메뉴 건너뛰기




Volumn 51, Issue 7, 2008, Pages 1253-1260

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity

Author keywords

Diabetes; Diacylglycerol; Fat mass; Lipids; Resistance; Training; Triacylglycerol

Indexed keywords

CERAMIDE;

EID: 44749085396     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-1014-z     Document Type: Article
Times cited : (109)

References (34)
  • 1
    • 19644394512 scopus 로고    scopus 로고
    • The metabolic syndrome: Requiescat in pace
    • Reaven GM (2005) The metabolic syndrome: requiescat in pace. Clin Chem 51:931-938
    • (2005) Clin Chem , vol.51 , pp. 931-938
    • Reaven, G.M.1
  • 2
    • 0035405847 scopus 로고    scopus 로고
    • Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects
    • Boden G, Lebed B, Schatz M, Homko C, Lemieux S (2001) Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50:1612-1617
    • (2001) Diabetes , vol.50 , pp. 1612-1617
    • Boden, G.1    Lebed, B.2    Schatz, M.3    Homko, C.4    Lemieux, S.5
  • 3
    • 0042767662 scopus 로고    scopus 로고
    • Effect of training on muscle triacylglycerol and structural lipids: A relation to insulin sensitivity?
    • Helge JW, Dela F (2003) Effect of training on muscle triacylglycerol and structural lipids: a relation to insulin sensitivity? Diabetes 52:1881-1887
    • (2003) Diabetes , vol.52 , pp. 1881-1887
    • Helge, J.W.1    Dela, F.2
  • 4
    • 0030969532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride levels are inversely related to insulin action
    • Pan DA, Lillioja S, Kriketos AD et al (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983-988
    • (1997) Diabetes , vol.46 , pp. 983-988
    • Pan, D.A.1    Lillioja, S.2    Kriketos, A.D.3
  • 5
    • 0036224883 scopus 로고    scopus 로고
    • 1H nuclear magnetic resonance spectroscopy in lean and obese adolescents: Relationships to insulin sensitivity, total body fat, and central adiposity
    • 1H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51:1022-1027
    • (2002) Diabetes , vol.51 , pp. 1022-1027
    • Sinha, R.1    Dufour, S.2    Petersen, K.F.3
  • 6
    • 0035487317 scopus 로고    scopus 로고
    • Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle
    • Virkamaki A, Korsheninnikova E, Seppala-Lindroos A et al (2001) Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 50:2337-2343
    • (2001) Diabetes , vol.50 , pp. 2337-2343
    • Virkamaki, A.1    Korsheninnikova, E.2    Seppala-Lindroos, A.3
  • 7
    • 0036097562 scopus 로고    scopus 로고
    • Insulin resistance in morbid obesity: Reversal with intramyocellular fat depletion
    • Greco AV, Mingrone G, Giancaterini A et al (2002) Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. Diabetes 51:144-151
    • (2002) Diabetes , vol.51 , pp. 144-151
    • Greco, A.V.1    Mingrone, G.2    Giancaterini, A.3
  • 8
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, White JV, Rossseti L (1994) Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossseti, L.5
  • 9
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • Summers SA (2006) Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 45:42-72
    • (2006) Prog Lipid Res , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 10
    • 0031841949 scopus 로고    scopus 로고
    • Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
    • Summers SA, Garza LA, Zhou H, Birnbaum MJ (1998) Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol 18:5457-5464
    • (1998) Mol Cell Biol , vol.18 , pp. 5457-5464
    • Summers, S.A.1    Garza, L.A.2    Zhou, H.3    Birnbaum, M.J.4
  • 11
    • 0346729968 scopus 로고    scopus 로고
    • Ceramide content is increased in skeletal muscle from obese insulin-resistant humans
    • Adams JM, Pratipanawatr T, Berria R et al (2004) Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 53:25-31
    • (2004) Diabetes , vol.53 , pp. 25-31
    • Adams, J.M.1    Pratipanawatr, T.2    Berria, R.3
  • 12
    • 34848921862 scopus 로고    scopus 로고
    • Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes
    • Straczkowski M, Kowalska I, Baranowski M et al (2007) Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes. Diabetologia 50:2366-2373
    • (2007) Diabetologia , vol.50 , pp. 2366-2373
