    • Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells
    • T. Yamagata, D. Mathis, and C. Benoist Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells Nat Immunol 5 2004 597 605
    • (2004) Nat Immunol , vol.5 , pp. 597-605
    • Yamagata, T.1    Mathis, D.2    Benoist, C.3
  • 55
    • 0025828817 scopus 로고
    • Expression of a fetal gamma delta T-cell receptor in adult mice triggers a non-MHC-linked form of selective depletion
    • M. Iwashima, A. Green, M. Bonyhadi, M.M. Davis, J.P. Allison, and Y.H. Chien Expression of a fetal gamma delta T-cell receptor in adult mice triggers a non-MHC-linked form of selective depletion Int Immunol 3 1991 385 393
    • (1991) Int Immunol , vol.3 , pp. 385-393
    • Iwashima, M.1    Green, A.2    Bonyhadi, M.3    Davis, M.M.4    Allison, J.P.5    Chien, Y.H.6
  • 56
    • 0032513352 scopus 로고    scopus 로고
    • Conservation of T cell receptor conformation in epidermal gammadelta cells with disrupted primary Vgamma gene usage
    • C.A. Mallick-Wood, J.M. Lewis, L.I. Richie, M.J. Owen, R.E. Tigelaar, and A.C. Hayday Conservation of T cell receptor conformation in epidermal gammadelta cells with disrupted primary Vgamma gene usage Science 279 1998 1729 1733
    • (1998) Science , vol.279 , pp. 1729-1733
    • Mallick-Wood, C.A.1    Lewis, J.M.2    Richie, L.I.3    Owen, M.J.4    Tigelaar, R.E.5    Hayday, A.C.6
  • 57
    • 0034292340 scopus 로고    scopus 로고
    • Development of dendritic epidermal T cells with a skewed diversity of gamma delta TCRs in V delta 1-deficient mice
    • H. Hara, K. Kishihara, G. Matsuzaki, H. Takimoto, T. Tsukiyama, R.E. Tigelaar, and K. Nomoto Development of dendritic epidermal T cells with a skewed diversity of gamma delta TCRs in V delta 1-deficient mice J Immunol 165 2000 3695 3705
    • (2000) J Immunol , vol.165 , pp. 3695-3705
    • Hara, H.1    Kishihara, K.2    Matsuzaki, G.3    Takimoto, H.4    Tsukiyama, T.5    Tigelaar, R.E.6    Nomoto, K.7
  • 58
    • 0035914840 scopus 로고    scopus 로고
    • T cell receptor specificity is critical for the development of epidermal gammadelta T cells
    • I. Ferrero, A. Wilson, F. Beermann, W. Held, and H.R. MacDonald T cell receptor specificity is critical for the development of epidermal gammadelta T cells J Exp Med 194 2001 1473 1483
    • (2001) J Exp Med , vol.194 , pp. 1473-1483
    • Ferrero, I.1    Wilson, A.2    Beermann, F.3    Held, W.4    MacDonald, H.R.5
  • 59
    • 3142783640 scopus 로고    scopus 로고
    • Positive selection of dendritic epidermal gammadelta T cell precursors in the fetal thymus determines expression of skin-homing receptors
    • + DETCs express high levels of the chemokine receptor CCR10, whose ligand CCL27 is specifically expressed in fetal and adult skin.
