-
1
-
-
64649104158
-
Banting Lecture. from the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
-
Defronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009; 58:773-795.
-
(2009)
Diabetes
, vol.58
, pp. 773-795
-
-
Defronzo, R.A.1
-
2
-
-
48149100986
-
Insulin action on glucose transporters through molecular switches, tracks and tethers
-
Zaid H, Antonescu CN, Randhawa VK, Klip A. Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem J 2008; 413:201-215.
-
(2008)
Biochem J
, vol.413
, pp. 201-215
-
-
Zaid, H.1
Antonescu, C.N.2
Randhawa, V.K.3
Klip, A.4
-
3
-
-
34248581989
-
Disordered lipid metabolism and the pathogenesis of insulin resistance
-
Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev 2007; 87:507-520.
-
(2007)
Physiol Rev
, vol.87
, pp. 507-520
-
-
Savage, D.B.1
Petersen, K.F.2
Shulman, G.I.3
-
4
-
-
43249083481
-
Free fatty acids and skeletal muscle insulin resistance
-
Kraegen EW, Cooney GJ. Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol 2008; 19:235-241.
-
(2008)
Curr Opin Lipidol
, vol.19
, pp. 235-241
-
-
Kraegen, E.W.1
Cooney, G.J.2
-
5
-
-
76049118432
-
Intramuscular triacylglycerol and insulin resistance: Guilty as charged or wrongly accused?
-
Muoio DM. Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused? Biochim Biophys Acta 2010; 1801:281-288.
-
(2010)
Biochim Biophys Acta
, vol.1801
, pp. 281-288
-
-
Muoio, D.M.1
-
6
-
-
67650831488
-
Insulin resistance, Prosperity's plague.
-
Taubes G. Insulin resistance. Prosperity's plague. Science 2009; 325:256-260.
-
(2009)
Science
, vol.325
, pp. 256-260
-
-
Taubes, G.1
-
7
-
-
42449097289
-
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
-
Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 2008; 9:367-377.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 367-377
-
-
Guilherme, A.1
Virbasius, J.V.2
Puri, V.3
Czech, M.P.4
-
8
-
-
68349110805
-
Obesity, inflammation, and insulin resistance: A mini-review
-
Zeyda M, Stulnig TM. Obesity, inflammation, and insulin resistance: a mini-review. Gerontology 2009; 55:379-386.
-
(2009)
Gerontology
, vol.55
, pp. 379-386
-
-
Zeyda, M.1
Stulnig, T.M.2
-
9
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444: 860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
10
-
-
51349156218
-
Insulin sensitivity: Modulation by nutrients and inflammation
-
Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 2008; 118:2992-3002.
-
(2008)
J Clin Invest
, vol.118
, pp. 2992-3002
-
-
Schenk, S.1
Saberi, M.2
Olefsky, J.M.3
-
11
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010; 72:219-246.
-
Annu Rev Physiol
, vol.2010
, Issue.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
12
-
-
0026087478
-
Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
-
Storlien LH, Jenkins AB, Chisholm DJ, et al. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 1991; 40:280-289.
-
(1991)
Diabetes
, vol.40
, pp. 280-289
-
-
Storlien, L.H.1
Jenkins, A.B.2
Chisholm, D.J.3
-
13
-
-
0026040907
-
Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats
-
Kraegen EW, Clark PW, Jenkins AB, et al. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 1991; 40:1397-1403.
-
(1991)
Diabetes
, vol.40
, pp. 1397-1403
-
-
Kraegen, E.W.1
Clark, P.W.2
Jenkins, A.B.3
-
14
-
-
0036316341
-
Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats.
-
Hegarty BD, Cooney GJ, Kraegen EW, FurlerSM. Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats. Diabetes 2002; 51:1477-1484.
