Positive selection is not required for thymic maturation of transgenic γδ T cells

Journal of Experimental Medicine

Volumn 183, Issue 5, 1996, Pages 2033-2041

  Schweighoffer, Edina ^a   Fowlkes, B J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL MATURATION; LYMPHOCYTE DIFFERENTIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; BETA 2-MICROGLOBULIN; BONE MARROW; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CHIMERA; CROSSES, GENETIC; FLOW CYTOMETRY; H-2 ANTIGENS; IMMUNOPHENOTYPING; LYMPH NODES; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0029936945     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.5.2033     Document Type: Article

References (32)

1. Penninger, J., V.A. Wallace, K. Kishihara, T. Molina, H. Krause, and T.W. Mak. 1991. Molecular organization, ontogeny and expression of murine αβ and γδ T cell receptors. Exp. Clin. Immunogenet. 8:57-74.
2. Dent, A.L., L.A. Matis, F. Hooshmand, S.M. Widacki, J.A. Bluestone, and S.M. Hedrick. 1990. Self-reactive γδ T cells are eliminated in the thymus. Nature (Lond.). 343:714-719.
3. Matis, L.A., R. Cron, and J.A. Bluestone. 1987. Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes. Nature (Lond.). 330:262-264.
4. - T lymphocytes. J. Exp. Med. 168: 1899-1916.
5. van Kaer, L., M. Wu, Y. Ichikawa, K. Ito, M. Bonneville, S. Ostrand-Rosenberg, D.B. Murphy, and S. Tonegawa. 1991. Recognition of MHC TL gene products by γδ T cells. Immunol. Rev. 120:89-115.
6. Wells, F.B., Y. Tatsumi, J.A. Bluestone, S.M. Hedrick, J.P. Allison, and L.A. Matis. 1993. Phenotypic and functional analysis of positive selection in the γ/δ T cell lineage. J. Exp. Med. 177:1061-1070.
7. Wells, F.B., S.J. Gahm, S.M. Hedrick, J.A. Bluestone, A. Dent, and L.A. Matis. 1991. Requirement for positive selection of γδ receptor-bearing T cells. Science (Wash. DC). 253: 903-905.
8. Ito, K., L. van Kaer, M. Bonneville, S. Hsu, D.B. Murphy, and S. Tonegawa. 1990. Recognition of the product of a novel MHC TL region gene (27b) by a mouse γδ T cell receptor. Cell. 62:549-561.
9. Haas, W., P. Pereira, and S. Tonegawa. 1993. Gamma/delta cells. Annu. Rev. Immunol. 11:637-685.
10. Correa, I., M. Bix, N.S. Liao, M. Zijlstra, R. Jaenisch, and D. Raulet. 1992. Most γδ T cells develop normally in β2-microglobulin-deficient mice. Proc. Natl. Acad. Sci. USA. 89:653-657.
11. Pereira, P., M. Zijlstra, J. McMaster, J.M. Loring, R. Jaenisch, and S. Tonegawa. 1992. Blockade of transgenic γδ T cell development in β2-inicroglobulin deficient mice. EMBO (Eur. Mol. Biol. Organ.) J. 11:25-31.
12. Shinkai, Y., G. Rathbun, K.P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, and F.W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangements. Cell. 68:855-867.
13. + T cells. Science (Wash. DC). 248:1227-1230.
14. Coligan, J.E., A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, eds. 1994. Current Protocols in Immunology. John Wiley & Sons, Inc., New York.
15. Koo, G.C., F.J. Dumont, M. Tutt, J. Hackett, and V. Kumar. 1986. The NK-1.1(-) mouse: a model to study differentiation of murine NK cells. J. Immunol. 137:3742-3747.
16. Bruce, J., F.W. Symington, T.J. McKearn, and J. Sprent. 1981. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 127:2496-2501.
17. Mark, C., F. Figueroa, Z.A. Nagy, and J. Klein. 1982. Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen. Immunogenetics. 16:95-97.
18. + cells. J. Immunol. 138:1009-1013.
19. high expression induced by thymic selection events. J. Exp. Med. 176:1657-1663.
20. Robey, E., and B.J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12:675-705.
21. Mombaerts, P., A.R. Glarke, M.A. Rudnicki, J. Iacomini, S. Itohara, J.J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M.L. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature (Lond.). 360:225-231.
22. Bigby, M., J.S. Markovitz, P.A. Bleicher, M.J. Grusby, S. Simba, M. Siebrecht, M. Wagner, C. Nagler-Anderson, and L.H. Glimcher. 1993. Most γδ T cells develop normally in the absence of MHC class II molecules. J. Immunol. 151: 4465-4475.
23. Weintraub, B.C., M.R. Jackson, and S.M. Hedrick. 1994. Gamma delta T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides. J. Immunol. 153: 3051-3058.
24. Schild, H., N. Mavaddat, C. Litzenberger, E.W. Ehrich, M.M. Davis, J.A. Bluestone, L. Matis, R.K. Draper, and Y.H. Chien. 1994. The nature of major histocompatibility complex recognition by γδ T cells. Cell. 76:29-37.
25. Flaherty, L., E. Elliott, J.A. Tine, A.C. Walsh, and J.B. Waters. 1990. Immunogenetics of the Q and TL regions of the mouse. Crit. Rev. Immunol. 10:131-175.
26. Pircher, H., U.H. Rohrer, D. Moskophidis, R.M. Zinkernagel, and H. Hengartner. 1991. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature (Lond.). 351:482-485.
27. Vasquez, N.J., J. Kaye, and S.M. Hedrick. 1992. In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175:1307-1316.
28. Vidovic, D., M. Roglic, K. McKune, S. Guerder, C. Mackay, and Z. Dembic. 1989. Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma. Nature (Lond.). 340:646-650.
29. Matis, L.A., A.M. Fry, R.Q. Cron, M.M. Cotterman, R.F. Dick, and J.A. Bluestone. 1989. Structure and specificity of a class II MHC alloreactive γδ T cell receptor heterodimer. Science (Wash. DC). 245:746-749.
30. Born, W., M.P. Happ, A. Dallas, C. Reardon, R. Kubo, T. Shinnick, P. Brennan, and R. O'Brien. 1990. Recognition of heat shock proteins and γδ cell function. Immunol. Today 11: 40-43.
31. Rajasekar, R., G.K. Sim, and A. Augustin. 1990. Self heat shock and γδ T-cell reactivity. Proc. Natl. Acact. Sci. USA. 87: 1767-1771.
32. Tanaka, Y., S. Shigetoshi, E. Nieves, G. DeLibero, D. Rosa, R.L. Modlin, M.B. Brenner, B.R. Bloom, and C.T. Morita. 1994. Nonpeptide ligands for human γδ T cells. Proc. Natl. Acad. Sci. USA. 91:8175-8179.