    • (2004) Immunity , vol.21 , pp. 121-131
    • Xiong, N.1    Kang, C.2    Raulet, D.H.3
  • 60
    • 0036785499 scopus 로고    scopus 로고
    • T cell receptor-gamma allele-specific selection of V gamma 1/V delta 4 cells in the intestinal epithelium
    • K. Grigoriadou, L. Boucontet, and P. Pereira T cell receptor-gamma allele-specific selection of V gamma 1/V delta 4 cells in the intestinal epithelium J Immunol 169 2002 3736 3743
    • (2002) J Immunol , vol.169 , pp. 3736-3743
    • Grigoriadou, K.1    Boucontet, L.2    Pereira, P.3
  • 61
    • 0036533388 scopus 로고    scopus 로고
    • Gut intraepithelial lymphocyte development
    • D. Guy-Grand, and P. Vassalli Gut intraepithelial lymphocyte development Curr Opin Immunol 14 2002 255 259
    • (2002) Curr Opin Immunol , vol.14 , pp. 255-259
    • Guy-Grand, D.1    Vassalli, P.2
  • 62
    • 0036498878 scopus 로고    scopus 로고
    • Evidence for the extrathymic origin of intestinal TCRgammadelta(+) T cells in normal rats and for an impairment of this differentiation pathway in BB rats
    • S. Ramanathan, L. Marandi, and P. Poussier Evidence for the extrathymic origin of intestinal TCRgammadelta(+) T cells in normal rats and for an impairment of this differentiation pathway in BB rats J Immunol 168 2002 2182 2187
    • (2002) J Immunol , vol.168 , pp. 2182-2187
    • Ramanathan, S.1    Marandi, L.2    Poussier, P.3
  • 65
    • 0037415594 scopus 로고    scopus 로고
    • Extrathymic T cell lymphopoiesis: Ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice
    • D. Guy-Grand, O. Azogui, S. Celli, S. Darche, M.C. Nussenzweig, P. Kourilsky, and P. Vassalli Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice J Exp Med 197 2003 333 341
    • (2003) J Exp Med , vol.197 , pp. 333-341
    • Guy-Grand, D.1    Azogui, O.2    Celli, S.3    Darche, S.4    Nussenzweig, M.C.5    Kourilsky, P.6    Vassalli, P.7
  • 66
    • 0141920522 scopus 로고    scopus 로고
    • Extrathymic TCR gene rearrangement in human small intestine: Identification of new splice forms of recombination activating gene-1 mRNA with selective tissue expression
    • A. Bas, S.G. Hammarstrom, and M.L. Hammarstrom Extrathymic TCR gene rearrangement in human small intestine: identification of new splice forms of recombination activating gene-1 mRNA with selective tissue expression J Immunol 171 2003 3359 3371
    • (2003) J Immunol , vol.171 , pp. 3359-3371
    • Bas, A.1    Hammarstrom, S.G.2    Hammarstrom, M.L.3
  • 67
    • 3042720708 scopus 로고    scopus 로고
    • Thymic origin of intestinal alphabeta T Cells Revealed by Fate Mapping of RORgammat+ Cells
    • G. Eberl, and D.R. Littman Thymic origin of intestinal alphabeta T Cells Revealed by Fate Mapping of RORgammat+ Cells Science 305 2004 248 251
    • (2004) Science , vol.305 , pp. 248-251
    • Eberl, G.1    Littman, D.R.2
  • 68
    • 0022475348 scopus 로고
    • Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
    • J.S. Heilig, and S. Tonegawa Diversity of murine gamma genes and expression in fetal and adult T lymphocytes Nature 322 1986 836 840
    • (1986) Nature , vol.322 , pp. 836-840
    • Heilig, J.S.1    Tonegawa, S.2
  • 69
    • 0023043253 scopus 로고
    • Diversity, rearrangement, and expression of murine T cell gamma genes
    • R.D. Garman, P.J. Doherty, and D.H. Raulet Diversity, rearrangement, and expression of murine T cell gamma genes Cell 45 1986 733 742
    • (1986) Cell , vol.45 , pp. 733-742
    • Garman, R.D.1    Doherty, P.J.2    Raulet, D.H.3
  • 70
    • 13644251707 scopus 로고    scopus 로고
    • Lymphotoxin-mediated regulation of γδ cell differentiation by αβ T cell progenitors
    • B. Silva-Santos, D.J. Pennington, and A.C. Hayday Lymphotoxin-mediated regulation of γδ cell differentiation by αβ T cell progenitors Science 2004 DOI: 10.1126/science.1103978 This paper shows that DP thymocytes are capable of inducing the expression of a γδ-biased gene profile in γδ cells and their DN progenitors via lymphotoxin β receptor (LTβR) signalling. In normal mice, but not in pre-TCR-deficient mice, DP cells express the transcription factor RORγt and lymphotoxin ligands that act on LTβR-expressing DN and γδ thymocytes, thus conditioning the differentiation of γδ T cells.
    • (2004) Science
    • Silva-Santos, B.1    Pennington, D.J.2    Hayday, A.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.