-
(2002)
Diabetes
, vol.51
, pp. 1477-1484
-
-
Hegarty, B.D.1
Cooney, G.J.2
Kraegen, E.W.3
Furler, S.M.4
-
15
-
-
3342919078
-
Fiber type-and fatty acid composition-dependent effects of high-fat diets on rat muscle triacylglyceride and fatty acid transporter protein-1 content
-
Marotta M, Ferrer-Martnez A, Parnau J, et al. Fiber type-and fatty acid composition-dependent effects of high-fat diets on rat muscle triacylglyceride and fatty acid transporter protein-1 content. Metabolism 2004; 53:1032-1036.
-
(2004)
Metabolism
, vol.53
, pp. 1032-1036
-
-
Marotta, M.1
Ferrer-Martnez, A.2
Parnau, J.3
-
16
-
-
0037304548
-
A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle
-
Cameron-Smith D, Burke LM, Angus DJ, et al. A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle. Am J Clin Nutr 2003; 77:313-318.
-
(2003)
Am J Clin Nutr
, vol.77
, pp. 313-318
-
-
Cameron-Smith, D.1
Burke, L.M.2
Angus, D.J.3
-
17
-
-
33644846005
-
Skeletal muscle lipid metabolism in exercise and insulin resistance
-
Kiens B. Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol Rev 2006; 86:205-243.
-
(2006)
Physiol Rev
, vol.86
, pp. 205-243
-
-
Kiens, B.1
-
18
-
-
69949089944
-
Influence of gender, obesity, and muscle lipase activity on intramyocellular lipids in sedentary individuals
-
Moro C, Galgani JE, Luu L, et al. Influence of gender, obesity, and muscle lipase activity on intramyocellular lipids in sedentary individuals. J Clin Endocrinol Metab 2009; 94:3440-3447.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 3440-3447
-
-
Moro, C.1
Galgani, J.E.2
Luu, L.3
-
19
-
-
58549108633
-
Storing up trouble: Does accumulation of intramyocellular triglyceride protect skeletal muscle from insulin resistance?
-
Watt MJ. Storing up trouble: does accumulation of intramyocellular triglyceride protect skeletal muscle from insulin resistance? Clin Exp Pharmacol Physiol 2009; 36:5-11.
-
(2009)
Clin Exp Pharmacol Physiol
, vol.36
, pp. 5-11
-
-
Watt, M.J.1
-
20
-
-
34249894505
-
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
-
Liu L, Zhang Y, Chen N, et al. Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J Clin Invest 2007; 117:1679-1689.
-
(2007)
J Clin Invest
, vol.117
, pp. 1679-1689
-
-
Liu, L.1
Zhang, Y.2
Chen, N.3
-
21
-
-
70350545945
-
Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1
-
Liu L, Shi X, Choi CS, et al. Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. Diabetes 2009; 58:2516-2524.
-
(2009)
Diabetes
, vol.58
, pp. 2516-2524
-
-
Liu, L.1
Shi, X.2
Choi, C.S.3
-
22
-
-
0035217707
-
Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
-
Goodpaster BH, He J, WatkinsS, Kelley DE. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 2001; 86:5755-5761.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 5755-5761
-
-
Goodpaster, B.H.1
He, J.2
Watkinss Kelley, D.E.3
-
23
-
-
34447511610
-
Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: Potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation
-
Crunkhorn S, Dearie F, Mantzoros C, et al. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem 2007; 282:15439-15450.
-
(2007)
J Biol Chem
, vol.282
, pp. 15439-15450
-
-
Crunkhorn, S.1
Dearie, F.2
Mantzoros, C.3
-
24
-
-
21344444333
-
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle
-
Sparks LM, Xie H, Koza RA, et al. A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 2005; 54:1926-1933.
-
(2005)
Diabetes
, vol.54
, pp. 1926-1933
-
-
Sparks, L.M.1
Xie, H.2
Koza, R.A.3
-
25
-
-
15444370639
-
Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle
-
Richardson DK, Kashyap S, Bajaj M, et al. Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle. J Biol Chem 2005; 280:10290-10297.
