Single chain variable fragment against nicastrin inhibits the γ-secretase activity

Journal of Biological Chemistry

Volumn 284, Issue 41, 2009, Pages 27838-27847

  Hayashi, Ikuo ^a   Takatori, Sho ^a   Urano, Yasuomi ^b   Iwanari, Hiroko ^b,c   Isoo, Noriko ^a   Osawa, Satoko ^a   Fukuda, Maiko A ^a   Kodama, Tatsuhiko ^b   Hamakubo, Takao ^b   Li, Tong ^d   Wong, Philip C ^d   Tomita, Taisuke ^a   Iwatsubo, Takeshi ^a,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Perseus Proteomics   (Japan)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BIOCHEMICAL ANALYSIS; CALNEXIN CYCLE; DUAL ROLE; ESSENTIAL COMPONENT; EXTRACELLULAR DOMAINS; GLYCOSYL; INTRAMEMBRANE PROTEOLYSIS; MEMBRANE PROTEIN COMPLEX; MEMBRANE PROTEINS; MOLECULAR TARGETING; NICASTRIN; OVER-EXPRESSION; PRECURSOR PROTEINS; PROTEOLYTIC ACTIVITIES; SECRETASE COMPLEX; SECRETASES; SINGLE CHAIN VARIABLE FRAGMENTS;

GLYCOPROTEINS;

PROTEINS;

CALNEXIN; GAMMA SECRETASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5201C; MONOCLONAL ANTIBODY 5201F; NICASTRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STABILITY; GLYCOSYLATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIBODIES; CELL LINE; ENZYME INHIBITORS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; INDOLIZINES; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

EID: 70350458706     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.055061     Document Type: Article

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