    • Straczkowski, M.1    Kowalska, I.2    Baranowski, M.3
  • 13
    • 33745841299 scopus 로고    scopus 로고
    • Endurance training in obese humans improves glucose tolerance, mitochondrial fatty acid oxidation and alters muscle lipid content
    • Bruce CR, Thrush AB, Mertz VA et al (2006) Endurance training in obese humans improves glucose tolerance, mitochondrial fatty acid oxidation and alters muscle lipid content. Am J Physiol Endocrinol Metab 291:E99-E107
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Bruce, C.R.1    Thrush, A.B.2    Mertz, V.A.3
  • 14
    • 1642503772 scopus 로고    scopus 로고
    • Exercise and training effects on ceramide metabolism in human skeletal muscle
    • Helge JW, Dobrzyn A, Saltin B, Gorski J (2004) Exercise and training effects on ceramide metabolism in human skeletal muscle. Exp Physiol 89:119-127
    • (2004) Exp Physiol , vol.89 , pp. 119-127
    • Helge, J.W.1    Dobrzyn, A.2    Saltin, B.3    Gorski, J.4
  • 15
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani SI, Ruderman NB, Schmieder F, Boden G (2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51:2005-2011
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 16
    • 2342621476 scopus 로고    scopus 로고
    • Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle
    • Straczkowski M, Kowalska I, Nikolajuk A et al (2004) Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle. Diabetes 53:1215-1221
    • (2004) Diabetes , vol.53 , pp. 1215-1221
    • Straczkowski, M.1    Kowalska, I.2    Nikolajuk, A.3
  • 17
    • 0002390471 scopus 로고
    • Muscle electrolytes in man: Determined by neutron activation analysis on needle biopsy specimens. a study on normal subjects, kidney patients and patients with chronic diarrhea
    • Bergström J (1962) Muscle electrolytes in man: determined by neutron activation analysis on needle biopsy specimens. A study on normal subjects, kidney patients and patients with chronic diarrhea. Scand J Clin Lab Invest Suppl 68:11-13
    • (1962) Scand J Clin Lab Invest Suppl , vol.68 , pp. 11-13
    • Bergström, J.1
  • 18
    • 0014838245 scopus 로고
    • Three 'myosin ATPase' systems: The nature of their pH lability and sulfhydryl dependence
    • Brooke MH, Kaiser KK (1970) Three 'myosin ATPase' systems: the nature of their pH lability and sulfhydryl dependence. J Histochem Cytochem 18:670-672
    • (1970) J Histochem Cytochem , vol.18 , pp. 670-672
    • Brooke, M.H.1    Kaiser, K.K.2
  • 19
    • 0030064775 scopus 로고    scopus 로고
    • Types of carbohydrate in an ordinary diet affect insulin action and muscle substrates in humans
    • Kiens B, Richter EA (1996) Types of carbohydrate in an ordinary diet affect insulin action and muscle substrates in humans. Am J Clin Nutr 63:47-53
    • (1996) Am J Clin Nutr , vol.63 , pp. 47-53
    • Kiens, B.1    Richter, E.A.2
  • 20
    • 33745761355 scopus 로고    scopus 로고
    • Muscle triacylglycerol and hormone-sensitive lipase activity in untrained and trained human muscles
    • Helge JW, Biba TO, Galbo H, Gaster M, Donsmark M (2006) Muscle triacylglycerol and hormone-sensitive lipase activity in untrained and trained human muscles. Eur J Appl Physiol 97:566-572
    • (2006) Eur J Appl Physiol , vol.97 , pp. 566-572
    • Helge, J.W.1    Biba, T.O.2    Galbo, H.3    Gaster, M.4    Donsmark, M.5
  • 21
    • 0036084833 scopus 로고    scopus 로고
    • Ceramides and sphingomyelins in skeletal muscles of the rat: Content and composition. Effect of prolonged exercise
    • Dobrzyn A, Gorski J (2002) Ceramides and sphingomyelins in skeletal muscles of the rat: content and composition. Effect of prolonged exercise. Am J Physiol Endocrinol 282:E277-E285
    • (2002) Am J Physiol Endocrinol , vol.282
    • Dobrzyn, A.1    Gorski, J.2
  • 22
    • 0036291379 scopus 로고    scopus 로고
    • The sphingomyelin-signaling pathway in skeletal muscles and its role in regulation of glucose uptake
    • Gorski J, Dobrzyn A, Zendzian-Piotrowska M (2002) The sphingomyelin-signaling pathway in skeletal muscles and its role in regulation of glucose uptake. Ann N Y Acad Sci 967:236-248
    • (2002) Ann N Y Acad Sci , vol.967 , pp. 236-248
    • Gorski, J.1    Dobrzyn, A.2    Zendzian-Piotrowska, M.3