-
(2005)
J Biol Chem
, vol.280
, pp. 10290-10297
-
-
Richardson, D.K.1
Kashyap, S.2
Bajaj, M.3
-
26
-
-
34547588219
-
Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
-
Turner N, Bruce CR, Beale SM, et al. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 2007; 56:2085-2092.
-
(2007)
Diabetes
, vol.56
, pp. 2085-2092
-
-
Turner, N.1
Bruce, C.R.2
Beale, S.M.3
-
27
-
-
45549089279
-
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
-
Hancock CR, Han DH, Chen M, et al. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci USA 2008; 105:7815-7820.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7815-7820
-
-
Hancock, C.R.1
Han, D.H.2
Chen, M.3
-
28
-
-
34547505089
-
Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle
-
Garcia-Roves P, Huss JM, Han DH, et al. Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. Proc Natl Acad Sci USA 2007; 104:10709-10713.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10709-10713
-
-
Garcia-Roves, P.1
Huss, J.M.2
Han, D.H.3
-
29
-
-
61849185113
-
Intramuscular lipid metabolism, insulin action, and obesity
-
Consitt LA, Bell JA, Houmard JA. Intramuscular lipid metabolism, insulin action, and obesity. IUBMB Life 2009; 61:47-55.
-
(2009)
IUBMB Life
, vol.61
, pp. 47-55
-
-
Consitt, L.A.1
Bell, J.A.2
Houmard, J.A.3
-
30
-
-
37449020075
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
-
Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008; 7:45-56.
-
(2008)
Cell Metab
, vol.7
, pp. 45-56
-
-
Koves, T.R.1
Ussher, J.R.2
Noland, R.C.3
-
31
-
-
21444460644
-
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes
-
Huang C, Thirone AC, Huang X, Klip A. Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes. J Biol Chem 2005; 280:19426-19435.
-
(2005)
J Biol Chem
, vol.280
, pp. 19426-19435
-
-
Huang, C.1
Thirone, A.C.2
Huang, X.3
Klip, A.4
-
32
-
-
55249098126
-
GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells
-
RandhawaVK, IshikuraS,Talior-Volodarsky I, etal.GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells. J Biol Chem 2008; 283:27208-27219.
-
(2008)
J Biol Chem
, vol.283
, pp. 27208-27219
-
-
Randhawa, V.K.1
Ishikura, S.2
Talior-Volodarsky, I.3
-
33
-
-
57049184703
-
Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation
-
Ishikura S, Klip A. Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation. Am J Physiol Cell Physiol 2008; 295: C1016-C1025.
-
(2008)
Am J Physiol Cell Physiol
, vol.295
-
-
Ishikura, S.1
Klip, A.2
-
34
-
-
42949084209
-
Muscular diacylglycerol metabolism and insulin resistance
-
Timmers S, Schrauwen P, de Vogel J. Muscular diacylglycerol metabolism and insulin resistance. Physiol Behav 2008; 94:242-251.
-
(2008)
Physiol Behav
, vol.94
, pp. 242-251
-
-
Timmers, S.1
Schrauwen, P.2
De Vogel, J.3
-
35
-
-
33845989841
-
Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
-
Gao Z, Wang Z, Zhang X, et al. Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. Am J Physiol Endocrinol Metab 2007; 292:E84-91.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.292
-
-
Gao, Z.1
Wang, Z.2
Zhang, X.3
-
36
-
-
70349338611
-
Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: Evidence for PKC activation and oxidative stress-activated signaling pathways
-
Ragheb R, Shanab GM, Medhat AM, et al. Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. Biochem Biophys Res Commun 2009; 389:211-216.
-
(2009)
Biochem Biophys Res Commun
, vol.389
, pp. 211-216
-
-
Ragheb, R.1
Shanab, G.M.2
Medhat, A.M.3
-
37
-
-
43849111991
-
Acute elevation of circulating fatty acids impairs downstream insulin signalling in rat skeletal muscle in vivo independent of effects on stress signalling
-
FrangioudakisG, CooneyGJ. Acute elevation of circulating fatty acids impairs downstream insulin signalling in rat skeletal muscle in vivo independent of effects on stress signalling. J Endocrinol 2008; 197:277-285.
