Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor B activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells

Endocrinology

Volumn 146, Issue 7, 2005, Pages 3087-3095

  Jové, Mireia ^a   Planavila, Anna ^a   Laguna, Juan Carlos ^a   Vázquez Carrera, Manuel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALPHOSTIN C; GLUCOSE TRANSPORTER 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PALMITIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PYRROLIDINE DITHIOCARBAMATE; CERAMIDE; GLUCOSE TRANSPORTER; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MUSCLE PROTEIN; PALMITIC ACID DERIVATIVE; SLC2A4 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE EXPRESSION; GLUCOSE TRANSPORT; INCUBATION TIME; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SKELETAL MUSCLE; TRANSCRIPTION INITIATION; ANIMAL; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL LINE; CERAMIDES; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE TRANSPORTER TYPE 4; INTERLEUKIN-6; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; NF-KAPPA B; PALMITATES; PROTEIN KINASE C; RNA, MESSENGER;

EID: 22144498471     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1560     Document Type: Article

References (48)

1. DeFronzo RA, Ferrannini E 1991 Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194
2. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C 1991 Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88:960-966
3. Boden G, Chen XH 1995 Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 96:1261-1268
4. Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI 1996 Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97:2859-2865
5. Boden G 1997 Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10
6. Bronfman M, Morales MN, Orellana A 1988 Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA. Biochem Biophys Res Commun 152:987-992
7. Nishizuka Y 1995 Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9:484-496
8. SchmitzPeiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ 1997 Alterations in the expression and cellular localization of protein kinase C isozymes ε and θ are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 46:169-178
9. Ruderman NB, Saha AK, Vavvas D, Witters LA 1999 Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol Endocrinol Metabol 276:E1-E18
10. Heydrick SJ, Ruderman NB, Kurowski TG, Adams HB, Chen KS 1991 Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle: altered protein kinase C activity and possible link to insulin resistance. Diabetes 40:1707-1711
11. Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI 1999 Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade. Diabetes 48:1270-1274
12. Cortright RN, Azevedo JL, Zhou Q, Sinha M, Pories WJ, Itani SI, Dohm GL 2000 Protein kinase C modulates insulin action in human skeletal muscle.AmJ Physiol Endocrinol Metabol 278:E553-E562
13. Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL 2000 Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes 49:1353-1358
14. Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA 2003 A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 278:10297-10303
15. Pickup JC, Mattock MB, Chusney GD, Burt D 1997 NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40:1286-1292
16. Kern PA, Ranganathan S, Li CL, Wood L, RanganathanG2001 Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metabol 280:E745-E751
17. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM 2001 C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334
18. Starkie RL, Arkinstall MJ, Koukoulas I, Hawley JA, Febbraio MA 2001 Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans. J Physiol 533:585-591
19. Pedersen BK, Steensberg A, Fischer C, Keller C, Ostrowski K, Schjerling P 2001 Exercise and cytokines with particular focus on muscle-derived IL-6. Exerc Immunol Rev 7:18-31
20. Carey AL, Lamont B, Andrikopoulos S, Koukoulas I, Proietto J, FebbraioMA 2003 Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation. Biochem Biophys Res Commun 302: 837-840
21. Kosmidou I, Vassilakopoulos T, Xagorari A, Zakynthinos S, Papapetropoulos A, Roussos C 2002 Production of interleukin-6 by skeletal myotubes; role of reactive oxygen species. Am J Respir Cell Mol Biol 26:587-593
22. Frost RA, Nystrom GJ, Lang CH 2002 Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle.AmJ Physiol Regul Integr Comp Physiol 283:R698-R709
23. Febbraio MA, Pedersen BK 2002 Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 16:1335-1347
