Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5

Rapid Communications in Mass Spectrometry

Volumn 20, Issue 3, 2006, Pages 456-462

  Brier, Sébastien ^a   Lemaire, David ^a   DeBonis, Salvatore ^a   Kozielski, Frank ^a   Forest, Eric ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DEUTERIUM; MASS SPECTROMETRY; PROTEINS;

DEUTERIUM INCORPORATIONS; EXPERIMENTAL PROCEDURE; HEAVY CHAIN; HYDROGEN/DEUTERIUM EXCHANGE; INCORPORATION RATES; KINESINS; MITOTIC KINESIN EG5; MOTOR DOMAIN; PROTEIN-BINDING; SECONDARY STRUCTURE ELEMENTS;

MUTAGENESIS;

EID: 32044442051     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.2329     Document Type: Article

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