-
(2008)
J Endocrinol
, vol.197
, pp. 277-285
-
-
Frangioudakis, G.1
Cooney, G.J.2
-
38
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidyli-nositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidyli-nositol 3-kinase activity in muscle. J Biol Chem 2002; 277:50230-50236.
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
-
39
-
-
33847797255
-
Skeletal muscle lipid deposition and insulin resistance: Effect of dietary fatty acids and exercise
-
Corcoran MP, Lamon-Fava S, Fielding RA. Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise. Am J Clin Nutr 2007; 85:662-677.
-
(2007)
Am J Clin Nutr
, vol.85
, pp. 662-677
-
-
Corcoran, M.P.1
Lamon-Fava, S.2
Fielding, R.A.3
-
40
-
-
8544244084
-
PKC-theta knockout mice are protected from fat-induced insulin resistance
-
KimJK, Fillmore JJ, Sunshine MJ, et al. PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest 2004; 114:823-827.
-
(2004)
J Clin Invest
, vol.114
, pp. 823-827
-
-
Kimj, K.1
Fillmore, J.J.2
Sunshine, M.J.3
-
41
-
-
8544233570
-
Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
-
Li Y, Soos TJ, Li X, et al. Protein kinase C theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem 2004; 279:45304-45307.
-
(2004)
J Biol Chem
, vol.279
, pp. 45304-45307
-
-
Li, Y.1
Soos, T.J.2
Li, X.3
-
42
-
-
0035126784
-
Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: Overexpression of protein kinase cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia
-
Ikeda Y, Olsen GS, Ziv E, et al. Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of protein kinase cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia. Diabetes 2001; 50:584-592.
-
(2001)
Diabetes
, vol.50
, pp. 584-592
-
-
Ikeda, Y.1
Olsen, G.S.2
Ziv, E.3
-
43
-
-
0037608687
-
Transgenic mice with dominant negative PKC-theta in skeletal muscle: A new model of insulin resistance and obesity
-
Serra C, Federici M, Buongiorno A, et al. Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity. J Cell Physiol 2003; 196:89-97.
-
(2003)
J Cell Physiol
, vol.196
, pp. 89-97
-
-
Serra, C.1
Federici, M.2
Buongiorno, A.3
-
44
-
-
67650069923
-
Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation
-
Hoy AJ, Brandon AE, Turner N, et al. Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. Am J Physiol Endocrinol Metab 2009; 297:E67-75.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
-
-
Hoy, A.J.1
Brandon, A.E.2
Turner, N.3
-
45
-
-
0038691609
-
IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress
-
Potashnik R, Bloch-Damti A, Bashan N, Rudich A. IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress. Diabetologia 2003; 46:639-648.
-
(2003)
Diabetologia
, vol.46
, pp. 639-648
-
-
Potashnik, R.1
Bloch-Damti, A.2
Bashan, N.3
Rudich, A.4
-
46
-
-
42649127400
-
IRS1-independent defects define major nodes of insulin resistance.
-
Hoehn KL, Hohnen-BehrensC, Cederberg A, et al. IRS1-independent defects define major nodes of insulin resistance. Cell Metab 2008; 7:421-433.
-
(2008)
Cell Metab
, vol.7
, pp. 421-433
-
-
Hoehn, K.L.1
Hohnen-Behrens, C.2
Cederberg, A.3
-
47
-
-
72649098413
-
Irs1 serine 307 promotes insulin sensitivity in mice
-
Copps KD, Hancer NJ, Opare-Ado L, et al. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab 2010; 11:84-92.
-
(2010)
Cell Metab
, vol.11
, pp. 84-92
-
-
Copps, K.D.1
Hancer, N.J.2
Opare-Ado, L.3
-
48
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
Holland WL, Brozinick JT, Wang LP, et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab 2007; 5:167-179.
