Peroxisome proliferator activator receptor γ coactivator-1 expression is reduced in obesity: Potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation

Journal of Biological Chemistry

Volumn 282, Issue 21, 2007, Pages 15439-15450

  Crunkhorn, Sarah ^a   Dearie, Farrell ^a   Mantzoros, Christos ^a   Gami, Hiral ^a   Da Silva, Wagner S ^b   Espinoza, Daniel ^a   Faucette, Ryan ^a   Barry, Kristen ^a   Bianco, Antonio C ^b   Patti, Mary Elizabeth ^a,c  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL GENES; MYOTUBES; PROTEIN KINASE ACTIVATION; SATURATED FATTY ACIDS;

CELL MEMBRANES; ENZYME ACTIVITY; FATTY ACIDS; PATHOGENS; PHOSPHORYLATION;

GENE EXPRESSION;

AMINO ACID; GLUCOSAMINE; GLUCOSE; HISTONE DEACETYLASE; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; OXYGEN; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; SATURATED FATTY ACID; SMALL INTERFERING RNA; STEARIC ACID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; MITOCHONDRIAL PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; SWEETENING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL MOUSE; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE ACTIVITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; LIPID DIET; MALE; MITOCHONDRIAL GENE; MOUSE; MUSCLE TISSUE; MYOTUBE; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REDUCTION; ADIPOSE TISSUE; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; FAT INTAKE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE MUTANT; MUSCLE CELL; SIGNAL TRANSDUCTION; TIME;

MUS;

ADIPOSE TISSUE; AMINO ACIDS; ANIMALS; CELL LINE; CITRIC ACID CYCLE; DIETARY FATS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GLUCOSAMINE; GLUCOSE; HISTONE DEACETYLASES; HYPOGLYCEMIC AGENTS; INSULIN; MAP KINASE SIGNALING SYSTEM; MICE; MICE, OBESE; MITOCHONDRIAL PROTEINS; MUSCLE FIBERS; OBESITY; OXIDATIVE PHOSPHORYLATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PALMITIC ACID; RNA, MESSENGER; SWEETENING AGENTS; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 34447511610     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611214200     Document Type: Article

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