  • 23
    • 34147145049 scopus 로고    scopus 로고
    • Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects
    • Serlie MJ, Meijer AJ, Groener JE et al (2007) Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects. J Clin Endocrinol Metab 92:1524-1529
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1524-1529
    • Serlie, M.J.1    Meijer, A.J.2    Groener, J.E.3
  • 24
    • 0030669471 scopus 로고    scopus 로고
    • Evidence of an increased number of type IIB muscle fibers in insulin resistant first degree relatives of patients with NIDDM
    • Nyholm B, Qu Zq, Kaal A et al (1997) Evidence of an increased number of type IIB muscle fibers in insulin resistant first degree relatives of patients with NIDDM. Diabetes 46:1822-1828
    • (1997) Diabetes , vol.46 , pp. 1822-1828
    • Nyholm, B.1    Zq, Q.2    Kaal, A.3
  • 25
    • 33646403717 scopus 로고    scopus 로고
    • Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patients
    • Ostergard T, Andersen JL, Nyholm B et al (2006) Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patients. Am J Physiol Endocrinol Metab 290:E998-E1005
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Ostergard, T.1    Andersen, J.L.2    Nyholm, B.3
  • 26
    • 33847332202 scopus 로고    scopus 로고
    • Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    • Holland WL, Brozinick JT, Wang LP et al (2007) Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab 5:167-179
    • (2007) Cell Metab , vol.5 , pp. 167-179
    • Holland, W.L.1    Brozinick, J.T.2    Wang, L.P.3
  • 27
    • 38949210754 scopus 로고    scopus 로고
    • Effect of gender on lipid-induced insulin resistance in obese subjects
    • Vistisen B, Hellgren LI, Vadset T et al (2008) Effect of gender on lipid-induced insulin resistance in obese subjects. Eur J Endocrinol 158:61-68
    • (2008) Eur J Endocrinol , vol.158 , pp. 61-68
    • Vistisen, B.1    Hellgren, L.I.2    Vadset, T.3
  • 28
    • 0033749620 scopus 로고    scopus 로고
    • Signalling aspects of insulin resistance in skeletal muscle: Mechanisms induced by lipid oversupply
    • Schmitz-Peiffer C (2000) Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply. Cell Signal 12:583-594
    • (2000) Cell Signal , vol.12 , pp. 583-594
    • Schmitz-Peiffer, C.1
  • 29
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer C, Craig DL, Biden TJ (1999) Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 274:24202-24210
    • (1999) J Biol Chem , vol.274 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 30
    • 3142624494 scopus 로고    scopus 로고
    • Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat
    • Dobrzyn A, Zendzian-Piotrowska M, Gorski J (2004) Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat. J Physiol Pharmacol 55:305-313
    • (2004) J Physiol Pharmacol , vol.55 , pp. 305-313
    • Dobrzyn, A.1    Zendzian-Piotrowska, M.2    Gorski, J.3
  • 31
    • 0035217707 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
    • Goodpaster BH, He J, Watkins S, Kelley DE (2001) Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86:5755-5761
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5755-5761
    • Goodpaster, B.H.1    He, J.2    Watkins, S.3    Kelley, D.E.4
  • 32
    • 33644846005 scopus 로고    scopus 로고
    • Skeletal muscle lipid metabolism in exercise and insulin resistance
    • Kiens B (2006) Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol Rev 86:205-243
    • (2006) Physiol Rev , vol.86 , pp. 205-243
    • Kiens, B.1
  • 33
    • 0036628008 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride: Marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?
    • Goodpaster BH, Kelley DE (2002) Skeletal muscle triglyceride: marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus? Curr Diab Rep 2:216-222
    • (2002) Curr Diab Rep , vol.2 , pp. 216-222
    • Goodpaster, B.H.1    Kelley, D.E.2
  • 34
    • 0035345532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance
    • Kelley DE, Goodpaster BH (2001) Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance. Diabetes Care 24:933-941
    • (2001) Diabetes Care , vol.24 , pp. 933-941
    • Kelley, D.E.1    Goodpaster, B.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.