-
(2007)
Cell Metab
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.P.3
-
49
-
-
59849098608
-
Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells
-
Watson ML, Coghlan M, Hundal HS. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells. Biochem J 2009; 417:791-801.
-
(2009)
Biochem J
, vol.417
, pp. 791-801
-
-
Watson, M.L.1
Coghlan, M.2
Hundal, H.S.3
-
50
-
-
73249127400
-
Skeletal muscle lipogenic protein expression is not different between lean and obese individuals: A potential factor in ceramide accumulation
-
Thrush AB, Brindley DN, Chabowski A, et al. Skeletal muscle lipogenic protein expression is not different between lean and obese individuals: a potential factor in ceramide accumulation. J Clin Endocrinol Metab 2009; 94:5053-5061.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 5053-5061
-
-
Thrush, A.B.1
Brindley, D.N.2
Chabowski, A.3
-
51
-
-
31644443192
-
Ceramides in insulin resistance and lipotoxicity
-
Summers SA. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 2006; 45:42-72.
-
(2006)
Prog Lipid Res
, vol.45
, pp. 42-72
-
-
Summers, S.A.1
-
52
-
-
45149106053
-
Sphingolipids, insulin resistance, and metabolic disease: New insights from in vivo manipulation of sphingolipid metabolism
-
Holland WL, Summers SA. Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr Rev 2008; 29:381-402.
-
(2008)
Endocr Rev
, vol.29
, pp. 381-402
-
-
Holland, W.L.1
Summers, S.A.2
-
53
-
-
4544242908
-
Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells.
-
Powell DJ, Turban S, Gray A, et al. Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J 2004; 382:619-629.
-
(2004)
Biochem J
, vol.382
, pp. 619-629
-
-
Powell, D.J.1
Turban, S.2
Gray, A.3
-
54
-
-
70449348631
-
Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells.
-
Bilan PJ, Samokhvalov V, KoshkinaA, et al. Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells. Arch Physiol Biochem 2009; 115:176-190.
-
(2009)
Arch Physiol Biochem
, vol.115
, pp. 176-190
-
-
Bilan, P.J.1
Samokhvalov, V.2
Koshkina, A.3
-
55
-
-
33847026801
-
Ceramide-and oxidant-induced insulin resistance involve loss of insulin-dependent rac-activation and actin remodeling in muscle cells.
-
JeBailey L, Wanono O, Niu W, et al. Ceramide-and oxidant-induced insulin resistance involve loss of insulin-dependent rac-activation and actin remodeling in muscle cells. Diabetes 2007; 56:394-403.
-
(2007)
Diabetes
, vol.56
, pp. 394-403
-
-
Jebailey, L.1
Wanono, O.2
Niu, W.3
-
56
-
-
34250303939
-
Key role for ceramides in mediating insulin resistance in human muscle cells
-
Pickersgill L, Litherland GJ, Greenberg AS, et al. Key role for ceramides in mediating insulin resistance in human muscle cells. J Biol Chem 2007; 282:12583-12589.
-
(2007)
J Biol Chem
, vol.282
, pp. 12583-12589
-
-
Pickersgill, L.1
Litherland, G.J.2
Greenberg, A.S.3
-
57
-
-
44749091972
-
Ceramide: A contributor to insulin resistance or an innocent bystander?
-
Boden G. Ceramide: a contributor to insulin resistance or an innocent bystander? Diabetologia 2008; 51:1095-1096.
-
(2008)
Diabetologia
, vol.51
, pp. 1095-1096
-
-
Boden, G.1
-
58
-
-
44749085396
-
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
-
Skovbro M, Baranowski M, Skov-Jensen C, et al. Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity. Diabetologia 2008; 51:1253-1260.
-
(2008)
Diabetologia
, vol.51
, pp. 1253-1260
-
-
Skovbro, M.1
Baranowski, M.2
Skov-Jensen, C.3
-
59
-
-
34848921862
-
Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes.
