Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18650-18661

  Kim, Elizabeth D ^a   Buckley, Rebecca ^a   Learman, Sarah ^b   Richard, Jessica ^a   Parke, Courtney ^a   Worthylake, David K ^a   Wojcik, Edward J ^a   Walker, Richard A ^b   Kim, Sunyoung ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SURFACE; BIOCHEMICAL KINETICS; BOUND STATE; DRUG EFFICACY; DRUG RESPONSE; DRUG SENSITIVITY; HYDROGEN BONDINGS; IR SPECTROSCOPY; KINESINS; LIGAND BINDING; LONG DISTANCES; LONG RANGE EFFECTS; MECHANOCHEMICAL COUPLINGS; MECHANOCHEMICALS; MULTI VARIATE ANALYSIS; SOLUTION STRUCTURES; WILD TYPES;

DECISION MAKING; HYDROGEN BONDS; INFRARED SPECTROSCOPY; LIGANDS; MULTIVARIANT ANALYSIS;

PRINCIPAL COMPONENT ANALYSIS;

ADENOSINE TRIPHOSPHATASE; ENZYME INHIBITOR; KINESIN; KINESIN 5; KINESIN 5 INHIBITOR; LIGAND; MYOSIN; NUCLEOTIDE TRIPHOSPHATASE; PHOSPHATASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME LOCALIZATION; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; WILD TYPE;

ALLOSTERIC SITE; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; KINESIN; LIGANDS; MITOSIS; MYOSINS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTON-TRANSLOCATING ATPASES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 77953315697     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.092072     Document Type: Article

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