Palmitate induces tumor necrosis factor-α expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-κB activation

Endocrinology

Volumn 147, Issue 1, 2006, Pages 552-561

  Jové, Mireia ^a   Planavila, Anna ^a   Sánchez, Rosa M ^a   Merlos, Manuel ^a   Laguna, Juan Carlos ^a   Vázquez Carrera, Manuel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALPHOSTIN C; CHELERYTHRINE; FATTY ACID; GLUCOSE TRANSPORTER 4; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; ISOENZYME; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PALMITIC ACID; PARTHENOLIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PYRROLIDINE DITHIOCARBAMATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CORRELATION ANALYSIS; DOWN REGULATION; ENZYME ACTIVATION; GLUCOSE TRANSPORT; INCUBATION TIME; INSULIN RESISTANCE; MOUSE; MUSCLE CELL; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INDUCTION; SKELETAL MUSCLE;

ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; BIOLOGICAL TRANSPORT; CELL LINE; ENZYME INHIBITORS; GLUCOSE; MICE; MUSCLE, SKELETAL; NAPHTHALENES; NF-KAPPA B; PALMITIC ACID; PHENANTHRIDINES; PROTEIN KINASE C; PYRROLIDINES; SESQUITERPENES; THIOCARBAMATES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 29344471474     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-0440     Document Type: Article

References (49)

1. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C 1991 Effects of fat on insulin-stimulated carbohydrate-metabolism in normal men. J Clin Invest 88:960-966
2. Boden G, Chen XH 1995 Effects of fat on glucose-uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 96:1261-1268
3. Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI 1996 Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97:2859-2865
4. Boden G 1997 Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10
5. Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA 1996 The expression of TNF α by human muscle-relationship to insulin resistance. J Clin Invest 97:1111-1116
6. Hotamisligil GS, Spiegelman BM 1994 Tumor-necrosis-factor-α-a key component of the obesity-diabetes link. Diabetes 43:1271-1278
7. Itani SI, Ruderman NB, Schmieder F, Boden G 2002 Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α. Diabetes 51:2005-2011
8. Evans JL, Goldfine ID, Maddux BA, Grodsky GM 2002 Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23:599-622
9. Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee JS, Yuan MS, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI 2001 Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 108:437-446
10. Yuan MS, Konstantopoulos N, Lee JS, Hansen L, Li ZW, Karin M, Shoelson SE 2001 Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ. Science 293:1673-1677
11. Bronfman M, Morales MN, Orellana A 1988 Diacylglycerol activation of protein kinase-C is modulated by long-chain acyl-CoA. Biochem Biophys Res Commun 152:987-992
12. Nishizuka Y 1995 Protein kinases. 5. Protein-kinase-C and lipid signaling for sustained cellular-responses. FASEB J 9:484-496
13. SchmitzPeiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ 1997 Alterations in the expression and cellular localization of protein kinase C isozymes ε and θ are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 46:169-178
14. Ruderman NB, Saha AK, Vavvas D, Witters LA 1999 Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol Endocrinol Metab 276:1
15. Heydrick SJ, Ruderman NB, Kurowski TG, Adams HB, Chen KS 1991 Enhanced stimulation of diacylglycerol and lipid-synthesis by insulin in denervated muscle-altered protein-kinase-C activity and possible link to insulin resistance. Diabetes 40:1707-1711
16. Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI 1999 Free fatty acid-induced insulin resistance is associated with activation of protein kinase Cθ and alterations in the insulin signaling cascade. Diabetes 48:1270-1274
17. Cortright RN, Azevedo JL, Zhou Q, Sinha M, Pories WJ, Itani SI, Dohm GL 2000 Protein kinase C modulates insulin action in human skeletal muscle.AmJ Physiol Endocrinol Metab 278:E553-E562
18. Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL 2000 Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes 49:1353-1358
19. Chavez JA, Knotts TA, Wang LP, Li GB, Dobrowsky RT, Florant GL, Summers SA 2003 A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 278:10297-10303
20. Cabrero A, Alegret M, Sanchez RM, Adzet T, Laguna JC, Vazquez M 2001 Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes. Diabetes 50:1883-1890
21. Freeman WM, Walker SJ, Vrana KE 1999 Quantitative RT-PCR: pitfalls and potential. Biotechniques 26:112-122, 124-125
22. Andrews NC, Faller DV 1991 A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian-cells. Nucleic Acids Res 19:2499
23. Gorski J, Nawrocki A, Murthy M 1998 Characterization of free and glyceride-esterified long chain fatty acids in different skeletal muscle types of the rat. Mol Cell Biochem 178:113-118
24. Schmitz-Peiffer C, Craig DL, Biden TJ 1999 Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 274:24202-24210
25. Mingrone G, Rosa G, Di Rocco P, Manco M, Capristo E, Castagneto M, Vettor R, Gasbarrini G, Greco AV 2002 Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-α reduction and GLUT4 expression enhancement. Int J Obes 26:1165-1172
26. Paumen MB, Ishida Y, Muramatsu M, Yamamoto M, Honjo T 1997 Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem 272:3324-3329
27. Miyake Y, Kozutsumi Y, Nakamura S, Fujita T, Kawasaki T 1995 Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, Isp-1/Myriocin. Biochem Biophys Res Commun 211:396-403
28. Poynter ME, Daynes RA 1998 Peroxisome proliferator-activated receptor activation modulates cellular redox status, represses nuclear factor κB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 273:32833-32841
29. Ghosh S, Baltimore D 1990 Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature 344:678-682
30. Hehner SP, Heinrich M, Bork PM, Vogt M, Ratter F, Lehmann V, Schulze-Osthoff K, Droge W, Schmitz ML 1998 Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J Biol Chem 273:1288-1297
31. Kobayashi E, Ando K, Nakano H, Iida T, Ohno H, Morimoto M, Tamaoki T 1989 Calphostins (Ucn-1028), novel and specific inhibitors of protein kinase-C. 1. Fermentation, isolation, physicochemical properties and biological-activities. J Antibiot 42:1470-1474
32. Herbert JM, Augereau JM, Gleye J, Maffrand JP 1990 Chelerythrine is a potent and specific inhibitor of protein-kinase-C. Biochem Biophys Res Commun 172:993-999
33. Randle PJ, Garland PB, Newsholme EA, Hales CN 1963 Glucose fatty-acid cycle-its role in insulin sensitivity and metabolic disturbances of diabetes mellitus. Lancet 1:785
34. Socher SH, Martinez D, Craig JB, Kuhn JG, Oliff A 1988 Tumor necrosis factor not detectable in patients with clinical cancer cachexia. J Natl Cancer Inst 80:595-598
35. Grunfeld C, Feingold KR 1992 Seminars in medicine of the Beth-Israel-Hospital, Boston-metabolic disturbances and wasting in the acquired-immunodeficiency-syndrome. N Engl J Med 327:329-337
36. de Alvaro C, Teruel T, Hernandez R, Lorenzo M 2004 Tumor necrosis factor α produces insulin resistance in skeletal muscle by activation of inhibitor κB kinase in a p38 MAPK-dependent manner. J Biol Chem 279:17070-17078
37. Fabris R, Nisoli E, Lombardi AM, Tonello C, Serra R, Granzotto M, Cusin I, Bohner-Jeanrenaud F, Federspil G, Carruba MO, Vettor R 2001 Preferential channeling of energy fuels toward fat rather than muscle during high free fatty acid availability in rats. Diabetes 50:601-608
38. Manco M, Mingrone G, Greco AV, Capristo E, Gniuli D, De GA, Gasbarrini G 2000 Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides. Metabolism 49:220-224
39. Liu LS, Spelleken M, Rohrig K, Hauner H, Eckel J 1998 Tumor necrosis factor-α acutely inhibits insulin signaling in human adipocytes- implication of the p80 tumor necrosis factor receptor. Diabetes 47:515-522
40. Peraldi P, Xu M, Spiegelman BM 1997 Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signaling. J Clin Invest 100:1863-1869
41. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS 1997 Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 389:610-614
42. Perseghin G, Scifo P, De Cobelli F, Pagliato E, Battezzati A, Arcelloni C, Vanzulli A, Testolin G, Pozza G, Del Maschio A, Luzi L 1999 Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans-a H-1-C-13 nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600-1606
43. Li Y, Soos TJ, Li XH, Wu J, DeGennaro M, Sun XJ, Littman DR, Birnbaum MJ, Polakiewicz RD 2004 Protein kinase Cθ inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem 279:45304-45307
44. Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D 2000 Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest 105:199-205
45. Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline GW, O'Brien WR, Littman DR, Shulman GI 2004 PKC-θ knockout mice are protected from fat-induced insulin resistance. J Clin Invest 114:823-827
46. Udalova IA, Kwiatkowski D 2001 Interaction of AP-1 with a cluster of NF-κB binding elements in the human TNF promoter region. Biochem Biophys Res Commun 289:25-33
47. Udalova IA, Vidal V, Scragg IG, Kwiatkowski D 2000 Direct evidence for involvement of NF-κB in transcriptional activation of tumor necrosis factor by a spirochetal lipoprotein. Infect Immun 68:5447-5449
48. Hagemann C, Blank JL 2001 The ups and downs of MEK kinase interactions. Cell Signal 13:863-875
49. Siow YL, Kalmar GB, Sanghera JS, Tai G, Oh SS, Pelech SL 1997 Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1-indirect activation by Pak3 and protein kinase C. J Biol Chem 272:7586-7594