-
Straczkowski M, Kowalska I, Baranowski M, et al. Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes. Diabetologia 2007; 50:2366-2373.
-
(2007)
Diabetologia
, vol.50
, pp. 2366-2373
-
-
Straczkowski, M.1
Kowalska, I.2
Baranowski, M.3
-
60
-
-
62749140758
-
Overexpression of carnitine palmitoyl-transferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance
-
Bruce CR, Hoy AJ, Turner N, et al. Overexpression of carnitine palmitoyl-transferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes 2009; 58:550-558.
-
(2009)
Diabetes
, vol.58
, pp. 550-558
-
-
Bruce, C.R.1
Hoy, A.J.2
Turner, N.3
-
61
-
-
65549085127
-
Medium-chain fatty acids ameliorate insulin resistance caused by high-fat diets in rats
-
Wein S, Wolffram S, Schrezenmeir J, et al. Medium-chain fatty acids ameliorate insulin resistance caused by high-fat diets in rats. Diabetes Metab Res Rev 2009; 25:185-194.
-
(2009)
Diabetes Metab Res Rev
, vol.25
, pp. 185-194
-
-
Wein, S.1
Wolffram, S.2
Schrezenmeir, J.3
-
62
-
-
75249106467
-
Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?
-
Samocha-Bonet D, Heilbronn LK, Lichtenberg D, Campbell LV. Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals? Trends Endocrinol Metab 2010; 21:83-88.
-
(2010)
Trends Endocrinol Metab
, vol.21
, pp. 83-88
-
-
Samocha-Bonet, D.1
Heilbronn, L.K.2
Lichtenberg, D.3
Campbell, L.V.4
-
63
-
-
58249110569
-
Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species.
-
Bashan N, Kovsan J, Kachko I, et al. Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species. Physiol Rev 2009; 89:27-71.
-
(2009)
Physiol Rev
, vol.89
, pp. 27-71
-
-
Bashan, N.1
Kovsan, J.2
Kachko, I.3
-
64
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006; 116:3015-3025.
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
-
66
-
-
40449086344
-
Skeletal muscle insulin resistance: Role of inflammatory cytokines and reactive oxygen species
-
Wei Y, Chen K, Whaley-Connell AT, et al. Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species. Am J Physiol Regul Integr Comp Physiol 2008; 294:R673-680.
-
(2008)
Am J Physiol Regul Integr Comp Physiol
, vol.294
-
-
Wei, Y.1
Chen, K.2
Whaley-Connell, A.T.3
-
67
-
-
29344471474
-
Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation
-
Jove M, Planavila A, Sanchez RM, et al. Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation. Endocrinology 2006; 147:552-561.
-
(2006)
Endocrinology
, vol.147
, pp. 552-561
-
-
Jove, M.1
Planavila, A.2
Sanchez, R.M.3
-
68
-
-
58249096193
-
Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent
-
Hommelberg PP, Plat J, Langen RC, et al. Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. Am J Physiol Endocrinol Metab 2009; 296:E114-120.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
Hommelberg, P.P.1
Plat, J.2
Langen, R.C.3
-
69
-
-
50949089015
-
SiRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle
-
Austin RL, Rune A, Bouzakri K, et al. siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. Diabetes 2008; 57:2066-2073.
-
(2008)
Diabetes
, vol.57
, pp. 2066-2073
-
-
Austin, R.L.1
Rune, A.2
Bouzakri, K.3
-
70
-
-
34247253249
-
MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-{alpha}-induced insulin resistance
-
Bouzakri K, Zierath JR. MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-{alpha}-induced insulin resistance. J Biol Chem 2007; 282:7783-7789.
-
(2007)
J Biol Chem
, vol.282
, pp. 7783-7789
-
-
Bouzakri, K.1
Zierath, J.R.2
-
71
-
-
63249117466
-
Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
-
Haus JM, Kashyap SR, Kasumov T, et al. Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 2009; 58:337-343.
