Crystal structure of HsEg5 in complex with clinical candidate CK0238273 provides insight into inhibitory mechanism, potency, and specificity

Biochemical and Biophysical Research Communications

Volumn 372, Issue 4, 2008, Pages 565-570

  Zhang, Bin ^a   Liu, Ji Feng ^a   Xu, Yingwu ^a   Ng, Shi Chung ^a  

^a ARQULE INC   (United States)

Author keywords

Allosteric inhibition; CK0238273; HsEg5; Mitotic kinesin; X ray structure

Indexed keywords

ARGININE; GLYCINE; HSEG5; ISPINESIB; KINESIN; MONASTROL; QUINAZOLINONE DERIVATIVE;

ALLOSTERISM; ARTICLE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; DRUG INHIBITION; DRUG POTENCY; DRUG SPECIFICITY; HYDROPHOBICITY; INTROSPECTION; PRIORITY JOURNAL; PROTEIN DOMAIN;

ALLOSTERIC REGULATION; ANTINEOPLASTIC AGENTS; ARGININE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GLYCINE; HUMANS; KINESIN; ORGANIC CHEMICALS; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; THIONES;

EID: 45449094955     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.05.074     Document Type: Article

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