24. Freeman WM, Walker SJ, Vrana KE 1999 Quantitative RT-PCR: pitfalls and potential. Biotechniques 26:112-115
25. Cabrero A, Alegret M, Sanchez RM, Adzet T, Laguna JC, Vázquez-Carrera M 2002 Increased reactive oxygen species production down-regulates peroxisome proliferator-activated pathway in C2C12 skeletal muscle cells. J Biol Chem 277:10100-10107
26. Andrews NC, Faller DV 1991 A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 19:2499
27. Gorski J, Nawrocki A, Murthy M 1998 Characterization of free and glycerideesterified long chain fatty acids in different skeletal muscle types of the rat. Mol Cell Biochem 178:113-118
28. Shimamura M, Matsuda M, Ando Y, Koishi R, Yasumo H, Furukawa H, Shimomura L 2004 Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor. Biochem Biophys Res Commun 322:1080-1085
29. Paumen MB, Ishida Y, Muramatsu M, Yamamoto M, Honjo T 1997 Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem 272:3324-3329
30. Miyake Y, Kozutsumi Y, Nakamura S, Fujita T, Kawasaki T 1995 Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, Isp-1/myriocin. Biochem Biophys Res Commun 211:396-403
31. Poynter ME, Daynes RA 1998 Peroxisome proliferator-activated receptor activation modulates cellular redox status, represses nuclear factor κB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 273:32833-32841
32. Hehner SP, Heinrich M, Bork PM, Vogt M, Ratter F, Lehmann V, Schulze-Osthoff K, Droge W, Schmitz ML 1998 Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J Biol Chem 273:1288-1297
33. Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee JS, Yuan MS, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI 2001 Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 108:437-446
34. Kobayashi E, Ando K, Nakano H, Iida T, Ohno H, Morimoto M, Tamaoki T 1989 Calphostins (UCN-1028), novel and specific inhibitors of protein kinase-C. 1. Fermentation, isolation, physicochemical properties and biological activities. J Antibiot (Tokyo) 42:1470-1474
35. Sanders JL, Stern PH 1996 Expression and phorbol ester sensitivity of protein kinase C (PKC) isozymes in osteoblasts. FASEB J 10:3923
36. Bordin L, Priante G, Musacchio E, Giunco S, Tibaldi E, Clari G, Baggio B2003 Arachidonic acid-induced IL-6 expression is mediated by PKC α activation in osteoblastic cells. Biochemistry 42:4485-4491
37. Ravichandran LV, Esposito DL, Chen J, Quon MJ 2001 Protein kinase C-ζ phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin. J Biol Chem 276:3543-3549
38. Sinha S, Perdomo G, Brown NF, O'Doherty RM 2004 Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor κB. J Biol Chem 279:41294-41301
39. Lagathu C, Bastard JP, Auclair M, Maachi M, Capeau J, Caron M 2003 Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocytes: prevention by rosiglitazone. Biochem Biophys Res Commun 311:372-379
40. Rotter V, Nagaev I, Smith U 2003 Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-α, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278:45777-45784
41. Senn JJ, Klover PJ, Nowak IA, MooneyRA2002 Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51:3391-3399
42. Klover PJ, Zimmers TA, Koniaris LG, Mooney RA 2003 Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52:2784-2789
43. Senn JJ, Klover PJ, Noway I, Furlanetto IR, Mooney RA 2002 Suppressor of cytokine signaling-3 (SOCS-3) is a potential mediator of interleukin-6 dependent insulin resistance. Diabetes 51:A324
44. GauthierRouviere C, Vandromme M, Tuil D, Lautredou N, Morris M, Soulez M, Kahn A, Fernandez A, Lamb N 1996 Expression and activity of serum response factor is required for expression of the muscle-determining factor MyoD in both dividing and differentiating mouse C2C12 myoblasts. Mol Biol Cell 7:719-729
45. Chin JE, Dickens M, Tavare JM, Roth RA 1993 Overexpression of protein kinase C isoenzymes-α, β-I, γ, and ε in cells overexpressing the insulin receptor: effects on receptor phosphorylation and signaling. J Biol Chem 268:6338-6347
46. Itani SI, Ruderman NB, Schmieder F, Boden G 2002 Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and I κ B-α. Diabetes 51:2005-2011
47. Ghosh S, Baltimore D 1990 Activation in vitro of NF-κB by phosphorylation of its inhibitor I-κB. Nature 344:678-682
48. Weigert C, Brodbeck K, Staiger H, Kausch C, Machicao F, Haring HU, Schleicher ED 2004 Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-κB. J Biol Chem 279: 23942-23952