-
(2009)
Diabetes
, vol.58
, pp. 337-343
-
-
Haus, J.M.1
Kashyap, S.R.2
Kasumov, T.3
-
72
-
-
64149103697
-
Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans
-
Kaddai V, Jager J, Gonzalez T, et al. Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans. Diabe-tologia 2009; 52:932-940.
-
(2009)
Diabe-tologia
, vol.52
, pp. 932-940
-
-
Kaddai, V.1
Jager, J.2
Gonzalez, T.3
-
73
-
-
21344439799
-
Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes
-
Shi J, Kandror KV. Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes. Dev Cell 2005; 9:99-108.
-
(2005)
Dev Cell
, vol.9
, pp. 99-108
-
-
Shi, J.1
Kandror, K.V.2
-
74
-
-
22144498471
-
Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells
-
Jove M, Planavila A, Laguna JC, Vazquez-Carrera M. Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells. Endocrinology 2005; 146:3087-3095.
-
(2005)
Endocrinology
, vol.146
, pp. 3087-3095
-
-
Jove, M.1
Planavila, A.2
Laguna, J.C.3
Vazquez-Carrera, M.4
-
75
-
-
58149345626
-
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle
-
Nieto-Vazquez I, Fernandez-Veledo S, de Alvaro C, Lorenzo M. Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle. Diabetes 2008; 57:3211-3221.
-
(2008)
Diabetes
, vol.57
, pp. 3211-3221
-
-
Nieto-Vazquez, I.1
Fernandez-Veledo, S.2
De Alvaro, C.3
Lorenzo, M.4
-
76
-
-
2642561229
-
Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB
-
Weigert C, Brodbeck K, Staiger H, et al. Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. J Biol Chem 2004; 279:23942-23952.
-
(2004)
J Biol Chem
, vol.279
, pp. 23942-23952
-
-
Weigert, C.1
Brodbeck, K.2
Staiger, H.3
-
77
-
-
41549158736
-
The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6
-
Roher N, Samokhvalov V, Diaz M, et al. The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6. Endocrinology 2008; 149:1880-1889.
-
(2008)
Endocrinology
, vol.149
, pp. 1880-1889
-
-
Roher, N.1
Samokhvalov, V.2
Diaz, M.3
-
78
-
-
51349111709
-
Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats
-
Holmes AG, Mesa JL, Neill BA, et al. Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats. J Endocrinol 2008; 198:367-374.
-
(2008)
J Endocrinol
, vol.198
, pp. 367-374
-
-
Holmes, A.G.1
Mesa, J.L.2
Neill, B.A.3
-
79
-
-
44749084540
-
Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice
-
Franckhauser S, Elias I, Rotter Sopasakis V, et al. Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice. Diabetologia 2008; 51:1306-1316.
-
(2008)
Diabetologia
, vol.51
, pp. 1306-1316
-
-
Franckhauser, S.1
Elias, I.2
Rotter Sopasakis, V.3
-
80
-
-
12144290761
-
Differential effects of interleukin-6 and-10 on skeletal muscle and liver insulin action in vivo
-
Kim HJ, Higashimori T, Park SY, et al. Differential effects of interleukin-6 and-10 on skeletal muscle and liver insulin action in vivo. Diabetes 2004; 53:1060-1067.
-
(2004)
Diabetes
, vol.53
, pp. 1060-1067
-
-
Kim, H.J.1
Higashimori, T.2
Park, S.Y.3
-
81
-
-
58249117853
-
Palmitate-and lipopolysacchar-ide-activated macrophages evoke contrasting insulin responses in muscle cells
-
Samokhvalov V, Bilan PJ, Schertzer JD, et al. Palmitate-and lipopolysacchar-ide-activated macrophages evoke contrasting insulin responses in muscle cells. Am J Physiol Endocrinol Metab 2009; 296:E37-46.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
Samokhvalov, V.1
Bilan, P.J.2
Schertzer, J.D.3
-
82
-
-
70350561703
-
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle
-
Hong EG, Ko HJ, Cho YR, et al. Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes 2009; 58:2525-2535.
