Antigen recognition determinants of γδ T cell receptors

Science

Volumn 308, Issue 5719, 2005, Pages 252-255

  Shin, Sunny ^a   El Diwany, Ramy ^a   Schaffert, Steven ^a   Adams, Erin J ^a   Garcia, K Christopher ^a   Pereira, Pablo ^b   Chien, Yueh Hsiu ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; BIODIVERSITY; CELLS; TISSUE;

COMPLEMENTARITY-DETERMINING REGION 3 (CDR3); HISTOCOMPATIBILITY; RESIDUES; T CELL RECEPTOR (TCR);

ANTIGENS;

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PENTAPEPTIDE; SERYLGLUTAMYLGLYCYLTYROSYLGLUTAMIC ACID; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR GAMMA DELTA CHAIN; TETRAMER; TRYPTOPHAN; UNCLASSIFIED DRUG; ANTIGEN; HLA ANTIGEN CLASS 1; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN; T22 ANTIGEN;

BIOLOGY;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTER; GERM LINE; HUMAN; HUMAN CELL; INTESTINE CELL; LEUKEMIA CELL LINE; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN MOTIF; SPLEEN CELL; T LYMPHOCYTE; AMINO ACID SEQUENCE; BINDING SITE; GENE REARRANGEMENT; GENETICS; IMMUNOLOGY; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANTIGENS; BINDING SITES; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; JURKAT CELLS; LIGANDS; PROTEIN CONFORMATION; PROTEINS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES;

EID: 16444371002     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1106480     Document Type: Article

References (28)

1. A. C. Hayday, Annu. Rev. Immunol. 18, 975 (2000).
2. Y-h. Chien, R. Jores, M. P. Crowley, Annu. Rev. Immunol. 14, 511 (1996).
3. M. P. Crowley et al., Science 287, 314 (2000).
4. P. Pereira, D. Gerber, S. Y. Huang, S. Tonegawa, J. Exp. Med. 182, 1921 (1995).
5. A. I. Sperling, R. Q. Cron, D. C. Decker, D. A. Stern, J. A. Bluestone, J. Immunol. 149, 3200 (1992).
6. D. M. Asarnow, T. Goodman, L. LeFrancois, J. P. Allison, Nature 341, 60 (1989).
7. C. A. Janeway Jr., B. Jones, A. Hayday, Immunol. Today 9, 73 (1988).
8. Materials and methods are available on Science Online.
9. M. Bonneville et al., Proc. Natl. Acad. Sci. U.S.A. 86, 5928 (1989).
10. J. A. Bluestone, R. Q. Cron, M. Cotterman, B. A. Houlden, L. A. Matis, J. Exp. Med. 168, 1899 (1988).
11. P. S. Ohashi et al., Nature 316, 606 (1985).
12. S. Shin et al., unpublished data.
13. E. A. Adams, Y. Chien, K. C. Garcia, Science 308, 227 (2005).
14. J. L. Xu, M. M. Davis, Immunity 13, 37 (2000).
15. M. M. Davis, Y. Chien, in Fundamental Immunology, W. E. Paul, Ed. (Lippincott, Philadelphia, 2003).
16. S. Candeias, C. Waltzinger, C. Benoist, D. Mathis, J. Exp. Med. 174, 989 (1991).
17. J. Wu, V. Groh, T. Spies, J. Immunol. 169, 1236 (2002).
18. F. M. Spada et al., J. Exp. Med. 191, 937 (2000).
19. E. Scotet et al., Immunity 22, 71 (2005).
20. M. G. McHeyzer-Williams, M. M. Davis, Science 268, 106 (1995).
21. P. Bousso et al., Immunity 9, 169 (1998).
22. Single-letter abbreviations for the amino add residues are as follows: A. Ala; C. Cys; D. Asp; E. Glu; F. Phe; G. Gly; H. His; I. Ile; K. Lys; L. Leu; M. Met; N. Asn; P. Pro; Q. Gln; R. Arg; S. Ser; T. Thr; V. Val; W. Trp; and Y. Tyr.
23. E. P. Rock, P. R. Sibbald, M. M. Davis, Y. H. Chien, J. Exp. Med. 179, 323 (1994).
24. P. A. Savage, J. J. Boniface, M. M. Davis, Immunity 10, 485 (1999).
25. P. Pereira et al., Eur. J. Immunol. 30, 1988 (2000).
26. V. Azuara, M. P. Lembezat, P. Pereira, Eur. J. Immunol. 28, 3456 (1998).
27. P. Pereira, L. Boucontet J. Immunol. 173, 3261 (2004).
28. We thank M. Davis for critical review of the manuscript; Y. Konigshofer, K. Jensen, M. Krogsgaard, M. Kuhns, J. Huppa, R. Sciammas, and I. Brodsky for advice and reagents; L. Boucontet for technical assistance; and L. Lefrancois and L. Puddington for the antibody against Vγ5. Supported by NIH grant AI33431 (Y.-h.C.), the Association pour la Recherche sur le Cancer (P.P.), a Stanford Immunology training grant fellowship (E.J.A.), a National Institute of Allergy and Infectious Diseases Richard A. Asofsky Research Award (R.E.-D.), and an NSF predoctoral fellowship (S.S.).