Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis

Archives of Biochemistry and Biophysics

Volumn 484, Issue 1, 2009, Pages 1-7

  Marshall, C Gary ^a   Torrent, Maricel ^a   Williams, Olusegun ^a   Hamilton, Kelly A ^a   Buser, Carolyn A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Allosteric; ATP competitive; Drug resistance; Inhibitor; Kinesin; KSP; L5 loop; Mutagenesis

Indexed keywords

ADENOSINE TRIPHOSPHATE; KINESIN; KINESIN SPINDLE PROTEIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CATALYSIS; ENZYME ACTIVITY; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; SPINDLE CELL; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING, COMPETITIVE; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINESIN; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 62349131427     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.01.015     Document Type: Article

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