-
(2009)
Diabetes
, vol.58
, pp. 2525-2535
-
-
Hong, E.G.1
Ko, H.J.2
Cho, Y.R.3
-
83
-
-
70350455753
-
The origin of intermuscular adipose tissue and its pathophysiological implications
-
Vettor R, Milan G, Franzin C, et al. The origin of intermuscular adipose tissue and its pathophysiological implications. Am J Physiol Endocrinol Metab 2009; 297:987-998.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
, pp. 987-998
-
-
Vettor, R.1
Milan, G.2
Franzin, C.3
-
84
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112:1796-1808.
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
-
85
-
-
36849005372
-
ASubpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via toll-like receptors 2 and 4 and JNK-dependent pathways
-
Nguyen MT, FavelyukisS, Nguyen AK, et al. ASubpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 2007; 282:35279-35292.
-
(2007)
J Biol Chem
, vol.282
, pp. 35279-35292
-
-
Nguyen, M.T.1
Favelyukiss Nguyen, A.K.2
-
86
-
-
52749092267
-
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
-
Patsouris D, Li PP, Thapar D, et al. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008; 8:301-309.
-
(2008)
Cell Metab
, vol.8
, pp. 301-309
-
-
Patsouris, D.1
Li, P.P.2
Thapar, D.3
-
87
-
-
34249907880
-
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
-
Hevener AL, Olefsky JM, Reichart D, et al. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 2007; 117:1658-1669.
-
(2007)
J Clin Invest
, vol.117
, pp. 1658-1669
-
-
Hevener, A.L.1
Olefsky, J.M.2
Reichart, D.3
-
88
-
-
66849093697
-
Muscle inflammatory response and insulin resistance: Synergistic interaction between macrophages and fatty acids leads to impaired insulin action
-
Varma V, Yao-Borengasser A, Rasouli N, et al. Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. Am J Physiol Endocrinol Metab 2009; 296:E1300-E1310.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
-
-
Varma, V.1
Yao-Borengasser, A.2
Rasouli, N.3
-
89
-
-
33646397556
-
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
-
Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab 2006; 290:E961-967.
-
(2006)
Am J Physiol Endocrinol Metab
, vol.290
-
-
Bruun, J.M.1
Helge, J.W.2
Richelsen, B.3
Stallknecht, B.4
-
90
-
-
23644446750
-
Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: Association with cytokine expression, insulin resistance, and reduction by pioglitazone
-
Di Gregorio GB, Yao-Borengasser A, Rasouli N, et al. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 2005; 54:2305-2313.
-
(2005)
Diabetes
, vol.54
, pp. 2305-2313
-
-
Di Gregorio, G.B.1
Yao-Borengasser, A.2
Rasouli, N.3
-
91
-
-
77949690002
-
DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation
-
Koliwad SK, Streeper RS, Monetti M, et al. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest 2010; 120:756-767.
-
(2010)
J Clin Invest
, vol.120
, pp. 756-767
-
-
Koliwad, S.K.1
Streeper, R.S.2
Monetti, M.3
-
92
-
-
54549096762
-
Mechanisms of macrophage activation in obesity-induced insulin resistance
-
Odegaard JI, Chawla A. Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat Clin Pract Endocrinol Metab 2008; 4:619-626.
-
(2008)
Nat Clin Pract Endocrinol Metab
, vol.4
, pp. 619-626
-
-
Odegaard, J.I.1
Chawla, A.2
-
93
-
-
4344614649
-
Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
-
Stratford S, Hoehn KL, Liu F, Summers SA. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J Biol Chem 2004; 279:36608-36615.
-
(2004)
J Biol Chem
, vol.279
, pp. 36608-36615
-
-
Stratford, S.1
Hoehn, K.L.2
Liu, F.3
Summers, S.A.4
|